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Case Report

Higher levels of minimal residual disease in peripheral blood than bone marrow before 1st and 2nd relapse/regrowth in a patient with high‑risk neuroblastoma: A case report

  • Authors:
    • Shotaro Inoue
    • Kaung Htet Nay Win
    • Cho Yee Mon
    • Tomoko Fujikawa
    • Sayaka Hyodo
    • Suguru Uemura
    • Toshiaki Ishida
    • Takeshi Mori
    • Daiichiro Hasegawa
    • Yoshiyuki Kosaka
    • Akihiro Nishimura
    • Naoko Nakatani
    • Nanako Nino
    • Akihiro Tamura
    • Nobuyuki Yamamoto
    • Kandai Nozu
    • Noriyuki Nishimura
  • View Affiliations / Copyright

    Affiliations: Department of Pediatrics, Kobe University Graduate School of Medicine, Kobe, Hyogo 650‑0017, Japan, Department of Public Health, Kobe University Graduate School of Health Science, Kobe, Hyogo 654‑0142, Japan, Department of Hematology and Oncology, Kobe Children's Hospital, Kobe, Hyogo 650‑0047, Japan
  • Article Number: 369
    |
    Published online on: July 14, 2023
       https://doi.org/10.3892/ol.2023.13955
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Abstract

More than half of patients with high‑risk neuroblastoma (HR‑NB) experience relapse/regrowth due to the activation of chemoresistant minimal residual disease (MRD). MRD in patients with HR‑NB can be evaluated by quantitating neuroblastoma‑associated mRNAs (NB‑mRNAs) in bone marrow (BM) and peripheral blood (PB) samples. Although several sets of NB‑mRNAs have been shown to possess a prognostic value for MRD in BM samples (BM‑MRD), MRD in PB samples (PB‑MRD) is considered to be low and difficult to evaluate. The present report describes an HR‑NB case presenting higher PB‑MRD than BM‑MRD before 1st and 2nd relapse/regrowth. A 3‑year‑old female presented with an abdominal mass, was diagnosed with HR‑NB, and treated according to the nationwide standard protocol for HR‑NB. Following systemic induction and consolidation therapy with local therapy, the patient achieved complete remission but experienced a 1st relapse/regrowth 6 months after maintenance therapy. The patient partially responded to salvage chemotherapy and anti‑GD2 immunotherapy but had a 2nd relapse/regrowth 14 months after the 1st relapse/regrowth. Consecutive PB‑MRD and BM‑MRD monitoring revealed that PB‑MRD was lower than BM‑MRD at diagnosis (100 times) and 1st and 2nd relapse/regrowth (1,000 and 3 times) but became higher than BM‑MRD before 1st and 2nd relapse/regrowth. The present case highlights that PB‑MRD can become higher than BM‑MRD before relapse/regrowth of patients with HR‑NB.
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1 

Cohn SL, Pearson AD, London WB, Monclair T, Ambros PF, Brodeur GM, Faldum A, Hero B, Iehara T, Machin D, et al: The International Neuroblastoma Risk Group (INRG) Classification system: An INRG task force report. J Clin Oncol. 27:289–297. 2009. View Article : Google Scholar : PubMed/NCBI

2 

Monclair T, Brodeur GM, Ambros PF, Brisse HJ, Cecchetto G, Holmes K, Kaneko M, London WB, Matthay KK, Nuchtern JG, et al: The International Neuroblastoma risk group (INRG) staging system: An INRG task force report. J Clin Oncol. 27:298–303. 2009. View Article : Google Scholar : PubMed/NCBI

3 

Brodeur GM: Neuroblastoma: Biological insights into a clinical enigma. Nat Rev Cancer. 3:203–216. 2003. View Article : Google Scholar : PubMed/NCBI

4 

Maris JM, Hogarty MD, Bagatell R and Cohn SL: Neuroblastoma. Lancet. 369:2106–2120. 2007. View Article : Google Scholar : PubMed/NCBI

