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Case Report Open Access

A three‑way complex translocation of (15;15;17)(q24;q14;q21) involving two breakpoints on chromosome 15 in acute promyelocytic leukemia: A case report

  • Authors:
    • Do-Hoon Kim
  • View Affiliations / Copyright

    Affiliations: Department of Laboratory Medicine, Keimyung University School of Medicine, Daegu, North Gyeongsang 42601, Republic of Korea
    Copyright: © Kim et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 309
    |
    Published online on: June 2, 2023
       https://doi.org/10.3892/ol.2023.13895
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Abstract

The present study described an extremely rare case of acute promyelocytic leukemia (APL) characterized by a complex three‑way (15;15;17)(q24;q14;q21) translocation. It was identified in a 59‑year‑old male through karyotype, molecular, and fluorescence in situ hybridization (FISH) analyses. The third translocation breakpoint 15q14 was identified on the same chromosome 15 that also contained the classical t(15;17)(q24;q21) and may have evolved from the classical t(15;17) clone, as indicated by interphase FISH analysis. A complex translocation involving two breakpoints on the same chromosome is extremely rare, such that this case can provide insights into complex translocations in APL.
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1 

de Thé H, Chomienne C, Lanotte M, Degos L and Dejean A: The t(15;17) translocation of acute promyelocytic leukaemia fuses the retinoic acid receptor alpha gene to a novel transcribed locus. Nature. 347:558–561. 1990. View Article : Google Scholar : PubMed/NCBI

2 

Gagnon MF, Berg HE, Meyer RG, Sukov WR, Van Dyke DL, Jenkins RB, Greipp PT, Thorland EC, Hoppman NL, Xu X, et al: Typical, atypical and cryptic t(15;17)(q24;q21) (PML::RARA) observed in acute promyelocytic leukemia: A retrospective review of 831 patients with concurrent chromosome and PML::RARA dual-color dual-fusion FISH studies. Genes Chromosomes Cancer. 61:629–634. 2022. View Article : Google Scholar : PubMed/NCBI

3 

Grimwade D, Biondi A, Mozziconacci MJ, Hagemeijer A, Berger R, Neat M, Howe K, Dastugue N, Jansen J, Radford-Weiss I, et al: Characterization of acute promyelocytic leukemia cases lacking the classic t(15;17): Results of the European working party. Groupe Français de Cytogénétique Hématologique, Groupe de Français d'Hematologie Cellulaire, UK Cancer Cytogenetics Group and BIOMED 1 European community-concerted action ‘molecular cytogenetic diagnosis in haematological malignancies’. Blood. 96:1297–1308. 2000.PubMed/NCBI

4 

Kakizuka A, Miller WH Jr, Umesono K, Warrell RP Jr, Frankel SR, Murty VV, Dmitrovsky E and Evans RM: Chromosomal translocation t(15;17) in human acute promyelocytic leukemia fuses RAR alpha with a novel putative transcription factor, PML. Cell. 66:663–674. 1991. View Article : Google Scholar : PubMed/NCBI

5 

Kato T, Hangaishi A, Ichikawa M, Motokura T, Takahashi T and Kurokawa M: A new three-way variant t(15;22;17)(q22;q11.2;q21) in acute promyelocytic leukemia. Int J Hematol. 89:204–208. 2009. View Article : Google Scholar : PubMed/NCBI

6 

Tirado CA, Jahn JA, Scheerle J, Eid M, Meister RJ, Christie RJ, Croft CD, Wallingford S, Heritage DW, Mowrey PN and Meloni-Ehrig AM: Variant acute promyelocytic leukemia translocation (15;17) originating from two subsequent balanced translocations involving the same chromosomes 15 and 17 while preserving the PML/RARA fusion. Cancer Genet Cytogenet. 161:70–73. 2005. View Article : Google Scholar : PubMed/NCBI

7 

Koboldt DC, Zhang Q, Larson DE, Shen D, McLellan MD, Lin L, Miller CA, Mardis ER, Ding L and Wilson RK: VarScan 2: Somatic mutation and copy number alteration discovery in cancer by exome sequencing. Genome Res. 22:568–576. 2012. View Article : Google Scholar : PubMed/NCBI

8 

Wang Y, Ma J, Liu X, Liu R, Xu L, Wang L, Cen J and Chu X: A complex translocation (3;17;15) in acute promyelocytic leukemia confirmed by fluorescence in situ hybridization. Oncol Lett. 12:4717–4719. 2016. View Article : Google Scholar : PubMed/NCBI

9 

Lv L, Yang L, Cui H and Ma T: A complex translocation (1;17;15) with spliced short-type PML-RARA fusion transcripts in acute promyelocytic leukemia: A case report. Exp Ther Med. 17:1360–1366. 2019.PubMed/NCBI

