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Article

Upregulation of ubiquitin carboxy‑terminal
hydrolase 47 (USP47) in papillary thyroid carcinoma ex vivo and
reduction of tumor cell malignant behaviors after USP47 knockdown by stabilizing SATB1 expression in vitro

  • Authors:
    • Guirong Luo
    • Liting Zhang
    • Wenyi Wu
    • Lihong Zhang
    • Jianqing Lin
    • Haihong Shi
    • Xinquan Wu
    • Yihuang Yu
    • Weigang Qiu
    • Jinyan Chen
    • Hansen Ding
    • Xinyao Chen
  • View Affiliations / Copyright

    Affiliations: Department of Thyroid and Breast Surgery, The Second Affiliated Clinical School of Medicine, Fujian Medical University, Quanzhou, Fujian 362000, P.R. China, Department of Endocrinology, The Number 910 Hospital, The Joint Logistics Support Force, Quanzhou, Fujian 362000, P.R. China, Jinshang Town Health Center, Shishi, Fujian 362000, P.R. China
  • Article Number: 370
    |
    Published online on: July 17, 2023
       https://doi.org/10.3892/ol.2023.13956
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Abstract

Aberrant ubiquitination contributes to cancer development, including thyroid carcinoma. The present study assessed the expression of ubiquitin carboxy‑terminal hydrolase 47 (USP47) and underlying molecular events in the development of papillary thyroid carcinoma (PTC). The effects of USP47 on PTC cell invasion and migration were analyzed by Transwell assays, while. the effects of USP47 and SATB1on PTC cell gene expression and changes in tumor cell metabolism were assayed by reverse transcription‑quantitative PCR, western bolt, or ELISA, respectively. The expression of USP47 mRNA and protein was upregulated in PTC tissue and associated with the PTC tumor size. Knockdown of USP47 expression in PTC cell lines (TPC‑1 and K1), decreased the cell proliferation mobility and invasion capacities, whereas USP47 overexpression in these cell lines showed an inverse effect and promoted cell glycolysis and glutamine metabolism. Moreover, expression of special AT‑rich sequence‑binding protein‑1 (SATB1) was high in PTC tissue and was associated with USP47 expression. SATB1 expression promoted tumor cell glycolysis and glutamine metabolism, while USP47 protein bound to and deubiquitinated SATB1 to increase its intracellular levels, thus promoting glycolysis and glutamine metabolism. USP47 promotion of PTC development may be due to its stabilization of SATB1 protein, suggesting that targeting the USP47/SATB1 signaling axis may serve as a therapeutic intervention for PTC.
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View References

1 

Sung H, Ferlay J, Siegel RL, Laversanne M, Soerjomataram I, Jemal A and Bray F: Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 71:209–249. 2021. View Article : Google Scholar : PubMed/NCBI

2 

Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA and Jemal A: Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 68:394–424. 2018. View Article : Google Scholar : PubMed/NCBI

3 

Kitahara CM, Schneider AB and Brenner AV: Thyroid cancer. Thun M, Linet MS, Cerhan JR, Haiman CA and Schottenfeld D: Cancer Epidemiology and Prevention. 4th edition. Oxford University Press; pp. 839–860. 2018

4 

Carling T and Udelsman R: Thyroid cancer. Annu Rev Med. 65:125–137. 2014. View Article : Google Scholar : PubMed/NCBI

5 

Chou R, Dana T, Haymart M, Leung AM, Tufano RP, Sosa JA and Ringel MD: Active surveillance versus thyroid surgery for differentiated thyroid cancer: A systematic review. Thyroid. 32:351–367. 2022. View Article : Google Scholar : PubMed/NCBI

6 

Udelsman R and Zhang YW: The epidemic of thyroid cancer in the United States: The role of endocrinologists and ultrasounds. Thyroid. 24:472–479. 2014. View Article : Google Scholar : PubMed/NCBI

7 

Stenman A, Backman S, Johansson K, Paulsson JO, Stålberg P, Zedenius J and Juhlin CC: Pan-genomic characterization of high-risk pediatric papillary thyroid carcinoma. Endocr Relat Cancer. 28:337–351. 2021. View Article : Google Scholar : PubMed/NCBI

