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Case Report Open Access

Gastric metastasis from nodular malignant melanoma of the auricle with multigene aberrations: A rare case report and literature review

  • Authors:
    • Ya-Chen Yuan
    • Ying Li
    • Yun Pan
    • Bo Gao
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    Affiliations: Department of Pathology, The First Affiliated Hospital of Dali University, Dali, Yunnan 671000, P.R. China, Department of Pathology, People's Hospital of Xiangyun County, Xiangyun, Yunnan 672100, P.R. China
    Copyright: © Yuan et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 368
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    Published online on: July 13, 2023
       https://doi.org/10.3892/ol.2023.13954
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Abstract

Primary malignant melanoma (MM) of the external ear accounts for a low proportion of cases of cutaneous MM, and its incidence in non‑white women is very low. The stomach is a rare metastatic site for MM. Gastric metastasis of MM of the external ear is extremely rare, and the associated gene alterations and mechanisms are poorly understood. The present report describes the case of a 58‑year‑old Asian woman who had a mass on the left auricle for 5 years and was diagnosed with nodular MM with the BRAF V600E mutation after surgical resection. Postoperative metastases to the stomach and descending duodenum appeared 1 year after resection. After 11 months of BRAF‑targeted therapy and immunotherapy, the patient developed drug resistance and died from systemic metastases to the brain, lungs, liver, left adrenal gland and peritoneum. Genetic testing revealed additional aberrations in MYB, p16, MYC and PTEN. The clinical characteristics of MM of the external ear and gastric metastatic MM were also summarized through a retrospective literature review. Immunohistochemical staining is critical in the diagnosis of gastric metastasis from MM of the external ear. This disease often requires a multidisciplinary treatment approach, including surgery, targeted therapy and immunotherapy. The present study provides some genetic information about this rare disease and discusses appropriate treatment strategies. The findings of the present study suggests that the surgical margin size, tumor histological type and number of genetic aberrations may be closely associated with metastasis potential, therapeutic efficacy and patient outcome.
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View References

1 

Siegel R, Naishadham D and Jemal A: Cancer statistics, 2013. CA Cancer J Clin. 63:11–30. 2013. View Article : Google Scholar : PubMed/NCBI

2 

Shashanka R and Smitha BR: Head and neck melanoma. ISRN Surg. 2012:9483022012. View Article : Google Scholar : PubMed/NCBI

3 

Deep NL, Glasgow AE, Habermann EB, Kasperbauer JL and Carlson ML: Melanoma of the external ear: A population-based study. Am J Otolaryngol. 38:309–315. 2017. View Article : Google Scholar : PubMed/NCBI

4 

Hao M, Zhao G, Du X, Yang Y and Yang J: Clinical characteristics and prognostic indicators for metastatic melanoma: Data from 446 patients in north China. Tumour Biol. 37:10339–10348. 2016. View Article : Google Scholar : PubMed/NCBI

5 

Amando García L, Suárez Nieto C, Madrigal Rubiales B and García García J: External ear melanoma. Acta Otorrinolaringol Esp. 54:89–93. 2003.(In Spanish). View Article : Google Scholar : PubMed/NCBI

6 

Hannan SA and Parikh A: Malignant melanoma of the external ear canal. Lancet. 368:16802006. View Article : Google Scholar : PubMed/NCBI

7 

Gowthami C, Kumar P, Ravikumar A, Joseph LD and Rajendiran S: Malignant melanoma of the external auditory canal. J Clin Diagn Res. 8:FD04–FD06. 2014.PubMed/NCBI

8 

Toia F, Garbo G, Tripoli M, Rinaldi G, Moschella F and Cordova A: A systematic review on external ear melanoma. J Plast Reconstr Aesthet Surg. 68:883–894. 2015. View Article : Google Scholar : PubMed/NCBI

9 

Frost J, Dunne JA and Powell BW: External ear melanoma: A 10 year assessment of management and outcomes. J Plast Reconstr Aesthet Surg. 70:551–552. 2017. View Article : Google Scholar : PubMed/NCBI

10 

Harrison C, Mikhail M, Potter M, Gore S and Cassell O: Sentinel lymph node biopsy for external ear melanoma: A 17 year experience with long term survival data. J Plast Reconstr Aesthet Surg. 70:1301–1303. 2017. View Article : Google Scholar : PubMed/NCBI

