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Advances in transcriptomics and proteomics in differentiated thyroid cancer: An updated perspective (Review)

  • Authors:
    • Shici Yang
    • Gaohong Zhu
    • Rui He
    • Dong Fang
    • Jiaojiao Feng
  • View Affiliations / Copyright

    Affiliations: Department of Nuclear Medicine, The First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan 650032, P.R. China
    Copyright: © Yang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 396
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    Published online on: July 27, 2023
       https://doi.org/10.3892/ol.2023.13982
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Abstract

Thyroid cancer (TC) is a broad classification of neoplasms that includes differentiated thyroid cancer (DTC) as a common histological subtype. DTC is characterized by an increased mortality rate in advanced stages, which contributes to the overall high mortality rate of DTC. This progression is mainly attributed to alterations in molecular driver genes, resulting in changes in phenotypes such as invasion, metastasis and dedifferentiation. Clinical management of DTC is challenging due to insufficient diagnostic and therapeutic options. The advent of‑omics technology has presented a promising avenue for the diagnosis and treatment of DTC. Identifying molecular markers that can predict the early progression of DTC to a late adverse outcome is essential for precise diagnosis and treatment. The present review aimed to enhance our understanding of DTC by integrating big data with biological systems through‑omics technology, specifically transcriptomics and proteomics, which can shed light on the molecular mechanisms underlying carcinogenesis.
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1 

Du L, Zhao Z, Zheng R, Li H, Zhang S, Li R, Wei W and He J: Epidemiology of thyroid cancer: Incidence and mortality in China, 2015. Front Oncol. 10:17022020. View Article : Google Scholar : PubMed/NCBI

2 

Chen W, Zheng R, Baade PD, Zhang S, Zeng H, Bray F, Jemal A, Yu XQ and He J: Cancer statistics in China, 2015. CA Cancer J Clin. 66:115–132. 2016. View Article : Google Scholar : PubMed/NCBI

3 

Global Burden of Disease Cancer Collaboration, . Fitzmaurice C, Dicker D, Pain A, Hamavid H, Moradi-Lakeh M, MacIntyre MF, Allen C, Hansen G, Woodbrook R, et al: The global burden of cancer 2013. JAMA Oncol. 1:505–527. 2015. View Article : Google Scholar : PubMed/NCBI

4 

Lim H, Devesa SS, Sosa JA, Check D and Kitahara CM: Trends in thyroid cancer incidence and mortality in the United States, 1974–2013. JAMA. 317:1338–1348. 2017. View Article : Google Scholar : PubMed/NCBI

5 

Kim J, Gosnell JE and Roman SA: Geographic influences in the global rise of thyroid cancer. Nat Rev Endocrinol. 16:17–29. 2020. View Article : Google Scholar : PubMed/NCBI

6 

Bilder RM: Phenomics: Building scaffolds for biological hypotheses in the post-genomic era. Biol Psychiatry. 63:439–440. 2008. View Article : Google Scholar : PubMed/NCBI

7 

Hyman DM, Taylor BS and Baselga J: Implementing genome-driven oncology. Cell. 168:584–599. 2017. View Article : Google Scholar : PubMed/NCBI

8 

Song YS and Park YJ: Genomic characterization of differentiated thyroid carcinoma. Endocrinol Metab (Seoul). 34:1–10. 2019. View Article : Google Scholar : PubMed/NCBI

9 

Kumar D, Bansal G, Narang A, Basak T, Abbas T and Dash D: Integrating transcriptome and proteome profiling: Strategies and applications. Proteomics. 16:2533–2544. 2016. View Article : Google Scholar : PubMed/NCBI

10 

Comiskey DF Jr, He H, Liyanarachchi S, Sheikh MS, Genutis LK, Hendrickson IV, Yu L, Brock PL and de la Chapelle A: Variants in LRRC34 reveal distinct mechanisms for predisposition to papillary thyroid carcinoma. J Med Genet. 57:519–527. 2020. View Article : Google Scholar : PubMed/NCBI

