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Early low blood MALT1 expression levels forecast better efficacy of PD‑1 inhibitor‑based treatment in patients with metastatic colorectal cancer

  • Authors:
    • Chuanming Li
    • Fan Yu
    • Wanli Xu
  • View Affiliations / Copyright

    Affiliations: Department of Anorectal Surgery, Wuhan No. 8 Hospital (Wuhan Anorectal Hospital), Wuhan, Hubei 430000, P.R. China, Department of Gastroenterology, Wuhan No. 8 Hospital (Wuhan Anorectal Hospital), Wuhan, Hubei 430000, P.R. China
    Copyright: © Li et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 329
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    Published online on: June 15, 2023
       https://doi.org/10.3892/ol.2023.13915
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Abstract

Mucosa‑associated lymphoid tissue lymphoma translocation protein 1 (MALT1) modulates colorectal cancer (CRC) malignant behaviors and tumor immune escape. The present study aimed to explore the association of MALT1 with treatment response and survival time among patients with metastatic CRC (mCRC) after programmed cell death protein‑1 (PD‑1) inhibitor‑based treatment. MALT1 from the blood samples of 75 patients with unresectable mCRC receiving PD‑1 inhibitor‑based treatment at baseline and after 2‑cycle treatment, as well as 20 healthy controls (HCs), was detected by reverse transcription‑quantitative PCR. In the patients with mCRC, the objective response rate (ORR), disease control rate (DCR), progression‑free survival (PFS) and overall survival (OS) were calculated. MALT1 expression was elevated in patients with mCRC compared with that in HCs (P<0.001). In patients with mCRC, MALT1 expression was positively correlated with multiple (vs. single) metastasis (P=0.032) and peritoneum metastasis (P=0.029). MALT1 levels before treatment were decreased in ORR patients vs. non‑ORR patients (P=0.043) and in DCR patients vs. non‑DCR patients (P=0.007). Additionally, MALT1 expression was reduced after treatment compared with that before treatment (P<0.001). Meanwhile, MALT1 expression after treatment was notably decreased in ORR patients vs. non‑ORR patients (P<0.001) and in DCR patients vs. non‑DCR patients (P<0.001). Furthermore, a low MALT1 level before treatment was associated with longer PFS (P=0.030) and OS (P=0.025) times. Decreased MALT1 expression after treatment and a decline in MALT1 expression of >30% after treatment (ratio to MALT1 before treatment) (both P≤0.001) presented more significant associations with prolonged PFS and OS times. In conclusion, early low levels of blood MALT1 during therapy may predict an improved response to PD‑1 inhibitor‑based treatment and survival time in patients with mCRC.
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Copy and paste a formatted citation
Spandidos Publications style
Li C, Yu F and Xu W: Early low blood MALT1 expression levels forecast better efficacy of PD‑1 inhibitor‑based treatment in patients with metastatic colorectal cancer. Oncol Lett 26: 329, 2023.
APA
Li, C., Yu, F., & Xu, W. (2023). Early low blood MALT1 expression levels forecast better efficacy of PD‑1 inhibitor‑based treatment in patients with metastatic colorectal cancer. Oncology Letters, 26, 329. https://doi.org/10.3892/ol.2023.13915
MLA
Li, C., Yu, F., Xu, W."Early low blood MALT1 expression levels forecast better efficacy of PD‑1 inhibitor‑based treatment in patients with metastatic colorectal cancer". Oncology Letters 26.2 (2023): 329.
Chicago
Li, C., Yu, F., Xu, W."Early low blood MALT1 expression levels forecast better efficacy of PD‑1 inhibitor‑based treatment in patients with metastatic colorectal cancer". Oncology Letters 26, no. 2 (2023): 329. https://doi.org/10.3892/ol.2023.13915
Copy and paste a formatted citation
x
Spandidos Publications style
Li C, Yu F and Xu W: Early low blood MALT1 expression levels forecast better efficacy of PD‑1 inhibitor‑based treatment in patients with metastatic colorectal cancer. Oncol Lett 26: 329, 2023.
APA
Li, C., Yu, F., & Xu, W. (2023). Early low blood MALT1 expression levels forecast better efficacy of PD‑1 inhibitor‑based treatment in patients with metastatic colorectal cancer. Oncology Letters, 26, 329. https://doi.org/10.3892/ol.2023.13915
MLA
Li, C., Yu, F., Xu, W."Early low blood MALT1 expression levels forecast better efficacy of PD‑1 inhibitor‑based treatment in patients with metastatic colorectal cancer". Oncology Letters 26.2 (2023): 329.
Chicago
Li, C., Yu, F., Xu, W."Early low blood MALT1 expression levels forecast better efficacy of PD‑1 inhibitor‑based treatment in patients with metastatic colorectal cancer". Oncology Letters 26, no. 2 (2023): 329. https://doi.org/10.3892/ol.2023.13915
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