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Review Open Access

Role of RNA methylation in the regulation of pancreatic cancer stem cells (Review)

  • Authors:
    • Yoshiko Tsuji
    • Tomoaki Hara
    • Sikun Meng
    • Hiromichi Sato
    • Yasuko Arao
    • Ken Ofusa
    • Hideshi Ishii
  • View Affiliations / Copyright

    Affiliations: Department of Medical Data Science, Center of Medical Innovation and Translational Research, Osaka University Graduate School of Medicine, Suita, Osaka 565‑0871, Japan
    Copyright: © Tsuji et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 336
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    Published online on: June 20, 2023
       https://doi.org/10.3892/ol.2023.13922
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Abstract

Pancreatic cancer stem cells (CSCs) play a key role in the initiation and progression of pancreatic adenocarcinoma (PDAC). CSCs are responsible for resistance to chemotherapy and radiation, and for cancer metastasis. Recent studies have indicated that RNA methylation, a type of RNA modification, predominantly occurring as m6A methylation, plays an important role in controlling the stemness of cancer cells, therapeutic resistance against chemotherapy and radiation therapy, and their overall relevance to a patient's prognosis. CSCs regulate various behaviors of cancer through cell‑cell communication by secreting factors, through their receptors, and through signal transduction. Recent studies have shown that RNA methylation is involved in the biology of the heterogeneity of PDAC. The present review provides an update on the current understanding of RNA modification‑based therapeutic targets against deleterious PDAC. Several key pathways and agents that can specifically target CSCs have been identified, thus providing novel insights into the early diagnosis and efficient treatment of PDAC.
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1 

McGuigan A, Kelly P, Turkington RC, Jones C, Coleman HG and McCain RS: Pancreatic cancer: A review of clinical diagnosis, epidemiology, treatment and outcomes. World J Gastroenterol. 24:4846–4861. 2018. View Article : Google Scholar : PubMed/NCBI

2 

Zeng S, Pöttler M, Lan B, Grützmann R, Pilarsky C and Yang H: Chemoresistance in pancreatic cancer. Int J Mol Sci. 20:45042019. View Article : Google Scholar : PubMed/NCBI

3 

Zhang L, Sanagapalli S and Stoita A: Challenges in diagnosis of pancreatic cancer. World J Gastroenterol. 24:2047–2060. 2018. View Article : Google Scholar : PubMed/NCBI

4 

Ansari D, Tingstedt B, Andersson B, Holmquist F, Sturesson C, Williamsson C, Sasor A, Borg D, Bauden M and Andersson R: Pancreatic cancer: Yesterday, today and tomorrow. Future Oncol. 12:1929–1946. 2016. View Article : Google Scholar : PubMed/NCBI

5 

Fialkow PJ, Singer JW, Raskind WH, Adamson JW, Jacobson RJ, Bernstein ID, Dow LW, Najfeld V and Veith R: Clonal development, stem-cell differentiation, and clinical remissions in acute nonlymphocytic leukemia. N Engl J Med. 317:468–473. 1987. View Article : Google Scholar : PubMed/NCBI

6 

McCulloch EA, Howatson AF, Buick RN, Minden MD and Izaguirre CA: Acute myeloblastic leukemia considered as a clonal hemopathy. Blood Cells. 5:261–282. 1979.PubMed/NCBI

7 

Vogelstein B, Fearon ER, Hamilton SR and Feinberg AP: Use of restriction fragment length polymorphisms to determine the clonal origin of human tumors. Science. 227:642–645. 1985. View Article : Google Scholar : PubMed/NCBI

8 

Shlush LI, Zandi S, Mitchell A, Chen WC, Brandwein JM, Gupta V, Kennedy JA, Schimmer AD, Schuh AC, Yee KW, et al: Identification of pre-leukaemic haematopoietic stem cells in acute leukaemia. Nature. 506:328–333. 2014. View Article : Google Scholar : PubMed/NCBI

9 

Reya T, Morrison SJ, Clarke MF and Weissman IL: Stem cells, cancer, and cancer stem cells. Nature. 414:105–111. 2001. View Article : Google Scholar : PubMed/NCBI

10 

O'Brien CA, Pollett A, Gallinger S and Dick JE: A human colon cancer cell capable of initiating tumour growth in immunodeficient mice. Nature. 445:106–110. 2007. View Article : Google Scholar : PubMed/NCBI

