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Case Report Open Access

Glioblastoma with a primitive neuronal component: A case report

  • Authors:
    • Qiang Ma
    • Limin Liu
    • Naiying Sun
    • Lixiang Gao
    • Ying Chen
    • Li Liu
    • Wenjun Guo
    • Xingjie Yang
  • View Affiliations / Copyright

    Affiliations: Department of Pathology, Sunshine Union Hospital, Weifang, Shandong 261000, P.R. China
    Copyright: © Ma et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 341
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    Published online on: June 22, 2023
       https://doi.org/10.3892/ol.2023.13927
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Abstract

The present study describes a rare case of glioblastoma with a primitive neuronal component (GBM‑PNC), and provides an in‑depth analysis of the clinical, pathological and differential diagnostic findings. A comprehensive literature review was conducted to enhance the understanding of GBM‑PNC, revealing its distinct characteristics and prognostic implications. A 57‑year‑old woman presented with acute onset headache, nausea and vomiting, leading to the identification of an intracranial mass through magnetic resonance imaging. Surgical resection revealed the coexistence of a glial component and a PNC within the tumor. Immunohistochemical analysis detected the expression of glial fibrillary acidic protein in the glial component and synaptin in the PNC. The pathological diagnosis confirmed the presence of GBM‑PNC. Gene detection analysis revealed no mutations in isocitrate dehydrogenase (IDH)1 and IDH2, and neurotrophic tyrosine kinase receptor‑1 (NTRK1), NTRK2 and NTRK3 genes. GBM‑PNC is characterized by a propensity for recurrence and metastasis, with a low 5‑year survival rate. The present case report highlights the importance of accurate diagnosis and comprehensive characterization of GBM‑PNC to guide treatment decisions and improve patient outcomes.
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Copy and paste a formatted citation
Spandidos Publications style
Ma Q, Liu L, Sun N, Gao L, Chen Y, Liu L, Guo W and Yang X: Glioblastoma with a primitive neuronal component: A case report. Oncol Lett 26: 341, 2023.
APA
Ma, Q., Liu, L., Sun, N., Gao, L., Chen, Y., Liu, L. ... Yang, X. (2023). Glioblastoma with a primitive neuronal component: A case report. Oncology Letters, 26, 341. https://doi.org/10.3892/ol.2023.13927
MLA
Ma, Q., Liu, L., Sun, N., Gao, L., Chen, Y., Liu, L., Guo, W., Yang, X."Glioblastoma with a primitive neuronal component: A case report". Oncology Letters 26.2 (2023): 341.
Chicago
Ma, Q., Liu, L., Sun, N., Gao, L., Chen, Y., Liu, L., Guo, W., Yang, X."Glioblastoma with a primitive neuronal component: A case report". Oncology Letters 26, no. 2 (2023): 341. https://doi.org/10.3892/ol.2023.13927
Copy and paste a formatted citation
x
Spandidos Publications style
Ma Q, Liu L, Sun N, Gao L, Chen Y, Liu L, Guo W and Yang X: Glioblastoma with a primitive neuronal component: A case report. Oncol Lett 26: 341, 2023.
APA
Ma, Q., Liu, L., Sun, N., Gao, L., Chen, Y., Liu, L. ... Yang, X. (2023). Glioblastoma with a primitive neuronal component: A case report. Oncology Letters, 26, 341. https://doi.org/10.3892/ol.2023.13927
MLA
Ma, Q., Liu, L., Sun, N., Gao, L., Chen, Y., Liu, L., Guo, W., Yang, X."Glioblastoma with a primitive neuronal component: A case report". Oncology Letters 26.2 (2023): 341.
Chicago
Ma, Q., Liu, L., Sun, N., Gao, L., Chen, Y., Liu, L., Guo, W., Yang, X."Glioblastoma with a primitive neuronal component: A case report". Oncology Letters 26, no. 2 (2023): 341. https://doi.org/10.3892/ol.2023.13927
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