S100 proteins in head and neck squamous cell carcinoma (Review)
- Authors:
- Yihong Hu
- Yucheng Han
- Minhui He
- Yanqun Zhang
- Xianqiong Zou
-
Affiliations: Department of Oral and Maxillofacial Surgery, Affiliated Stomatology Hospital of Guilin Medical University, Guilin, Guangxi 541004, P.R. China, Department of Oncology, Xiangya Hospital, Central South University, Changsha, Hunan 410008, P.R. China - Published online on: July 6, 2023 https://doi.org/10.3892/ol.2023.13948
- Article Number: 362
-
Copyright: © Hu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
This article is mentioned in:
Abstract
Sapkota D, Costea DE, Blo M, Bruland O, Lorens JB, Vasstrand EN and Ibrahim SO: S100A14 inhibits proliferation of oral carcinoma derived cells through G1-arrest. Oral Oncol. 48:219–225. 2012. View Article : Google Scholar : PubMed/NCBI | |
Gonzalez LL, Garrie K and Turner MD: Role of S100 proteins in health and disease. Biochim Biophys Acta Mol Cell Res. 1867:1186772020. View Article : Google Scholar : PubMed/NCBI | |
Zaia AA, Sappington KJ, Nisapakultorn K, Chazin WJ, Dietrich EA, Ross KF and Herzberg MC: Subversion of antimicrobial calprotectin (S100A8/S100A9 complex) in the cytoplasm of TR146 epithelial cells after invasion by Listeria monocytogenes. Mucosal Immunol. 2:43–53. 2009. View Article : Google Scholar : PubMed/NCBI | |
Zou X, Sorenson BS, Ross KF and Herzberg MC: Augmentation of epithelial resistance to invading bacteria by using mRNA transfections. Infect Immun. 81:3975–3983. 2013. View Article : Google Scholar : PubMed/NCBI | |
Singh P and Ali SA: Multifunctional role of S100 protein family in the immune system: An Update. Cells. 11:22742022. View Article : Google Scholar : PubMed/NCBI | |
Crowe LAN, McLean M, Kitson SM, Melchor EG, Patommel K, Cao HM, Reilly JH, Leach WJ, Rooney BP, Spencer SJ, et al: S100A8 & S100A9: Alarmin mediated inflammation in tendinopathy. Sci Rep. 9:14632019. View Article : Google Scholar : PubMed/NCBI | |
Schenten V, Plançon S, Jung N, Hann J, Bueb JL, Bréchard S, Tschirhart EJ and Tolle F: Secretion of the phosphorylated form of S100A9 from neutrophils is essential for the proinflammatory functions of extracellular S100A8/A9. Front Immunol. 9:4472018. View Article : Google Scholar : PubMed/NCBI | |
De Veirman K, De Beule N, Maes K, Menu E, De Bruyne E, De Raeve H, Fostier K, Moreaux J, Kassambara A, Hose D, et al: Extracellular S100A9 protein in bone marrow supports multiple myeloma survival by stimulating angiogenesis and cytokine secretion. Cancer Immunol Res. 5:839–846. 2017. View Article : Google Scholar : PubMed/NCBI | |
Wu Z, Jiang D, Huang X, Cai M, Yuan K and Huang P: S100A8 as a promising biomarker and oncogenic immune protein in the tumor microenvironment: An integrative pancancer analysis. J Oncol. 2022:69476522022.PubMed/NCBI | |
Basso D, Fogar P and Plebani M: The S100A8/A9 complex reduces CTLA4 expression by immature myeloid cells: Implications for pancreatic cancer-driven immunosuppression. Oncoimmunology. 2:e244412013. View Article : Google Scholar : PubMed/NCBI | |
Kligman D and Hilt DC: The S100 protein family. Trends Biochem Sci. 13:437–443. 1988. View Article : Google Scholar : PubMed/NCBI | |
Allgower C, Kretz AL, von Karstedt S, Wittau M, Henne-Bruns D and Lemke J: Friend or Foe: S100 proteins in cancer. Cancers (Basel). 12:20372020. View Article : Google Scholar : PubMed/NCBI | |
