Open Access

S100 proteins in head and neck squamous cell carcinoma (Review)

  • Authors:
    • Yihong Hu
    • Yucheng Han
    • Minhui He
    • Yanqun Zhang
    • Xianqiong Zou
  • View Affiliations

  • Published online on: July 6, 2023     https://doi.org/10.3892/ol.2023.13948
  • Article Number: 362
  • Copyright: © Hu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

The most common tumor affecting the head and neck is head and neck squamous cell carcinoma (HNSCC). The characteristics of HNSCC include a rapid onset, a lack of early diagnosis, drug resistance, relapse and systemic adverse effects, leading to inadequate prevention, diagnosis and treatment. Notably, previous research suggests that there is an association between S100 proteins and HNSCC. S100A8, S100A9 and S100A14 interfere with tumor cell proliferation by blocking the cell cycle. The present review discusses this association. S100A4 enhances cancer stem cell properties, and interacts with actin and tropomyosin to promote tumor cell migration. S100A1, S100A8, S100A9, S100A10, S100A14 and S100P are involved in the initiation and progression of HNSCC via Hippo, nuclear factor κB, phosphatidylinositol kinase/protein kinase B/mammalian target of rapamycin and other signaling pathways. In addition, certain long non‑coding RNAs and microRNAs are involved in regulating the expression of S100 proteins in HNSCC. Reducing the expression of certain members of the S100 protein family may enhance the chemosensitivity of HNSCC. Collectively, it is suggested that S100 proteins may function as markers and targets for the prevention, diagnosis and treatment of HNSCC.
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August-2023
Volume 26 Issue 2

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Hu Y, Han Y, He M, Zhang Y and Zou X: S100 proteins in head and neck squamous cell carcinoma (Review). Oncol Lett 26: 362, 2023
APA
Hu, Y., Han, Y., He, M., Zhang, Y., & Zou, X. (2023). S100 proteins in head and neck squamous cell carcinoma (Review). Oncology Letters, 26, 362. https://doi.org/10.3892/ol.2023.13948
MLA
Hu, Y., Han, Y., He, M., Zhang, Y., Zou, X."S100 proteins in head and neck squamous cell carcinoma (Review)". Oncology Letters 26.2 (2023): 362.
Chicago
Hu, Y., Han, Y., He, M., Zhang, Y., Zou, X."S100 proteins in head and neck squamous cell carcinoma (Review)". Oncology Letters 26, no. 2 (2023): 362. https://doi.org/10.3892/ol.2023.13948