5 

Tolbert VP and Matthay KK: Neuroblastoma: Clinical and biological approach to risk stratification and treatment. Cell Tissue Res. 372:195–209. 2018. View Article : Google Scholar : PubMed/NCBI

6 

Mordant P, Loriot Y, Lahon B, Castier Y, Leseche G, Soria JC, Massard C and Deutsch E: Minimal residual disease in solid neoplasia: New frontier or red-herring? Cancer Treat Rev. 38:101–110. 2012. View Article : Google Scholar : PubMed/NCBI

7 

Uemura S, Ishida T, Thwin KKM, Yamamoto N, Tamura A, Kishimoto K, Hasegawa D, Kosaka Y, Nino N, Lin KS, et al: Dynamics of minimal residual disease in neuroblastoma patients. Front Oncol. 9:4552019. View Article : Google Scholar : PubMed/NCBI

8 

Beiske K, Ambros PF, Burchill SA, Cheung IY and Swerts K: Detecting minimal residual disease in neuroblastoma patients-the present state of the art. Cancer Lett. 228:229–240. 2005. View Article : Google Scholar : PubMed/NCBI

9 

Brownhill SC and Burchill SA: PCR-based amplification of circulating RNAs as prognostic and predictive biomarkers-Focus on neuroblastoma. Pract Lab Med. 7:41–44. 2016. View Article : Google Scholar : PubMed/NCBI

10 

Stutterheim J, Zappeij-Kannegieter L, Versteeg R, Caron HN, van der Schoot CE and Tytgat GA: The prognostic value of fast molecular response of marrow disease in patients aged over 1 year with stage 4 neuroblastoma. Eur J Cancer. 47:1193–1202. 2011. View Article : Google Scholar : PubMed/NCBI

11 

Viprey VF, Gregory WM, Corrias MV, Tchirkov A, Swerts K, Vicha A, Dallorso S, Brock P, Luksch R, Valteau-Couanet D, et al: Neuroblastoma mRNAs predict outcome in children with stage 4 neuroblastoma: A European HR-NBL1/SIOPEN study. J Clin Oncol. 32:1074–1083. 2014. View Article : Google Scholar : PubMed/NCBI

12 

Cheung NK, Ostrovnaya I, Kuk D and Cheung IY: Bone marrow minimal residual disease was an early response marker and a consistent independent predictor of survival after anti-GD2 immunotherapy. J Clin Oncol. 33:755–763. 2015. View Article : Google Scholar : PubMed/NCBI

13 

Marachelian A, Villablanca JG, Liu CW, Liu B, Goodarzian F, Lai HA, Shimada H, Tran HC, Parra JA, Gallego R, et al: Expression of five neuroblastoma genes in bone marrow or blood of patients with relapsed/refractory neuroblastoma provides a new biomarker for disease and prognosis. Clin Cancer Res. 23:5374–5383. 2017. View Article : Google Scholar : PubMed/NCBI

14 

Thwin KKM, Ishida T, Uemura S, Yamamoto N, Lin KS, Tamura A, Kozaki A, Saito A, Kishimoto K, Mori T, et al: Level of seven neuroblastoma-associated mRNAs detected by droplet digital PCR is associated with tumor relapse/regrowth of high-risk neuroblastoma patients. J Mol Diagn. 22:236–246. 2020. View Article : Google Scholar : PubMed/NCBI

15 

Park JR, Bagatell R, Cohn SL, Pearson AD, Villablanca JG, Berthold F, Burchill S, Boubaker A, McHugh K, Nuchtern JG, et al: Revisions to the International Neuroblastoma Response Criteria: A consensus statement from the National cancer institute clinical trials planning meeting. J Clin Oncol. 35:2580–2587. 2017. View Article : Google Scholar : PubMed/NCBI

16 

Bustin SA, Benes V, Garson JA, Hellemans J, Huggett J, Kubista M, Mueller R, Nolan T, Pfaffl MW, Shipley GL, et al: The MIQE guidelines: Minimum information for publication of quantitative real-time PCR experiments. Clin Chem. 55:611–622. 2009. View Article : Google Scholar : PubMed/NCBI