11 

Haraguchi N, Ohkuma M, Sakashita H, Matsuzaki S, Tanaka F, Mimori K, Kamohara Y, Inoue H and Mori M: CD133+CD44+ population efficiently enriches colon cancer initiating cells. Ann Surg Oncol. 15:2927–2933. 2008. View Article : Google Scholar : PubMed/NCBI

12 

Haraguchi N, Ishii H, Mimori K, Tanaka F, Ohkuma M, Kim HM, Akita H, Takiuchi D, Hatano H, Nagano H, et al: CD13 is a therapeutic target in human liver cancer stem cells. J Clin Invest. 120:3326–3339. 2010. View Article : Google Scholar : PubMed/NCBI

13 

Ishiwata T, Matsuda Y, Yoshimura H, Sasaki N, Ishiwata S, Ishikawa N, Takubo K, Arai T and Aida J: Pancreatic cancer stem cells: Features and detection methods. Pathol Oncol Res. 24:797–805. 2018. View Article : Google Scholar : PubMed/NCBI

14 

Li H, Wang C, Lan L, Yan L, Li W, Evans I, Ruiz EJ, Su Q, Zhao G, Wu W, et al: METTL3 promotes oxaliplatin resistance of gastric cancer CD133+ stem cells by promoting PARP1 mRNA stability. Cell Mol Life Sci. 79:1352022. View Article : Google Scholar : PubMed/NCBI

15 

Li B, Jiang J, Assaraf YG, Xiao H, Chen ZS and Huang C: Surmounting cancer drug resistance: New insights from the perspective of N6-methyladenosine RNA modification. Drug Resist Updat. 53:1007202020. View Article : Google Scholar : PubMed/NCBI

16 

Gao Q, Zheng J, Ni Z, Sun P, Yang C, Cheng M, Wu M, Zhang X, Yuan L, Zhang Y and Li Y: The m6A methylation-regulated AFF4 promotes self-renewal of bladder cancer stem cells. Stem Cells Int. 2020:88492182020. View Article : Google Scholar : PubMed/NCBI

17 

Ziegenhain C, Vieth B, Parekh S, Reinius B, Guillaumet-Adkins A, Smets M, Leonhardt H, Heyn H, Hellmann I and Enard W: Comparative analysis of single-cell RNA sequencing methods. Mol Cell. 65:631–643.e4. 2017. View Article : Google Scholar : PubMed/NCBI

18 

Lei Y, Tang R, Xu J, Wang W, Zhang B, Liu J, Yu X and Shi S: Applications of single-cell sequencing in cancer research: Progress and perspectives. J Hematol Oncol. 14:912021. View Article : Google Scholar : PubMed/NCBI

19 

Ren X, Zhou C, Lu Y, Ma F, Fan Y and Wang C: Single-cell RNA-seq reveals invasive trajectory and determines cancer stem cell-related prognostic genes in pancreatic cancer. Bioengineered. 12:5056–5068. 2021. View Article : Google Scholar : PubMed/NCBI

20 

Karmakar S, Rauth S, Nallasamy P, Perumal N, Nimmakayala RK, Leon F, Gupta R, Barkeer S, Venkata RC, Raman V, et al: RNA polymerase II-associated factor 1 regulates stem cell features of pancreatic cancer cells, independently of the PAF1 complex, via interactions with PHF5A and DDX3. Gastroenterology. 159:1898–1915.e6. 2020. View Article : Google Scholar : PubMed/NCBI

21 

Wood A, Schneider J, Dover J, Johnston M and Shilatifard A: The Paf1 complex is essential for histone monoubiquitination by the Rad6-Bre1 complex, which signals for histone methylation by COMPASS and Dot1p. J Biol Chem. 278:34739–34742. 2003. View Article : Google Scholar : PubMed/NCBI

22 

Chaudhary K, Deb S, Moniaux N, Ponnusamy MP and Batra SK: Human RNA polymerase II-associated factor complex: Dysregulation in cancer. Oncogene. 26:7499–7507. 2007. View Article : Google Scholar : PubMed/NCBI

23 

Cao Y, Wang Z, Yan Y, Ji L, He J, Xuan B, Shen C, Ma Y, Jiang S, Ma D, et al: Enterotoxigenic bacteroidesfragilis promotes intestinal inflammation and malignancy by inhibiting exosome-packaged miR-149-3p. Gastroenterology. 161:1552–1566.e12. 2021. View Article : Google Scholar : PubMed/NCBI

