Indolent mucinous tubular and spindle cell carcinoma of the kidney: A case report and review of the literature<strong><br /></strong>

Wu,Guangrong; Zhang,Jiaren; Jiang,Lin; Liu,Jiaji; Zhang,Lunyou; Yang,Wei

doi:10.3892/ol.2023.13992

Indolent mucinous tubular and spindle cell carcinoma of the kidney: A case report and review of the literature

Authors:
- Guangrong Wu
- Jiaren Zhang
- Lin Jiang
- Jiaji Liu
- Lunyou Zhang
- Wei Yang
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Affiliations: Department of Radiology, The First People's Hospital of Zunyi, The Third Affiliated Hospital of Zunyi Medical University, Zunyi, Guizhou 563000, P.R. China, Department of Radiology, The First People's Hospital of Zunyi, The Third Affiliated Hospital of Zunyi Medical University, Zunyi, Guizhou 563000, P.R. China
Published online on: August 1, 2023 https://doi.org/10.3892/ol.2023.13992
Article Number: 406
Copyright: © Wu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Mucinous tubular and spindle cell carcinoma of the kidney (MTSCC) is a rare subtype of renal cancer. It consists of tubules separated by mucus stroma and a spindle cell. Few cases have been reported; thus, the imaging features of MTSCC are not well characterized. An MTSCC in the left kidney of a 65‑year‑old woman was incidentally discovered during a medical checkup. A review of the patient's medical history revealed that this kidney lump had an indolent growth process. The current study presented this case and reviewed the pathological features, imaging findings and treatment options of MTSCC to strengthen the recognition of this rare renal neoplasm by radiologists.

