Long noncoding RNAs, glucose metabolism and cancer (Review)
- Authors:
- Xin-Rui Hou
- Zhen-Dong Zhang
- Xiao-Lan Cao
- Xiao-Ping Wang
-
Affiliations: Graduate School, Xizang Minzu University, Xianyang, Shaanxi 712082, P.R. China, Graduate School, Xizang Minzu University, Xianyang, Shaanxi 712082, P.R. China, Key Laboratory of High Altitude Hypoxia Environment and Life Health, Xizang Minzu University, Xianyang, Shaanxi 712082, P.R. China - Published online on: June 22, 2023 https://doi.org/10.3892/ol.2023.13925
- Article Number: 340
-
Copyright: © Hou et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
This article is mentioned in:
Abstract
 |
 |
|
Ma Y, Yang Y, Wang F, Moyer MP, Wei Q, Zhang P, Yang Z, Liu W, Zhang H, Chen N, et al: Long non-coding RNA CCAL regulates colorectal cancer progression by activating Wnt/β-catenin signalling pathway via suppression of activator protein 2α. Gut. 65:1494–1504. 2016. View Article : Google Scholar : PubMed/NCBI | |
|
Yang X, Xie Z, Lei X and Gan R: Long non-coding RNA GAS5 in human cancer. Oncol Lett. 20:2587–2594. 2020. View Article : Google Scholar : PubMed/NCBI | |
|
Cabili MN, Trapnell C, Goff L, Koziol M, Tazon-Vega B, Regev A and Rinn JL: Integrative annotation of human large intergenic noncoding RNAs reveals global properties and specific subclasses. Genes Dev. 25:1915–1927. 2011. View Article : Google Scholar : PubMed/NCBI | |
|
Hansen TB, Jensen TI, Clausen BH, Bramsen JB, Finsen B, Damgaard CK and Kjems J: Natural RNA circles function as efficient microRNA sponges. Nature. 495:384–388. 2013. View Article : Google Scholar : PubMed/NCBI | |
|
Huang Z, Zhou JK, Peng Y, He W and Huang C: The role of long noncoding RNAs in hepatocellular carcinoma. Mol Cancer. 19:772020. View Article : Google Scholar : PubMed/NCBI | |
|
Chen B, Dragomir MP, Fabris L, Bayraktar R, Knutsen E, Liu X, Tang C, Li Y, Shimura T, Ivkovic TC, et al: The long noncoding RNA CCAT2 induces chromosomal instability through BOP1-AURKB signaling. Gastroenterology. 159:2146–2162.e33. 2020. View Article : Google Scholar : PubMed/NCBI | |
|
Ji D, Wang Y, Li H, Sun B and Luo X: Long non-coding RNA LINC00461/miR-149-5p/LRIG2 axis regulates hepatocellular carcinoma progression. Biochem Biophys Res Commun. 512:176–181. 2019. View Article : Google Scholar : PubMed/NCBI | |
|
Gil N and Ulitsky I: Regulation of gene expression by cis-acting long non-coding RNAs. Nat Rev Genet. 21:102–117. 2020. View Article : Google Scholar : PubMed/NCBI | |
|
Shi H, Li K, Feng J, Liu G, Feng Y and Zhang X: LncRNA-DANCR Interferes With miR-125b-5p/HK2 axis to desensitize colon cancer cells to cisplatin vis activating anaerobic glycolysis. Front Oncol. 10:10342020. View Article : Google Scholar : PubMed/NCBI | |
|
Dimitrova N, Zamudio JR, Jong RM, Soukup D, Resnick R, Sarma K, Ward AJ, Raj A, Lee JT, Sharp PA and Jacks T: LincRNA-p21 activates p21 in cis to promote Polycomb target gene expression and to enforce the G1/S checkpoint. Mol Cell. 54:777–790. 2014. View Article : Google Scholar : PubMed/NCBI | |
|
Feng J, Ma J, Liu S, Wang J and Chen Y: A noncoding RNA LINC00504 interacts with c-Myc to regulate tumor metabolism in colon cancer. J Cell Biochem. 120:14725–14734. 2019. View Article : Google Scholar : PubMed/NCBI | |
|
Wang Y, Lu JH, Wu QN, Jin Y, Wang DS, Chen YX, Liu J, Luo XJ, Meng Q, Pu HY, et al: LncRNA LINRIS stabilizes IGF2BP2 and promotes the aerobic glycolysis in colorectal cancer. Mol Cancer. 18:1742019. View Article : Google Scholar : PubMed/NCBI | |
|
