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CLPTM1L expression predicts recurrence of patients with intermediate‑ and high‑risk stage IB‑IIB cervical cancer undergoing radical hysterectomy followed by TP as adjuvant chemotherapy

  • Authors:
    • Yuichiro Awazu
    • Takeshi Fukuda
    • Takuya Noda
    • Eijiro Uchikura
    • Shigenori Nanno
    • Kenji Imai
    • Makoto Yamauchi
    • Tomoyo Yasui
    • Toshiyuki Sumi
  • View Affiliations / Copyright

    Affiliations: Department of Obstetrics and Gynecology, Osaka City University Graduate School of Medicine, Osaka, Osaka 5454‑8585, Japan, Department of Obstetrics and Gynecology, Osaka Metropolitan University Graduate School of Medicine, Osaka, Osaka 5454‑8585, Japan
    Copyright: © Awazu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 353
    |
    Published online on: July 4, 2023
       https://doi.org/10.3892/ol.2023.13939
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Abstract

According to the National Comprehensive Cancer Network clinical practice guidelines of cervical cancer, concurrent chemoradiotherapy or radiotherapy is suggested for patients who receive radical hysterectomy and have intermediate‑ and high‑risk cervical cancer. However, adjuvant chemotherapy has been increasingly chosen given the adverse events associated with chemoradiotherapy or radiotherapy and the increase in evidence regarding the efficacy of adjuvant chemotherapy. Given that adjuvant chemotherapy is not a standard treatment at present, if recurrence after adjuvant chemotherapy could be predicted, it would assist the decision of gynecological oncologists selecting which adjuvant therapy (chemotherapy or radiation therapy) to use. Cleft lip and palate transmembrane protein 1‑like protein (CLPTM1L; also known as cisplatin resistance‑related protein 9) is associated with apoptotic mechanisms and is related to the proliferation of the tumor cells and resistance against chemotherapy. In the present study, the association between CLPTM1L expression and recurrence of intermediate‑ and high‑risk stage IB‑IIB cervical cancer in patients undergoing radical hysterectomy followed by treatment with cisplatin and paclitaxel (TP) as adjuvant chemotherapy was determined. Patients were divided into two groups: Recurrence group and no‑recurrence group. CLPTM1L expression was examined using immunohistochemistry in paraffin‑embedded sections using weighted scores. Regarding the characteristics of the patients, a histology of non‑squamous cell carcinoma, lymph node metastasis and parametrium invasion were more common in the recurrence group compared with the non‑recurrence group. In the recurrence group, CLPTM1L expression was significantly higher than that in the no‑recurrence group. Next, patients were divided into low and high‑expression groups based on the weighted score with a cut‑off value of 6. In the high expression group, patients exhibited a higher rate of recurrence (37.5 vs. 5.1%) and had worse overall survival. Multivariate analysis revealed that high CLPTM1L expression was independently related to recurrence. In in vitro analysis, small interfering RNA‑mediated knockdown of CLPTM1L enhanced the sensitivity of cervical cancer cells to cisplatin. In conclusion, the present study revealed that CLPTM1L expression may be a predictive biomarker of recurrence of intermediate‑ and high‑risk stage IB‑IIB cervical cancer in patients undergoing radical hysterectomy followed by TP as adjuvant chemotherapy.
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View References

1 

Sung H, Ferlay J, Siegel RL, Laversanne M, Soerjomataram I, Jemal A and Bray F: Global Cancer Statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 71:209–249. 2021. View Article : Google Scholar : PubMed/NCBI

2 

Abu-Rustum NR, Yashar CM, Bean S, Bradley K, Campos SM, Chon HS, Chu C, Cohn D, Crispens MA, Damast S, et al: NCCN guidelines insights: Cervical cancer, version 1.2020. J Natl Compr Canc Netw. 18:660–666. 2020. View Article : Google Scholar : PubMed/NCBI

3 

Ebina Y, Mikami M, Nagase S, Tabata T, Kaneuchi M, Tashiro H, Mandai M, Enomoto T, Kobayashi Y, Katabuchi H, et al: Japan Society of Gynecologic Oncology guidelines 2017 for the treatment of uterine cervical cancer. Int J Clin Oncol. 24:1–19. 2019. View Article : Google Scholar : PubMed/NCBI

4 

Matoda M, Takeshima N, Michimae H, Iwata T, Yokota H, Torii Y, Yamamoto Y, Takehara K, Nishio S, Takano H, et al: Postoperative chemotherapy for node-positive cervical cancer: Results of a multicenter phase II trial (JGOG1067). Gynecol Oncol. 149:513–519. 2018. View Article : Google Scholar : PubMed/NCBI