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1	Moch H, Cubilla AL, Humphrey PA, Reuter VE and Ulbright TM: The 2016 WHO classification of tumours of the urinary system and male genital organs-part A: Renal, penile, and testicular tumours. Eur Urol. 70:93–105. 2016. View Article : Google Scholar : PubMed/NCBI
2	Xu X, Zhong J, Zhou X, Wei Z, Xia Q, Huang P, Shi C, Da J, Tang C, Cheng W and Ge J: Mucinous tubular and spindle cell carcinoma of the kidney: A study of clinical, imaging features and treatment outcomes. Front Oncol. 12:8652632022. View Article : Google Scholar : PubMed/NCBI
3	Li XS, Yao L, Gong K, Yu W, He Q, Zhou LQ and He ZS: Growth pattern of renal cell carcinoma (RCC) in patients with delayed surgical intervention. J Cancer Res Clin Oncol. 138:269–274. 2012. View Article : Google Scholar : PubMed/NCBI
4	Cornelis F, Ambrosetti D, Rocher L, Derchi LE, Renard B, Puech P, Claudon M, Rouvière O, Ferlicot S, Roy C, et al: CT and MR imaging features of mucinous tubular and spindle cell carcinoma of the kidneys. A multi-institutional review. Eur Radiol. 27:1087–1095. 2017. View Article : Google Scholar : PubMed/NCBI
5	Wu J, Zhu Q, Zhu W, Chen W and Wang S: Comparative study of CT appearances in mucinous tubular and spindle cell carcinoma and collecting duct carcinoma of the kidney. Br J Radiol. 88:201404342015. View Article : Google Scholar : PubMed/NCBI
6	Nathany S and Monappa V: Mucinous tubular and spindle cell carcinoma: A review of histopathology and clinical and prognostic implications. Arch Pathol Lab Med. 144:115–118. 2020. View Article : Google Scholar : PubMed/NCBI
7	Ivey JA III, Cortese C, Baird BA, Thiel DD and Lyon TD: Mucinous tubular and spindle cell carcinoma of the kidney with nodal metastasis managed with surgical resection. Eur Urol Open Sci. 29:10–14. 2021. View Article : Google Scholar : PubMed/NCBI
8	Fine SW, Argani P, DeMarzo AM, Delahunt B, Sebo TJ, Reuter VE and Epstein JI: Expanding the histologic spectrum of mucinous tubular and spindle cell carcinoma of the kidney. Am J Surg Pathol. 30:1554–1560. 2006. View Article : Google Scholar : PubMed/NCBI
9	Ged Y, Chen YB, Knezevic A, Donoghue MTA, Carlo MI, Lee CH, Feldman DR, Patil S, Hakimi AA, Russo P, et al: Mucinous tubular and spindle-cell carcinoma of the kidney: Clinical features, genomic profiles, and treatment outcomes. Clin Genitourin Cancer. 17:268–274.e1. 2019. View Article : Google Scholar : PubMed/NCBI
10	Trpkov K, Hes O, Williamson SR, Adeniran AJ, Agaimy A, Alaghehbandan R, Amin MB, Argani P, Chen YB, Cheng L, et al: New developments in existing WHO entities and evolving molecular concepts: The genitourinary pathology society (GUPS) update on renal neoplasia. Mod Pathol. 34:1392–1424. 2021. View Article : Google Scholar : PubMed/NCBI
11	Farghaly H: Mucin poor mucinous tubular and spindle cell carcinoma of the kidney, with nonclassic morphologic variant of spindle cell predominance and psammomatous calcification. Ann Diagn Pathol. 16:59–62. 2012. View Article : Google Scholar : PubMed/NCBI
12	Thway K, du Parcq J, Larkin JMG, Fisher C and Livni N: Metastatic renal mucinous tubular and spindle cell carcinoma. Atypical behavior of a rare, morphologically bland tumor. Ann Diagn Pathol. 16:407–410. 2012. View Article : Google Scholar : PubMed/NCBI
13	Yang C, Cimera RS, Aryeequaye R, Jayakumaran G, Sarungbam J, Al-Ahmadie HA, Gopalan A, Sirintrapun SJ, Fine SW, Tickoo SK, et al: Adverse histology, homozygous loss of CDKN2A/B, and complex genomic alterations in locally advanced/metastatic renal mucinous tubular and spindle cell carcinoma. Mod Pathol. 34:445–456. 2021. View Article : Google Scholar : PubMed/NCBI
14	Brandal P, Lie AK, Bassarova A, Svindland A, Risberg B, Danielsen H and Heim S: Genomic aberrations in mucinous tubular and spindle cell renal cell carcinomas. Mod Pathol. 19:186–194. 2006. View Article : Google Scholar : PubMed/NCBI
15	Cossu-Rocca P, Eble JN, Delahunt B, Zhang S, Martignoni G, Brunelli M and Cheng L: Renal mucinous tubular and spindle carcinoma lacks the gains of chromosomes 7 and 17 and losses of chromosome Y that are prevalent in papillary renal cell carcinoma. Mod Pathol. 19:488–493. 2006. View Article : Google Scholar : PubMed/NCBI
16	Wang L, Zhang Y, Chen YB, Skala SL, Al-Ahmadie HA, Wang X, Cao X, Veeneman BA, Chen J, Cieślik M, et al: VSTM2A overexpression is a sensitive and specific biomarker for mucinous tubular and spindle cell carcinoma (MTSCC) of the kidney. Am J Surg Pathol. 42:1571–1584. 2018. View Article : Google Scholar : PubMed/NCBI
17	Zhao M, He XL and Teng XD: Mucinous tubular and spindle cell renal cell carcinoma: A review of clinicopathologic aspects. Diagn Pathol. 10:1682015. View Article : Google Scholar : PubMed/NCBI
18	Truong LD and Shen SS: Immunohistochemical diagnosis of renal neoplasms. Arch Pathol Lab Med. 135:92–109. 2011. View Article : Google Scholar : PubMed/NCBI
19	Paner GP, Srigley JR, Radhakrishnan A, Cohen C, Skinnider BF, Tickoo SK, Young AN and Amin MB: Immunohistochemical analysis of mucinous tubular and spindle cell carcinoma and papillary renal cell carcinoma of the kidney: Significant immunophenotypic overlap warrants diagnostic caution. Am J Surg Pathol. 30:13–19. 2006. View Article : Google Scholar : PubMed/NCBI
20	Moll R, Divo M and Langbein L: The human keratins: Biology and pathology. Histochem Cell Biol. 129:705–733. 2008. View Article : Google Scholar : PubMed/NCBI
21	Ferlicot S, Allory Y, Compérat E, Mege-Lechevalier F, Dimet S, Sibony M, Couturier J and Vieillefond A: Mucinous tubular and spindle cell carcinoma: A report of 15 cases and a review of the literature. Virchows Arch. 447:978–983. 2005. View Article : Google Scholar : PubMed/NCBI
22	Szlasa W, Wilk K, Knecht-Gurwin K, Gurwin A, Froń A, Sauer N, Krajewski W, Saczko J, Szydełko T, Kulbacka J and Małkiewicz B: Prognostic and therapeutic role of CD15 and CD15s in cancer. Cancers (Basel). 14:22032022. View Article : Google Scholar : PubMed/NCBI
23	Kenney PA, Vikram R, Prasad SR, Tamboli P, Matin SF, Wood CG and Karam JA: Mucinous tubular and spindle cell carcinoma (MTSCC) of the kidney: A detailed study of radiological, pathological and clinical outcomes. BJU Int. 116:85–92. 2015. View Article : Google Scholar : PubMed/NCBI
24	Lu D, Yuan W, Zhu Q, Ye J, Zhu W and Chen W: Comparative study of CT and MRI appearances in mucinous tubular and spindle cell carcinoma and papillary renal cell carcinoma. Br J Radiol. 94:202105482021. View Article : Google Scholar : PubMed/NCBI
25	Adamane SA, Menon S, Prakash G, Bakshi G, Joshi A, Popat P and Desai SB: Mucinous tubular and spindle cell carcinoma of the kidney: A case series with a brief review of the literature. Indian J Cancer. 57:267–281. 2020.PubMed/NCBI
26	Zhu Q, Zhu W, Wang Z and Wu J: Clinical and CT imaging features of mucinous tubular and spindle cell carcinoma. Chin Med J (Engl). 127:1278–1283. 2014.PubMed/NCBI
27	Israel GM and Bosniak MA: How i do it: Evaluating renal masses. Radiology. 236:441–450. 2005. View Article : Google Scholar : PubMed/NCBI
28	Oliva MR, Glickman JN, Zou KH, Teo SY, Mortelé KJ, Rocha MS and Silverman SG: Renal cell carcinoma: t1 and t2 signal intensity characteristics of papillary and clear cell types correlated with pathology. AJR Am J Roentgenol. 192:1524–1530. 2009. View Article : Google Scholar : PubMed/NCBI
29	Furubayashi N, Taguchi K, Negishi T, Miura A, Sato Y, Miyoshi M and Nakamura M: Cytoreductive nephrectomy after combination of nivolumab plus ipilimumab for mucinous tubular and spindle cell carcinoma of the kidney with bone metastases: A case report. In Vivo. 36:510–521. 2022. View Article : Google Scholar : PubMed/NCBI