11 

Straccia P, Martini M and Pierconti F: Pleural metastasis from auricular melanoma: A brief report. Diagn Cytopathol. 48:376–379. 2020. View Article : Google Scholar : PubMed/NCBI

12 

Truong A, Hyngstrom JR, Andtbacka RHI, Noyes RD, Wright M, Snyder J, Winters A, Sause WT, Grossmann KF, Khong HT, et al: Recurrence risk of early-stage melanoma of the external ear: An investigation of surgical approach and sentinel lymph node status. Melanoma Res. 30:173–178. 2020. View Article : Google Scholar : PubMed/NCBI

13 

Fiorio LM, Diniz LM, Spelta K and Badaró BA: Ear melanoma: A four-case series. An Bras Dermatol. 96:64–67. 2021. View Article : Google Scholar : PubMed/NCBI

14 

Pająk J, Lelonek E, Chlebicka I and Szepietowski JC: Nodular melanoma of the external ear: A rare tumour successfully treated with simple excision. Postepy Dermatol Alergol. 39:635–636. 2022. View Article : Google Scholar : PubMed/NCBI

15 

Davis GH and Zollinger RW: Metastatic melanoma of the stomach. Am J Surg. 99:94–96. 1960. View Article : Google Scholar : PubMed/NCBI

16 

Morini S, Bassi O and Colavolpe V: Malignant melanoma metastatic to the stomach: Endoscopic diagnosis and findings. Endoscopy. 12:86–89. 1980. View Article : Google Scholar : PubMed/NCBI

17 

Mimica M and Tomić I: Endoscopic diagnosis of malignant melanoma metastatic to the stomach. Am J Gastroenterol. 97:1572–1573. 2002. View Article : Google Scholar : PubMed/NCBI

18 

Malladi V, Palanivelu C, Mathew S, Rajan PS, Jani K, Senthilkumar R, Senthilkumaran S and Kavalkat AJ: Malignant melanoma metastatic to the stomach and duodenum. Indian J Gastroenterol. 24:1332005.PubMed/NCBI

19 

Matsubayashi H, Takizawa K, Nishide N and Ono H: Metastatic malignant melanoma of the gastric mucosa. Intern Med. 49:1243–1244. 2010. View Article : Google Scholar : PubMed/NCBI

20 

Wu PR, Yen HH and Chen CJ: Gastrointestinal: Primary esophageal melanoma with gastric metastasis. J Gastroenterol Hepatol. 26:13382011. View Article : Google Scholar : PubMed/NCBI

21 

Law ST, Li MK and Lo WH: Gastric melanoma. Hong Kong Med J. 17:503–504. 2011.PubMed/NCBI

22 

Eivazi-Ziaei J and Esmaili H: Metastatic malignant melanoma affecting stomach. J Cancer Res Ther. 10:733–736. 2014. View Article : Google Scholar : PubMed/NCBI

23 

El-Sourani N, Troja A, Raab HR and Antolovic D: Gastric metastasis of malignant melanoma: Report of a case and review of available literature. Viszeralmedizin. 30:273–275. 2014.PubMed/NCBI

24 

Zhao L, Yan J, Li L, Wei J, Li L, Qian X, Liu B and Zou Z: Gastric metastasis from sphenoid sinus melanoma: A case report. Oncol Lett. 9:609–613. 2015. View Article : Google Scholar : PubMed/NCBI

25 

Ruiz-Cuesta P, Hervás-Molina AJ, Villar-Pastor CM, Jurado-García J and Barrera-Baena P: Late gastric metastasis from cutaneous melanoma. Gastroenterol Hepatol. 37:564–565. 2014.(In Spanish). View Article : Google Scholar : PubMed/NCBI

26 

Morita S, Suda T and Terai S: Gastric metastasis from uveal melanoma. Clin Gastroenterol Hepatol. 7:A202019. View Article : Google Scholar : PubMed/NCBI

27 

Farshad S, Keeney S, Halalau A and Ghaith G: A case of gastric metastatic melanoma 15 years after the initial diagnosis of cutaneous melanoma. Case Rep Gastrointest Med. 2018:76849642018.PubMed/NCBI

28 

Santos-Seoane SM, Pérez-Casado L, Helguera-Amezua C and Diez-Fernández M: Metastatic melanoma of the stomach. Cir Esp (Engl Ed). 97:512019.(In English, Spanish). View Article : Google Scholar : PubMed/NCBI