10 

Wan TS, Chim CS, So CK, Chan LC and Ma SK: Complex variant 15;17 translocations in acute promyelocytic leukemia. A case report and review of three-way translocations. Cancer Genet Cytogenet. 111:139–143. 1999. View Article : Google Scholar : PubMed/NCBI

11 

Tirado CA, Golembiewski-Ruiz V, Horvatinovich J, Moore JO, Buckley PJ, Stenzel TT and Goodman BK: Cytogenetic and molecular analysis of an unusual case of acute promyelocytic leukemia with a t(15;17;17)(q22;q23;q21). Cancer Genet Cytogenet. 145:31–37. 2003. View Article : Google Scholar : PubMed/NCBI

12 

Liu S, Li Q, Pang W, Bo L, Qin S, Liu X, Teng Q, Qian L and Wang J: A new complex variant t(4;15;17) in acute promyelocytic leukemia: Fluorescence in situ hybridization confirmation and literature review. Cancer Genet Cytogenet. 130:33–37. 2001. View Article : Google Scholar : PubMed/NCBI

13 

Yoo SJ, Seo EJ, Lee JH, Seo YH, Park PW and Ahn JY: A complex, four-way variant t(15;17) in acute promyelocytic leukemia. Cancer Genet Cytogenet. 167:168–171. 2006. View Article : Google Scholar : PubMed/NCBI

14 

Morel F, Herry A, Le Bris MJ, Morice P, Bouquard P, Abgrall JF, Berthou C and De Braekeleer M: Contribution of fluorescence in situ hybridization analyses to the characterization of masked and complex Philadelphia chromosome translocations in chronic myelocytic leukemia. Cancer Genet Cytogenet. 147:115–120. 2003. View Article : Google Scholar : PubMed/NCBI

15 

Reddy KS and Sulcova V: A FISH study of variant Philadelphia rearrangements. Cancer Genet Cytogenet. 118:121–131. 2000. View Article : Google Scholar : PubMed/NCBI

16 

Mrózek K: Molecular cytogenetics in acute myeloid leukemia in adult patients: Practical implications. Pol Arch Intern Med. 132:163002022.PubMed/NCBI

17 

Zhang Y and Rowley JD: Chromatin structural elements and chromosomal translocations in leukemia. DNA Repair (Amst). 5:1282–1297. 2006. View Article : Google Scholar : PubMed/NCBI

18 

Viguié F, Aboura A, Ramond S, Bouscary D, Baudard M, Chomienne C and Marie JP: Submicroscopic insertion of RARalpha gene into chromosome 15 in two cases of acute promyelocytic leukemia. Cancer Genet Cytogenet. 119:162–164. 2000. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Kim D: A three‑way complex translocation of (15;15;17)(q24;q14;q21) involving two breakpoints on chromosome 15 in acute promyelocytic leukemia: A case report. Oncol Lett 26: 309, 2023.
APA
Kim, D. (2023). A three‑way complex translocation of (15;15;17)(q24;q14;q21) involving two breakpoints on chromosome 15 in acute promyelocytic leukemia: A case report. Oncology Letters, 26, 309. https://doi.org/10.3892/ol.2023.13895
MLA
Kim, D."A three‑way complex translocation of (15;15;17)(q24;q14;q21) involving two breakpoints on chromosome 15 in acute promyelocytic leukemia: A case report". Oncology Letters 26.1 (2023): 309.
Chicago
Kim, D."A three‑way complex translocation of (15;15;17)(q24;q14;q21) involving two breakpoints on chromosome 15 in acute promyelocytic leukemia: A case report". Oncology Letters 26, no. 1 (2023): 309. https://doi.org/10.3892/ol.2023.13895
Copy and paste a formatted citation
x
Spandidos Publications style
Kim D: A three‑way complex translocation of (15;15;17)(q24;q14;q21) involving two breakpoints on chromosome 15 in acute promyelocytic leukemia: A case report. Oncol Lett 26: 309, 2023.
APA
Kim, D. (2023). A three‑way complex translocation of (15;15;17)(q24;q14;q21) involving two breakpoints on chromosome 15 in acute promyelocytic leukemia: A case report. Oncology Letters, 26, 309. https://doi.org/10.3892/ol.2023.13895
MLA
Kim, D."A three‑way complex translocation of (15;15;17)(q24;q14;q21) involving two breakpoints on chromosome 15 in acute promyelocytic leukemia: A case report". Oncology Letters 26.1 (2023): 309.
Chicago
Kim, D."A three‑way complex translocation of (15;15;17)(q24;q14;q21) involving two breakpoints on chromosome 15 in acute promyelocytic leukemia: A case report". Oncology Letters 26, no. 1 (2023): 309. https://doi.org/10.3892/ol.2023.13895
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