Gao P, Xia JH, Sipeky C, Dong XM, Zhang Q, Yang Y, Zhang P, Cruz SP, Zhang K, Zhu J, et al: Biology and clinical implications of the 19q13 aggressive prostate cancer susceptibility locus. Cell. 174:576–589.e18. 2018. View Article : Google Scholar : PubMed/NCBI | |
|
Bian Z, Zhang J, Li M, Feng Y, Wang X, Zhang J, Yao S, Jin G, Du J, Han W, et al: LncRNA-FEZF1-AS1 promotes tumor proliferation and metastasis in colorectal cancer by regulating PKM2 Signaling. Clin Cancer Res. 24:4808–4819. 2018. View Article : Google Scholar : PubMed/NCBI | |
|
Liu PY, Tee AE, Milazzo G, Hannan KM, Maag J, Mondal S, Atmadibrata B, Bartonicek N, Peng H, Ho N, et al: The long noncoding RNA lncNB1 promotes tumorigenesis by interacting with ribosomal protein RPL35. Nat Commun. 10:50262019. View Article : Google Scholar : PubMed/NCBI | |
|
Goodall GJ and Wickramasinghe VO: RNA in cancer. Nat Rev Cancer. 21:22–36. 2021. View Article : Google Scholar : PubMed/NCBI | |
|
Li W, Huang K, Wen F, Cui G, Guo H, He Z and Zhao S: LINC00184 silencing inhibits glycolysis and restores mitochondrial oxidative phosphorylation in esophageal cancer through demethylation of PTEN. EBioMedicine. 44:298–310. 2019. View Article : Google Scholar : PubMed/NCBI | |
|
Hua JT, Ahmed M, Guo H, Zhang Y, Chen S, Soares F, Lu J, Zhou S, Wang M, Li H, et al: Risk SNP-Mediated promoter-enhancer switching drives prostate cancer through lncRNA PCAT19. Cell. 174:564–575.e18. 2018. View Article : Google Scholar : PubMed/NCBI | |
|
Guo W, Dong Z, Liu S, Qiao Y, Kuang G, Guo Y, Shen S and Liang J: Promoter hypermethylation-mediated downregulation of miR-770 and its host gene MEG3, a long non-coding RNA, in the development of gastric cardia adenocarcinoma. Mol Carcinog. 56:1924–1934. 2017. View Article : Google Scholar : PubMed/NCBI | |
|
Ganapathy-Kanniappan S and Geschwind JF: Tumor glycolysis as a target for cancer therapy: Progress and prospects. Mol Cancer. 12:1522013. View Article : Google Scholar : PubMed/NCBI | |
|
Warburg O: On the origin of cancer cells. Science. 123:309–314. 1956. View Article : Google Scholar : PubMed/NCBI | |
|
Chen C, Wei M, Wang C, Sun D, Liu P, Zhong X and Yu W: Long noncoding RNA KCNQ1OT1 promotes colorectal carcinogenesis by enhancing aerobic glycolysis via hexokinase-2. Aging (Albany NY). 12:11685–11697. 2020. View Article : Google Scholar : PubMed/NCBI | |
|
Wei L, Sun J, Zhang N, Zheng Y, Wang X, Lv L, Liu J, Xu Y, Shen Y and Yang M: Noncoding RNAs in gastric cancer: Implications for drug resistance. Mol Cancer. 19:622020. View Article : Google Scholar : PubMed/NCBI | |
|
Liu Y, He X, Chen Y and Cao D: Long non-coding RNA LINC00504 regulates the Warburg effect in ovarian cancer through inhibition of miR-1244. Mol Cell Biochem. 464:39–50. 2020. View Article : Google Scholar : PubMed/NCBI | |
|
Liu G, Wang L and Li Y: Inhibition of lncRNA-UCA1 suppresses pituitary cancer cell growth and prolactin (PRL) secretion via attenuating glycolysis pathway. In Vitro Cell Dev Biol Anim. 56:642–649. 2020. View Article : Google Scholar : PubMed/NCBI | |
|
Fan L, Huang C, Li J, Gao T, Lin Z and Yao T: Long non-coding RNA urothelial cancer associated 1 regulates radioresistance via the hexokinase 2/glycolytic pathway in cervical cancer. Int J Mol Med. 42:2247–2259. 2018.PubMed/NCBI | |
|
Tang J, Yan T, Bao Y, Shen C, Yu C, Zhu X, Tian X, Guo F, Liang Q, Liu Q, et al: LncRNA GLCC1 promotes colorectal carcinogenesis and glucose metabolism by stabilizing c-Myc. Nat Commun. 10:34992019. View Article : Google Scholar : PubMed/NCBI | |