29 

Sachdeva S, Dalal A, Kumar A and George R: Multifocal gastric metastasis of malignant melanoma: An ominous endoscopic appearance: Gastric metastasis of malignant melanoma. Dig Liver Dis. 52:15122020. View Article : Google Scholar : PubMed/NCBI

30 

Anandabaskaran S, Fewtrell M, Ismail K and Prakoso E: A case of delayed metastatic melanoma to the stomach. Intern Med J. 50:1590–1591. 2020. View Article : Google Scholar : PubMed/NCBI

31 

Groudan K, Ma W and Joshi K: Metastatic melanoma presenting as a gastric mass. Cureus. 12:e118742020.PubMed/NCBI

32 

Yoshimoto T, Okamoto T and Fukuda K: Giant gastric metastasis of malignant melanoma. Oxf Med Case Reports. 2021:omab0502021. View Article : Google Scholar : PubMed/NCBI

33 

Monti M, Guidoboni M, Oboldi D, Bartolini G, Pieri F, Ruscelli S, Passardi A, Ridolfi L, De Rosa F, Sullo FG and Frassineti GL: Melanoma metastasis mimicking gastric cancer: A challenge that starts from diagnosis. Therap Adv Gastroenterol. 14:17562848219895592021. View Article : Google Scholar : PubMed/NCBI

34 

Zhu M, Zhang DY, Zhang GJ, Wang ZB and Lid MY: Amelanotic metastatic gastric malignant melanoma: A case report. Anticancer Drugs. 33:e808–e812. 2022. View Article : Google Scholar : PubMed/NCBI

35 

Maksimaityte V, Reivytyte R, Milaknyte G, Mickys U, Razanskiene G, Stundys D, Kazenaite E, Valantinas J and Stundiene I: Metastatic multifocal melanoma of multiple organ systems: A case report. World J Clin Cases. 10:10136–10145. 2022. View Article : Google Scholar : PubMed/NCBI

36 

Bharwad A, Shah H and Salyers WJ Jr: Malignant melanoma of the stomach. Eur J Case Rep Intern Med. 9:0036402022.PubMed/NCBI

37 

Patel TD, Chin OY, Baredes S, Eloy JA and Ying YM: A population based analysis of melanoma of the external ear. Otol Neurotol. 39:e137–e142. 2018. View Article : Google Scholar : PubMed/NCBI

38 

Oliver JD, Boczar D, Sisti A, Huayllani MT, Restrepo DJ, Spaulding AC, Gabriel E, Bagaria S, Rinker BD and Forte AJ: National Analysis of Patients With External Ear Melanoma in the United States. J Craniofac Surg. 30:e787–e790. 2019. View Article : Google Scholar : PubMed/NCBI

39 

Augenstein AC, Capello ZJ, Little JA, McMasters KM and Bumpous JM: The importance of ulceration of cutaneous melanoma of the head and neck: A comparison of ear (pinna) and nonear sites. Laryngoscope. 122:2468–2472. 2012. View Article : Google Scholar : PubMed/NCBI

40 

Kang S, Barnhill RL, Graeme-Cook F, Randolph G, Nadol JB and Sober AJ: Primary malignant melanoma of the external auditory canal: A case report with presentation as an aural polyp. Am J Otol. 13:194–196. 1992.PubMed/NCBI

41 

Hoshikawa H, Miyashita T and Mori N: Surgical procedures for external auditory canal carcinoma and the preservation of postoperative hearing. Case Rep Surg. 2012:8413722012.PubMed/NCBI

42 

López RG, Santomé PM, Porto EI, Moreiras MI, Gómez CG, Villanueva JM, Canosa MA, Veiga OR, Gutiérrez AE, Ares IM and Val FA: Intestinal perforation due to cutaneous malignant melanoma mestastatic implants. Rev Esp Enferm Dig. 103:386–388. 2011.(In English, Spanish). View Article : Google Scholar : PubMed/NCBI

43 

Lens M, Bataille V and Krivokapic Z: Melanoma of the small intestine. Lancet Oncol. 10:516–521. 2009. View Article : Google Scholar : PubMed/NCBI

44 

Benmeir P, Baruchin A, Weinberg A, Nahlieli O, Neuman A and Wexler MR: Rare sites of melanoma: Melanoma of the external ear. J Craniomaxillofac Surg. 23:50–53. 1995. View Article : Google Scholar : PubMed/NCBI