5 

Li S, Hu T, Chen Y, Zhou H, Li X, Cheng X, Yang R, Wang S, Xie X and Ma D: Adjuvant chemotherapy, a valuable alternative option in selected patients with cervical cancer. PLoS One. 8:e738372013. View Article : Google Scholar : PubMed/NCBI

6 

Hosaka M, Watari H, Takeda M, Moriwaki M, Hara Y, Todo Y, Ebina Y and Sakuragi N: Treatment of cervical cancer with adjuvant chemotherapy versus adjuvant radiotherapy after radical hysterectomy and systematic lymphadenectomy. J Obstet Gynaecol Res. 34:552–556. 2008. View Article : Google Scholar : PubMed/NCBI

7 

Zhang H, Yu R, Zhang L, Wang R and Xiao L: Chemotherapy versus chemoradiotherapy for FIGO stages IB1 and IIA1 cervical squamous cancer patients with lymphovascular space invasion: A retrospective study. BMC Cancer. 22:2022022. View Article : Google Scholar : PubMed/NCBI

8 

Weng D, Xiong H, Zhu C, Wan X, Chen Y, Wang X, Zhang Y, Jiang J, Zhang X, Gao Q, et al: Adjuvant chemotherapy versus adjuvant concurrent chemoradiotherapy after radical surgery for early-stage cervical cancer: A randomized, non-inferiority, multicenter trial. Front Med. 17:93–104. 2023. View Article : Google Scholar : PubMed/NCBI

9 

Zhang YF, Fan Y, Zhang P, Ruan JY, Mu Y and Li JK: Cervical cancer recurrence and patient survival after radical hysterectomy followed by either adjuvant chemotherapy or adjuvant radiotherapy with optional concurrent chemotherapy: A systematic review and meta-analysis. Front Oncol. 12:8230642022. View Article : Google Scholar : PubMed/NCBI

10 

Ikeda M, Shida M, Shigeta S, Nagase S, Takahashi F, Yamagami W, Katabuchi H, Yaegashi N, Aoki D and Mikami M: The trend and outcome of postsurgical therapy for high-risk early-stage cervical cancer with lymph node metastasis in Japan: A report from the Japan Society of Gynecologic Oncology (JSGO) guidelines evaluation committee. J Gynecol Oncol. 32:e442021. View Article : Google Scholar : PubMed/NCBI

11 

Matsuo K, Nusbaum DJ, Matsuzaki S, Klar M, Shimada M, Takekuma M and Roman LD: Utilization and outcomes of adjuvant systemic chemotherapy alone in high risk, early stage cervical cancer in the United States. Int J Gynecol Cancer. 31:991–1000. 2021. View Article : Google Scholar : PubMed/NCBI

12 

Yamamoto K, Okamoto A, Isonishi S, Ochiai K and Ohtake Y: A novel gene, CRR9, which was up-regulated in CDDP-resistant ovarian tumor cell line, was associated with apoptosis. Biochem Biophys Res Commun. 280:1148–1154. 2001. View Article : Google Scholar : PubMed/NCBI

13 

Chen XF, Cai S, Chen QG, Ni ZH, Tang JH, Xu DW and Wang XB: Multiple variants of TERT and CLPTM1L constitute risk factors for lung adenocarcinoma. Genet Mol Res. 11:370–378. 2012. View Article : Google Scholar : PubMed/NCBI

14 

Pande M, Spitz MR, Wu X, Gorlov IP, Chen WV and Amos CI: Novel genetic variants in the chromosome 5p15.33 region associate with lung cancer risk. Carcinogenesis. 32:1493–1499. 2011. View Article : Google Scholar : PubMed/NCBI

15 

Wang S, Wu J, Hu L, Ding C, Kan Y, Shen Y, Chen X, Shen H, Guo X and Hu Z: Common genetic variants in TERT contribute to risk of cervical cancer in a Chinese population. Mol Carcinog. 51 (Suppl 1):E118–E122. 2012. View Article : Google Scholar : PubMed/NCBI

16 

Petersen GM, Amundadottir L, Fuchs CS, Kraft P, Stolzenberg-Solomon RZ, Jacobs KB, Arslan AA, Bueno-de-Mesquita HB, Gallinger S, Gross M, et al: A genome-wide association study identifies pancreatic cancer susceptibility loci on chromosomes 13q22.1, 1q32.1 and 5p15.33. Nat Genet. 42:224–228. 2010. View Article : Google Scholar : PubMed/NCBI

17 

Rothman N, Garcia-Closas M, Chatterjee N, Malats N, Wu X, Figueroa JD, Real FX, Van Den Berg D, Matullo G, Baris D, et al: A multi-stage genome-wide association study of bladder cancer identifies multiple susceptibility loci. Nat Genet. 42:978–984. 2010. View Article : Google Scholar : PubMed/NCBI