|
Zhai S, Xu Z, Xie J, Zhang J, Wang X, Peng C, Li H, Chen H, Shen B and Deng X: Epigenetic silencing of LncRNA LINC00261 promotes c-myc-mediated aerobic glycolysis by regulating miR-222-3p/HIPK2/ERK axis and sequestering IGF2BP1. Oncogene. 40:277–291. 2021. View Article : Google Scholar : PubMed/NCBI | |
|
Zhao S, Guan B, Mi Y, Shi D, Wei P, Gu Y, Cai S, Xu Y, Li X, Yan D, et al: LncRNA MIR17HG promotes colorectal cancer liver metastasis by mediating a glycolysis-associated positive feedback circuit. Oncogene. 40:4709–4724. 2021. View Article : Google Scholar : PubMed/NCBI | |
|
Wu X, Qiu L, Feng H, Zhang H, Yu H, Du Y, Wu H, Zhu S, Ruan Y and Jiang H: KHDRBS3 promotes paclitaxel resistance and induces glycolysis through modulated MIR17HG/CLDN6 signaling in epithelial ovarian cancer. Life Sci. 293:1203282022. View Article : Google Scholar : PubMed/NCBI | |
|
Wu K, Wang Z, Huang Y, Yao L, Kang N, Ge W, Zhang R and He W: LncRNA PTPRG-AS1 facilitates glycolysis and stemness properties of esophageal squamous cell carcinoma cells through miR-599/PDK1 axis. J Gastroenterol Hepatol. 37:507–517. 2022. View Article : Google Scholar : PubMed/NCBI | |
|
Sun L, Li J, Yan W, Yao Z, Wang R, Zhou X, Wu H, Zhang G, Shi T and Chen W: H19 promotes aerobic glycolysis, proliferation, and immune escape of gastric cancer cells through the microRNA-519d-3p/lactate dehydrogenase A axis. Cancer Sci. 112:2245–2259. 2021. View Article : Google Scholar : PubMed/NCBI | |
|
Yu T, Li G, Wang C, Gong G, Wang L, Li C, Chen Y and Wang X: MIR210HG regulates glycolysis, cell proliferation, and metastasis of pancreatic cancer cells through miR-125b-5p/HK2/PKM2 axis. RNA Biol. 18:2513–2530. 2021. View Article : Google Scholar : PubMed/NCBI | |
|
Feng X and Yang S: Long non-coding RNA LINC00243 promotes proliferation and glycolysis in non-small cell lung cancer cells by positively regulating PDK4 through sponging miR-507. Mol Cell Biochem. 463:127–136. 2020. View Article : Google Scholar : PubMed/NCBI | |
|
Li Y, Li H, Wang W, Yu X and Xu Q: LINC00346 regulates glycolysis by modulation of glucose transporter 1 in breast cancer cells. Mol Cell Probes. 54:1016672020. View Article : Google Scholar : PubMed/NCBI | |
|
Shi Z, Li G, Li Z, Liu J and Tang Y: TMEM161B-AS1 suppresses proliferation, invasion and glycolysis by targeting miR-23a-3p/HIF1AN signal axis in oesophageal squamous cell carcinoma. J Cell Mol Med. 25:6535–6549. 2021. View Article : Google Scholar : PubMed/NCBI | |
|
Zhang H, Shen X, Xiong S, Peng L, Mai W and Xin L: HEIH promotes malignant progression of gastric cancer by regulating STAT3-Mediated autophagy and glycolysis. Dis Markers. 2022:26345262022.PubMed/NCBI | |
|
Chen G, Jiang J, Wang X, Feng K and Ma K: lncENST suppress the warburg effect regulating the tumor progress by the Nkx2-5/ErbB2 Axis in hepatocellular carcinoma. Comput Math Methods Med. 2021:69595572021. View Article : Google Scholar : PubMed/NCBI | |
|
Cao W, Chen HD, Yu YW, Li N and Chen WQ: Changing profiles of cancer burden worldwide and in China: A secondary analysis of the global cancer statistics 2020. Chin Med J (Engl). 134:783–791. 2021. View Article : Google Scholar : PubMed/NCBI | |
|
Vargas RE and Wang W: Significance of long non-coding RNA AGPG for the metabolism of esophageal cancer. Cancer Commun (Lond). 40:313–315. 2020. View Article : Google Scholar : PubMed/NCBI | |
|
Smyth EC, Nilsson M, Grabsch HI, van Grieken NC and Lordick F: Gastric cancer. Lancet. 396:635–648. 2020. View Article : Google Scholar : PubMed/NCBI | |