24 

Sato H, Sasaki K, Hara T, Kobayashi S, Doki Y, Eguchi H, Satoh T and Ishii H: Targeting the regulation of aberrant protein production pathway in gastrointestinal cancer treatment. Front Oncol. 12:10183332022. View Article : Google Scholar : PubMed/NCBI

25 

Konno M, Taniguchi M and Ishii H: Significant epitranscriptomes in heterogeneous cancer. Cancer Sci. 110:2318–2327. 2019. View Article : Google Scholar : PubMed/NCBI

26 

Desrosiers R, Friderici K and Rottman F: Identification of methylated nucleosides in messenger RNA from Novikoff hepatoma cells. Porc Natl Acad Sci USA. 71:3971–3975. 1974. View Article : Google Scholar : PubMed/NCBI

27 

Perry RP and Kelley DE: Existence of methylated messenger RNA in mouse L cells. Cell. 1:37–42. 1974. View Article : Google Scholar

28 

Dominissini D, Moshitch-Moshkovitz S, Schwartz S, Salmon-Divon M, Ungar L, Osenberg S, Cesarkas K, Jacob-Hirsch J, Amariglio N, Kupiec M, et al: Topology of the human and mouse m6A RNA methylomes revealed by m6A-seq. Nature. 485:201–206. 2012. View Article : Google Scholar : PubMed/NCBI

29 

Meyer KD, Saletore Y, Zumbo P, Elemento O, Mason CE and Jaffrey SR: Comprehensive analysis of mRNA methylation reveals enrichment in 3´ UTRs and near stop codons. Cell. 149:1635–1646. 2012. View Article : Google Scholar : PubMed/NCBI

30 

Jia G, Fu Y, Zhao X, Dai Q, Zheng G, Yang Y, Yi C, Lindahl T, Pan T, Yang YG and He C: N6-Methyladenosine in nuclear RNA is a major substrate of the obesity-associated FTO. Nat Chem Biol. 7:885–887. 2011. View Article : Google Scholar : PubMed/NCBI

31 

Meyer KD and Jaffrey SR: Rethinking m6A readers, writers, and erasers. Annu Rev Cell Dev Biol. 33:319–342. 2017. View Article : Google Scholar : PubMed/NCBI

32 

Wang L, Zhang S, Li H and Xu Y, Wu Q, Shen J, Li T and Xu Y: Quantification of m6A RNA methylation modulators pattern was a potential biomarker for prognosis and associated with tumor immune microenvironment of pancreatic adenocarcinoma. BMC Cancer. 21:8762021. View Article : Google Scholar : PubMed/NCBI

33 

Xu F, Zhang Z, Yuan M, Zhao Y, Zhou Y, Pei H and Bai L: M6A regulatory genes play an important role in the prognosis, progression and immune microenvironment of pancreatic adenocarcinoma. Cancer Invest. 39:39–54. 2021. View Article : Google Scholar : PubMed/NCBI

34 

Li F, He C, Yao H, Zhao Y, Ye X, Zhou S, Zou J, Li Y, Li J, Chen S, et al: Glutamate from nerve cells promotes perineural invasion in pancreatic cancer by regulating tumor glycolysis through HK2 mRNA-m6A modification. Pharmacol Res. 187:1065552023. View Article : Google Scholar : PubMed/NCBI

35 

Jiang X, Liu B, Nie Z, Duan L, Xiong Q, Jin Z, Yang C and Chen Y: The role of m6A modification in the biological functions and diseases. Signal Transduct Target Ther. 6:742021. View Article : Google Scholar : PubMed/NCBI

36 

Li J, Wang F, Liu Y, Wang H and Ni B: N6-methyladenosine (m6A) in pancreatic cancer: Regulatory mechanisms and future direction. Int J Biol Sci. 17:2323–2335. 2021. View Article : Google Scholar : PubMed/NCBI

37 

Guo X, Li K, Jiang W, Hu Y, Xiao W, Huang Y, Feng Y, Pan Q and Wan R: RNA demethylase ALKBH5 prevents pancreatic cancer progression by posttranscriptional activation of PER1 in an m6A-YTHDF2-dependent manner. Mol Cancer. 19:912020. View Article : Google Scholar : PubMed/NCBI

