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Article

Pretreatment high cholesterol and low neutrophils predict complete pathological response after neoadjuvant short‑course radiotherapy followed by chemotherapy and immunotherapy in locally advanced rectal cancer

  • Authors:
    • Fangyuan Zhang
    • Dandan Yu
    • Jinru Yang
    • Menglan Zhai
    • Lisha Li
    • Lei Zhao
    • Jing Wang
    • Tao Zhang
    • Zhenyu Lin
  • View Affiliations / Copyright

    Affiliations: Cancer Center, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430022, P.R. China, Cancer Center, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430022, P.R. China
  • Article Number: 319
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    Published online on: June 7, 2023
       https://doi.org/10.3892/ol.2023.13905
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Abstract

The present study was aimed at looking for hematological indicators that could predict pathological complete response (pCR) in patients with locally advanced rectal cancer (LARC) treated with short‑course radiotherapy (SCRT) followed by chemotherapy and immunotherapy. A total of 171 patients were enrolled in this observational retrospective study. Pretreatment values of albumin, total cholesterol, lactate dehydrogenase, neutrophil, platelet and lymphocytes were available. Univariate and multivariate logistics analyses were used to determine the prognostic factor for pCR. SCRT followed by chemotherapy and immunotherapy was demonstrated to double the pCR rate (50.5%) compared with long‑course chemoradiotherapy. For the former group, baseline high platelet to lymphocyte ratio (P=0.047), high cholesterol (P=0.026) and low neutrophils (P=0.012) level were associated with high pCR rate and baseline high cholesterol (P=0.016) and low neutrophils (P=0.020) level were the independent prognostic factors for pCR. In conclusion, pretreatment high cholesterol and low neutrophils were the independent prognostic predictors of pCR in patients with LARC treated with SCRT followed by chemotherapy and immunotherapy. Clinical trial no. NCT04928807, June 16, 2021.
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Copy and paste a formatted citation
Spandidos Publications style
Zhang F, Yu D, Yang J, Zhai M, Li L, Zhao L, Wang J, Zhang T and Lin Z: Pretreatment high cholesterol and low neutrophils predict complete pathological response after neoadjuvant short‑course radiotherapy followed by chemotherapy and immunotherapy in locally advanced rectal cancer. Oncol Lett 26: 319, 2023.
APA
Zhang, F., Yu, D., Yang, J., Zhai, M., Li, L., Zhao, L. ... Lin, Z. (2023). Pretreatment high cholesterol and low neutrophils predict complete pathological response after neoadjuvant short‑course radiotherapy followed by chemotherapy and immunotherapy in locally advanced rectal cancer. Oncology Letters, 26, 319. https://doi.org/10.3892/ol.2023.13905
MLA
Zhang, F., Yu, D., Yang, J., Zhai, M., Li, L., Zhao, L., Wang, J., Zhang, T., Lin, Z."Pretreatment high cholesterol and low neutrophils predict complete pathological response after neoadjuvant short‑course radiotherapy followed by chemotherapy and immunotherapy in locally advanced rectal cancer". Oncology Letters 26.1 (2023): 319.
Chicago
Zhang, F., Yu, D., Yang, J., Zhai, M., Li, L., Zhao, L., Wang, J., Zhang, T., Lin, Z."Pretreatment high cholesterol and low neutrophils predict complete pathological response after neoadjuvant short‑course radiotherapy followed by chemotherapy and immunotherapy in locally advanced rectal cancer". Oncology Letters 26, no. 1 (2023): 319. https://doi.org/10.3892/ol.2023.13905
Copy and paste a formatted citation
x
Spandidos Publications style
Zhang F, Yu D, Yang J, Zhai M, Li L, Zhao L, Wang J, Zhang T and Lin Z: Pretreatment high cholesterol and low neutrophils predict complete pathological response after neoadjuvant short‑course radiotherapy followed by chemotherapy and immunotherapy in locally advanced rectal cancer. Oncol Lett 26: 319, 2023.
APA
Zhang, F., Yu, D., Yang, J., Zhai, M., Li, L., Zhao, L. ... Lin, Z. (2023). Pretreatment high cholesterol and low neutrophils predict complete pathological response after neoadjuvant short‑course radiotherapy followed by chemotherapy and immunotherapy in locally advanced rectal cancer. Oncology Letters, 26, 319. https://doi.org/10.3892/ol.2023.13905
MLA
Zhang, F., Yu, D., Yang, J., Zhai, M., Li, L., Zhao, L., Wang, J., Zhang, T., Lin, Z."Pretreatment high cholesterol and low neutrophils predict complete pathological response after neoadjuvant short‑course radiotherapy followed by chemotherapy and immunotherapy in locally advanced rectal cancer". Oncology Letters 26.1 (2023): 319.
Chicago
Zhang, F., Yu, D., Yang, J., Zhai, M., Li, L., Zhao, L., Wang, J., Zhang, T., Lin, Z."Pretreatment high cholesterol and low neutrophils predict complete pathological response after neoadjuvant short‑course radiotherapy followed by chemotherapy and immunotherapy in locally advanced rectal cancer". Oncology Letters 26, no. 1 (2023): 319. https://doi.org/10.3892/ol.2023.13905
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