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Article Open Access

Clinical features and treatment of bone marrow metastasis

  • Authors:
    • Hongliang Yang
    • Feng He
    • Tian Yuan
    • Wen Xu
    • Zeng Cao
  • View Affiliations / Copyright

    Affiliations: Institute of Medical Engineering and Translational Medicine, Tianjin University, Tianjin 300072, P.R. China, Department of Hematology, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin's Clinical Research Center for Cancer, Tianjin 300060, P.R. China, Department of Hematology, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin's Clinical Research Center for Cancer, Tianjin 300060, P.R. China
    Copyright: © Yang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 332
    |
    Published online on: June 16, 2023
       https://doi.org/10.3892/ol.2023.13918
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Abstract

Bone marrow metastasis (BMM) refers to the metastasis of malignant tumours originating from nonhematopoietic tissues to the bone marrow. The nonhematopoietic malignant tumour cells metastasize to the bone marrow via heterogeneous dissemination or direct invasion to form metastases and the bone marrow is infiltrated by tumour cells, resulting in the destruction of its structure and the development of haematopoietic disorders. In the present study, the clinical characteristics, prognosis and treatment of BMMs were investigated. The main clinical manifestations were moderate anaemia and thrombocytopenia. Out of 52 cases, a total of 18 patients were not treated and the remaining patients underwent chemotherapy, radiotherapy, surgery or autologous stem cell transplantation in the Affiliated Tumour Hospital of Tianjin Medical University from September 2010 to October 2021. The primary tumours of bone marrow metastatic cancer were usually neuroblastoma and tumours originating from the breast and stomach. When bone metastases occur, patients are not necessarily accompanied by BMMs. In the present study, bone metastases occurred mainly in patients with breast and prostate cancers. The median overall survival of patients treated with antitumor therapy was significantly higher than that of untreated patients (11.5 vs. 3.3 months P<0.01). For patients with BMM, it is of great importance to actively evaluate the patient's condition and select the appropriate treatment plan for improving their prognosis.
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Copy and paste a formatted citation
Spandidos Publications style
Yang H, He F, Yuan T, Xu W and Cao Z: Clinical features and treatment of bone marrow metastasis. Oncol Lett 26: 332, 2023.
APA
Yang, H., He, F., Yuan, T., Xu, W., & Cao, Z. (2023). Clinical features and treatment of bone marrow metastasis. Oncology Letters, 26, 332. https://doi.org/10.3892/ol.2023.13918
MLA
Yang, H., He, F., Yuan, T., Xu, W., Cao, Z."Clinical features and treatment of bone marrow metastasis". Oncology Letters 26.2 (2023): 332.
Chicago
Yang, H., He, F., Yuan, T., Xu, W., Cao, Z."Clinical features and treatment of bone marrow metastasis". Oncology Letters 26, no. 2 (2023): 332. https://doi.org/10.3892/ol.2023.13918
Copy and paste a formatted citation
x
Spandidos Publications style
Yang H, He F, Yuan T, Xu W and Cao Z: Clinical features and treatment of bone marrow metastasis. Oncol Lett 26: 332, 2023.
APA
Yang, H., He, F., Yuan, T., Xu, W., & Cao, Z. (2023). Clinical features and treatment of bone marrow metastasis. Oncology Letters, 26, 332. https://doi.org/10.3892/ol.2023.13918
MLA
Yang, H., He, F., Yuan, T., Xu, W., Cao, Z."Clinical features and treatment of bone marrow metastasis". Oncology Letters 26.2 (2023): 332.
Chicago
Yang, H., He, F., Yuan, T., Xu, W., Cao, Z."Clinical features and treatment of bone marrow metastasis". Oncology Letters 26, no. 2 (2023): 332. https://doi.org/10.3892/ol.2023.13918
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