38 

Ma Z and Ji J: N6-methyladenosine (m6A) RNA modification in cancer stem cells. Stem Cells. 38:1511–1519. 2020. View Article : Google Scholar

39 

Shen C, Sheng Y, Zhu AC, Robinson S, Jiang X, Dong L, Chen H, Su R, Yin Z, Li W, et al: RNA demethylase ALKBH5 selectively promotes tumorigenesis and cancer stem cell self-renewal in acute myeloid leukemia. Cell Stem Cell. 27:64–80.e9. 2020. View Article : Google Scholar : PubMed/NCBI

40 

Paris J, Morgan M, Campos J, Spencer GJ, Shmakova A, Ivanova I, Mapperley C, Lawson H, Wotherspoon DA, Sepulveda C, et al: Targeting the RNA m6A reader YTHDF2 selectively compromises cancer stem cells in acute myeloid leukemia. Cell Stem Cell. 25:137–148.e6. 2019. View Article : Google Scholar : PubMed/NCBI

41 

Zhang C, Samanta D, Lu H, Bullen JW, Zhang H, Chen I, He X and Semenza GL: Hypoxia induces the breast cancer stem cell phenotype by HIF-dependent and ALKBH5-mediated m6A-demethylation of NANOG mRNA. Proc Natl Acad Sci USA. 113:E2047–E2056. 2016.PubMed/NCBI

42 

Zhu P, He F, Hou Y, Tu G, Li Q, Jin T, Zeng H, Qin Y, Wan X, Qiao Y, et al: A novel hypoxic long noncoding RNA KB-1980E6.3 maintains breast cancer stem cell stemness via interacting with IGF2BP1 to facilitate c-Myc mRNA stability. Oncogene. 40:1609–1627. 2021. View Article : Google Scholar : PubMed/NCBI

43 

Dixit D, Prager BC, Gimple RC, Poh HX, Wang Y, Wu Q, Qiu Z, Kidwell RL, Kim LJY, Xie Q, et al: The RNA m6A reader YTHDF2 maintains oncogene expression and is a targetable dependency in glioblastoma stem cells. Cancer Discov. 11:480–499. 2021. View Article : Google Scholar : PubMed/NCBI

44 

Zhang S, Zhao BS, Zhou A, Lin K, Zheng S, Lu Z, Chen Y, Sulman EP, Xie K, Bögler O, et al: m6A Demethylase ALKBH5 maintains tumorigenicity of glioblastoma Stem-like Cells by sustaining FOXM1 expression and cell proliferation program. Cancer Cell. 31:591–606.e6. 2017. View Article : Google Scholar : PubMed/NCBI

45 

Cui Q, Shi H, Ye P, Li L, Qu Q, Sun G, Sun G, Lu Z, Huang Y, Yang CG, et al: m6A RNA methylation regulates the self-renewal and tumorigenesis of glioblastoma stem cells. Cell Rep. 18:2622–2634. 2017. View Article : Google Scholar : PubMed/NCBI

46 

Ma S, Chen C, Ji X, Liu J, Zhou Q, Wang G, Yuan W, Kan Q and Sun Z: The interplay between m6A RNA methylation and noncoding RNA in cancer. J Hematol Oncol. 12:1212019. View Article : Google Scholar : PubMed/NCBI

47 

Dai D, Wang H, Zhu L, Jin H and Wang X: N6-methyladenosine links RNA metabolism to cancer progression. Cell Death Dis. 9:1242018. View Article : Google Scholar : PubMed/NCBI

48 

Ma X, Cao J, Zhou Z, Lu Y, Li Q, Jin Y, Chen G, Wang W, Ge W, Chen X, et al: N6-methyladenosine modification-mediated mRNA metabolism is essential for human pancreatic lineage specification and islet organogenesis. Nat Commun. 13:41482022. View Article : Google Scholar : PubMed/NCBI

49 

Garg R, Melstrom L, Chen J, He C and Goel A: Targeting FTO suppresses pancreatic carcinogenesis via regulating stem cell maintenance and EMT pathway. Cancers (Basel). 14:59192022. View Article : Google Scholar : PubMed/NCBI