11 

Corrado A, Aceto R, Silvestri R, Dell'Anno I, Ricci B, Miglietta S, Romei C, Giovannoni R, Poliseno L, Evangelista M, et al: Pro64His (rs4644) polymorphism within galectin-3 is a risk factor of differentiated thyroid carcinoma and affects the transcriptome of thyrocytes engineered via CRISPR/Cas9 system. Thyroid. 31:1056–1066. 2021. View Article : Google Scholar : PubMed/NCBI

12 

Ye L, Zhou X, Huang F, Wang W, Qi Y, Xu H, Yang S, Shen L, Fei X, Xie J, et al: The genetic landscape of benign thyroid nodules revealed by whole exome and transcriptome sequencing. Nat Commun. 8:155332017. View Article : Google Scholar : PubMed/NCBI

13 

Song YS, Kang BH, Lee S, Yoo SK, Choi YS, Park J, Park DY, Lee KE, Seo JS and Park YJ: Genomic and transcriptomic characteristics according to size of papillary thyroid microcarcinoma. Cancers (Basel). 12:13452020. View Article : Google Scholar : PubMed/NCBI

14 

He H, Liyanarachchi S, Li W, Comiskey DF Jr, Yan P, Bundschuh R, Turkoglu AM, Brock P, Ringel MD and de la Chapelle A: Transcriptome analysis discloses dysregulated genes in normal appearing tumor-adjacent thyroid tissues from patients with papillary thyroid carcinoma. Sci Rep. 11:141262021. View Article : Google Scholar : PubMed/NCBI

15 

Morillo-Bernal J, Fernández LP and Santisteban P: FOXE1 regulates migration and invasion in thyroid cancer cells and targets ZEB1. Endocr Relat Cancer. 27:137–151. 2020. View Article : Google Scholar : PubMed/NCBI

16 

Barros-Filho MC, de Mello JBH, Marchi FA, Pinto CAL, da Silva IC, Damasceno PKF, Soares MBP, Kowalski LP and Rogatto SR: GADD45B transcript is a prognostic marker in papillary thyroid carcinoma patients treated with total thyroidectomy and radioiodine therapy. Front Endocrinol (Lausanne). 11:2692020. View Article : Google Scholar : PubMed/NCBI

17 

Ma B, Jiang H, Wen D, Hu J, Han L, Liu W, Xu W, Shi X, Wei W, Liao T, et al: Transcriptome analyses identify a metabolic gene signature indicative of dedifferentiation of papillary thyroid cancer. J Clin Endocrinol Metab. 104:3713–3725. 2019. View Article : Google Scholar : PubMed/NCBI

18 

Credendino SC, Moccia C, Amendola E, D'Avino G, Di Guida L, Clery E, Greco A, Bellevicine C, Brunetti A, De Felice M and De Vita G: FOXE1 gene dosage affects thyroid cancer histology and differentiation in vivo. Int J Mol Sci. 22:252020. View Article : Google Scholar : PubMed/NCBI

19 

Zhao B, Huang Z, Zhu X, Cai H, Huang Y, Zhang X, Zhang Z, Lu H, An C, Niu L and Li Z: Clinical significance of the expression of co-stimulatory molecule B7-H3 in papillary thyroid carcinoma. Front Cell Dev Biol. 10:8192362022. View Article : Google Scholar : PubMed/NCBI

20 

Akyay OZ, Gov E, Kenar H, Arga KY, Selek A, Tarkun İ, Canturk Z, Cetinarslan B, Gurbuz Y and Sahin B: Mapping the molecular basis and markers of papillary thyroid carcinoma progression and metastasis using global transcriptome and microRNA profiling. OMICS. 24:148–159. 2020. View Article : Google Scholar : PubMed/NCBI

21 

Li Q, Wang P, Sun C, Wang C and Sun Y: Integrative analysis of methylation and transcriptome identified epigenetically regulated lncRNAs with prognostic relevance for thyroid cancer. Front Bioeng Biotechnol. 7:4392020. View Article : Google Scholar : PubMed/NCBI

22 

Guan Y, Bhandari A, Xia E, Kong L, Zhang X and Wang O: Downregulating integrin subunit alpha 7 (ITGA7) promotes proliferation, invasion, and migration of papillary thyroid carcinoma cells through regulating epithelial-to-mesenchymal transition. Acta Biochim Biophys Sin (Shanghai). 52:116–124. 2020. View Article : Google Scholar : PubMed/NCBI