8 

Ito Y, Miyauchi A, Kihara M, Fukushima M, Higashiyama T and Miya A: Overall survival of papillary thyroid carcinoma patients: A single-institution long-term follow-up of 5897 patients. World J Surg. 42:615–622. 2018. View Article : Google Scholar : PubMed/NCBI

9 

Peng J, Li W, Tan N, Lai X, Jiang W and Chen G: USP47 stabilizes BACH1 to promote the Warburg effect and non-small cell lung cancer development via stimulating Hk2 and Gapdh transcription. Am J Cancer Res. 12:91–107. 2022.PubMed/NCBI

10 

Vander Heiden MG, Cantley LC and Thompson CB: Understanding the Warburg effect: The metabolic requirements of cell proliferation. Science. 324:1029–1033. 2009. View Article : Google Scholar : PubMed/NCBI

11 

López-Lázaro M: The warburg effect: Why and how do cancer cells activate glycolysis in the presence of oxygen? Anticancer Agents Med Chem. 8:305–212. 2008. View Article : Google Scholar : PubMed/NCBI

12 

Ding H, Jiang L, Xu J, Bai F, Zhou Y, Yuan Q, Luo J, Zen K and Yang JW: Inhibiting aerobic glycolysis suppresses renal interstitial fibroblast activation and renal fibrosis. Am J Physiol Renal Physiol. 313:F561–F575. 2017. View Article : Google Scholar : PubMed/NCBI

13 

Yu H, Zhu J, Chang L, Liang C, Li X and Wang W: 3-Bromopyruvate decreased kidney fibrosis and fibroblast activation by suppressing aerobic glycolysis in unilateral ureteral obstruction mice model. Life Sci. 272:1192062021. View Article : Google Scholar : PubMed/NCBI

14 

Jing YY, Cai FF, Zhang L, Han J, Yang L, Tang F, Li YB, Chang JF, Sun F, Yang XM, et al: Epigenetic regulation of the Warburg effect by H2B monoubiquitination. Cell Death Differ. 27:1660–1676. 2020. View Article : Google Scholar : PubMed/NCBI

15 

Li J, He Y, Tan Z, Lu J, Li L, Song X, Shi F, Xie L, You S, Luo X, et al: Wild-type IDH2 promotes the Warburg effect and tumor growth through HIF1α in lung cancer. Theranostics. 8:4050–4061. 2018. View Article : Google Scholar : PubMed/NCBI

16 

Cha YJ, Kim ES and Koo JS: Amino acid transporters and glutamine metabolism in breast cancer. Int J Mol Sci. 19:9072018. View Article : Google Scholar : PubMed/NCBI

17 

van Geldermalsen M, Wang Q, Nagarajah R, Marshall AD, Thoeng A, Gao D, Ritchie W, Feng Y, Bailey CG, Deng N, et al: ASCT2/SLC1A5 controls glutamine uptake and tumour growth in triple-negative basal-like breast cancer. Oncogene. 35:3201–3208. 2016. View Article : Google Scholar : PubMed/NCBI

18 

Bernhardt S, Bayerlová M, Vetter M, Wachter A, Mitra D, Hanf V, Lantzsch T, Uleer C, Peschel S, John J, et al: Proteomic profiling of breast cancer metabolism identifies SHMT2 and ASCT2 as prognostic factors. Breast Cancer Res. 19:1122017. View Article : Google Scholar : PubMed/NCBI

19 

Mukha A, Kahya U and Dubrovska A: Targeting glutamine metabolism and autophagy: The combination for prostate cancer radiosensitization. Autophagy. 17:3879–3881. 2021. View Article : Google Scholar : PubMed/NCBI

20 

Wang Q, Beaumont KA, Otte NJ, Font J, Bailey CG, van Geldermalsen M, Sharp DM, Tiffen JC, Ryan RM, Jormakka M, et al: Targeting glutamine transport to suppress melanoma cell growth. Int J Cancer. 135:1060–1071. 2014. View Article : Google Scholar : PubMed/NCBI