50 

Chijimatsu R, Kobayashi S, Takeda Y, Kitakaze M, Tatekawa S, Arao Y, Nakayama M, Tachibana N, Saito T, Ennishi D, et al: Establishment of a reference single-cell RNA sequencing dataset for human pancreatic adenocarcinoma. iScience. 25:1046592022. View Article : Google Scholar : PubMed/NCBI

51 

Ishii H, Iwatsuki M, Ieta K, Ohta D, Haraguchi N, Mimori K and Mori M: Cancer stem cells and chemoradiation resistance. Cancer Science. 99:1871–1877. 2008. View Article : Google Scholar : PubMed/NCBI

52 

Mehdi A and Rabbani SA: Role of methylation in pro- and anti-cancer immunity. Cancers (Basel). 13:5452021. View Article : Google Scholar : PubMed/NCBI

53 

Tatekawa S, Ofusa K, Chijimatsu R, Vecchione A, Tamari K, Ogawa K and Ishii H: Methylosystem for cancer sieging strategy. Cancers (Basel). 13:50882021. View Article : Google Scholar : PubMed/NCBI

54 

Monné M, Marobbio CMT, Agrimi G, Palmieri L and Palmieri F: Mitochondrial transport and metabolism of the major methyl donor and versatile cofactor S-adenosylmethionine, and related diseases: A review. IUBMB Life. 74:573–591. 2022. View Article : Google Scholar : PubMed/NCBI

55 

Wu X and Zhang Y: TET-mediated active DNA demethylation: Mechanism, function and beyond. Nat Rev Genet. 18:517–534. 2017. View Article : Google Scholar : PubMed/NCBI

56 

He L, Li H, Wu A, Peng Y, Shu G and Yin G: Functions of N6-methyladenosine and its role in cancer. Mol Cancer. 18:1762019. View Article : Google Scholar : PubMed/NCBI

57 

Lan Q, Liu PY, Haase J, Bell JL, Hüttelmaier S and Liu T: The critical role of RNA m6A methylation in cancer. Cancer Res. 79:1285–1292. 2019. View Article : Google Scholar : PubMed/NCBI

58 

Ryall JG, Cliff T, Dalton S and Sartorelli V: Metabolic reprogramming of stem cell epigenetics. Cell Stem Cell. 17:651–662. 2015. View Article : Google Scholar : PubMed/NCBI

59 

Nuñez JK, Chen J, Pommier GC, Cogan JZ, Replogle JM, Adriaens C, Ramadoss GN, Shi Q, Hung KL, Samelson AJ, et al: Genome-wide programmable transcriptional memory by CRISPR-based epigenome editing. Cell. 184:2503–2519.e17. 2021. View Article : Google Scholar : PubMed/NCBI

60 

Yankova E, Blackaby W, Albertella M, Rak J, De Braekeleer E, Tsagkogeorga G, Pilka ES, Aspris D, Leggate D, Hendrick AG, et al: Small molecule inhibition of METTL3 as a strategy against myeloid leukaemia. Nature. 593:597–601. 2021. View Article : Google Scholar : PubMed/NCBI

61 

Huff S, Tiwari SK, Gonzalez GM, Wang Y and Rana TM: m6A-RNA demethylase FTO inhibitors impair self-renewal in glioblastoma stem cells. ACS Chem Biol. 16:324–333. 2021. View Article : Google Scholar : PubMed/NCBI

62 

Wang JN, Wang F, Ke J, Li Z, Xu CH, Yang Q, Chen X, He XY, He Y, Suo XG, et al: Inhibition of METTL3 attenuates renal injury and inflammation by alleviating TAB3 m6A modifications via IGF2BP2-dependent mechanisms. Sci Transl Med. 14:eabk27092022. View Article : Google Scholar : PubMed/NCBI

63 

Huang B, Liu C, Wu Q, Zhang J, Min Q, Sheng T, Wang X and Zou Y: Long non-coding RNA NEAT1 facilitates pancreatic cancer progression through negative modulation of miR-506-3p. Biochem Biophys Res Commun. 482:828–834. 2017. View Article : Google Scholar : PubMed/NCBI

64 

Gupta VK and Banerjee S: Isolation of lipid raft proteins from CD133+ cancer stem cells. Methods Mol Biol. 1609:25–31. 2017. View Article : Google Scholar : PubMed/NCBI