17 

Huggett JF, Foy CA, Benes V, Emslie K, Garson JA, Haynes R, Hellemans J, Kubista M, Mueller RD, Nolan T, et al: The digital MIQE guidelines: Minimum information for publication of quantitative digital PCR experiments. Clin Chem. 59:892–902. 2013. View Article : Google Scholar : PubMed/NCBI

18 

Kaneko M, Tsuchida Y, Mugishima H, Ohnuma N, Yamamoto K, Kawa K, Iwafuchi M, Sawada T and Suita S: Intensified chemotherapy increases the survival rates in patients with stage 4 neuroblastoma with MYCN amplification. J Pediatr Hematol Oncol. 24:613–621. 2002. View Article : Google Scholar : PubMed/NCBI

19 

Donfrancesco A, Jenkner A, Castellano A, Ilari I, Milano GM, De Sio L, Cozza R, Fidani P, Deb G, De Laurentis C, et al: Ifosfamide/carboplatin/etoposide (ICE) as front-line, topotecan/cyclophosphamide as second-line and oral temozolomide as third-line treatment for advanced neuroblastoma over one year of age. Acta Paediatr Suppl. 93:6–11. 2007. View Article : Google Scholar

20 

Coustan-Smith E, Sancho J, Hancock ML, Razzouk BI, Ribeiro RC, Rivera GK, Rubnitz JE, Sandlund JT, Pui CH and Campana D: Use of peripheral blood instead of bone marrow to monitor residual disease in children with acute lymphoblastic leukemia. Blood. 100:2399–2402. 2002. View Article : Google Scholar : PubMed/NCBI

21 

Kitamura K, Nishiyama T, Ishiyama K, Miyawaki S, Miyazaki K, Suzuki K, Masaie H, Okada M, Ogawa H, Imai K, et al: Clinical usefulness of WT1 mRNA expression in bone marrow detected by a new WT1 mRNA assay kit for monitoring acute myeloid leukemia: A comparison with expression of WT1 mRNA in peripheral blood. Int J Hematol. 103:53–62. 2016. View Article : Google Scholar : PubMed/NCBI

22 

Jiang Q, Zhao XY, Qin YZ, Liu YR, Lai YY, Jiang B and Huang XJ: The differences and correlations of BCR-ABL transcripts between peripheral blood and bone marrow assays are associated with the molecular responses in the bone marrow for chronic myelogenous leukemia. Am J Hematol. 87:1065–1069. 2012. View Article : Google Scholar : PubMed/NCBI

23 

Moss TJ and Sanders DG: Detection of neuroblastoma cells in blood. J Clin Oncol. 8:736–740. 1990. View Article : Google Scholar : PubMed/NCBI

24 

Seeger RC, Reynolds CP, Gallego R, Stram DO, Gerbing RB and Matthay KK: Quantitative tumor cell content of bone marrow and blood as a predictor of outcome in stage IV neuroblastoma: A Children's Cancer Group Study. J Clin Oncol. 18:4067–4076. 2000. View Article : Google Scholar : PubMed/NCBI

25 

Yanez Y, Hervas D, Grau E, Oltra S, Perez G, Palanca S, Bermudez M, Marquez C, Canete A and Castel V: TH and DCX mRNAs in peripheral blood and bone marrow predict outcome in metastatic neuroblastoma patients. J Cancer Res Clin Oncol. 142:573–580. 2016. View Article : Google Scholar : PubMed/NCBI