Delangre E, Oppliger E, Berkcan S, Gjorgjieva M, Correia de Sousa M and Foti M: S100 proteins in fatty liver disease and hepatocellular carcinoma. Int J Mol Sci. 23:110302022. View Article : Google Scholar : PubMed/NCBI | |
Austermann J, Spiekermann C and Roth J: S100 proteins in rheumatic diseases. Nat Rev Rheumatol. 14:528–541. 2018. View Article : Google Scholar : PubMed/NCBI | |
Raffat MA, Hadi NI, Hosein M, Mirza S, Ikram S and Akram Z: S100 proteins in oral squamous cell carcinoma. Clin Chim Acta. 480:143–149. 2018. View Article : Google Scholar : PubMed/NCBI | |
Zhang S, Wang Z, Liu W, Lei R, Shan J, Li L and Wang X: Distinct prognostic values of S100 mRNA expression in breast cancer. Sci Rep. 7:397862017. View Article : Google Scholar : PubMed/NCBI | |
Bai Y, Li LD, Li J and Lu X: Prognostic values of S100 family members in ovarian cancer patients. BMC Cancer. 18:12562018. View Article : Google Scholar : PubMed/NCBI | |
Kleindienst A, Hesse F, Bullock MR and Buchfelder M: The neurotrophic protein S100B: Value as a marker of brain damage and possible therapeutic implications. Prog Brain Res. 161:317–325. 2007. View Article : Google Scholar : PubMed/NCBI | |
Li HB, Wang JL, Jin XD, Zhao L, Ye HL, Kuang YB, Ma Y, Jiang XY and Yu ZY: Comprehensive analysis of the transcriptional expressions and prognostic value of S100A family in pancreatic ductal adenocarcinoma. BMC Cancer. 21:10392021. View Article : Google Scholar : PubMed/NCBI | |
Arantes L, De Carvalho AC, Melendez ME and Lopes Carvalho A: Serum, plasma and saliva biomarkers for head and neck cancer. Expert Rev Mol Diagn. 18:85–112. 2018. View Article : Google Scholar : PubMed/NCBI | |
Chi H, Xie X, Yan Y, Peng G, Strohmer DF, Lai G, Zhao S, Xia Z and Tian G: Natural killer cell-related prognosis signature characterizes immune landscape and predicts prognosis of HNSCC. Front Immunol. 13:10186852022. View Article : Google Scholar : PubMed/NCBI | |
Xu J, Lai F, Liu Y, Tan Z, Zheng C, Wang J, Guo H, Jiang L, Ge X, Lan X, et al: Novel computer-aided reconstruction of soft tissue defects following resection of oral and oropharyngeal squamous cell carcinoma. World J Surg Oncol. 20:1962022. View Article : Google Scholar : PubMed/NCBI | |
Runge A, Mayr M, Schwaiger T, Sprung S, Chetta P, Gottfried T, Dudas J, Greier MC, Glatz MC, Haybaeck J, et al: Patient-derived head and neck tumor slice cultures: A versatile tool to study oncolytic virus action. Sci Rep. 12:153342022. View Article : Google Scholar : PubMed/NCBI | |
Mei Z, Zhang K, Lam AK, Huang J, Qiu F, Qiao B and Zhang Y: MUC1 as a target for CAR-T therapy in head and neck squamous cell carinoma. Cancer Med. 9:640–652. 2020. View Article : Google Scholar : PubMed/NCBI | |
Chen Y, Li ZY, Zhou GQ and Sun Y: An Immune-related gene prognostic index for head and neck squamous cell carcinoma. Clin Cancer Res. 27:330–341. 2021. View Article : Google Scholar : PubMed/NCBI | |
Chen Y, Jiang N, Chen M, Sui B and Liu X: Identification of tumor antigens and immune subtypes in head and neck squamous cell carcinoma for mRNA vaccine development. Front Cell Dev Biol. 10:10647542022. View Article : Google Scholar : PubMed/NCBI | |
Wei T, Leisegang M, Xia M, Kiyotani K, Li N, Zeng C, Deng C, Jiang J, Harada M, Agrawal N, et al: Generation of neoantigen-specific T cells for adoptive cell transfer for treating head and neck squamous cell carcinoma. Oncoimmunology. 10:19297262021. View Article : Google Scholar : PubMed/NCBI | |