65 

Li C, Heidt DG, Dalerba P, Burant CF, Zhang L, Adsay V, Wicha M, Clarke MF and Simeone DM: Identification of pancreatic cancer stem cells. Cancer Res. 67:1030–1037. 2007. View Article : Google Scholar : PubMed/NCBI

66 

Zhou T, Liu J, Xie Y, Yuan S, Guo Y, Bai W, Zhao K, Jiang W, Wang H, Wang H, et al: ESE3/EHF, a promising target of rosiglitazone, suppresses pancreatic cancer stemness by downregulating CXCR4. Gut. 71:357–371. 2022. View Article : Google Scholar : PubMed/NCBI

67 

Hamada S, Satoh K, Hirota M, Kanno A, Umino J, Ito H, Masamune A, Kikuta K, Kume K and Shimosegawa T: The homeobox gene MSX2 determines chemosensitivity of pancreatic cancer cells via the regulation of transporter gene ABCG2. J Cell Physiol. 227:729–738. 2012. View Article : Google Scholar : PubMed/NCBI

68 

Ling X, Wu W, Fan C, Xu C, Liao J, Rich LJ, Huang RY, Repasky EA, Wang X and Li F: An ABCG2 non-substrate anticancer agent FL118 targets drug-resistant cancer stem-like cells and overcomes treatment resistance of human pancreatic cancer. J Exp Clin Cancer Res. 37:2402018. View Article : Google Scholar : PubMed/NCBI

69 

Li C, Wu JJ, Hynes M, Dosch J, Sarkar B, Welling TH, Pasca di Magliano M and Simeone DM: c-Met is a marker of pancreatic cancer stem cells and therapeutic target. Gastroenterology. 141:2218–2227.e5. 2011. View Article : Google Scholar : PubMed/NCBI

70 

Aliebrahimi S, Kouhsari SM, Arab SS, Shadboorestan A and Ostad SN: Phytochemicals, withaferin A and carnosol, overcome pancreatic cancer stem cells as c-Met inhibitors. Biomed Pharmacother. 106:1527–1536. 2018. View Article : Google Scholar : PubMed/NCBI

71 

Nimmakayala RK, Leon F, Rachagani S, Rauth S, Nallasamy P, Marimuthu S, Shailendra GK, Chhonker YS, Chugh S, Chirravuri R, et al: Metabolic programming of distinct cancer stem cells promotes metastasis of pancreatic ductal adenocarcinoma. Oncogene. 40:215–231. 2021. View Article : Google Scholar : PubMed/NCBI

72 

Matsuda Y, Tanaka M, Sawabe M, Mori S, Muramatsu M, Mieno MN, Ishiwata T and Arai T: The stem cell-specific intermediate filament nestin missense variation p.A1199P is associated with pancreatic cancer. Oncol Lett. 17:4647–4654. 2019.PubMed/NCBI

73 

Xia T, Wu X, Cao M, Zhang P, Shi G, Zhang J, Lu Z, Wu P, Cai B, Miao Y and Jiang K: The RNA m6A methyltransferase METTL3 promotes pancreatic cancer cell proliferation and invasion. Pathol Res Pract. 215:1526662019. View Article : Google Scholar : PubMed/NCBI

74 

Zhang J, Bai R, Li M, Ye H, Wu C, Wang C, Li S, Tan L, Mai D, Li G, et al: Excessive miR-25-3p maturation via N6-methyladenosine stimulated by cigarette smoke promotes pancreatic cancer progression. Nat Commun. 10:18582019. View Article : Google Scholar : PubMed/NCBI

75 

Tang Y, Gao G, Xia WW and Wang JB: METTL3 promotes the growth and metastasis of pancreatic cancer by regulating the m6A modification and stability of E2F5. Cell Signal. 99:1104402022. View Article : Google Scholar : PubMed/NCBI

76 

Guo Z, Zhang X, Lin C, Huang Y, Zhong Y, Guo H, Zheng Z and Weng S: METTL3-IGF2BP3-axis mediates the proliferation and migration of pancreatic cancer by regulating spermine synthase m6A modification. Front Oncol. 12:9622042022. View Article : Google Scholar : PubMed/NCBI

77 

Li Y, Huang H, Zhu Y, Xu B, Chen J, Liu Y, Zheng X and Chen L: Increased expression of METTL3 in pancreatic cancer tissues associates with poor survival of the patients. World J Surg Oncol. 20:2832022. View Article : Google Scholar : PubMed/NCBI

