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LGALS1 regulates cell adhesion to promote the progression of ovarian cancer

  • Authors:
    • Xuejian Li
    • Huifei Wang
    • Aran Jia
    • Yuanyuan Cao
    • Liuqing Yang
    • Zanhui Jia
  • View Affiliations / Copyright

    Affiliations: Department of Gynecology, The Second Hospital of Jilin University, Changchun, Jilin 130041, P.R. China, Department of Gynecology, Jinan Maternal and Child Health Hospital, Jinan, Shandong 250000, P.R. China
    Copyright: © Li et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 326
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    Published online on: June 13, 2023
       https://doi.org/10.3892/ol.2023.13912
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Abstract

The present study aimed to explore the significance and molecular mechanisms of galectin‑1 (LGALS1) in ovarian cancer (OC). Using the Gene Expression Omnibus database and The Cancer Genome Atlas database, the results of the present study demonstrated that LGALS1 mRNA expression was markedly increased in OC and associated with advanced tumor, lymphatic metastasis and residual lesions. In Kaplan‑Meier analysis, patients who expressed LGALS1 highly had a poor prognosis. Furthermore, using The Cancer Genome Atlas database, differentially expressed genes that are potentially regulated by LGALS1 in OC were determined. Gene Ontology, Kyoto Encyclopedia of Genes and Genomes, and Gene Set Enrichment Analysis were used to build a biological network of upregulated differentially expressed genes. The results of the enrichment analysis revealed that the upregulated differentially expressed genes were primarily associated with ‘ECM-receptor interaction’, ‘cell‑matrix adhesion’ and ‘focal adhesion’, which are closely associated with the metastasis of cancer cells. Subsequently, cell adhesion was selected for further analysis. The results demonstrated that LGALS1 was co‑expressed with the candidate genes. Subsequently, the elevated expression levels of candidate genes were verified in OC tissues, and survival analysis indicated that high expression of candidate genes was associated with shortened overall survival of patients with OC. In the present study, OC samples were also collected to verify the high protein expression levels of LGALS1 and fibronectin 1. The results of the present study highlighted that LGALS1 may regulate cell adhesion and participate in the development of OC. Therefore, LGALS1 exhibits potential as a therapeutic target in OC.
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Copy and paste a formatted citation
Spandidos Publications style
Li X, Wang H, Jia A, Cao Y, Yang L and Jia Z: LGALS1 regulates cell adhesion to promote the progression of ovarian cancer. Oncol Lett 26: 326, 2023.
APA
Li, X., Wang, H., Jia, A., Cao, Y., Yang, L., & Jia, Z. (2023). LGALS1 regulates cell adhesion to promote the progression of ovarian cancer. Oncology Letters, 26, 326. https://doi.org/10.3892/ol.2023.13912
MLA
Li, X., Wang, H., Jia, A., Cao, Y., Yang, L., Jia, Z."LGALS1 regulates cell adhesion to promote the progression of ovarian cancer". Oncology Letters 26.2 (2023): 326.
Chicago
Li, X., Wang, H., Jia, A., Cao, Y., Yang, L., Jia, Z."LGALS1 regulates cell adhesion to promote the progression of ovarian cancer". Oncology Letters 26, no. 2 (2023): 326. https://doi.org/10.3892/ol.2023.13912
Copy and paste a formatted citation
x
Spandidos Publications style
Li X, Wang H, Jia A, Cao Y, Yang L and Jia Z: LGALS1 regulates cell adhesion to promote the progression of ovarian cancer. Oncol Lett 26: 326, 2023.
APA
Li, X., Wang, H., Jia, A., Cao, Y., Yang, L., & Jia, Z. (2023). LGALS1 regulates cell adhesion to promote the progression of ovarian cancer. Oncology Letters, 26, 326. https://doi.org/10.3892/ol.2023.13912
MLA
Li, X., Wang, H., Jia, A., Cao, Y., Yang, L., Jia, Z."LGALS1 regulates cell adhesion to promote the progression of ovarian cancer". Oncology Letters 26.2 (2023): 326.
Chicago
Li, X., Wang, H., Jia, A., Cao, Y., Yang, L., Jia, Z."LGALS1 regulates cell adhesion to promote the progression of ovarian cancer". Oncology Letters 26, no. 2 (2023): 326. https://doi.org/10.3892/ol.2023.13912
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