23 

Ramírez-Moya J, Miliotis C, Baker AR, Gregory RI, Slack FJ and Santisteban P: An ADAR1-dependent RNA editing event in the cyclin-dependent kinase CDK13 promotes thyroid cancer hallmarks. Mol Cancer. 20:1152021. View Article : Google Scholar : PubMed/NCBI

24 

Wang ML and Liu JX: MALAT1 rs619586 polymorphism functions as a prognostic biomarker in the management of differentiated thyroid carcinoma. J Cell Physiol. 235:1700–1710. 2020. View Article : Google Scholar : PubMed/NCBI

25 

Saqcena M, Leandro-Garcia LJ, Maag J, Tchekmedyian V, Krishnamoorthy GP, Tamarapu PP, Tiedje V, Reuter V, Knauf JA, de Stanchina E, et al: SWI/SNF Complex Mutations Promote Thyroid Tumor Progression and Insensitivity to Redifferentiation Therapies. Cancer Discov. 11:1158–1175. 2021. View Article : Google Scholar : PubMed/NCBI

26 

Augenlicht A, Saiselet M, Decaussin-Petrucci M, Andry G, Dumont JE and Maenhaut C: MiR-7-5p inhibits thyroid cell proliferation by targeting the EGFR/MAPK and IRS2/PI3K signaling pathways. Oncotarget. 12:1587–1599. 2021. View Article : Google Scholar : PubMed/NCBI

27 

Hou S, Xie X, Zhao J, Wu C, Li N, Meng Z, Cai C and Tan J: Downregulation of miR-146b-3p inhibits proliferation and migration and modulates the expression and location of sodium/iodide symporter in dedifferentiated thyroid cancer by potentially targeting MUC20. Front Oncol. 10:5663652021. View Article : Google Scholar : PubMed/NCBI

28 

Huang J, Sun W, Wang Z, Lv C, Zhang T, Zhang D, Dong W, Shao L, He L, Ji X, et al: FTO suppresses glycolysis and growth of papillary thyroid cancer via decreasing stability of APOE mRNA in an N6-methyladenosine-dependent manner. J Exp Clin Cancer Res. 41:422022. View Article : Google Scholar : PubMed/NCBI

29 

Li X, Ruan X, Zhang P, Yu Y, Gao M, Yuan S, Zhao Z, Yang J and Zhao L: TBX3 promotes proliferation of papillary thyroid carcinoma cells through facilitating PRC2-mediated p57KIP2 repression. Oncogene. 37:2773–2792. 2018. View Article : Google Scholar : PubMed/NCBI

30 

Liao Y, Hua Y, Li Y, Zhang C, Yu W, Guo P, Zou K, Li W, Sun Y, Wang R, et al: CRSP8 promotes thyroid cancer progression by antagonizing IKKα-induced cell differentiation. Cell Death Differ. 28:1347–1363. 2021. View Article : Google Scholar : PubMed/NCBI

31 

Long MY, Chen JW, Zhu Y, Luo DY, Lin SJ, Peng XZ, Tan LP and Li HH: Comprehensive circular RNA profiling reveals the regulatory role of circRNA_0007694 in papillary thyroid carcinoma. Am J Transl Res. 12:1362–1378. 2020.PubMed/NCBI

32 

Ramírez-Moya J, Wert-Lamas L, Acuña-Ruíz A, Fletcher A, Wert-Carvajal C, McCabe CJ, Santisteban P and Riesco-Eizaguirre G: Identification of an interactome network between lncRNAs and miRNAs in thyroid cancer reveals SPTY2D1-AS1 as a new tumor suppressor. Sci Rep. 12:77062022. View Article : Google Scholar : PubMed/NCBI

33 

Cancer Genome Atlas Research Network, . Integrated genomic characterization of papillary thyroid carcinoma. Cell. 159:676–690. 2014. View Article : Google Scholar : PubMed/NCBI