78 

Song Z, Wang X, Chen F, Chen Q, Liu W, Yang X, Zhu X, Liu X and Wang P: LncRNA MALAT1 regulates METTL3-mediated PD-L1 expression and immune infiltrates in pancreatic cancer. Front Oncol. 12:10042122022. View Article : Google Scholar : PubMed/NCBI

79 

Taketo K, Konno M, Asai A, Koseki J, Toratani M, Satoh T, Doki Y, Mori M, Ishii H and Ogawa K: The epitranscriptome m6A writer METTL3 promotes chemo- and radioresistance in pancreatic cancer cells. Int J Oncol. 52:621–629. 2018.PubMed/NCBI

80 

Jiang Z, Song X, Wei Y, Li Y, Kong D and Sun J: N(6)-methyladenosine-mediated miR-380-3p maturation and upregulation promotes cancer aggressiveness in pancreatic cancer. Bioengineered. 13:14460–14471. 2022. View Article : Google Scholar : PubMed/NCBI

81 

Chen JQ, Tao YP, Hong YG, Li HF, Huang ZP, Xu XF, Zheng H and Hu LK: M6A-mediated up-regulation of LncRNA LIFR-AS1 enhances the progression of pancreatic cancer via miRNA-150-5p/VEGFA/Akt signaling. Cell Cycle. 20:2507–2518. 2021. View Article : Google Scholar : PubMed/NCBI

82 

He Y, Liu Y, Wu D, Chen L, Luo Z, Shi X, Li K, Hu H, Qu G, Zhao Q and Lian C: Linc-UROD stabilizes ENO1 and PKM to strengthen glycolysis, proliferation and migration of pancreatic cancer cells. Transl Oncol. 27:1015832023. View Article : Google Scholar : PubMed/NCBI

83 

Tatekawa S, Tamari K, Chijimatsu R, Konno M, Motooka D, Mitsufuji S, Akita H, Kobayashi S, Murakumo Y, Doki Y, et al: N(6)-methyladenosine methylation-regulated polo-like kinase 1 cell cycle homeostasis as a potential target of radiotherapy in pancreatic adenocarcinoma. Sci Rep. 12:110742022. View Article : Google Scholar : PubMed/NCBI

84 

Ye X, Wang LP, Han C, Hu H, Ni CM, Qiao GL, Ouyang L and Ni JS: Increased m6A modification of lncRNA DBH-AS1 suppresses pancreatic cancer growth and gemcitabine resistance via the miR-3163/USP44 axis. Ann Transl Med. 10:3042022. View Article : Google Scholar : PubMed/NCBI

85 

Huang C, Zhou S, Zhang C, Jin Y, Xu G, Zhou L, Ding G, Pang T, Jia S and Cao L: ZC3H13-mediated N6-methyladenosine modification of PHF10 is impaired by fisetin which inhibits the DNA damage response in pancreatic cancer. Cancer Lett. 530:16–28. 2022. View Article : Google Scholar : PubMed/NCBI

86 

Hou J, Wang Z, Li H, Zhang H and Luo L: Gene signature and identification of clinical trait-related m6 A regulators in pancreatic cancer. Front Genet. 11:5222020. View Article : Google Scholar : PubMed/NCBI

87 

Wang W, He Y, Zhai LL, Chen LJ, Yao LC, Wu L, Tang ZG and Ning JZ: m6A RNA demethylase FTO promotes the growth, migration and invasion of pancreatic cancer cells through inhibiting TFPI-2. Epigenetics. 17:1738–1752. 2022. View Article : Google Scholar : PubMed/NCBI

88 

Huang R, Yang L, Zhang Z, Liu X, Fei Y, Tong WM, Niu Y and Liang Z: RNA m6A demethylase ALKBH5 protects against pancreatic ductal adenocarcinoma via targeting regulators of iron metabolism. Front Cell Dev Biol. 9:7242822021. View Article : Google Scholar : PubMed/NCBI

89 

Cui L, Ma R, Cai J, Guo C, Chen Z, Yao L, Wang Y, Fan R, Wang X and Shi Y: RNA modifications: Importance in immune cell biology and related diseases. Signal Transduct Target Ther. 7:3342022. View Article : Google Scholar : PubMed/NCBI

