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Long non‑coding RNA PTCSC3 suppresses triple‑negative breast cancer by downregulating long non‑coding RNA MIR100HG

  • Authors:
    • Guojun Zhang
    • Lei Gao
    • Junliang Zhang
    • Rui Wang
    • Xiangdong Wei
  • View Affiliations / Copyright

    Affiliations: Department of General Surgery, Changle People's Hospital, Changle County, Shandong 262499, P.R. China
    Copyright: © Zhang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 331
    |
    Published online on: June 15, 2023
       https://doi.org/10.3892/ol.2023.13917
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Abstract

Long non‑coding RNA (lncRNA) PTCSC3 is characterized as a tumor suppressor in thyroid cancer and glioma. The present study aimed to investigate the role of PTCSC3 in triple‑negative breast cancer (TNBC). A total of 82 patients with TNBC were enrolled in the present study. The results showed that PTCSC3 was downregulated, while lncRNA MIR100HG was upregulated in tumor tissues compared with that in adjacent non‑cancerous tissues of patients with TNBC. The follow‑up study showed that low expression levels of PTCSC3 and high expression levels of MIR100HG were closely associated with poor survival of patients with TNBC. The expression levels of MIR100HG were decreased with the clinic stages of TNBC, while the expression levels of MIR100HG showed the opposite trend. Correlation analysis showed that the expression levels of PTCSC3 and MIR100HG were significantly correlated in both tumor tissues and adjacent non‑cancerous tissues. The overexpression of PTCSC3 inhibited the expression level of MIR100HG in TNBC cells, while the expression level of PTCSC3 was unaffected. Cell Counting Kit‑8 and Annexin V‑FITC Apoptosis flow cytometry assays showed that overexpression of PTCSC3 led to inhibition, while overexpression of MIR100HG led to the promotion of TNBC cells viability and inhibited apoptosis of TNBC cells. In addition, overexpression of MIR100HG attenuated the effects of PTCSC3 overexpression on cancer cell viability. However, the overexpression of PTCSC3 did not affect cancer cell migration and invasion. Western‑blot analysis showed that PTCSC3 suppressed viability and promoted apoptosis of TNBC cells through the Hippo signaling pathway. Thus, the present study demonstrated that lncRNA PTCSC3 inhibits cancer cell viability and promotes cancer cell apoptosis in TNBC by downregulating MIR100HG.
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1 

Djebali S, Davis CA, Merkel A, Dobin A, Lassmann T, Mortazavi A, Tanzer A, Lagarde J, Lin W, Schlesinger F, et al: Landscape of transcription in human cells. Nature. 489:101–108. 2012. View Article : Google Scholar : PubMed/NCBI

2 

Zhao XB and Ren GS: lncRNA Taurine-Upregulated Gene 1 promotes cell proliferation by inhibiting microRNA-9 in MCF-7 cells. J Breast Cancer. 19:349–357. 2016. View Article : Google Scholar : PubMed/NCBI

3 

Fatica A and Bozzoni I: Long non-coding RNAs: New players in cell differentiation and development. Nat Rev Genet. 15:7–21. 2014. View Article : Google Scholar : PubMed/NCBI

4 

Engreitz JM, Ollikainen N and Guttman M: Long non-coding RNAs: Spatial amplifiers that control nuclear structure and gene expression. Nat Rev Mol Cell Biol. 17:756–770. 2016. View Article : Google Scholar : PubMed/NCBI

5 

Gutschner T and Diederichs S: The hallmarks of cancer: A long non-coding RNA point of view. RNA Biol. 9:703–719. 2012. View Article : Google Scholar : PubMed/NCBI

6 

Spizzo R, Almeida MI, Colombatti A and Calin GA: Long non-coding RNAs and cancer: A new frontier of translational research? Oncogene. 31:4577–4587. 2012. View Article : Google Scholar : PubMed/NCBI

7 

Peto R, Boreham J, Clarke M, Davies C and Beral V: UK and USA breast cancer deaths down 25% in year 2000 at ages 20–69 years. Lancet. 355:18222000. View Article : Google Scholar : PubMed/NCBI

8 

Foulkes WD, Smith IE and Reis-Filho JS: Triple-negative breast cancer. N Engl J Med. 363:1938–1948. 2010. View Article : Google Scholar : PubMed/NCBI

9 

Lin A, Li C, Xing Z, Hu Q, Liang K, Han L, Wang C, Hawke DH, Wang S, Zhang Y, et al: The LINK-A lncRNA activates normoxic HIF1α signaling in triple-negative breast cancer. Nat Cell Biol. 18:213–224. 2016. View Article : Google Scholar : PubMed/NCBI

10 

Eades G, Wolfson B, Zhang Y, Li Q, Yao Y and Zhou Q: lincRNA-RoR and miR-145 regulate invasion in triple-negative breast cancer via targeting ARF6. Mol Cancer Res. 13:330–338. 2015. View Article : Google Scholar : PubMed/NCBI