26 

Lin KS, Uemura S, Thwin KKM, Nakatani N, Ishida T, Yamamoto N, Tamura A, Saito A, Mori T, Hasegawa D, et al: Minimal residual disease in high-risk neuroblastoma shows a dynamic and disease burden-dependent correlation between bone marrow and peripheral blood. Transl Oncol. 14:1010192021. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Inoue S, Nay Win KH, Mon CY, Fujikawa T, Hyodo S, Uemura S, Ishida T, Mori T, Hasegawa D, Kosaka Y, Kosaka Y, et al: Higher levels of minimal residual disease in peripheral blood than bone marrow before 1st and 2nd relapse/regrowth in a patient with high‑risk neuroblastoma: A case report. Oncol Lett 26: 369, 2023.
APA
Inoue, S., Nay Win, K.H., Mon, C.Y., Fujikawa, T., Hyodo, S., Uemura, S. ... Nishimura, N. (2023). Higher levels of minimal residual disease in peripheral blood than bone marrow before 1st and 2nd relapse/regrowth in a patient with high‑risk neuroblastoma: A case report. Oncology Letters, 26, 369. https://doi.org/10.3892/ol.2023.13955
MLA
Inoue, S., Nay Win, K. H., Mon, C. Y., Fujikawa, T., Hyodo, S., Uemura, S., Ishida, T., Mori, T., Hasegawa, D., Kosaka, Y., Nishimura, A., Nakatani, N., Nino, N., Tamura, A., Yamamoto, N., Nozu, K., Nishimura, N."Higher levels of minimal residual disease in peripheral blood than bone marrow before 1st and 2nd relapse/regrowth in a patient with high‑risk neuroblastoma: A case report". Oncology Letters 26.3 (2023): 369.
Chicago
Inoue, S., Nay Win, K. H., Mon, C. Y., Fujikawa, T., Hyodo, S., Uemura, S., Ishida, T., Mori, T., Hasegawa, D., Kosaka, Y., Nishimura, A., Nakatani, N., Nino, N., Tamura, A., Yamamoto, N., Nozu, K., Nishimura, N."Higher levels of minimal residual disease in peripheral blood than bone marrow before 1st and 2nd relapse/regrowth in a patient with high‑risk neuroblastoma: A case report". Oncology Letters 26, no. 3 (2023): 369. https://doi.org/10.3892/ol.2023.13955
Copy and paste a formatted citation
x
Spandidos Publications style
Inoue S, Nay Win KH, Mon CY, Fujikawa T, Hyodo S, Uemura S, Ishida T, Mori T, Hasegawa D, Kosaka Y, Kosaka Y, et al: Higher levels of minimal residual disease in peripheral blood than bone marrow before 1st and 2nd relapse/regrowth in a patient with high‑risk neuroblastoma: A case report. Oncol Lett 26: 369, 2023.
APA
Inoue, S., Nay Win, K.H., Mon, C.Y., Fujikawa, T., Hyodo, S., Uemura, S. ... Nishimura, N. (2023). Higher levels of minimal residual disease in peripheral blood than bone marrow before 1st and 2nd relapse/regrowth in a patient with high‑risk neuroblastoma: A case report. Oncology Letters, 26, 369. https://doi.org/10.3892/ol.2023.13955
MLA
Inoue, S., Nay Win, K. H., Mon, C. Y., Fujikawa, T., Hyodo, S., Uemura, S., Ishida, T., Mori, T., Hasegawa, D., Kosaka, Y., Nishimura, A., Nakatani, N., Nino, N., Tamura, A., Yamamoto, N., Nozu, K., Nishimura, N."Higher levels of minimal residual disease in peripheral blood than bone marrow before 1st and 2nd relapse/regrowth in a patient with high‑risk neuroblastoma: A case report". Oncology Letters 26.3 (2023): 369.
Chicago
Inoue, S., Nay Win, K. H., Mon, C. Y., Fujikawa, T., Hyodo, S., Uemura, S., Ishida, T., Mori, T., Hasegawa, D., Kosaka, Y., Nishimura, A., Nakatani, N., Nino, N., Tamura, A., Yamamoto, N., Nozu, K., Nishimura, N."Higher levels of minimal residual disease in peripheral blood than bone marrow before 1st and 2nd relapse/regrowth in a patient with high‑risk neuroblastoma: A case report". Oncology Letters 26, no. 3 (2023): 369. https://doi.org/10.3892/ol.2023.13955
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