|
Pei LJ, Sun PJ, Ma K, Guo YY, Wang LY and Liu FD: LncRNA-SNHG7 interferes with miR-34a to de-sensitize gastric cancer cells to cisplatin. Cancer Biomark. 30:127–137. 2021. View Article : Google Scholar : PubMed/NCBI | |
|
Hu J, Huang L, Ding Q, Lv J and Chen Z: Long noncoding RNA HAGLR sponges miR-338-3p to promote 5-Fu resistance in gastric cancer through targeting the LDHA-glycolysis pathway. Cell Biol Int. 46:173–184. 2022. View Article : Google Scholar : PubMed/NCBI | |
|
Qian Y, Song W, Wu X, Hou G, Wang H, Hang X and Xia T: DLX6 Antisense RNA 1 modulates glucose metabolism and cell growth in gastric cancer by targeting microRNA-4290. Dig Dis Sci. 66:460–473. 2021. View Article : Google Scholar : PubMed/NCBI | |
|
Deng P, Li K, Gu F, Zhang T, Zhao W, Sun M and Hou B: LINC00242/miR-1-3p/G6PD axis regulates Warburg effect and affects gastric cancer proliferation and apoptosis. Mol Med. 27:92021. View Article : Google Scholar : PubMed/NCBI | |
|
Dai T, Zhang X, Zhou X, Hu X, Huang X, Xing F, Tian H and Li Y: Long non-coding RNA VAL facilitates PKM2 enzymatic activity to promote glycolysis and malignancy of gastric cancer. Clin Transl Med. 12:e10882022. View Article : Google Scholar : PubMed/NCBI | |
|
Jin X, Qiao L, Fan H, Liao C, Zheng J, Wang W, Ma X, Yang M, Sun X and Zhao W: Long non-coding RNA MSC-AS1 facilitates the proliferation and glycolysis of gastric cancer cells by regulating PFKFB3 expression. Int J Med Sci. 18:546–554. 2021. View Article : Google Scholar : PubMed/NCBI | |
|
Xu Z, Lv H, Wang Y, Hu C, Chen S, Du Y and Shi Can Cheng X: HAND2-AS1 inhibits gastric adenocarcinoma cells proliferation and aerobic glycolysis via miRNAs Sponge. Cancer Manag Res. 12:3053–3068. 2020. View Article : Google Scholar : PubMed/NCBI | |
|
Qian C, Xu Z, Chen L, Wang Y and Yao J: Long noncoding RNA LINC01391 restrained gastric cancer aerobic glycolysis and tumorigenesis via targeting miR-12116/CMTM2 axis. J Cancer. 11:6264–6276. 2020. View Article : Google Scholar : PubMed/NCBI | |
|
Yan B, Ren Z, Sun J, Ding C and Yang D: IGF2-AS knockdown inhibits glycolysis and accelerates apoptosis of gastric cancer cells through targeting miR-195/CREB1 axis. Biomed Pharmacother. 130:1106002020. View Article : Google Scholar : PubMed/NCBI | |
|
Tan HY, Wang C, Liu G and Zhou X: Long noncoding RNA NEAT1-modulated miR-506 regulates gastric cancer development through targeting STAT3. J Cell Biochem. 120:4827–4836. 2019. View Article : Google Scholar : PubMed/NCBI | |
|
Sun K, Hu P and Xu F: LINC00152/miR-139-5p regulates gastric cancer cell aerobic glycolysis by targeting PRKAA1. Biomed Pharmacother. 97:1296–1302. 2018. View Article : Google Scholar : PubMed/NCBI | |
|
Li M, Cai O, Yu Y and Tan S: Paeonol inhibits the malignancy of Apatinib-resistant gastric cancer cells via LINC00665/miR-665/MAPK1 axis. Phytomedicine. 96:1539032022. View Article : Google Scholar : PubMed/NCBI | |
|
Bertuccio P, Turati F, Carioli G, Rodriguez T, La Vecchia C, Malvezzi M and Negri E: Global trends and predictions in hepatocellular carcinoma mortality. J Hepatol. 67:302–309. 2017. View Article : Google Scholar : PubMed/NCBI | |
|
Wang Y, Yang F, Peng Q, Mei K, He H and Yang Q: Long non-coding RNA SNHG1 activates glycolysis to promote hepatocellular cancer progression through the miR-326/PKM2 axis. J Gene Med. 24:e34402022. View Article : Google Scholar : PubMed/NCBI | |
|
Guan YF, Huang QL, Ai YL, Chen QT, Zhao WX, Wang XM, Wu Q and Chen HZ: Nur77-activated lncRNA WFDC21P attenuates hepatocarcinogenesis via modulating glycolysis. Oncogene. 39:2408–2423. 2020. View Article : Google Scholar : PubMed/NCBI | |