Massarelli E, William W, Johnson F, Kies M, Ferrarotto R, Guo M, Feng L, Lee JJ, Tran H, Kim YU, et al: Combining immune checkpoint blockade and tumor-specific vaccine for patients with incurable human papillomavirus 16-related cancer: A phase 2 clinical trial. JAMA Oncol. 5:67–73. 2019. View Article : Google Scholar : PubMed/NCBI | |
Sasahira T, Kurihara-Shimomura M, Shimojjukoku Y, Shima K and Kirita T: Searching for new molecular targets for oral squamous cell carcinoma with a view to clinical implementation of precision medicine. J Pers Med. 12:4132022. View Article : Google Scholar : PubMed/NCBI | |
Sundriyal D, Arya L, Saha R, Walia M and Nayak PP: Hypercalcemia of malignancy: Time to pull the brakes. Indian J Surg Oncol. 13:28–32. 2022. View Article : Google Scholar : PubMed/NCBI | |
Roesch Ely M, Nees M, Karsai S, Magele I, Bogumil R, Vorderwulbecke S, Ruess A, Dietz A, Schnolzer M and Bosch FX: Transcript and proteome analysis reveals reduced expression of calgranulins in head and neck squamous cell carcinoma. Eur J Cell Biol. 84:431–444. 2005. View Article : Google Scholar : PubMed/NCBI | |
Argyris PP, Slama Z, Malz C, Koutlas IG, Pakzad B, Patel K, Kademani D, Khammanivong A and Herzberg MC: Intracellular calprotectin (S100A8/A9) controls epithelial differentiation and caspase-mediated cleavage of EGFR in head and neck squamous cell carcinoma. Oral Oncol. 95:1–10. 2019. View Article : Google Scholar : PubMed/NCBI | |
Oliveira MV, Fraga CA, Barros LO, Pereira CS, Santos SH, Basile JR, Gomez RS, Guimaraes AL and De-Paula AM: High expression of S100A4 and endoglin is associated with metastatic disease in head and neck squamous cell carcinoma. Clin Exp Metastasis. 31:639–649. 2014. View Article : Google Scholar : PubMed/NCBI | |
Tripathi SC, Matta A, Kaur J, Grigull J, Chauhan SS, Thakar A, Shukla NK, Duggal R, DattaGupta S, Ralhan R and Siu KW: Nuclear S100A7 is associated with poor prognosis in head and neck cancer. PLoS One. 5:e119392010. View Article : Google Scholar : PubMed/NCBI | |
Sapkota D, Bruland O, Bøe OE, Bakeer H, Elgindi OA, Vasstrand EN and Ibrahim SO: Expression profile of the S100 gene family members in oral squamous cell carcinomas. J Oral Pathol Med. 37:607–615. 2008. View Article : Google Scholar : PubMed/NCBI | |
Driemel O, Murzik U, Escher N, Melle C, Bleul A, Dahse R, Reichert TE, Ernst G and von Eggeling F: Protein profiling of oral brush biopsies: S100A8 and S100A9 can differentiate between normal, premalignant, and tumor cells. Proteomics Clin Appl. 1:486–493. 2007. View Article : Google Scholar : PubMed/NCBI | |
Hu S, Arellano M, Boontheung P, Wang J, Zhou H, Jiang J, Elashoff D, Wei R, Loo JA and Wong DT: Salivary proteomics for oral cancer biomarker discovery. Clin Cancer Res. 14:6246–6252. 2008. View Article : Google Scholar : PubMed/NCBI | |
Kesting MR, Sudhoff H, Hasler RJ, Nieberler M, Pautke C, Wolff KD, Wagenpfeil S, Al-Benna S, Jacobsen F and Steinstraesser L: Psoriasin (S100A7) up-regulation in oral squamous cell carcinoma and its relation to clinicopathologic features. Oral Oncol. 45:731–736. 2009. View Article : Google Scholar : PubMed/NCBI | |
Sapkota D, Bruland O, Costea DE, Haugen H, Vasstrand EN and Ibrahim SO: S100A14 regulates the invasive potential of oral squamous cell carcinoma derived cell-lines in vitro by modulating expression of matrix metalloproteinases, MMP1 and MMP9. Eur J Cancer. 47:600–710. 2011. View Article : Google Scholar : PubMed/NCBI | |