21 

Fraile JM, Quesada V, Rodriguez D, Freije JMP and López-Otín C: Deubiquitinases in cancer: New functions and therapeutic options. Oncogene. 31:2373–2388. 2012. View Article : Google Scholar : PubMed/NCBI

22 

Pan B, Yang Y, Li J, Wang Y, Fang C, Yu FX and Xu Y: USP47-mediated deubiquitination and stabilization of YAP contributes to the progression of colorectal cancer. Protein Cell. 11:138–143. 2020. View Article : Google Scholar : PubMed/NCBI

23 

Hu L, Kolibaba H, Zhang S, Cao M, Niu H, Mei H, Hao Y, Xu Y and Yin Q: MicroRNA-204-5p inhibits ovarian cancer cell proliferation by down-regulating USP47. Cell Transplant. 28 (1 Suppl):51S–58S. 2019. View Article : Google Scholar : PubMed/NCBI

24 

Zhang S, Ding L, Gao F and Fan H: Long non-coding RNA DSCAM-AS1 upregulates USP47 expression through sponging miR-101-3p to accelerate osteosarcoma progression. Biochem Cell Biol. 98:600–611. 2020. View Article : Google Scholar : PubMed/NCBI

25 

Silvestrini VC, Thomé CH, Albuquerque D, de Souza Palma C, Ferreira GA, Lanfredi GP, Masson AP, Delsin LEA, Ferreira FU, de Souza FC, et al: Proteomics analysis reveals the role of ubiquitin specific protease (USP47) in epithelial to mesenchymal transition (EMT) induced by TGFβ2 in breast cells. J Proteomics. 219:1037342020. View Article : Google Scholar : PubMed/NCBI

26 

Cameselle-Teijeiro JM: Changes and perspectives in the new 2022 WHO classification of thyroid neoplasms. Rev Esp Patol. 55:145–148. 2022.(In Spanish). PubMed/NCBI

27 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(−Delta Delta C(T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

28 

Yang L, Moss T, Mangala LS, Marini J, Zhao H, Wahlig S, Armaiz-Pena G, Jiang D, Achreja A, Win J, et al: Metabolic shifts toward glutamine regulate tumor growth, invasion and bioenergetics in ovarian cancer. Mol Syst Biol. 10:7282014. View Article : Google Scholar : PubMed/NCBI

29 

Yu L, Dong L, Wang Y, Liu L, Long H, Li H, Li J, Yang X, Liu Z, Duan G, et al: Reversible regulation of SATB1 ubiquitination by USP47 and SMURF2 mediates colon cancer cell proliferation and tumor progression. Cancer Lett. 448:40–51. 2019. View Article : Google Scholar : PubMed/NCBI

30 

Lin Q, ZL, Wu W, Lin J, Shi H, Wu X, Yu Y, Ding M, Huang Z and Qiu J: Role of specific nuclear matrix binding domain binding protein 1 and microRNA-495-3P in the invasion and metastasis of papillary thyroid carcinoma. Chin J Exp Surg. 38:139–143. 2021.(In Chinese).

31 

Piao J, Tashiro A, Nishikawa M, Aoki Y, Moriyoshi E, Hattori A and Kakeya H: Expression, purification and enzymatic characterization of a recombinant human ubiquitin-specific protease 47. J Biochem. 158:477–484. 2015.PubMed/NCBI

32 

Cho J, Park J, Shin SC, Jang M, Kim JH, Kim EE and Song EJ: USP47 promotes tumorigenesis by negative regulation of p53 through deubiquitinating ribosomal protein S2. Cancers (Basel). 12:11372020. View Article : Google Scholar : PubMed/NCBI

33 

Peschiaroli A, Skaar JR, Pagano M and Melino G: The ubiquitin-specific protease USP47 is a novel beta-TRCP interactor regulating cell survival. Oncogene. 29:1384–1393. 2010. View Article : Google Scholar : PubMed/NCBI