|
Wang C, Li Y, Yan S, Wang H, Shao X, Xiao M, Yang B, Qin G, Kong R, Chen R and Zhang N: Interactome analysis reveals that lncRNA HULC promotes aerobic glycolysis through LDHA and PKM2. Nat Commun. 11:31622020. View Article : Google Scholar : PubMed/NCBI | |
|
Shang R, Wang M, Dai B, Du J, Wang J, Liu Z, Qu S, Yang X, Liu J, Xia C, et al: Long noncoding RNA SLC2A1-AS1 regulates aerobic glycolysis and progression in hepatocellular carcinoma via inhibiting the STAT3/FOXM1/GLUT1 pathway. Mol Oncol. 14:1381–1396. 2020. View Article : Google Scholar : PubMed/NCBI | |
|
Lin YH, Wu MH, Huang YH, Yeh CT, Cheng ML, Chi HC, Tsai CY, Chung IH, Chen CY and Lin KH: Taurine up-regulated gene 1 functions as a master regulator to coordinate glycolysis and metastasis in hepatocellular carcinoma. Hepatology. 67:188–203. 2018. View Article : Google Scholar : PubMed/NCBI | |
|
Li S, Li J, Dai W, Zhang Q, Feng J, Wu L, Liu T, Yu Q, Xu S, Wang W, et al: Genistein suppresses aerobic glycolysis and induces hepatocellular carcinoma cell death. Br J Cancer. 117:1518–1528. 2017. View Article : Google Scholar : PubMed/NCBI | |
|
Li S, Dai W, Mo W, Li J, Feng J, Wu L, Liu T, Yu Q, Xu S, Wang W, et al: By inhibiting PFKFB3, aspirin overcomes sorafenib resistance in hepatocellular carcinoma. Int J Cancer. 141:2571–2584. 2017. View Article : Google Scholar : PubMed/NCBI | |
|
Zhao YH, Zhou M, Liu H, Ding Y, Khong HT, Yu D, Fodstad O and Tan M: Upregulation of lactate dehydrogenase A by ErbB2 through heat shock factor 1 promotes breast cancer cell glycolysis and growth. Oncogene. 28:3689–3701. 2009. View Article : Google Scholar : PubMed/NCBI | |
|
Hu M, Fu Q, Jing C, Zhang X, Qin T and Pan Y: LncRNA HOTAIR knockdown inhibits glycolysis by regulating miR-130a-3p/HIF1A in hepatocellular carcinoma under hypoxia. Biomed Pharmacother. 125:1097032020. View Article : Google Scholar : PubMed/NCBI | |
|
Li Y, Guo D, Zhao Y, Ren M, Lu G, Wang Y, Zhang J, Mi C, He S and Lu X: Long non-coding RNA SNHG5 promotes human hepatocellular carcinoma progression by regulating miR-26a-5p/GSK3β signal pathway. Cell Death Dis. 9:8882018. View Article : Google Scholar : PubMed/NCBI | |
|
Huang Y, Xiang B, Liu Y, Wang Y and Kan H: LncRNA CDKN2B-AS1 promotes tumor growth and metastasis of human hepatocellular carcinoma by targeting let-7c-5p/NAP1L1 axis. Cancer Lett. 437:56–66. 2018. View Article : Google Scholar : PubMed/NCBI | |
|
Zhang H, Su X, Burley SK and Zheng XFS: mTOR regulates aerobic glycolysis through NEAT1 and nuclear paraspeckle-mediated mechanism in hepatocellular carcinoma. Theranostics. 12:3518–3533. 2022. View Article : Google Scholar : PubMed/NCBI | |
|
He H, Chen T, Mo H, Chen S, Liu Q and Guo C: Hypoxia-inducible long noncoding RNA NPSR1-AS1 promotes the proliferation and glycolysis of hepatocellular carcinoma cells by regulating the MAPK/ERK pathway. Biochem Biophys Res Commun. 533:886–892. 2020. View Article : Google Scholar : PubMed/NCBI | |
|
Li X, Zhao Q, Qi J, Wang W, Zhang D, Li Z and Qin C: lncRNA Ftx promotes aerobic glycolysis and tumor progression through the PPARγ pathway in hepatocellular carcinoma. Int J Oncol. 53:551–566. 2018.PubMed/NCBI | |
|
Ma X, Mao Z, Zhu J, Liu H and Chen F: lncRNA PANTR1 Upregulates BCL2A1 expression to promote tumorigenesis and warburg effect of hepatocellular carcinoma through restraining miR-587. J Immunol Res. 2021:17368192021. View Article : Google Scholar : PubMed/NCBI | |