34 

Yoo SK, Lee S, Kim SJ, Jee HG, Kim BA, Cho H, Song YS, Cho SW, Won JK, Shin JY, et al: Comprehensive analysis of the transcriptional and mutational landscape of follicular and papillary thyroid cancers. PLoS Genet. 12:e10062392016. View Article : Google Scholar : PubMed/NCBI

35 

Costa V, Esposito R, Ziviello C, Sepe R, Bim LV, Cacciola NA, Decaussin-Petrucci M, Pallante P, Fusco A and Ciccodicola A: New somatic mutations and WNK1-B4GALNT3 gene fusion in papillary thyroid carcinoma. Oncotarget. 6:11242–11251. 2015. View Article : Google Scholar : PubMed/NCBI

36 

Song YS, Won JK, Yoo SK, Jung KC, Kim MJ, Kim SJ, Cho SW, Lee KE, Yi KH, Seo JS and Park YJ: Comprehensive transcriptomic and genomic profiling of subtypes of follicular variant of papillary thyroid carcinoma. Thyroid. 28:1468–1478. 2018. View Article : Google Scholar : PubMed/NCBI

37 

Johnson DN, Furtado LV, Long BC, Zhen CJ, Wurst M, Mujacic I, Kadri S, Segal JP, Antic T and Cipriani NA: Noninvasive follicular thyroid neoplasms with papillary-like nuclear features are genetically and biologically similar to adenomatous nodules and distinct from papillary thyroid carcinomas with extensive follicular growth. Arch Pathol Lab Med. 142:838–850. 2018. View Article : Google Scholar : PubMed/NCBI

38 

Nikiforov YE, Seethala RR, Tallini G, Baloch ZW, Basolo F, Thompson LD, Barletta JA, Wenig BM, Al Ghuzlan A, Kakudo K, et al: Nomenclature revision for encapsulated follicular variant of papillary thyroid carcinoma: A paradigm shift to reduce overtreatment of indolent tumors. JAMA Oncol. 2:1023–1029. 2016. View Article : Google Scholar : PubMed/NCBI

39 

Pool C, Walter V, Bann D, Goldenberg D, Broach J, Hennessy M, Cottrill E, Washburn E, Williams N, Crist H, et al: Molecular characterization of tumors meeting diagnostic criteria for the non-invasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP). Virchows Arch. 474:341–351. 2019. View Article : Google Scholar : PubMed/NCBI

40 

Yoo SK, Song YS, Lee EK, Hwang J, Kim HH, Jung G, Kim YA, Kim SJ, Cho SW, Won JK, et al: Integrative analysis of genomic and transcriptomic characteristics associated with progression of aggressive thyroid cancer. Nat Commun. 10:27642019. View Article : Google Scholar : PubMed/NCBI

41 

Berdelou A, Lamartina L, Klain M, Leboulleux S and Schlumberger M: Treatment of refractory thyroid cancer. Endocr Relat Cancer. 25:R209–R223. 2018. View Article : Google Scholar : PubMed/NCBI

42 

Goossens N, Nakagawa S, Sun X and Hoshida Y: Cancer biomarker discovery and validation. Transl Cancer Res. 4:256–269. 2015.PubMed/NCBI

43 

Bossuyt PM: Where are all the new omics-based tests? Clin Chem. 60:1256–1257. 2014. View Article : Google Scholar : PubMed/NCBI

44 

Boutros PC: The path to routine use of genomic biomarkers in the cancer clinic. Genome Res. 25:1508–1513. 2015. View Article : Google Scholar : PubMed/NCBI

45 

Capdevila J, Matos I, Mancuso FM, Iglesias C, Nuciforo P, Zafon C, Palmer HG, Ogbah Z, Muiños L, Hernando J, et al: Identification of expression profiles defining distinct prognostic subsets of radioactive-iodine refractory differentiated thyroid cancer from the DECISION trial. Mol Cancer Ther. 19:312–317. 2020. View Article : Google Scholar : PubMed/NCBI

46 

Colombo C, Minna E, Gargiuli C, Muzza M, Dugo M, De Cecco L, Pogliaghi G, Tosi D, Bulfamante G, Greco A, et al: The molecular and gene/miRNA expression profiles of radioiodine resistant papillary thyroid cancer. J Exp Clin Cancer Res. 39:2452020. View Article : Google Scholar : PubMed/NCBI