34 

Lei H, Xu HZ, Shan HZ, Liu M, Lu Y, Fang ZX, Jin J, Jing B, Xiao XH, Gao SM, et al: Targeting USP47 overcomes tyrosine kinase inhibitor resistance and eradicates leukemia stem/progenitor cells in chronic myelogenous leukemia. Nat Commun. 12:512021. View Article : Google Scholar : PubMed/NCBI

35 

Zhang S, Ju X, Yang Q, Zhu Y, Fan D, Su G, Kong L and Li Y: USP47 maintains the stemness of colorectal cancer cells and is inhibited by parthenolide. Biochem Biophys Res Commun. 562:21–28. 2021. View Article : Google Scholar : PubMed/NCBI

36 

Glatzel-Plucińska N, Piotrowska A, Dzięgiel P and Podhorska-Okołów M: The role of SATB1 in tumour progression and metastasis. Int J Mol Sci. 20:41562019. View Article : Google Scholar : PubMed/NCBI

37 

Kohwi-Shigematsu T, Kohwi Y, Takahashi K, Richards HW, Ayers SD, Han HJ and Cai S: SATB1-mediated functional packaging of chromatin into loops. Methods. 58:243–254. 2012. View Article : Google Scholar : PubMed/NCBI

38 

Ding M, Pan J, Guo Z, Liu Q, Yang C and Mao L: SATB1 is a novel molecular target for cancer therapy. Cancer Invest. 36:28–36. 2018. View Article : Google Scholar : PubMed/NCBI

39 

Qi H, Fu X, Li Y, Pang X, Chen S, Zhu X, Li F and Tan W: SATB1 promotes epithelial-mesenchymal transition and metastasis in prostate cancer. Oncol Lett. 13:2577–2582. 2017. View Article : Google Scholar : PubMed/NCBI

40 

Zhang S, Tong YX, Xu XS, Lin H and Chao TF: Prognostic significance of SATB1 in gastrointestinal cancer: A meta-analysis and literature review. Oncotarget. 8:48410–48423. 2017. View Article : Google Scholar : PubMed/NCBI

41 

Zhou D, Ye C, Pan Z and Deng Y: SATB1 knockdown inhibits proliferation and invasion and decreases chemoradiation resistance in nasopharyngeal carcinoma cells by reversing EMT and suppressing MMP-9. Int J Med Sci. 18:42–52. 2021. View Article : Google Scholar : PubMed/NCBI

42 

Mukhopadhyay D and Riezman H: Proteasome-independent functions of ubiquitin in endocytosis and signaling. Science. 315:201–205. 2007. View Article : Google Scholar : PubMed/NCBI

43 

Peng J, Schwartz D, Elias JE, Thoreen CC, Cheng D, Marsischky G, Roelofs J, Finley D and Gygi SP: A proteomics approach to understanding protein ubiquitination. Nat Biotechnol. 21:921–926. 2003. View Article : Google Scholar : PubMed/NCBI

44 

Reyes-Turcu FE, Ventii KH and Wilkinson KD: Regulation and cellular roles of ubiquitin-specific deubiquitinating enzymes. Annu Rev Biochem. 78:363–397. 2009. View Article : Google Scholar : PubMed/NCBI

45 

Heger K, Wickliffe KE, Ndoja A, Zhang J, Murthy A, Dugger DL, Maltzman A, de Sousa E Melo F, Hung J, Zeng Y, et al: OTULIN limits cell death and inflammation by deubiquitinating LUBAC. Nature. 559:120–124. 2018. View Article : Google Scholar : PubMed/NCBI

46 

Naghavi L, Schwalbe M, Ghanem A and Naumann M: Deubiquitinylase USP47 promotes RelA phosphorylation and survival in gastric cancer cells. Biomedicines. 6:622018. View Article : Google Scholar : PubMed/NCBI

47 

Yu L, Fu J and Shen C: Ubiquitin specific peptidase 47 promotes proliferation of lung squamous cell carcinoma. Genes Genomics. 44:721–731. 2022. View Article : Google Scholar : PubMed/NCBI