45 

Appelbaum EN, Gross ND, Diab A, Bishop AJ, Nader ME and Gidley PW: Melanoma of the external auditory canal: A review of seven cases at a tertiary care referral center. Laryngoscope. 131:165–172. 2021. View Article : Google Scholar : PubMed/NCBI

46 

Jahn V, Breuninger H, Garbe C and Moehrle M: Melanoma of the ear: Prognostic factors and surgical strategies. Br J Dermatol. 154:310–318. 2006. View Article : Google Scholar : PubMed/NCBI

47 

Ohsie SJ, Sarantopoulos GP, Cochran AJ and Binder SW: Immunohistochemical characteristics of melanoma. J Cutan Pathol. 35:433–444. 2008. View Article : Google Scholar : PubMed/NCBI

48 

Davies H, Bignell GR, Cox C, Stephens P, Edkins S, Clegg S, Teague J, Woffendin H, Garnett MJ, Bottomley W, et al: Mutations of the BRAF gene in human cancer. Nature. 417:949–954. 2002. View Article : Google Scholar : PubMed/NCBI

49 

Melis C, Rogiers A, Bechter O and van den Oord JJ: Molecular genetic and immunotherapeutic targets in metastatic melanoma. Virchows Arch. 471:281–293. 2017. View Article : Google Scholar : PubMed/NCBI

50 

Long GV, Menzies AM, Nagrial AM, Haydu LE, Hamilton AL, Mann GJ, Hughes TM, Thompson JF, Scolyer RA and Kefford RF: Prognostic and clinicopathologic associations of oncogenic BRAF in metastatic melanoma. J Clin Oncol. 29:1239–1246. 2011. View Article : Google Scholar : PubMed/NCBI

51 

Hauschild A, Grob JJ, Demidov LV, Jouary T, Gutzmer R, Millward M, Rutkowski P, Blank CU, Miller WH Jr, Kaempgen E, et al: Dabrafenib in BRAF-mutated metastatic melanoma: A multicentre, open-label, phase 3 randomised controlled trial. Lancet. 380:358–365. 2012. View Article : Google Scholar : PubMed/NCBI

52 

Sarkisian S and Davar D: MEK inhibitors for the treatment of NRAS mutant melanoma. Drug Des Devel Ther. 12:2553–2565. 2018. View Article : Google Scholar : PubMed/NCBI

53 

Robert C, Lewis KD, Gutzmer R, Stroyakovskiy D, Gogas H, Protsenko S, Pereira RP, Eigentler T, Rutkowski P, Demidov L, et al: Biomarkers of treatment benefit with atezolizumab plus vemurafenib plus cobimetinib in BRAFV600 mutation-positive melanoma. Ann Oncol. 33:544–555. 2022. View Article : Google Scholar : PubMed/NCBI

54 

Abd Elmageed ZY, Moore RF, Tsumagari K, Lee MM, Sholl AB, Friedlander P, AI-Qurayshi Z, Hassan M, Wang AR, Boulares HA and Kandil E: Prognostic role of BRAFV600E cellular localization in melanoma. J Am Coll Surg. 226:526–537. 2018. View Article : Google Scholar : PubMed/NCBI

55 

Cheng L, Lopez-Beltran A, Massari F, MacLennan GT and Montironi R: Molecular testing for BRAF mutations to inform melanoma treatment decisions: A move toward precision medicine. Mod Pathol. 31:24–38. 2018. View Article : Google Scholar : PubMed/NCBI

56 

Bandarchi B, Jabbari CA, Vedadi A and Navab R: Molecular biology of normal melanocytes and melanoma cells. J Clin Pathol. 66:644–648. 2013. View Article : Google Scholar : PubMed/NCBI

57 

Greulich KM, Utikal J, Peter RU and Krähn G: c-MYC and nodular malignant melanoma. A case report. Cancer. 89:97–103. 2000. View Article : Google Scholar : PubMed/NCBI

58 

Parrella P, Caballero OL, Sidransky D and Merbs SL: Detection of c-myc amplification in uveal melanoma by fluorescent in situ hybridization. Invest Ophthalmol Vis Sci. 42:1679–1684. 2001.PubMed/NCBI

59 

Su J, Yu W, Liu J, Zheng J, Huang S, Wang Y, Qi S, Ma X, Chen J and Zhang Y: Fluorescence in situ hybridisation as an ancillary tool in the diagnosis of acral melanoma: A review of 44 cases. Pathology. 49:740–749. 2017. View Article : Google Scholar : PubMed/NCBI