|
Siegel RL, Miller KD and Jemal A: Cancer statistics, 2019. CA Cancer J Clin. 69:7–34. 2019. View Article : Google Scholar : PubMed/NCBI | |
|
Neoptolemos JP, Kleeff J, Michl P, Costello E, Greenhalf W and Palmer DH: Therapeutic developments in pancreatic cancer: Current and future perspectives. Nat Rev Gastroenterol Hepatol. 15:333–348. 2018. View Article : Google Scholar : PubMed/NCBI | |
|
Rahib L, Smith BD, Aizenberg R, Rosenzweig AB, Fleshman JM and Matrisian LM: Projecting cancer incidence and deaths to 2030: The unexpected burden of thyroid, liver, and pancreas cancers in the United States. Cancer Res. 74:2913–2921. 2014. View Article : Google Scholar : PubMed/NCBI | |
|
Xu F, Huang M, Chen Q, Niu Y, Hu Y, Hu P, Chen D, He C, Huang K, Zeng Z, et al: LncRNA HIF1A-AS1 promotes gemcitabine resistance of pancreatic cancer by enhancing glycolysis through modulating the AKT/YB1/HIF1α pathway. Cancer Res. 81:5678–5691. 2021. View Article : Google Scholar : PubMed/NCBI | |
|
Miller KD, Nogueira L, Devasia T, Mariotto AB, Yabroff KR, Jemal A, Kramer J and Siegel RL: Cancer treatment and survivorship statistics, 2022. CA Cancer J Clin. 72:409–436. 2022. View Article : Google Scholar : PubMed/NCBI | |
|
Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA and Jemal A: Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 68:394–424. 2018. View Article : Google Scholar : PubMed/NCBI | |
|
Wu C, Li M, Meng H, Liu Y, Niu W, Zhou Y, Zhao R, Duan Y, Zeng Z, Li X, et al: Analysis of status and countermeasures of cancer incidence and mortality in China. Sci China Life Sci. 62:640–647. 2019. View Article : Google Scholar : PubMed/NCBI | |
|
Yan T, Shen C, Jiang P, Yu C, Guo F, Tian X, Zhu X, Lu S, Han B, Zhong M, et al: Risk SNP-induced lncRNA-SLCC1 drives colorectal cancer through activating glycolysis signaling. Signal Transduct Target Ther. 6:702021. View Article : Google Scholar : PubMed/NCBI | |
|
Huang JZ, Chen M, Chen D, Gao XC, Zhu S, Huang H, Hu M, Zhu H and Yan GR: A peptide encoded by a putative lncRNA HOXB-AS3 suppresses colon cancer growth. Mol Cell. 68:171–184.e6. 2017. View Article : Google Scholar : PubMed/NCBI | |
|
Li S, Zhu K, Liu L, Gu J, Niu H and Guo J: lncARSR sponges miR-34a-5p to promote colorectal cancer invasion and metastasis via hexokinase-1-mediated glycolysis. Cancer Sci. 111:3938–3952. 2020. View Article : Google Scholar : PubMed/NCBI | |
|
Lan Z, Yao X, Sun K, Li A, Liu S and Wang X: The interaction between lncRNA SNHG6 and hnRNPA1 contributes to the growth of colorectal cancer by enhancing aerobic glycolysis through the regulation of alternative splicing of PKM. Front Oncol. 10:3632020. View Article : Google Scholar : PubMed/NCBI | |
|
Zheng H, Zhang M, Ke X, Deng X, Li D and Wang Q, Yan S, Xue Y and Wang Q: LncRNA XIST/miR-137 axis strengthens chemo-resistance and glycolysis of colorectal cancer cells by hindering transformation from PKM2 to PKM1. Cancer Biomark. 30:395–406. 2021. View Article : Google Scholar : PubMed/NCBI | |
|
Cui K, Wu H, Fan J, Zhang L, Li H, Guo H, Yang R and Li Z: The mixture of ferulic acid and P-Coumaric acid suppresses colorectal cancer through lncRNA 495810/PKM2 mediated aerobic glycolysis. Int J Mol Sci. 23:121062022. View Article : Google Scholar : PubMed/NCBI | |
|
Wang Y, Yu G, Liu Y, Xie L, Ge J, Zhao G and Lin J: Hypoxia-induced PTTG3P contributes to colorectal cancer glycolysis and M2 phenotype of macrophage. Biosci Rep. 41:BSR202107642021. View Article : Google Scholar : PubMed/NCBI | |
|