11 

Fan M, Li X, Jiang W, Huang Y, Li J and Wang Z: A long non-coding RNA, PTCSC3, as a tumor suppressor and a target of miRNAs in thyroid cancer cells. Exp Ther Med. 5:1143–1146. 2013. View Article : Google Scholar : PubMed/NCBI

12 

Wang X, Lu X, Geng Z, Yang G and Shi Y: lncRNA PTCSC3/miR-574-5p governs cell proliferation and migration of papillary thyroid carcinoma via Wnt/β-catenin signaling. J Cell Biochem. 118:4745–4752. 2017. View Article : Google Scholar : PubMed/NCBI

13 

Xia S, Ji R and Zhan W: Long noncoding RNA papillary thyroid carcinoma susceptibility candidate 3 (PTCSC3) inhibits proliferation and invasion of glioma cells by suppressing the Wnt/β-catenin signaling pathway. BMC Neurol. 17:302017. View Article : Google Scholar : PubMed/NCBI

14 

Wang S, Ke H, Zhang H, Ma Y, Ao L, Zou L, Yang Q, Zhu H, Nie J, Wu C and Jiao B: lncRNA MIR100HG promotes cell proliferation in triple-negative breast cancer through triplex formation with p27 loci. Cell Death Dis. 9:8052018. View Article : Google Scholar : PubMed/NCBI

15 

Xu J, Zhang Y, You Q, Fu H, Zhao X, Lu K, Yan R and Yang D: lncRNA PTCSC3 Alleviates the postoperative distant recurrence of gastric cancer by suppression of lncRNA HOXA11-AS. Cancer Manag Res. 12:2623–2629. 2020. View Article : Google Scholar : PubMed/NCBI

16 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(−Delta Delta C(T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

17 

Fang X, Zhang J, Li C, Liu J, Shi Z and Zhou P: Long non-coding RNA SNHG22 facilitates the malignant phenotypes in triple-negative breast cancer via sponging miR-324-3p and upregulating SUDS3. Cancer Cell Int. 20:2522020. View Article : Google Scholar : PubMed/NCBI

18 

Li Y, Ma HY, Hu XW, Qu YY, Wen X, Zhang Y and Xu QY: lncRNA H19 promotes triple-negative breast cancer cells invasion and metastasis through the p53/TNFAIP8 pathway. Cancer Cell Int. 20:2002020. View Article : Google Scholar : PubMed/NCBI

19 

Luo L, Tang H, Ling L, Li N, Jia X, Zhang Z, Wang X, Shi L, Yin J, Qiu N, et al: LINC01638 lncRNA activates MTDH-Twist1 signaling by preventing SPOP-mediated c-Myc degradation in triple-negative breast cancer. Ocogene. 37:6166–6179. 2018.

20 

Chen FY, Zhou ZY, Zhang KJ, Pang J and Wang SM: Long non-coding RNA MIR100HG promotes the migration, invasion and proliferation of triple-negative breast cancer cells by targeting the miR-5590-3p/OTX1 axis. Cancer Cell Int. 20:5082020. View Article : Google Scholar : PubMed/NCBI

21 

Han J, Han B, Wu X, Hao J, Dong X, Shen Q and Pang H: Knockdown of lncRNA H19 restores chemo-sensitivity in paclitaxel-resistant triple-negative breast cancer through triggering apoptosis and regulating Akt signaling pathway. Toxicol Appl Pharmacol. 359:55–61. 2018. View Article : Google Scholar : PubMed/NCBI

22 

Zuo Y, Li Y, Zhou Z, Ma M and Fu K: Long non-coding RNA MALAT1 promotes proliferation and invasion via targeting miR-129-5p in triple-negative breast cancer. Biomed Pharmacother. 95:922–928. 2017. View Article : Google Scholar : PubMed/NCBI

23 

Wang N, Hou M, Zhan Y and Sheng X: lncRNA PTCSC3 inhibits triple-negative breast cancer cell proliferation by downregulating lncRNA H19. J Cell Biochem. 120:15083–15088. 2019. View Article : Google Scholar : PubMed/NCBI

24 

Li P, Ge D, Li P, Hu F, Chu J, Chen X, Song W, Wang A, Tian G and Gu X: CXXC finger protein 4 inhibits the CDK18-ERK1/2 axis to suppress the immune escape of gastric cancer cells with involvement of ELK1/MIR100HG pathway. J Cell Mol Med. 24:10151–10165. 2020. View Article : Google Scholar : PubMed/NCBI

25 

Huang Y, Zhang C and Zhou Y: lncRNA MIR100HG promotes cancer cell proliferation, migration and invasion in laryngeal squamous cell carcinoma through the downregulation of miR-204-5p. Onco Targets Ther. 12:2967–2973. 2019. View Article : Google Scholar : PubMed/NCBI

