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A three‑way complex translocation of (15;15;17)(q24;q14;q21) involving two breakpoints on chromosome 15 in acute promyelocytic leukemia: A case report

  • Authors:
    • Do-Hoon Kim
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  • Published online on: June 2, 2023     https://doi.org/10.3892/ol.2023.13895
  • Article Number: 309
  • Copyright: © Kim . This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

The present study described an extremely rare case of acute promyelocytic leukemia (APL) characterized by a complex three‑way (15;15;17)(q24;q14;q21) translocation. It was identified in a 59‑year‑old male through karyotype, molecular, and fluorescence in situ hybridization (FISH) analyses. The third translocation breakpoint 15q14 was identified on the same chromosome 15 that also contained the classical t(15;17)(q24;q21) and may have evolved from the classical t(15;17) clone, as indicated by interphase FISH analysis. A complex translocation involving two breakpoints on the same chromosome is extremely rare, such that this case can provide insights into complex translocations in APL.
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July-2023
Volume 26 Issue 1

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Kim D: A three‑way complex translocation of (15;15;17)(q24;q14;q21) involving two breakpoints on chromosome 15 in acute promyelocytic leukemia: A case report. Oncol Lett 26: 309, 2023
APA
Kim, D. (2023). A three‑way complex translocation of (15;15;17)(q24;q14;q21) involving two breakpoints on chromosome 15 in acute promyelocytic leukemia: A case report. Oncology Letters, 26, 309. https://doi.org/10.3892/ol.2023.13895
MLA
Kim, D."A three‑way complex translocation of (15;15;17)(q24;q14;q21) involving two breakpoints on chromosome 15 in acute promyelocytic leukemia: A case report". Oncology Letters 26.1 (2023): 309.
Chicago
Kim, D."A three‑way complex translocation of (15;15;17)(q24;q14;q21) involving two breakpoints on chromosome 15 in acute promyelocytic leukemia: A case report". Oncology Letters 26, no. 1 (2023): 309. https://doi.org/10.3892/ol.2023.13895