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CD47 polymorphism for predicting nivolumab benefit in patients with advanced non‑small‑cell lung cancer

  • Authors:
    • Tatsuya Ogimoto
    • Hiroaki Ozasa
    • Hironori Yoshida
    • Takashi Nomizo
    • Tomoko Funazo
    • Hiroshi Yoshida
    • Kentaro Hashimoto
    • Kazutaka Hosoya
    • Masatoshi Yamazoe
    • Hitomi Ajimizu
    • Takahiro Tsuji
    • Yuichi Sakamori
    • Kiyomitsu Kuninaga
    • Satoshi Morita
    • Toyohiro Hirai
  • View Affiliations / Copyright

    Affiliations: Department of Respiratory Medicine, Graduate School of Medicine, Kyoto University, Kyoto 606‑8507, Japan, Department of Biomedical Statistics and Bioinformatics, Graduate School of Medicine, Kyoto University, Kyoto 606‑8507, Japan
    Copyright: © Ogimoto et al. This is an open access article distributed under the terms of Creative Commons Attribution License [CC BY 4.0].
  • Article Number: 364
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    Published online on: July 10, 2023
       https://doi.org/10.3892/ol.2023.13950
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Abstract

Immune checkpoint inhibitors (ICIs), such as nivolumab, play an essential role in non‑small‑cell lung cancer (NSCLC) treatment. Programmed death ligand‑1 has been used as a predictive biomarker for the efficacy of ICI treatment in patients with NSCLC; however, its predictive value is considered insufficient. Therefore, there is an urgent need for better predictive biomarkers. The present study focused on the CD47 molecule, which is associated with macrophages and tumor immunity. The study aimed to investigate the association between CD47 single nucleotide polymorphism (SNP) and the therapeutic effect of nivolumab in patients with NSCLC. The CD47 SNP genotypes and clinical outcomes were retrospectively analyzed in 164 patients with NSCLC treated with nivolumab at Kyoto University Hospital (Kyoto, Japan). Patients with the G/G genotype of the CD47 SNP rs3804639 had significantly longer progression‑free survival than those with the G/T or T/T genotypes [2.6 months vs. 2.1 months, hazard ratio (HR), 0.70; P=0.026]. Moreover, the G/G genotype of the CD47 SNP rs3804639 was associated with a significantly longer median overall survival than the G/T or T/T genotypes of the CD47 SNP rs3804639 (24.8 months vs. 12.0 months, HR, 0.64; P=0.021). In conclusion, CD47 polymorphism may be a novel predictive biomarker of nivolumab efficacy in patients with advanced NSCLC.
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Copy and paste a formatted citation
Spandidos Publications style
Ogimoto T, Ozasa H, Yoshida H, Nomizo T, Funazo T, Yoshida H, Hashimoto K, Hosoya K, Yamazoe M, Ajimizu H, Ajimizu H, et al: <em>CD47</em> polymorphism for predicting nivolumab benefit in patients with advanced non‑small‑cell lung cancer. Oncol Lett 26: 364, 2023.
APA
Ogimoto, T., Ozasa, H., Yoshida, H., Nomizo, T., Funazo, T., Yoshida, H. ... Hirai, T. (2023). <em>CD47</em> polymorphism for predicting nivolumab benefit in patients with advanced non‑small‑cell lung cancer. Oncology Letters, 26, 364. https://doi.org/10.3892/ol.2023.13950
MLA
Ogimoto, T., Ozasa, H., Yoshida, H., Nomizo, T., Funazo, T., Yoshida, H., Hashimoto, K., Hosoya, K., Yamazoe, M., Ajimizu, H., Tsuji, T., Sakamori, Y., Kuninaga, K., Morita, S., Hirai, T."<em>CD47</em> polymorphism for predicting nivolumab benefit in patients with advanced non‑small‑cell lung cancer". Oncology Letters 26.2 (2023): 364.
Chicago
Ogimoto, T., Ozasa, H., Yoshida, H., Nomizo, T., Funazo, T., Yoshida, H., Hashimoto, K., Hosoya, K., Yamazoe, M., Ajimizu, H., Tsuji, T., Sakamori, Y., Kuninaga, K., Morita, S., Hirai, T."<em>CD47</em> polymorphism for predicting nivolumab benefit in patients with advanced non‑small‑cell lung cancer". Oncology Letters 26, no. 2 (2023): 364. https://doi.org/10.3892/ol.2023.13950
Copy and paste a formatted citation
x
Spandidos Publications style
Ogimoto T, Ozasa H, Yoshida H, Nomizo T, Funazo T, Yoshida H, Hashimoto K, Hosoya K, Yamazoe M, Ajimizu H, Ajimizu H, et al: <em>CD47</em> polymorphism for predicting nivolumab benefit in patients with advanced non‑small‑cell lung cancer. Oncol Lett 26: 364, 2023.
APA
Ogimoto, T., Ozasa, H., Yoshida, H., Nomizo, T., Funazo, T., Yoshida, H. ... Hirai, T. (2023). <em>CD47</em> polymorphism for predicting nivolumab benefit in patients with advanced non‑small‑cell lung cancer. Oncology Letters, 26, 364. https://doi.org/10.3892/ol.2023.13950
MLA
Ogimoto, T., Ozasa, H., Yoshida, H., Nomizo, T., Funazo, T., Yoshida, H., Hashimoto, K., Hosoya, K., Yamazoe, M., Ajimizu, H., Tsuji, T., Sakamori, Y., Kuninaga, K., Morita, S., Hirai, T."<em>CD47</em> polymorphism for predicting nivolumab benefit in patients with advanced non‑small‑cell lung cancer". Oncology Letters 26.2 (2023): 364.
Chicago
Ogimoto, T., Ozasa, H., Yoshida, H., Nomizo, T., Funazo, T., Yoshida, H., Hashimoto, K., Hosoya, K., Yamazoe, M., Ajimizu, H., Tsuji, T., Sakamori, Y., Kuninaga, K., Morita, S., Hirai, T."<em>CD47</em> polymorphism for predicting nivolumab benefit in patients with advanced non‑small‑cell lung cancer". Oncology Letters 26, no. 2 (2023): 364. https://doi.org/10.3892/ol.2023.13950
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