47 

Siraj S, Masoodi T, Siraj AK, Azam S, Qadri Z, Parvathareddy SK, Bu R, Siddiqui KS, Al-Sobhi SS, AlDawish M and Al-Kuraya KS: APOBEC SBS13 mutational signature-A novel predictor of radioactive iodine refractory papillary thyroid carcinoma. Cancers (Basel). 14:15842022. View Article : Google Scholar : PubMed/NCBI

48 

Franco AT, Ricarte-Filho JC, Laetsch TW and Bauer AJ: Oncogene-specific inhibition in the treatment of advanced pediatric thyroid cancer. J Clin Invest. 131:e1526962021. View Article : Google Scholar : PubMed/NCBI

49 

Boufraqech M and Nilubol N: Multi-omics signatures and translational potential to improve thyroid cancer patient outcome. Cancers (Basel). 11:19882019. View Article : Google Scholar : PubMed/NCBI

50 

Mainini V, Lalowski M, Gotsopoulos A, Bitsika V, Baumann M and Magni F: MALDI-imaging mass spectrometry on tissues. Methods Mol Biol. 1243:139–164. 2015. View Article : Google Scholar : PubMed/NCBI

51 

Ucal Y, Eravci M, Tokat F, Duren M, Ince U and Ozpinar A: Proteomic analysis reveals differential protein expression in variants of papillary thyroid carcinoma. EuPA Open Proteom. 17:1–6. 2017. View Article : Google Scholar : PubMed/NCBI

52 

Ucal Y, Tokat F, Duren M, Ince U and Ozpinar A: Peptide profile differences of noninvasive follicular thyroid neoplasm with papillary-like nuclear features, encapsulated follicular variant, and classical papillary thyroid carcinoma: An application of matrix-assisted laser desorption/ionization mass spectrometry imaging. Thyroid. 29:1125–1137. 2019. View Article : Google Scholar : PubMed/NCBI

53 

Lai X, Umbricht CB, Fisher K, Bishop J, Shi Q and Chen S: Identification of novel biomarker and therapeutic target candidates for diagnosis and treatment of follicular carcinoma. J Proteomics. 166:59–67. 2017. View Article : Google Scholar : PubMed/NCBI

54 

Gawin M, Wojakowska A, Pietrowska M, Marczak Ł, Chekan M, Jelonek K, Lange D, Jaksik R, Gruca A and Widłak P: Proteome profiles of different types of thyroid cancers. Mol Cell Endocrinol. 472:68–79. 2018. View Article : Google Scholar : PubMed/NCBI

55 

Kurczyk A, Gawin M, Chekan M, Wilk A, Łakomiec K, Mrukwa G, Frątczak K, Polanska J, Fujarewicz K, Pietrowska M and Widlak P: Classification of thyroid tumors based on mass spectrometry imaging of tissue microarrays; a single-pixel approach. Int J Mol Sci. 21:62892020. View Article : Google Scholar : PubMed/NCBI

56 

Farrokhi Yekta R, Arefi Oskouie A, Rezaei Tavirani M, Mohajeri-Tehrani MR and Soroush AR: Decreased apolipoprotein A4 and increased complement component 3 as potential markers for papillary thyroid carcinoma: A proteomic study. Int J Biol Markers. 33:455–462. 2018. View Article : Google Scholar : PubMed/NCBI

57 

Zhang Y, Zhao W, Zhao Y, Mao Y, Su T, Zhong Y, Wang S, Zhai R, Cheng J, Fang X, et al: Comparative glycoproteomic profiling of human body fluid between healthy controls and patients with papillary thyroid carcinoma. J Proteome Res. 19:2539–2552. 2020. View Article : Google Scholar : PubMed/NCBI

58 

Wang Y, Zhou S, Wang D, Wei T, Zhu J and Li Z: Complement C4-A and plasminogen as potential biomarkers for prediction of papillary thyroid carcinoma. Front Endocrinol (Lausanne). 12:7376382021. View Article : Google Scholar : PubMed/NCBI