Sun S, Li W, Ma X and Luan H: Long Noncoding RNA LINC00265 promotes glycolysis and lactate production of colorectal cancer through regulating of miR-216b-5p/TRIM44 Axis. Digestion. 101:391–400. 2020. View Article : Google Scholar : PubMed/NCBI | |
|
Yu Z, Wang Y, Deng J, Liu D, Zhang L, Shao H, Wang Z, Zhu W, Zhao C and Ke Q: Long non-coding RNA COL4A2-AS1 facilitates cell proliferation and glycolysis of colorectal cancer cells via miR-20b-5p/hypoxia inducible factor 1 alpha subunit axis. Bioengineered. 12:6251–6263. 2021. View Article : Google Scholar : PubMed/NCBI | |
|
Li C, Wang P, Du J, Chen J, Liu W and Ye K: LncRNA RAD51-AS1/miR-29b/c-3p/NDRG2 crosstalk repressed proliferation, invasion and glycolysis of colorectal cancer. IUBMB Life. 73:286–298. 2021. View Article : Google Scholar : PubMed/NCBI | |
|
Zhang Z, Yang W, Li N, Chen X, Ma F, Yang J, Zhang Y, Chai X, Zhang B, Hou X, et al: LncRNA MCF2L-AS1 aggravates proliferation, invasion and glycolysis of colorectal cancer cells via the crosstalk with miR-874-3p/FOXM1 signaling axis. Carcinogenesis. 42:263–271. 2021. View Article : Google Scholar : PubMed/NCBI | |
|
Guo X, Zhang Y, Liu L, Yang W and Zhang Q: HNF1A-AS1 regulates cell migration, invasion and glycolysis via modulating miR-124/MYO6 in colorectal cancer cells. Onco Targets Ther. 13:1507–1518. 2020. View Article : Google Scholar : PubMed/NCBI | |
|
Li YL, Zhang XX, Yao JN, Gao B, Gao SL, Wang CF, Zhou HN and Zhang LF: ZEB2-AS1 regulates the expression of TAB3 and promotes the development of colon cancer by adsorbing microRNA-188. Eur Rev Med Pharmacol Sci. 24:4180–4189. 2020.PubMed/NCBI | |
|
Wang X, Zhang H, Yin S, Yang Y, Yang H, Yang J, Zhou Z, Li S, Ying G and Ba Y: lncRNA-encoded pep-AP attenuates the pentose phosphate pathway and sensitizes colorectal cancer cells to Oxaliplatin. EMBO Rep. 23:e531402022. View Article : Google Scholar : PubMed/NCBI | |
|
Hong J, Guo F, Lu SY, Shen C, Ma D, Zhang X, Xie Y, Yan T, Yu T, Sun T, et al: F. nucleatum targets lncRNA ENO1-IT1 to promote glycolysis and oncogenesis in colorectal cancer. Gut. 70:2123–2137. 2021. View Article : Google Scholar : PubMed/NCBI | |
|
Zhang H, Qin D, Jiang Z and Zhang J: SNHG9/miR-199a-5p/Wnt2 axis regulates cell growth and aerobic glycolysis in glioblastoma. J Neuropathol Exp Neurol. 78:939–948. 2019. View Article : Google Scholar : PubMed/NCBI | |
|
Lu J, Liu X, Zheng J, Song J, Liu Y, Ruan X, Shen S, Shao L, Yang C, Wang D, et al: Lin28A promotes IRF6-regulated aerobic glycolysis in glioma cells by stabilizing SNHG14. Cell Death Dis. 11:4472020. View Article : Google Scholar : PubMed/NCBI | |
|
Liu X, Zhu Q, Guo Y, Xiao Z, Hu L and Xu Q: LncRNA LINC00689 promotes the growth, metastasis and glycolysis of glioma cells by targeting miR-338-3p/PKM2 axis. Biomed Pharmacother. 117:1090692019. View Article : Google Scholar : PubMed/NCBI | |
|
He Z, You C and Zhao D: Long non-coding RNA UCA1/miR-182/PFKFB2 axis modulates glioblastoma-associated stromal cells-mediated glycolysis and invasion of glioma cells. Biochem Biophys Res Commun. 500:569–576. 2018. View Article : Google Scholar : PubMed/NCBI | |
|
Liu Y, He D, Xiao M, Zhu Y, Zhou J and Cao K: Long noncoding RNA LINC00518 induces radioresistance by regulating glycolysis through an miR-33a-3p/HIF-1α negative feedback loop in melanoma. Cell Death Dis. 12:2452021. View Article : Google Scholar : PubMed/NCBI | |
|