90 

Sato H, Hara T, Tatekawa S, Sasaki K, Kobayashi S, Kitagawa T, Doki Y, Eguchi H, Ogawa K, Uchida S and Ishii H: Emerging roles of long noncoding and circular RNAs in pancreatic ductal adenocarcinoma. Front Physiol. 13:10259232022. View Article : Google Scholar : PubMed/NCBI

91 

Takeda Y, Chijimatsu R, Vecchione A, Arai T, Kitagawa T, Ofusa K, Yabumoto M, Hirotsu T, Eguchi H, Doki Y and Ishii H: Impact of one-carbon metabolism-driving epitranscriptome as a therapeutic target for gastrointestinal cancer. Int J Mol Sci. 22:72782021. View Article : Google Scholar : PubMed/NCBI

92 

Takeda Y, Chijimatsu R, Ofusa K, Kobayashi S, Doki Y, Eguchi H and Ishii H: Cancer metabolism challenges genomic instability and clonal evolution as therapeutic targets. Cancer Sci. 113:1097–1104. 2022. View Article : Google Scholar : PubMed/NCBI

93 

Zagorac S, Garcia-Bermejo L and Sainz B Jr: The epigenetic landscape of pancreatic cancer stem cells. Epigenomes. 2:102018. View Article : Google Scholar

94 

Liu Y, Tang G and Li J: Long non-coding RNA NEAT1 participates in ventilator-induced lung injury by regulating miR-20b expression. Mol Med Rep. 25:662022. View Article : Google Scholar : PubMed/NCBI

95 

Xia L, Li F, Qiu J, Feng Z, Xu Z, Chen Z and Sun J: Oncogenic miR-20b-5p contributes to malignant behaviors of breast cancer stem cells by bidirectionally regulating CCND1 and E2F1. BMC Cancer. 20:9492020. View Article : Google Scholar : PubMed/NCBI

96 

Kroeze LI, van der Reijden BA and Jansen JH: 5-Hydroxymethylcytosine: An epigenetic mark frequently deregulated in cancer. Biochim Biophys Acta. 1855:144–154. 2015.PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Tsuji Y, Hara T, Meng S, Sato H, Arao Y, Ofusa K and Ishii H: Role of RNA methylation in the regulation of pancreatic cancer stem cells (Review). Oncol Lett 26: 336, 2023.
APA
Tsuji, Y., Hara, T., Meng, S., Sato, H., Arao, Y., Ofusa, K., & Ishii, H. (2023). Role of RNA methylation in the regulation of pancreatic cancer stem cells (Review). Oncology Letters, 26, 336. https://doi.org/10.3892/ol.2023.13922
MLA
Tsuji, Y., Hara, T., Meng, S., Sato, H., Arao, Y., Ofusa, K., Ishii, H."Role of RNA methylation in the regulation of pancreatic cancer stem cells (Review)". Oncology Letters 26.2 (2023): 336.
Chicago
Tsuji, Y., Hara, T., Meng, S., Sato, H., Arao, Y., Ofusa, K., Ishii, H."Role of RNA methylation in the regulation of pancreatic cancer stem cells (Review)". Oncology Letters 26, no. 2 (2023): 336. https://doi.org/10.3892/ol.2023.13922
Copy and paste a formatted citation
x
Spandidos Publications style
Tsuji Y, Hara T, Meng S, Sato H, Arao Y, Ofusa K and Ishii H: Role of RNA methylation in the regulation of pancreatic cancer stem cells (Review). Oncol Lett 26: 336, 2023.
APA
Tsuji, Y., Hara, T., Meng, S., Sato, H., Arao, Y., Ofusa, K., & Ishii, H. (2023). Role of RNA methylation in the regulation of pancreatic cancer stem cells (Review). Oncology Letters, 26, 336. https://doi.org/10.3892/ol.2023.13922
MLA
Tsuji, Y., Hara, T., Meng, S., Sato, H., Arao, Y., Ofusa, K., Ishii, H."Role of RNA methylation in the regulation of pancreatic cancer stem cells (Review)". Oncology Letters 26.2 (2023): 336.
Chicago
Tsuji, Y., Hara, T., Meng, S., Sato, H., Arao, Y., Ofusa, K., Ishii, H."Role of RNA methylation in the regulation of pancreatic cancer stem cells (Review)". Oncology Letters 26, no. 2 (2023): 336. https://doi.org/10.3892/ol.2023.13922
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