59 

Belousov PV, Afanasyeva MA, Gubernatorova EO, Bogolyubova AV, Uvarova AN, Putlyaeva LV, Ramanauskaite EM, Kopylov AT, Demin DE, Tatosyan KA, et al: Multi-dimensional immunoproteomics coupled with in vitro recapitulation of oncogenic NRASQ61R identifies diagnostically relevant autoantibody biomarkers in thyroid neoplasia. Cancer Lett. 467:96–106. 2019. View Article : Google Scholar : PubMed/NCBI

60 

Capitoli G, Piga I, Galimberti S, Leni D, Pincelli AI, Garancini M, Clerici F, Mahajneh A, Brambilla V, Smith A, et al: MALDI-MSI as a complementary diagnostic tool in cytopathology: A pilot study for the characterization of thyroid nodules. Cancers (Basel). 11:13772019. View Article : Google Scholar : PubMed/NCBI

61 

García-Vence M, Chantada-Vázquez MDP, Cameselle-Teijeiro JM, Bravo SB and Núñez C: A novel nanoproteomic approach for the identification of molecular targets associated with thyroid tumors. Nanomaterials (Basel). 10:23702020. View Article : Google Scholar : PubMed/NCBI

62 

Dai J, Yu X, Han Y, Chai L, Liao Y, Zhong P, Xie R, Sun X, Huang Q, Wang J, et al: TMT-labeling proteomics of papillary thyroid carcinoma reveal invasive biomarkers. J Cancer. 11:6122–6132. 2020. View Article : Google Scholar : PubMed/NCBI

63 

Zhan S, Wang T, Wang M, Li J and Ge W: In-depth proteomics analysis to identify biomarkers of papillary thyroid cancer patients older than 45 years with different degrees of lymph node metastases. Proteomics Clin Appl. 13:e19000302019. View Article : Google Scholar : PubMed/NCBI

64 

Wei X, Zhang Y, Yu S, Li S, Jiang W, Zhu Y, Xu Y, Yang C, Tian G, Mi J, et al: PDLIM5 identified by label-free quantitative proteomics as a potential novel biomarker of papillary thyroid carcinoma. Biochem Biophys Res Commun. 499:338–344. 2018. View Article : Google Scholar : PubMed/NCBI

65 

Orlandella FM, Mariniello RM, Iervolino PLC, Auletta L, De Stefano AE, Ugolini C, Greco A, Mirabelli P, Pane K, Franzese M, et al: Junctional adhesion molecule-A is down-regulated in anaplastic thyroid carcinomas and reduces cancer cell aggressiveness by modulating p53 and GSK3 α/β pathways. Mol Carcinog. 58:1181–1193. 2019. View Article : Google Scholar : PubMed/NCBI

66 

Luo D, Zhan S, Xia W, Huang L, Ge W and Wang T: Proteomics study of serum exosomes from papillary thyroid cancer patients. Endocr Relat Cancer. 25:879–891. 2018. View Article : Google Scholar : PubMed/NCBI

67 

Jin S, Bao W, Yang YT, Fu Q, Bai Y and Liu Y: Proteomic analysis of the papillary thyroid microcarcinoma. Ann Endocrinol (Paris). 80:293–300. 2019. View Article : Google Scholar : PubMed/NCBI

68 

Mondaza-Hernandez JL, Moura DS, Lopez-Alvarez M, Sanchez-Bustos P, Blanco-Alcaina E, Castilla-Ramirez C, Collini P, Merino-Garcia J, Zamora J, Carrillo-Garcia J, et al: ISG15 as a prognostic biomarker in solitary fibrous tumour. Cell Mol Life Sci. 79:4342022. View Article : Google Scholar : PubMed/NCBI

69 

Kariri YA, Alsaleem M, Joseph C, Alsaeed S, Aljohani A, Shiino S, Mohammed OJ, Toss MS, Green AR and Rakha EA: The prognostic significance of interferon-stimulated gene 15 (ISG15) in invasive breast cancer. Breast Cancer Res Treat. 185:293–305. 2021. View Article : Google Scholar : PubMed/NCBI