Roman E, Lunde ML, Miron T, Warnakulasauriya S, Johannessen AC, Vasstrand EN and Ibrahim SO: Analysis of protein expression profile of oral squamous cell carcinoma by MALDI-TOF-MS. Anticancer Res. 33:837–845. 2013.PubMed/NCBI | |
Jou YJ, Hua CH, Lin CD, Lai CH, Huang SH, Tsai MH, Kao JY and Lin CW: S100A8 as potential salivary biomarker of oral squamous cell carcinoma using nanoLC-MS/MS. Clin Chim Acta. 436:121–129. 2014. View Article : Google Scholar : PubMed/NCBI | |
Natarajan J, Hunter K, Mutalik VS and Radhakrishnan R: Overexpression of S100A4 as a biomarker of metastasis and recurrence in oral squamous cell carcinoma. J Appl Oral Sci. 22:426–433. 2014. View Article : Google Scholar : PubMed/NCBI | |
Kumar M, Srivastava G, Kaur J, Assi J, Alyass A, Leong I, MacMillan C, Witterick I, Shukla NK, Thakar A, et al: Prognostic significance of cytoplasmic S100A2 overexpression in oral cancer patients. J Transl Med. 13:82015. View Article : Google Scholar : PubMed/NCBI | |
Sapkota D, Bruland O, Parajuli H, Osman TA, Teh MT, Johannessen AC and Costea DE: S100A16 promotes differentiation and contributes to a less aggressive tumor phenotype in oral squamous cell carcinoma. BMC Cancer. 15:6312015. View Article : Google Scholar : PubMed/NCBI | |
Sood A, Mishra D, Kharbanda OP, Chauhan SS, Gupta SD, Deo SSV, Yadav R, Ralhan R, Kumawat R and Kaur H: Role of S100 A7 as a diagnostic biomarker in oral potentially malignant disorders and oral cancer. J Oral Maxillofac Pathol. 26:166–172. 2022. View Article : Google Scholar : PubMed/NCBI | |
Pandey S, Osman TA, Sharma S, Vallenari EM, Shahdadfar A, Pun CB, Gautam DK, Uhlin-Hansen L, Rikardsen O, Johannessen AC, et al: Loss of S100A14 expression at the tumor-invading front correlates with poor differentiation and worse prognosis in oral squamous cell carcinoma. Head Neck. 42:2088–2098. 2020. View Article : Google Scholar : PubMed/NCBI | |
Tyszkiewicz T, Jarzab M, Szymczyk C, Kowal M, Krajewska J, Jaworska M, Fraczek M, Krajewska A, Hadas E, Swierniak M, et al: Epidermal differentiation complex (locus 1q21) gene expression in head and neck cancer and normal mucosa. Folia Histochem Cytobiol. 52:79–89. 2014. View Article : Google Scholar : PubMed/NCBI | |
Qu ZF, Ma H, Duan XF, Wu R and Zou Y: The expression and significance of S100A9 in oral squamous cell carcinoma. Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 31:219–222. 2017.(In Chinese). PubMed/NCBI | |
Suzuki S, Honda K, Nanjo H, Iikawa N, Tsuji T, Kawasaki Y, Yamazaki K, Sato T, Saito H, Shiina K and Ishikawa K: CD147 expression correlates with lymph node metastasis in T1-T2 squamous cell carcinoma of the tongue. Oncol Lett. 14:4670–4676. 2017. View Article : Google Scholar : PubMed/NCBI | |
Argyris PP, Slama ZM, Ross KF, Khammanivong A and Herzberg MC: Calprotectin and the initiation and progression of head and neck cancer. J Dent Res. 97:674–682. 2018. View Article : Google Scholar : PubMed/NCBI | |
Mints M, Landin D, Nasman A, Mirzaie L, Ursu RG, Zupancic M, Marklund L, Dalianis T, Munck-Wikland E and Ramqvist T: Tumour inflammation signature and expression of S100A12 and HLA class I improve survival in HPV-negative hypopharyngeal cancer. Sci Rep. 11:17822021. View Article : Google Scholar : PubMed/NCBI | |
Ohnishi Y, Yasui H, Kakudo K and Nozaki M: Lapatinib-resistant cancer cells possessing epithelial cancer stem cell properties develop sensitivity during sphere formation by activation of the ErbB/AKT/cyclin D2 pathway. Oncol Rep. 36:3058–3064. 2016. View Article : Google Scholar : PubMed/NCBI | |
