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Expression and clinical value of NLRP1 and NLRC4 inflammasomes in prostate cancer

  • Authors:
    • Ke Liang
    • Zunjin Ke
    • Jianhong Huang
    • Xijiong Zhang
  • View Affiliations / Copyright

    Affiliations: Department of Urology, The First People's Hospital of Pinghu, Pinghu, Zhejiang 314200, P.R. China, Department of Urology, The First People's Hospital of Pinghu, Pinghu, Zhejiang 314200, P.R. China, Department of Pathology, The First People's Hospital of Pinghu, Pinghu, Zhejiang 314200, P.R. China
    Copyright: © Liang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 385
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    Published online on: July 20, 2023
       https://doi.org/10.3892/ol.2023.13971
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Abstract

The present study explored the clinical value of the protein expression levels of nucleotide binding oligomerization‑like receptor family pyrin domain containing 1 (NLRP1) and nucleotide‑binding oligomerization domain leucine‑rich repeat and caspase recruitment domain‑containing 4 (NLRC4) inflammasomes in the diagnosis and treatment of prostate cancer. A total of 54 patients with prostatic hyperplasia and 58 patients with prostate cancer were recruited at The First People's Hospital of Pinghu between January and May 2022. Immunohistochemical staining was used to determine the protein expression levels of the NLRP1 and NLRC4 inflammasomes in addition to the proinflammatory cytokines IL‑18 and IL‑1β in the two groups of patients. The protein expression levels of NLRP1 and NLRC4 inflammasome were significantly increased in patients with prostate cancer compared with patients with prostate hyperplasia. The differences in expression of NLRP1 and NLRC4 inflammatory vesicles in prostate cancer of different stages were also compared based on data from The Cancer Genome Atlas. The protein expression level of NLRP1 demonstrated a significant positive correlation with IL‑1β and IL‑18 expression, and the protein expression level of the NLRC4 inflammasome was significantly positively correlated with IL‑18 expression. The protein expression levels of both NLRP1 and NLRC4 demonstrated a significant positive correlation with the Gleason score of prostate cancer. The expression of NLRP1 in tumor (T)3/T4 was significantly higher compared with T1 and expression of the NLRC4 inflammasome in T2 and T3/T4 was significantly higher compared with T1. Expression of the NLRP1 and NLRC4 inflammasomes was significantly higher in patients with prostate cancer, compared with patients with prostatic hyperplasia. Therefore, expression of NLRP1 and NLRC4 may promote tumorigenesis by promoting the maturation and release of proinflammatory cytokines IL‑1β and IL‑18. Expression of the NLRP1 and NLRC4 inflammasomes demonstrated a significant positive correlation with the risk of prostate cancer. Expression of the NLRP1 and NLRC4 inflammasomes in middle‑ and advanced‑stage tumors was higher compared with early‑stage tumors. These results suggested that inflammasome expression may serve a significant role in the progression of tumors and could provide a fixed value for the risk assessment and prognosis prediction of prostate cancer.
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Copy and paste a formatted citation
Spandidos Publications style
Liang K, Ke Z, Huang J and Zhang X: Expression and clinical value of NLRP1 and NLRC4 inflammasomes in prostate cancer. Oncol Lett 26: 385, 2023.
APA
Liang, K., Ke, Z., Huang, J., & Zhang, X. (2023). Expression and clinical value of NLRP1 and NLRC4 inflammasomes in prostate cancer. Oncology Letters, 26, 385. https://doi.org/10.3892/ol.2023.13971
MLA
Liang, K., Ke, Z., Huang, J., Zhang, X."Expression and clinical value of NLRP1 and NLRC4 inflammasomes in prostate cancer". Oncology Letters 26.3 (2023): 385.
Chicago
Liang, K., Ke, Z., Huang, J., Zhang, X."Expression and clinical value of NLRP1 and NLRC4 inflammasomes in prostate cancer". Oncology Letters 26, no. 3 (2023): 385. https://doi.org/10.3892/ol.2023.13971
Copy and paste a formatted citation
x
Spandidos Publications style
Liang K, Ke Z, Huang J and Zhang X: Expression and clinical value of NLRP1 and NLRC4 inflammasomes in prostate cancer. Oncol Lett 26: 385, 2023.
APA
Liang, K., Ke, Z., Huang, J., & Zhang, X. (2023). Expression and clinical value of NLRP1 and NLRC4 inflammasomes in prostate cancer. Oncology Letters, 26, 385. https://doi.org/10.3892/ol.2023.13971
MLA
Liang, K., Ke, Z., Huang, J., Zhang, X."Expression and clinical value of NLRP1 and NLRC4 inflammasomes in prostate cancer". Oncology Letters 26.3 (2023): 385.
Chicago
Liang, K., Ke, Z., Huang, J., Zhang, X."Expression and clinical value of NLRP1 and NLRC4 inflammasomes in prostate cancer". Oncology Letters 26, no. 3 (2023): 385. https://doi.org/10.3892/ol.2023.13971
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