70 

Zhang Q, Wang J, Qiao H, Huyan L, Liu B, Li C, Jiang J, Zhao F, Wang H and Yan J: ISG15 is downregulated by KLF12 and implicated in maintenance of cancer stem cell-like features in cisplatin-resistant ovarian cancer. J Cell Mol Med. 25:4395–4407. 2021. View Article : Google Scholar : PubMed/NCBI

71 

Qu T, Zhang W, Yan C, Ren D, Wang Y, Guo Y, Guo Q, Wang J, Liu L, Han L, et al: ISG15 targets glycosylated PD-L1 and promotes its degradation to enhance antitumor immune effects in lung adenocarcinoma. J Transl Med. 21:3412023. View Article : Google Scholar : PubMed/NCBI

72 

Lin P, Yao Z, Sun Y, Li W, Liu Y, Liang K, Liu Y, Qin J, Hou X and Chen L: Deciphering novel biomarkers of lymph node metastasis of thyroid papillary microcarcinoma using proteomic analysis of ultrasound-guided fine-needle aspiration biopsy samples. J Proteomics. 204:1034142019. View Article : Google Scholar : PubMed/NCBI

73 

Mishall KM, Beadnell TC, Kuenzi BM, Klimczak DM, Superti-Furga G, Rix U and Schweppe RE: Sustained activation of the AKT/mTOR and MAP kinase pathways mediate resistance to the Src inhibitor, dasatinib, in thyroid cancer. Oncotarget. 8:103014–103031. 2017. View Article : Google Scholar : PubMed/NCBI

74 

Krishnan A, Berthelet J, Renaud E, Rosigkeit S, Distler U, Stawiski E, Wang J, Modrusan Z, Fiedler M, Bienz M, et al: Proteogenomics analysis unveils a TFG-RET gene fusion and druggable targets in papillary thyroid carcinomas. Nat Commun. 11:20562020. View Article : Google Scholar : PubMed/NCBI

75 

Rajalingam K and Dikic I: SnapShot: Expanding the ubiquitin code. Cell. 164:1074–1074.e1. 2016. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Yang S, Zhu G, He R, Fang D and Feng J: Advances in transcriptomics and proteomics in differentiated thyroid cancer: An updated perspective (Review). Oncol Lett 26: 396, 2023.
APA
Yang, S., Zhu, G., He, R., Fang, D., & Feng, J. (2023). Advances in transcriptomics and proteomics in differentiated thyroid cancer: An updated perspective (Review). Oncology Letters, 26, 396. https://doi.org/10.3892/ol.2023.13982
MLA
Yang, S., Zhu, G., He, R., Fang, D., Feng, J."Advances in transcriptomics and proteomics in differentiated thyroid cancer: An updated perspective (Review)". Oncology Letters 26.3 (2023): 396.
Chicago
Yang, S., Zhu, G., He, R., Fang, D., Feng, J."Advances in transcriptomics and proteomics in differentiated thyroid cancer: An updated perspective (Review)". Oncology Letters 26, no. 3 (2023): 396. https://doi.org/10.3892/ol.2023.13982
Copy and paste a formatted citation
x
Spandidos Publications style
Yang S, Zhu G, He R, Fang D and Feng J: Advances in transcriptomics and proteomics in differentiated thyroid cancer: An updated perspective (Review). Oncol Lett 26: 396, 2023.
APA
Yang, S., Zhu, G., He, R., Fang, D., & Feng, J. (2023). Advances in transcriptomics and proteomics in differentiated thyroid cancer: An updated perspective (Review). Oncology Letters, 26, 396. https://doi.org/10.3892/ol.2023.13982
MLA
Yang, S., Zhu, G., He, R., Fang, D., Feng, J."Advances in transcriptomics and proteomics in differentiated thyroid cancer: An updated perspective (Review)". Oncology Letters 26.3 (2023): 396.
Chicago
Yang, S., Zhu, G., He, R., Fang, D., Feng, J."Advances in transcriptomics and proteomics in differentiated thyroid cancer: An updated perspective (Review)". Oncology Letters 26, no. 3 (2023): 396. https://doi.org/10.3892/ol.2023.13982
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