26 

Zhang M, Song Y and Yu L: lncRNA PTCSC3 suppressed cervical carcinoma cell invasion and proliferation via regulating miR-574-5p. Am J Transl Res. 11:7186–7194. 2019.PubMed/NCBI

27 

Wang XM, Liu Y, Fan YX, Liu Z, Yuan QL, Jia M, Geng ZS, Gu L and Lu XB: lncRNA PTCSC3 affects drug resistance of anaplastic thyroid cancer through STAT3/INO80 pathway. Cancer Biol Ther. 19:590–597. 2018. View Article : Google Scholar : PubMed/NCBI

28 

Cai Y, Li Y, Sun B, Wang H, Zhang W, Zhao Y, Zhao H, Zhang J, Xu J and Wang Y: lncRNA PTCSC3 and lncRNA HULC negatively affect each other to regulate cancer cell invasion and migration in gastric cancer. Cancer Manag Res. 12:8535–8543. 2020. View Article : Google Scholar : PubMed/NCBI

29 

Hong L, Wang H, Wang J, Wei S, Zhang F, Han J, Liu Y, Ma M, Liu C, Xu Y and Jiang D: lncRNA PTCSC3 inhibits tumor growth and cancer cell stemness in gastric cancer by interacting with lncRNA Linc-pint. Cancer Manag Res. 11:10393–10399. 2019. View Article : Google Scholar : PubMed/NCBI

30 

Zhang G, Chi N, Lu Q, Zhu D and Zhuang Y: lncRNA PTCSC3 Is a biomarker for the treatment and prognosis of gastric cancer. Cancer Biother Radiopharm. 35:77–81. 2020.PubMed/NCBI

31 

Ma J, Fan Z, Tang Q, Xia H, Zhang T and Bi F: Aspirin attenuates YAP and β-catenin expression by promoting β-TrCP to overcome docetaxel and vinorelbine resistance in triple-negative breast cancer. Cell Death Dis. 11:5302020. View Article : Google Scholar : PubMed/NCBI

32 

Zhang K, Zhang M, Yao Q, Han X, Zhao Y, Zheng L, Li G, Liu Q, Chang Y, Zhang P, et al: The hepatocyte-specifically expressed lnc-HSER alleviates hepatic fibrosis by inhibiting hepatocyte apoptosis and epithelial-mesenchymal transition. Theranostics. 9:7566–7582. 2019. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Zhang G, Gao L, Zhang J, Wang R and Wei X: Long non‑coding RNA PTCSC3 suppresses triple‑negative breast cancer by downregulating long non‑coding RNA MIR100HG. Oncol Lett 26: 331, 2023.
APA
Zhang, G., Gao, L., Zhang, J., Wang, R., & Wei, X. (2023). Long non‑coding RNA PTCSC3 suppresses triple‑negative breast cancer by downregulating long non‑coding RNA MIR100HG. Oncology Letters, 26, 331. https://doi.org/10.3892/ol.2023.13917
MLA
Zhang, G., Gao, L., Zhang, J., Wang, R., Wei, X."Long non‑coding RNA PTCSC3 suppresses triple‑negative breast cancer by downregulating long non‑coding RNA MIR100HG". Oncology Letters 26.2 (2023): 331.
Chicago
Zhang, G., Gao, L., Zhang, J., Wang, R., Wei, X."Long non‑coding RNA PTCSC3 suppresses triple‑negative breast cancer by downregulating long non‑coding RNA MIR100HG". Oncology Letters 26, no. 2 (2023): 331. https://doi.org/10.3892/ol.2023.13917
Copy and paste a formatted citation
x
Spandidos Publications style
Zhang G, Gao L, Zhang J, Wang R and Wei X: Long non‑coding RNA PTCSC3 suppresses triple‑negative breast cancer by downregulating long non‑coding RNA MIR100HG. Oncol Lett 26: 331, 2023.
APA
Zhang, G., Gao, L., Zhang, J., Wang, R., & Wei, X. (2023). Long non‑coding RNA PTCSC3 suppresses triple‑negative breast cancer by downregulating long non‑coding RNA MIR100HG. Oncology Letters, 26, 331. https://doi.org/10.3892/ol.2023.13917
MLA
Zhang, G., Gao, L., Zhang, J., Wang, R., Wei, X."Long non‑coding RNA PTCSC3 suppresses triple‑negative breast cancer by downregulating long non‑coding RNA MIR100HG". Oncology Letters 26.2 (2023): 331.
Chicago
Zhang, G., Gao, L., Zhang, J., Wang, R., Wei, X."Long non‑coding RNA PTCSC3 suppresses triple‑negative breast cancer by downregulating long non‑coding RNA MIR100HG". Oncology Letters 26, no. 2 (2023): 331. https://doi.org/10.3892/ol.2023.13917
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