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Article

Cytopenia after CAR‑T cell therapy: Analysis of 63 patients with relapsed and refractory B‑cell non‑Hodgkin lymphoma

  • Authors:
    • Tingting Qiu
    • Luan Hu
    • Yongtian Zhang
    • Ying Wang
    • Sha Ma
    • Depeng Li
    • Zhenyu Li
    • Kailin Xu
  • View Affiliations / Copyright

    Affiliations: Department of Hematology, The Affiliated Hospital of Xuzhou Medical University, Xuzhou, Jiangsu 221002, P.R. China
  • Article Number: 338
    |
    Published online on: June 22, 2023
       https://doi.org/10.3892/ol.2023.13924
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Abstract

The present study aimed to determine the clinical characteristics of cytopenia in patients with relapsed and refractory B‑cell non‑Hodgkin lymphoma (B‑NHL) who were treated with chimeric antigen receptor T‑cell (CAR‑T) therapy. Thus, a total of 63 patients with relapsed and refractory B‑NHL who underwent CAR‑T therapy between March 2017 and October 2021 were retrospectively selected for analysis. Neutropenia, anemia and thrombocytopenia at grade ≥3 occurred in 48 (76.19%), 16 (25.39%) and 15 (23.80%) cases, respectively. The results of a multivariate analysis demonstrated that the baseline absolute neutrophil count (ANC) and hemoglobin concentration were independent risk factors for grade ≥3 cytopenia. A total of 3 patients died early and were therefore excluded from the present study. Furthermore, cell recovery was examined at day +28 after infusion; 21 patients (35%) did not recover from cytopenia and 39 patients (65%) recovered. A multivariate analysis demonstrated that the baseline ANC <2.29x109/l, baseline hemoglobin <114.50 g/l and baseline IL‑6 >21.43 pg/l were independent risk factors affecting hemocyte recovery. In conclusion, patients with relapsed and refractory B‑NHL exhibited an increased incidence of grade ≥3 hematologic toxicity following CAR‑T cell therapy, while baseline blood cell and IL‑6 levels are independent risk factors for hemocyte recovery.
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Copy and paste a formatted citation
Spandidos Publications style
Qiu T, Hu L, Zhang Y, Wang Y, Ma S, Li D, Li Z and Xu K: Cytopenia after CAR‑T cell therapy: Analysis of 63 patients with relapsed and refractory B‑cell non‑Hodgkin lymphoma. Oncol Lett 26: 338, 2023.
APA
Qiu, T., Hu, L., Zhang, Y., Wang, Y., Ma, S., Li, D. ... Xu, K. (2023). Cytopenia after CAR‑T cell therapy: Analysis of 63 patients with relapsed and refractory B‑cell non‑Hodgkin lymphoma. Oncology Letters, 26, 338. https://doi.org/10.3892/ol.2023.13924
MLA
Qiu, T., Hu, L., Zhang, Y., Wang, Y., Ma, S., Li, D., Li, Z., Xu, K."Cytopenia after CAR‑T cell therapy: Analysis of 63 patients with relapsed and refractory B‑cell non‑Hodgkin lymphoma". Oncology Letters 26.2 (2023): 338.
Chicago
Qiu, T., Hu, L., Zhang, Y., Wang, Y., Ma, S., Li, D., Li, Z., Xu, K."Cytopenia after CAR‑T cell therapy: Analysis of 63 patients with relapsed and refractory B‑cell non‑Hodgkin lymphoma". Oncology Letters 26, no. 2 (2023): 338. https://doi.org/10.3892/ol.2023.13924
Copy and paste a formatted citation
x
Spandidos Publications style
Qiu T, Hu L, Zhang Y, Wang Y, Ma S, Li D, Li Z and Xu K: Cytopenia after CAR‑T cell therapy: Analysis of 63 patients with relapsed and refractory B‑cell non‑Hodgkin lymphoma. Oncol Lett 26: 338, 2023.
APA
Qiu, T., Hu, L., Zhang, Y., Wang, Y., Ma, S., Li, D. ... Xu, K. (2023). Cytopenia after CAR‑T cell therapy: Analysis of 63 patients with relapsed and refractory B‑cell non‑Hodgkin lymphoma. Oncology Letters, 26, 338. https://doi.org/10.3892/ol.2023.13924
MLA
Qiu, T., Hu, L., Zhang, Y., Wang, Y., Ma, S., Li, D., Li, Z., Xu, K."Cytopenia after CAR‑T cell therapy: Analysis of 63 patients with relapsed and refractory B‑cell non‑Hodgkin lymphoma". Oncology Letters 26.2 (2023): 338.
Chicago
Qiu, T., Hu, L., Zhang, Y., Wang, Y., Ma, S., Li, D., Li, Z., Xu, K."Cytopenia after CAR‑T cell therapy: Analysis of 63 patients with relapsed and refractory B‑cell non‑Hodgkin lymphoma". Oncology Letters 26, no. 2 (2023): 338. https://doi.org/10.3892/ol.2023.13924
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