18 

Zhao Y, Chen G, Zhao Y, Song X, Chen H, Mao Y and Lu D: Fine-mapping of a region of chromosome 5p15.33 (TERT-CLPTM1L) suggests a novel locus in TERT and a CLPTM1L haplotype are associated with glioma susceptibility in a Chinese population. Int J Cancer. 131:1569–1576. 2012. View Article : Google Scholar : PubMed/NCBI

19 

Mandour I, Hussein SAM, Essam R and El-Hossainy MA: Study of genetic variants in chromosome 5p15.33 region in non-smoker lung cancer patients. Adv Respir Med. 88:485–494. 2020. View Article : Google Scholar : PubMed/NCBI

20 

Thomsen H, Chattopadhyay S, Hoffmann P, Nöthen MM, Kalirai H, Coupland SE, Jonas JB, Hemminki K and Försti A: Genome-wide study on uveal melanoma patients finds association to DNA repair gene TDP1. Melanoma Res. 30:166–172. 2020. View Article : Google Scholar : PubMed/NCBI

21 

Clarke WR, Amundadottir L and James MA: CLPTM1L/CRR9 ectodomain interaction with GRP78 at the cell surface signals for survival and chemoresistance upon ER stress in pancreatic adenocarcinoma cells. Int J Cancer. 144:1367–1378. 2019. View Article : Google Scholar : PubMed/NCBI

22 

Karami S, Han Y, Pande M, Cheng I, Rudd J, Pierce BL, Nutter EL, Schumacher FR, Kote-Jarai Z, Lindstrom S, et al: Telomere structure and maintenance gene variants and risk of five cancer types. Int J Cancer. 139:2655–2670. 2016. View Article : Google Scholar : PubMed/NCBI

23 

Parashar D, Geethadevi A, McAllister D, Ebben J, Peterson FC, Jensen DR, Bishop E, Pradeep S, Volkman BF, Dwinell MB, et al: Targeted biologic inhibition of both tumor cell-intrinsic and intercellular CLPTM1L/CRR9-mediated chemotherapeutic drug resistance. NPJ Precis Oncol. 5:162021. View Article : Google Scholar : PubMed/NCBI

24 

Sinicrope FA, Ruan SB, Cleary KR, Stephens LC, Lee JJ and Levin B: bcl-2 and p53 oncoprotein expression during colorectal tumorigenesis. Cancer Res. 55:237–241. 1995.PubMed/NCBI

25 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(−Delta Delta C(T)) Method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

26 

Ni Z, Chen Q, Lai Y, Wang Z, Sun L, Luo X and Wang X: Prognostic significance of CLPTM1L expression and its effects on migration and invasion of human lung cancer cells. Cancer Biomark. 16:445–452. 2016. View Article : Google Scholar : PubMed/NCBI

27 

Trezise S, Karnowski A, Fedele PL, Mithraprabhu S, Liao Y, D'Costa K, Kueh AJ, Hardy MP, Owczarek CM, Herold MJ, et al: Mining the plasma cell transcriptome for novel cell surface proteins. Int J Mol Sci. 19:21612018. View Article : Google Scholar : PubMed/NCBI

28 

Jia J, Bosley AD, Thompson A, Hoskins JW, Cheuk A, Collins I, Parikh H, Xiao Z, Ylaya K, Dzyadyk M, et al: CLPTM1L promotes growth and enhances aneuploidy in pancreatic cancer cells. Cancer Res. 74:2785–2795. 2014. View Article : Google Scholar : PubMed/NCBI

29 

Ye Y, Li Z, Kang S, Zhan X, Zhang Y, Xu Y, Li W, Lang J, Liu P and Chen C: Impact of different postoperative adjuvant therapies on the survival of early-stage cervical cancer patients with one intermediate-risk factor: A multicenter study of 14 years. J Obstet Gynaecol Res. 49:1579–1591. 2023. View Article : Google Scholar : PubMed/NCBI

30 

Curtin JP, Hoskins WJ, Venkatraman ES, Almadrones L, Podratz KC, Long H, Teneriello M, Averette HA and Sevin BU: Adjuvant chemotherapy versus chemotherapy plus pelvic irradiation for high-risk cervical cancer patients after radical hysterectomy and pelvic lymphadenectomy (RH-PLND): A randomized phase III trial. Gynecol Oncol. 61:3–10. 1996. View Article : Google Scholar : PubMed/NCBI

31 

James MA, Vikis HG, Tate E, Rymaszewski AL and You M: CRR9/CLPTM1L regulates cell survival signaling and is required for Ras transformation and lung tumorigenesis. Cancer Res. 74:1116–1127. 2014. View Article : Google Scholar : PubMed/NCBI