Ohnishi Y, Yasui H, Nozaki M and Nakajima M: Molecularly-targeted therapy for the oral cancer stem cells. Jpn Dent Sci Rev. 54:88–103. 2018. View Article : Google Scholar : PubMed/NCBI | |
Moriyama-Kita M, Endo Y, Yonemura Y, Heizmann CW, Miyamori H, Sato H, Yamamoto E and Sasaki T: S100A4 regulates E-cadherin expression in oral squamous cell carcinoma. Cancer Lett. 230:211–218. 2005. View Article : Google Scholar : PubMed/NCBI | |
Sun Q, Wang R, Wang Y, Luo J, Wang P and Cheng B: Notch1 is a potential therapeutic target for the treatment of human hepatitis B virus X protein-associated hepatocellular carcinoma. Oncol Rep. 31:933–939. 2014. View Article : Google Scholar : PubMed/NCBI | |
Khammanivong A, Wang C, Sorenson BS, Ross KF and Herzberg MC: S100A8/A9 (calprotectin) negatively regulates G2/M cell cycle progression and growth of squamous cell carcinoma. PLoS One. 8:e693952013. View Article : Google Scholar : PubMed/NCBI | |
Cheng S, Zhang X, Huang N, Qiu Q, Jin Y and Jiang D: Down-regulation of S100A9 inhibits osteosarcoma cell growth through inactivating MAPK and NF-κB signaling pathways. BMC Cancer. 16:2532016. View Article : Google Scholar : PubMed/NCBI | |
Li R, Li W, He F, Zhang M, Luo H and Tang H: Systematic screening identifies a TEAD4-S100A13 axis modulating cisplatin sensitivity of oral squamous cell carcinoma cells. J Oral Pathol Med. 50:882–890. 2021. View Article : Google Scholar : PubMed/NCBI | |
Takeuchi S, Kasamatsu A, Yamatoji M, Nakashima D, Endo-Sakamoto Y, Koide N, Takahara T, Shimizu T, Iyoda M, Ogawara K, et al: TEAD4-YAP interaction regulates tumoral growth by controlling cell-cycle arrest at the G1 phase. Biochem Biophys Res Commun. 486:385–390. 2017. View Article : Google Scholar : PubMed/NCBI | |
Sivadasan P, Gupta MK, Sathe G, Sudheendra HV, Sunny SP, Renu D, Hari PS, Gowda H, Suresh A, Kuriakose MA and Sirdeshmukh R: Salivary proteins from dysplastic leukoplakia and oral squamous cell carcinoma and their potential for early detection. J Proteomics. 212:1035742020. View Article : Google Scholar : PubMed/NCBI | |
Shan J, Sun Z, Yang J, Xu J, Shi W, Wu Y, Fan Y and Li H: Discovery and preclinical validation of proteomic biomarkers in saliva for early detection of oral squamous cell carcinomas. Oral Dis. 25:97–107. 2019. View Article : Google Scholar : PubMed/NCBI | |
Cheng YS, Rees T and Wright J: A review of research on salivary biomarkers for oral. Clin Transl Med. 3:32014. View Article : Google Scholar : PubMed/NCBI | |
Xu J, Gross N, Zang Y, Cao S, Yang F, Yang Z, Yu W, Lei D and Pan X: Overexpression of S100A4 predicts migration, invasion, and poor prognosis of hypopharyngeal squamous cell carcinoma. Mol Diagn Ther. 23:407–417. 2019. View Article : Google Scholar : PubMed/NCBI | |
Cheng LH, Hung KF, Huang TF, Hsieh HP, Wang SY, Huang CY and Lo JF: Attenuation of cancer-initiating cells stemness properties by abrogating S100A4 calcium binding ability in head and neck cancers. Oncotarget. 7:78946–78957. 2016. View Article : Google Scholar : PubMed/NCBI | |
Wu P, Quan H, Kang J, He J, Luo S, Xie C, Xu J, Tang Y and Zhao S: Downregulation of Calcium-Binding Protein S100A9 Inhibits Hypopharyngeal Cancer Cell Proliferation and Invasion Ability Through Inactivation of NF-kappaB Signaling. Oncol Res. 25:1479–1488. 2017. View Article : Google Scholar : PubMed/NCBI | |
Wang C, Lin C, Tao Q, Zhao S, Liu H and Li L: Evaluation of calcium-binding protein A11 promotes the carcinogenesis of hypopharygeal squamous cell carcinoma via the PI3K/AKT signaling pathway. Am J Transl Res. 11:3472–3480. 2019.PubMed/NCBI | |