60 

Meese E, Meltzer PS, Witkowski CM and Trent JM: Molecular mapping of the oncogene MYB and rearrangements in malignant melanoma. Genes Chromosomes Cancer. 1:88–94. 1989. View Article : Google Scholar : PubMed/NCBI

61 

Romano RC, Shon W and Sukov WR: Malignant melanoma of the nail apparatus: A fluorescence in situ hybridization analysis of 7 cases. Int J Surg Pathol. 24:512–518. 2016. View Article : Google Scholar : PubMed/NCBI

62 

Straume O, Sviland L and Akslen LA: Loss of nuclear p16 protein expression correlates with increased tumor cell proliferation (Ki-67) and poor prognosis in patients with vertical growth phase melanoma. Clin Cancer Res. 6:1845–1853. 2000.PubMed/NCBI

63 

Ince FA, Shariev A and Dixon K: PTEN as a target in melanoma. J Clin Pathol jclinpath-2021-208008. 9–May;2022.(Epub ahead of print).

64 

Giles KM, Rosenbaum BE, Berger M, Izsak A, Li Y, Illa Bochaca I, Vega-Saenz de Miera E, Wang J, Darvishian F, Zhong H and Osman I: Revisiting the clinical and biologic relevance of partial PTEN loss in melanoma. J Invest Dermatol. 139:430–438. 2019. View Article : Google Scholar : PubMed/NCBI

65 

Aguissa-Touré AH and Li G: Genetic alterations of PTEN in human melanoma. Cell Mol Life Sci. 69:1475–1491. 2012. View Article : Google Scholar : PubMed/NCBI

66 

Dankort D, Curley DP, Cartlidge RA, Nelson B, Karnezis AN, Damsky WE Jr, You MJ, DePinho RA, McMahon M and Bosenberg M: Braf(V600E) cooperates with Pten loss to induce metastatic melanoma. Nat Genet. 41:544–552. 2009. View Article : Google Scholar : PubMed/NCBI

67 

Cabrita R, Mitra S, Sanna A, Ekedahl H, Lövgren K, Olsson H, Ingvar C, Isaksson K, Lauss M, Carneiro A and Jönsson G: The role of PTEN loss in immune escape, melanoma prognosis and therapy response. Cancers (Basel). 12:7422020. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Yuan Y, Li Y, Pan Y and Gao B: Gastric metastasis from nodular malignant melanoma of the auricle with multigene aberrations: A rare case report and literature review. Oncol Lett 26: 368, 2023.
APA
Yuan, Y., Li, Y., Pan, Y., & Gao, B. (2023). Gastric metastasis from nodular malignant melanoma of the auricle with multigene aberrations: A rare case report and literature review. Oncology Letters, 26, 368. https://doi.org/10.3892/ol.2023.13954
MLA
Yuan, Y., Li, Y., Pan, Y., Gao, B."Gastric metastasis from nodular malignant melanoma of the auricle with multigene aberrations: A rare case report and literature review". Oncology Letters 26.3 (2023): 368.
Chicago
Yuan, Y., Li, Y., Pan, Y., Gao, B."Gastric metastasis from nodular malignant melanoma of the auricle with multigene aberrations: A rare case report and literature review". Oncology Letters 26, no. 3 (2023): 368. https://doi.org/10.3892/ol.2023.13954
Copy and paste a formatted citation
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Spandidos Publications style
Yuan Y, Li Y, Pan Y and Gao B: Gastric metastasis from nodular malignant melanoma of the auricle with multigene aberrations: A rare case report and literature review. Oncol Lett 26: 368, 2023.
APA
Yuan, Y., Li, Y., Pan, Y., & Gao, B. (2023). Gastric metastasis from nodular malignant melanoma of the auricle with multigene aberrations: A rare case report and literature review. Oncology Letters, 26, 368. https://doi.org/10.3892/ol.2023.13954
MLA
Yuan, Y., Li, Y., Pan, Y., Gao, B."Gastric metastasis from nodular malignant melanoma of the auricle with multigene aberrations: A rare case report and literature review". Oncology Letters 26.3 (2023): 368.
Chicago
Yuan, Y., Li, Y., Pan, Y., Gao, B."Gastric metastasis from nodular malignant melanoma of the auricle with multigene aberrations: A rare case report and literature review". Oncology Letters 26, no. 3 (2023): 368. https://doi.org/10.3892/ol.2023.13954
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