Natural products as drug candidates for breast cancer (Review)

  • Authors:
    • Nitin T. Telang
  • View Affiliations

  • Published online on: June 28, 2023     https://doi.org/10.3892/ol.2023.13935
  • Article Number: 349
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Abstract

Progression of early‑stage breast cancer to advanced‑stage metastatic disease represents a major cause of death in women. Long‑term conventional and targeted therapy for breast cancer includes multi‑drug combinations of cytotoxic chemotherapeutics and pathway‑selective small molecule inhibitors. These treatment options are frequently associated with systemic toxicity, intrinsic/acquired therapy resistance and emergence of a drug‑resistant cancer stem cell population. This stem cell population has a chemo‑resistant, cancer‑initiating, premalignant phenotype that is accompanied by cellular plasticity and metastatic potential. These limitations emphasize an unmet need to identify testable alternatives against therapy‑resistant metastatic breast cancer. Natural products such as dietary phytochemicals, nutritional herbs and their constitutive bioactive agents have documented human consumption, and lack detectable systemic toxicity and resultant off‑target unfavorable side effects. Because of these advantages, natural products may represent testable alternatives for therapy‑resistant breast cancer. The present review discusses published evidence for growth inhibitory efficacy of natural products on cellular models for molecular subtypes of clinical breast cancer and development of drug‑resistant stem cell models. Collectively, this evidence validates mechanism‑based experimental approaches to screen and prioritize efficacious bioactive agents from natural products as novel drug candidates that may function as therapeutic alternatives for breast cancer.
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August-2023
Volume 26 Issue 2

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Telang NT: Natural products as drug candidates for breast cancer (Review). Oncol Lett 26: 349, 2023
APA
Telang, N.T. (2023). Natural products as drug candidates for breast cancer (Review). Oncology Letters, 26, 349. https://doi.org/10.3892/ol.2023.13935
MLA
Telang, N. T."Natural products as drug candidates for breast cancer (Review)". Oncology Letters 26.2 (2023): 349.
Chicago
Telang, N. T."Natural products as drug candidates for breast cancer (Review)". Oncology Letters 26, no. 2 (2023): 349. https://doi.org/10.3892/ol.2023.13935