48 

Gong L, Han Y, Chen R, Yang P and Zhang C: LncRNA ZNF883-mediated NLRP3 inflammasome activation and epilepsy development involve USP47 upregulation. Mol Neurobiol. 59:5207–5221. 2022. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Luo G, Zhang L, Wu W, Zhang L, Lin J, Shi H, Wu X, Yu Y, Qiu W, Chen J, Chen J, et al: Upregulation of ubiquitin carboxy‑terminal <br />hydrolase 47 (USP47) in papillary thyroid carcinoma ex vivo and <br />reduction of tumor cell malignant behaviors after USP47 knockdown by stabilizing SATB1 expression in vitro. Oncol Lett 26: 370, 2023.
APA
Luo, G., Zhang, L., Wu, W., Zhang, L., Lin, J., Shi, H. ... Chen, X. (2023). Upregulation of ubiquitin carboxy‑terminal <br />hydrolase 47 (USP47) in papillary thyroid carcinoma ex vivo and <br />reduction of tumor cell malignant behaviors after USP47 knockdown by stabilizing SATB1 expression in vitro. Oncology Letters, 26, 370. https://doi.org/10.3892/ol.2023.13956
MLA
Luo, G., Zhang, L., Wu, W., Zhang, L., Lin, J., Shi, H., Wu, X., Yu, Y., Qiu, W., Chen, J., Ding, H., Chen, X."Upregulation of ubiquitin carboxy‑terminal <br />hydrolase 47 (USP47) in papillary thyroid carcinoma ex vivo and <br />reduction of tumor cell malignant behaviors after USP47 knockdown by stabilizing SATB1 expression in vitro". Oncology Letters 26.3 (2023): 370.
Chicago
Luo, G., Zhang, L., Wu, W., Zhang, L., Lin, J., Shi, H., Wu, X., Yu, Y., Qiu, W., Chen, J., Ding, H., Chen, X."Upregulation of ubiquitin carboxy‑terminal <br />hydrolase 47 (USP47) in papillary thyroid carcinoma ex vivo and <br />reduction of tumor cell malignant behaviors after USP47 knockdown by stabilizing SATB1 expression in vitro". Oncology Letters 26, no. 3 (2023): 370. https://doi.org/10.3892/ol.2023.13956
Copy and paste a formatted citation
x
Spandidos Publications style
Luo G, Zhang L, Wu W, Zhang L, Lin J, Shi H, Wu X, Yu Y, Qiu W, Chen J, Chen J, et al: Upregulation of ubiquitin carboxy‑terminal <br />hydrolase 47 (USP47) in papillary thyroid carcinoma ex vivo and <br />reduction of tumor cell malignant behaviors after USP47 knockdown by stabilizing SATB1 expression in vitro. Oncol Lett 26: 370, 2023.
APA
Luo, G., Zhang, L., Wu, W., Zhang, L., Lin, J., Shi, H. ... Chen, X. (2023). Upregulation of ubiquitin carboxy‑terminal <br />hydrolase 47 (USP47) in papillary thyroid carcinoma ex vivo and <br />reduction of tumor cell malignant behaviors after USP47 knockdown by stabilizing SATB1 expression in vitro. Oncology Letters, 26, 370. https://doi.org/10.3892/ol.2023.13956
MLA
Luo, G., Zhang, L., Wu, W., Zhang, L., Lin, J., Shi, H., Wu, X., Yu, Y., Qiu, W., Chen, J., Ding, H., Chen, X."Upregulation of ubiquitin carboxy‑terminal <br />hydrolase 47 (USP47) in papillary thyroid carcinoma ex vivo and <br />reduction of tumor cell malignant behaviors after USP47 knockdown by stabilizing SATB1 expression in vitro". Oncology Letters 26.3 (2023): 370.
Chicago
Luo, G., Zhang, L., Wu, W., Zhang, L., Lin, J., Shi, H., Wu, X., Yu, Y., Qiu, W., Chen, J., Ding, H., Chen, X."Upregulation of ubiquitin carboxy‑terminal <br />hydrolase 47 (USP47) in papillary thyroid carcinoma ex vivo and <br />reduction of tumor cell malignant behaviors after USP47 knockdown by stabilizing SATB1 expression in vitro". Oncology Letters 26, no. 3 (2023): 370. https://doi.org/10.3892/ol.2023.13956
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