Hu W, Tao Z, Zhou Q, Zhao D, Gu L, Zhu S and Chen J: Effects of S100 calcium-binding protein A8 (S100A8) and S100 calcium-binding protein A9 (S100A9) on matrix metalloproteinase (MMP) expression in nasopharyngeal carcinoma CNE-2 cells. Transl Cancer Res. 10:1874–1884. 2021. View Article : Google Scholar : PubMed/NCBI | |
Isaksen B and Fagerhol MK: Calprotectin inhibits matrix metalloproteinases by sequestration of zinc. Mol Pathol. 54:289–292. 2001. View Article : Google Scholar : PubMed/NCBI | |
Carlsson H, Yhr M, Petersson S, Collins N, Polyak K and Enerback C: Psoriasin (S100A7) and calgranulin-B (S100A9) induction is dependent on reactive oxygen species and is downregulated by Bcl-2 and antioxidants. Cancer Biol Ther. 4:998–1005. 2005. View Article : Google Scholar : PubMed/NCBI | |
Ichikawa M, Williams R, Wang L, Vogl T and Srikrishna G: S100A8/A9 activate key genes and pathways in colon tumor progression. Mol Cancer Res. 9:133–148. 2011. View Article : Google Scholar : PubMed/NCBI | |
Xiao Z, Li M, Li G, Fu Y, Peng F, Chen Y and Chen Z: Proteomic characterization reveals a molecular portrait of nasopharyngeal carcinoma differentiation. J Cancer. 8:570–577. 2017. View Article : Google Scholar : PubMed/NCBI | |
Li A, Shi D, Xu B, Wang J, Tang YL, Xiao W, Shen G, Deng W and Zhao C: S100A6 promotes cell proliferation in human nasopharyngeal carcinoma via the p38/MAPK signaling pathway. Mol Carcinog. 56:972–984. 2017. View Article : Google Scholar : PubMed/NCBI | |
Wen L, Ding Y, Chen X, Tian K, Li D, Liang K and Yue B: Influences of S100A8 and S100A9 on proliferation of nasopharyngeal carcinoma cells through PI3K/Akt signaling pathway. Biomed Res Int. 2021:99173652021. View Article : Google Scholar : PubMed/NCBI | |
Wang C, Wang X, Han A, Wang Y and Jiang H: Proof-of-concept study investigating the role of S100P-RAGE in nasopharyngeal carcinoma. Exp Ther Med. 21:4702021. View Article : Google Scholar : PubMed/NCBI | |
Liu L, Liu S, Deng P, Liang Y, Xiao R, Tang LQ, Chen J, Chen QY, Guan P, Yan SM, et al: Targeting the IRAK1-S100A9 axis overcomes resistance to paclitaxel in nasopharyngeal carcinoma. Cancer Res. 81:1413–1425. 2021. View Article : Google Scholar : PubMed/NCBI | |
Meng DF, Sun R, Liu GY, Peng LX, Zheng LS, Xie P, Lin ST, Mei Y, Qiang YY, Li CZ, et al: S100A14 suppresses metastasis of nasopharyngeal carcinoma by inhibition of NF-kB signaling through degradation of IRAK1. Oncogene. 39:5307–5322. 2020. View Article : Google Scholar : PubMed/NCBI | |
Png YT, Yang AZY, Lee MY, Chua MJM and Lim CM: The role of NK cells in EBV infection and EBV-associated NPC. Viruses. 13:3002021. View Article : Google Scholar : PubMed/NCBI | |
Lin Z, Deng L, Ji J, Cheng C, Wan X, Jiang R, Tang J, Zhuo H, Sun B and Chen Y: S100A4 hypomethylation affects epithelial-mesenchymal transition partially induced by LMP2A in nasopharyngeal carcinoma. Mol Carcinog. 55:1467–1476. 2016. View Article : Google Scholar : PubMed/NCBI | |
Hino R, Uozaki H, Murakami N, Ushiku T, Shinozaki A, Ishikawa S, Morikawa T, Nakaya T, Sakatani T, Takada K and Fukayama M: Activation of DNA methyltransferase 1 by EBV latent membrane protein 2A leads to promoter hypermethylation of PTEN gene in gastric carcinoma. Cancer Res. 69:2766–2774. 2009. View Article : Google Scholar : PubMed/NCBI | |