Wang Y, Zhang X, Wang Z, Hu Q, Wu J, Li Y, Ren X, Wu T, Tao X, Chen X, et al: LncRNA-p23154 promotes the invasion-metastasis potential of oral squamous cell carcinoma by regulating Glut1-mediated glycolysis. Cancer Lett. 434:172–183. 2018. View Article : Google Scholar : PubMed/NCBI | |
|
Yang X, Ye H, He M, Zhou X, Sun N, Guo W, Lin X, Huang H, Lin Y, Yao R and Wang H: LncRNA PDIA3P interacts with c-Myc to regulate cell proliferation via induction of pentose phosphate pathway in multiple myeloma. Biochem Biophys Res Commun. 498:207–213. 2018. View Article : Google Scholar : PubMed/NCBI | |
|
Huo N, Cong R, Sun ZJ, Li WC, Zhu X, Xue CY, Chen Z, Ma LY, Chu Z, Han YC, et al: STAT3/LINC00671 axis regulates papillary thyroid tumor growth and metastasis via LDHA-mediated glycolysis. Cell Death Dis. 12:7992021. View Article : Google Scholar : PubMed/NCBI | |
|
Xue L, Li J, Lin Y, Liu D, Yang Q, Jian J and Peng J: m6 A transferase METTL3-induced lncRNA ABHD11-AS1 promotes the Warburg effect of non-small-cell lung cancer. J Cell Physiol. 236:2649–2658. 2021. View Article : Google Scholar : PubMed/NCBI | |
|
Song J, Wu X, Liu F, Li M, Sun Y, Wang Y, Wang C, Zhu K, Jia X, Wang B and Ma X: Long non-coding RNA PVT1 promotes glycolysis and tumor progression by regulating miR-497/HK2 axis in osteosarcoma. Biochem Biophys Res Commun. 490:217–224. 2017. View Article : Google Scholar : PubMed/NCBI | |
|
Han X and Yang Y, Sun Y, Qin L and Yang Y: LncRNA TUG1 affects cell viability by regulating glycolysis in osteosarcoma cells. Gene. 674:87–92. 2018. View Article : Google Scholar : PubMed/NCBI | |
|
Shen Y, Xu J, Pan X, Zhang Y, Weng Y, Zhou D and He S: LncRNA KCNQ1OT1 sponges miR-34c-5p to promote osteosarcoma growth via ALDOA enhanced aerobic glycolysis. Cell Death Dis. 11:2782020. View Article : Google Scholar : PubMed/NCBI | |
|
Xu S, Jia G, Zhang H, Wang L, Cong Y, Lv M, Xu J, Ruan H, Jia X, Xu P and Wang Y: LncRNA HOXB-AS3 promotes growth, invasion and migration of epithelial ovarian cancer by altering glycolysis. Life Sci. 264:1186362021. View Article : Google Scholar : PubMed/NCBI | |
|
Feng Z, Chen R, Huang N and Luo C: Long non-coding RNA ASMTL-AS1 inhibits tumor growth and glycolysis by regulating the miR-93-3p/miR-660/FOXO1 axis in papillary thyroid carcinoma. Life Sci. 244:1172982020. View Article : Google Scholar : PubMed/NCBI | |
|
Chen Z, Hu Z, Sui Q, Huang Y, Zhao M, Li M, Liang J, Lu T, Zhan C, Lin Z, et al: LncRNA FAM83A-AS1 facilitates tumor proliferation and the migration via the HIF-1α/glycolysis axis in lung adenocarcinoma. Int J Biol Sci. 18:522–535. 2022. View Article : Google Scholar : PubMed/NCBI | |
|
Song H, Li D, Wang X, Fang E, Yang F, Hu A, Wang J, Guo Y, Liu Y, Li H, et al: HNF4A-AS1/hnRNPU/CTCF axis as a therapeutic target for aerobic glycolysis and neuroblastoma progression. J Hematol Oncol. 13:242020. View Article : Google Scholar : PubMed/NCBI | |
|
Wan J, Liu Y, Long F, Tian J and Zhang C: circPVT1 promotes osteosarcoma glycolysis and metastasis by sponging miR-423-5p to activate Wnt5a/Ror2 signaling. Cancer Sci. 112:1707–1722. 2021. View Article : Google Scholar : PubMed/NCBI | |
|
Zhao L, Ji G, Le X, Wang C, Xu L, Feng M, Zhang Y, Yang H, Xuan Y, Yang Y, et al: Long Noncoding RNA LINC00092 acts in cancer-associated fibroblasts to drive glycolysis and progression of ovarian cancer. Cancer Res. 77:1369–1382. 2017. View Article : Google Scholar : PubMed/NCBI | |
|
Lin X, Feng D, Li P and Lv Y: LncRNA LINC00857 regulates the progression and glycolysis in ovarian cancer by modulating the Hippo signaling pathway. Cancer Med. 9:8122–8132. 2020. View Article : Google Scholar : PubMed/NCBI |