32 

James MA, Wen W, Wang Y, Byers LA, Heymach JV, Coombes KR, Girard L, Minna J and You M: Functional characterization of CLPTM1L as a lung cancer risk candidate gene in the 5p15.33 locus. PLoS One. 7:e361162012. View Article : Google Scholar : PubMed/NCBI

33 

Puskás LG, Mán I, Szebeni G, Tiszlavicz L, Tsai S and James MA: Novel Anti-CRR9/CLPTM1L antibodies with antitumorigenic activity inhibit cell surface accumulation, PI3K interaction, and survival signaling. Mol Cancer Ther. 15:985–997. 2016. View Article : Google Scholar : PubMed/NCBI

34 

Grad JM, Zeng XR and Boise LH: Regulation of Bcl-xL: A little bit of this and a little bit of STAT. Curr Opin Oncol. 12:543–549. 2000. View Article : Google Scholar : PubMed/NCBI

35 

Shimada M, Nishimura R, Nogawa T, Hatae M, Takehara K, Yamada H, Kurachi H, Yokoyama Y, Sugiyama T and Kigawa J: Comparison of the outcome between cervical adenocarcinoma and squamous cell carcinoma patients with adjuvant radiotherapy following radical surgery: SGSG/TGCU Intergroup Surveillance. Mol Clin Oncol. 1:780–784. 2013. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Awazu Y, Fukuda T, Noda T, Uchikura E, Nanno S, Imai K, Yamauchi M, Yasui T and Sumi T: CLPTM1L expression predicts recurrence of patients with intermediate‑ and high‑risk stage IB‑IIB cervical cancer undergoing radical hysterectomy followed by TP as adjuvant chemotherapy. Oncol Lett 26: 353, 2023.
APA
Awazu, Y., Fukuda, T., Noda, T., Uchikura, E., Nanno, S., Imai, K. ... Sumi, T. (2023). CLPTM1L expression predicts recurrence of patients with intermediate‑ and high‑risk stage IB‑IIB cervical cancer undergoing radical hysterectomy followed by TP as adjuvant chemotherapy. Oncology Letters, 26, 353. https://doi.org/10.3892/ol.2023.13939
MLA
Awazu, Y., Fukuda, T., Noda, T., Uchikura, E., Nanno, S., Imai, K., Yamauchi, M., Yasui, T., Sumi, T."CLPTM1L expression predicts recurrence of patients with intermediate‑ and high‑risk stage IB‑IIB cervical cancer undergoing radical hysterectomy followed by TP as adjuvant chemotherapy". Oncology Letters 26.2 (2023): 353.
Chicago
Awazu, Y., Fukuda, T., Noda, T., Uchikura, E., Nanno, S., Imai, K., Yamauchi, M., Yasui, T., Sumi, T."CLPTM1L expression predicts recurrence of patients with intermediate‑ and high‑risk stage IB‑IIB cervical cancer undergoing radical hysterectomy followed by TP as adjuvant chemotherapy". Oncology Letters 26, no. 2 (2023): 353. https://doi.org/10.3892/ol.2023.13939
Copy and paste a formatted citation
x
Spandidos Publications style
Awazu Y, Fukuda T, Noda T, Uchikura E, Nanno S, Imai K, Yamauchi M, Yasui T and Sumi T: CLPTM1L expression predicts recurrence of patients with intermediate‑ and high‑risk stage IB‑IIB cervical cancer undergoing radical hysterectomy followed by TP as adjuvant chemotherapy. Oncol Lett 26: 353, 2023.
APA
Awazu, Y., Fukuda, T., Noda, T., Uchikura, E., Nanno, S., Imai, K. ... Sumi, T. (2023). CLPTM1L expression predicts recurrence of patients with intermediate‑ and high‑risk stage IB‑IIB cervical cancer undergoing radical hysterectomy followed by TP as adjuvant chemotherapy. Oncology Letters, 26, 353. https://doi.org/10.3892/ol.2023.13939
MLA
Awazu, Y., Fukuda, T., Noda, T., Uchikura, E., Nanno, S., Imai, K., Yamauchi, M., Yasui, T., Sumi, T."CLPTM1L expression predicts recurrence of patients with intermediate‑ and high‑risk stage IB‑IIB cervical cancer undergoing radical hysterectomy followed by TP as adjuvant chemotherapy". Oncology Letters 26.2 (2023): 353.
Chicago
Awazu, Y., Fukuda, T., Noda, T., Uchikura, E., Nanno, S., Imai, K., Yamauchi, M., Yasui, T., Sumi, T."CLPTM1L expression predicts recurrence of patients with intermediate‑ and high‑risk stage IB‑IIB cervical cancer undergoing radical hysterectomy followed by TP as adjuvant chemotherapy". Oncology Letters 26, no. 2 (2023): 353. https://doi.org/10.3892/ol.2023.13939
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