Chakladar J, Li WT, Bouvet M, Chang EY, Wang-Rodriguez J and Ongkeko WM: Papillary thyroid carcinoma variants are characterized by Co-dysregulation of immune and cancer associated genes. Cancers (Basel). 11:11792019. View Article : Google Scholar : PubMed/NCBI | |
Martinez-Aguilar J, Clifton-Bligh R and Molloy MP: A multiplexed, targeted mass spectrometry assay of the S100 protein family uncovers the isoform-specific expression in thyroid tumours. BMC Cancer. 15:1992015. View Article : Google Scholar : PubMed/NCBI | |
Nipp M, Elsner M, Balluff B, Meding S, Sarioglu H, Ueffing M, Rauser S, Unger K, Höfler H, Walch A and Zitzelsberger H: S100-A10, thioredoxin, and S100-A6 as biomarkers of papillary thyroid carcinoma with lymph node metastasis identified by MALDI imaging. J Mol Med (Berl). 90:163–174. 2012. View Article : Google Scholar : PubMed/NCBI | |
Zhao M, Wang KJ, Tan Z, Zheng CM, Liang Z and Zhao JQ: Identification of potential therapeutic targets for papillary thyroid carcinoma by bioinformatics analysis. Oncol Lett. 11:51–58. 2016. View Article : Google Scholar : PubMed/NCBI | |
Wang X, Sun Z, Tian W, Piao C, Xie X, Zang J, Peng S, Yu X and Wang Y: S100A12 is a promising biomarker in papillary thyroid cancer. Sci Rep. 10:17242020. View Article : Google Scholar : PubMed/NCBI | |
Wang G, Li HN, Cui XQ, Xu T, Dong ML, Li SY and Li XR: S100A1 is a potential biomarker for papillary thyroid carcinoma diagnosis and prognosis. J Cancer. 12:5760–5771. 2021. View Article : Google Scholar : PubMed/NCBI | |
Huang P and Xue J: Long non-coding RNA FOXD2-AS1 regulates the tumorigenesis and progression of breast cancer via the S100 calcium binding protein A1/Hippo signaling pathway. Int J Mol Med. 46:1477–1489. 2020.PubMed/NCBI | |
Tian J and Luo B: Identification of three prognosis-related differentially expressed lncRNAs driven by copy number variation in thyroid cancer. J Immunol Res. 2022:92037962022. View Article : Google Scholar : PubMed/NCBI | |
Xia F, Chen Y, Jiang B, Du X, Peng Y, Wang W, Huang W, Feng T and Li X: Long Noncoding RNA HOXA-AS2 promotes papillary thyroid cancer progression by regulating miR-520c-3p/S100A4 pathway. Cell Physiol Biochem. 50:1659–1672. 2018. View Article : Google Scholar : PubMed/NCBI | |
Cheon MG, Son YW, Lee JH, Jang HH and Chung YS: Mts1 Up-regulation is associated with aggressive pathological features in thyroid cancer. Cancer Genomics Proteomics. 16:369–376. 2019. View Article : Google Scholar : PubMed/NCBI | |
Wang Y, Ye H, Yang Y, Li J, Cen A and Zhao L: microRNA-181a promotes the oncogene S100A2 and enhances papillary thyroid carcinoma growth by mediating the expression of histone demethylase KDM5C. J Endocrinol Invest. 45:17–28. 2022. View Article : Google Scholar : PubMed/NCBI | |
Economopoulou P, Kotsantis I and Psyrri A: Special issue about head and neck cancers: HPV positive cancers. Int J Mol Sci. 21:33882020. View Article : Google Scholar : PubMed/NCBI | |
Tokuzen N, Nakashiro KI, Tojo S, Goda H, Kuribayashi N and Uchida D: Human papillomavirus-16 infection and p16 expression in oral squamous cell carcinoma. Oncol Lett. 22:5282021. View Article : Google Scholar : PubMed/NCBI | |
Mork J, Lie AK, Glattre E, Hallmans G, Jellum E, Koskela P, Møller B, Pukkala E, Schiller JT, Youngman L, et al: Human papillomavirus infection as a risk factor for squamous-cell carcinoma of the head and neck. N Engl J Med. 344:1125–1131. 2001. View Article : Google Scholar : PubMed/NCBI | |
