Open Access

Tumor organoid model of colorectal cancer (Review)

  • Authors:
    • Chi Yang
    • Wangwen Xiao
    • Rui Wang
    • Yan Hu
    • Ke Yi
    • Xuan Sun
    • Guanghui Wang
    • Xiaohui Xu
  • View Affiliations

  • Published online on: June 15, 2023     https://doi.org/10.3892/ol.2023.13914
  • Article Number: 328
  • Copyright: © Yang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

The establishment of self‑organizing ‘mini‑gut’ organoid models has brought about a significant breakthrough in biomedical research. Patient‑derived tumor organoids have emerged as valuable tools for preclinical studies, offering the retention of genetic and phenotypic characteristics of the original tumor. These organoids have applications in various research areas, including in vitro modelling, drug discovery and personalized medicine. The present review provided an overview of intestinal organoids, focusing on their unique characteristics and current understanding. The progress made in colorectal cancer (CRC) organoid models was then delved into, discussing their role in drug development and personalized medicine. For instance, it has been indicated that patient‑derived tumor organoids are able to predict response to irinotecan‑based neoadjuvant chemoradiotherapy. Furthermore, the limitations and challenges associated with current CRC organoid models were addressed, along with proposed strategies for enhancing their utility in future basic and translational research.14
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August-2023
Volume 26 Issue 2

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Copy and paste a formatted citation
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Spandidos Publications style
Yang C, Xiao W, Wang R, Hu Y, Yi K, Sun X, Wang G and Xu X: Tumor organoid model of colorectal cancer (Review). Oncol Lett 26: 328, 2023
APA
Yang, C., Xiao, W., Wang, R., Hu, Y., Yi, K., Sun, X. ... Xu, X. (2023). Tumor organoid model of colorectal cancer (Review). Oncology Letters, 26, 328. https://doi.org/10.3892/ol.2023.13914
MLA
Yang, C., Xiao, W., Wang, R., Hu, Y., Yi, K., Sun, X., Wang, G., Xu, X."Tumor organoid model of colorectal cancer (Review)". Oncology Letters 26.2 (2023): 328.
Chicago
Yang, C., Xiao, W., Wang, R., Hu, Y., Yi, K., Sun, X., Wang, G., Xu, X."Tumor organoid model of colorectal cancer (Review)". Oncology Letters 26, no. 2 (2023): 328. https://doi.org/10.3892/ol.2023.13914