Ang KK, Harris J, Wheeler R, Weber R, Rosenthal DI, Nguyen-Tân PF, Westra WH, Chung CH, Jordan RC, Lu C, et al: Human papillomavirus and survival of patients with oropharyngeal cancer. N Engl J Med. 363:24–35. 2010. View Article : Google Scholar : PubMed/NCBI | |
Wuerdemann N, Wittekindt C, Sharma SJ, Prigge ES, Reuschenbach M, Gattenlöhner S, Klussmann JP and Wagner S: Risk factors for overall survival outcome in surgically treated human papillomavirus-negative and positive patients with oropharyngeal cancer. Oncol Res Treat. 40:320–327. 2017. View Article : Google Scholar : PubMed/NCBI | |
Granata R, Miceli R, Orlandi E, Perrone F, Cortelazzi B, Franceschini M, Locati LD, Bossi P, Bergamini C, Mirabile A, et al: Tumor stage, human papillomavirus and smoking status affect the survival of patients with oropharyngeal cancer: An Italian validation study. Ann Oncol. 23:1832–1837. 2012. View Article : Google Scholar : PubMed/NCBI | |
Paver EC, Currie AM, Gupta R and Dahlstrom JE: Human papilloma virus related squamous cell carcinomas of the head and neck: Diagnosis, clinical implications and detection of HPV. Pathology. 52:179–191. 2020. View Article : Google Scholar : PubMed/NCBI | |
Lo WY, Lai CC, Hua CH, Tsai MH, Huang SY, Tsai CH and Tsai FJ: S100A8 is identified as a biomarker of HPV18-infected oral squamous cell carcinomas by suppression subtraction hybridization, clinical proteomics analysis, and immunohistochemistry staining. J Proteome Res. 6:2143–2151. 2007. View Article : Google Scholar : PubMed/NCBI | |
Liu S, Xie Y, Luo W, Dou Y, Xiong H, Xiao Z and Zhang XL: PE_PGRS31-S100A9 interaction promotes mycobacterial survival in macrophages through the regulation of NF-κB-TNF-α signaling and arachidonic acid metabolism. Front Microbiol. 11:8452020. View Article : Google Scholar : PubMed/NCBI | |
Khammanivong A, Sorenson BS, Ross KF, Dickerson EB, Hasina R, Lingen MW and Herzberg MC: Involvement of calprotectin (S100A8/A9) in molecular pathways associated with HNSCC. Oncotarget. 7:14029–14047. 2016. View Article : Google Scholar : PubMed/NCBI | |
Gyöngyösi E, Szalmás A, Ferenczi A, Póliska S, Kónya J and Veress G: Transcriptional regulation of genes involved in keratinocyte differentiation by human papillomavirus 16 oncoproteins. Arch Virol. 160:389–398. 2015. View Article : Google Scholar : PubMed/NCBI | |
Alghamdi MA, Al-Eitan LN, Tarkhan AH and Al-Qarqaz FA: Global gene methylation profiling of common warts caused by human papillomaviruses infection. Saudi J Biol Sci. 28:612–622. 2021. View Article : Google Scholar : PubMed/NCBI | |
Han S, Locke AK, Oaks LA, Cheng YL and Coté GL: Nanoparticle-based assay for detection of S100P mRNA using surface-enhanced Raman spectroscopy. J Biomed Opt. 24:1–9. 2019. | |
Jiao X, Zhang H, Xu X, Yu Y, Zhang H, Zhang J, Ning L, Hao F, Liu X, Niu M, et al: S100A4 knockout sensitizes anaplastic thyroid carcinoma cells harboring BRAFV600E/Mt to Vemurafenib. Cell Physiol Biochem. 49:1143–1162. 2018. View Article : Google Scholar : PubMed/NCBI | |
Björk P, Björk A, Vogl T, Stenström M, Liberg D, Olsson A, Roth J, Ivars F and Leanderson T: Identification of human S100A9 as a novel target for treatment of autoimmune disease via binding to quinoline-3-carboxamides. PLoS Biol. 7:e972009. View Article : Google Scholar : PubMed/NCBI | |
Mouta Carreira C, LaVallee TM, Tarantini F, Jackson A, Lathrop JT, Hampton B, Burgess WH and Maciag T: S100A13 is involved in the regulation of fibroblast growth factor-1 and p40 synaptotagmin-1 release in vitro. J Biol Chem. 273:22224–22231. 1998. View Article : Google Scholar : PubMed/NCBI |