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Case Report Open Access

Unusual localization and clinical presentation of primary central nervous system extranodal marginal zone B‑cell lymphoma: A case report

  • Authors:
    • Vincenzo Fiorentino
    • Cristina Pizzimenti
    • Francesco Pierconti
    • Maria Lentini
    • Antonio Ieni
    • Maria Caffo
    • Filippo Angileri
    • Giovanni Tuccari
    • Guido Fadda
    • Maurizio Martini
    • Luigi Maria Larocca
  • View Affiliations / Copyright

    Affiliations: Department of Human Pathology in Adult and Developmental Age ‘Gaetano Barresi’, Pathology Section, University Hospital ‘G. Martino’, University of Messina, I‑98125 Messina, Italy, Department of Biomedical and Dental Sciences and Morphofunctional Imaging, University Hospital ‘G. Martino’, University of Messina, I‑98125 Messina, Italy, Institute of Pathology, Division of Anatomic Pathology and Histology, A. Gemelli‑Scientific Institute for Research, Hospitalization and Healthcare University Hospital Foundation, I‑00168 Rome, Italy, Department of Biomedical and Dental Sciences and Morphofunctional Imaging, Section of Neurosurgery, University Hospital ‘G. Martino’, I‑98125 Messina, Italy, Department of Medicine and Surgery, Unicamillus, Saint Camillus International University of Health Sciences, International Medical University in Rome, I‑00131 Rome, Italy
    Copyright: © Fiorentino et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 408
    |
    Published online on: August 4, 2023
       https://doi.org/10.3892/ol.2023.13994
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Abstract

Primary central nervous system (CNS) extranodal marginal zone B‑cell lymphoma (MZBL) is a rare low‑grade non‑Hodgkin lymphoma, characterised predominantly by small B cells, plasma cells, monocytoid cells and scattered large immunoblasts. Primary CNS MZBL is a slow‑growing tumour that remains localised and is characterised by an excellent clinical prognosis. The present study describes the case of a 48‑year‑old HIV‑negative female patient with a history of head trauma 1 year prior, who presented with worsening neurological symptoms and a magnetic resonance imaging finding of a ~3‑cm extra‑axial mass within the left lateral ventricle. From histopathology and immunohistochemistry, the lesion was diagnosed as a CNS MZBL; as no other primary lesions were found, the base of the choroid plexuses of the left lateral ventricle was considered the primary site. To the best of our knowledge, the current case is the first study to report on primary CNS MZBL arising in this anatomical site and paves the way for further studies on the role of chronic inflammation (in the present case resulting from trauma) in the pathogenesis not only of primary CNS MZBL but also of lymphoma in general. Additionally, this report could serve as a starting point for studies analysing the role of meningothelial cells in the pathogenesis of primary CNS MZBL.
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Copy and paste a formatted citation
Spandidos Publications style
Fiorentino V, Pizzimenti C, Pierconti F, Lentini M, Ieni A, Caffo M, Angileri F, Tuccari G, Fadda G, Martini M, Martini M, et al: Unusual localization and clinical presentation of primary central nervous system extranodal marginal zone B‑cell lymphoma: A case report. Oncol Lett 26: 408, 2023.
APA
Fiorentino, V., Pizzimenti, C., Pierconti, F., Lentini, M., Ieni, A., Caffo, M. ... Larocca, L.M. (2023). Unusual localization and clinical presentation of primary central nervous system extranodal marginal zone B‑cell lymphoma: A case report. Oncology Letters, 26, 408. https://doi.org/10.3892/ol.2023.13994
MLA
Fiorentino, V., Pizzimenti, C., Pierconti, F., Lentini, M., Ieni, A., Caffo, M., Angileri, F., Tuccari, G., Fadda, G., Martini, M., Larocca, L. M."Unusual localization and clinical presentation of primary central nervous system extranodal marginal zone B‑cell lymphoma: A case report". Oncology Letters 26.3 (2023): 408.
Chicago
Fiorentino, V., Pizzimenti, C., Pierconti, F., Lentini, M., Ieni, A., Caffo, M., Angileri, F., Tuccari, G., Fadda, G., Martini, M., Larocca, L. M."Unusual localization and clinical presentation of primary central nervous system extranodal marginal zone B‑cell lymphoma: A case report". Oncology Letters 26, no. 3 (2023): 408. https://doi.org/10.3892/ol.2023.13994
Copy and paste a formatted citation
x
Spandidos Publications style
Fiorentino V, Pizzimenti C, Pierconti F, Lentini M, Ieni A, Caffo M, Angileri F, Tuccari G, Fadda G, Martini M, Martini M, et al: Unusual localization and clinical presentation of primary central nervous system extranodal marginal zone B‑cell lymphoma: A case report. Oncol Lett 26: 408, 2023.
APA
Fiorentino, V., Pizzimenti, C., Pierconti, F., Lentini, M., Ieni, A., Caffo, M. ... Larocca, L.M. (2023). Unusual localization and clinical presentation of primary central nervous system extranodal marginal zone B‑cell lymphoma: A case report. Oncology Letters, 26, 408. https://doi.org/10.3892/ol.2023.13994
MLA
Fiorentino, V., Pizzimenti, C., Pierconti, F., Lentini, M., Ieni, A., Caffo, M., Angileri, F., Tuccari, G., Fadda, G., Martini, M., Larocca, L. M."Unusual localization and clinical presentation of primary central nervous system extranodal marginal zone B‑cell lymphoma: A case report". Oncology Letters 26.3 (2023): 408.
Chicago
Fiorentino, V., Pizzimenti, C., Pierconti, F., Lentini, M., Ieni, A., Caffo, M., Angileri, F., Tuccari, G., Fadda, G., Martini, M., Larocca, L. M."Unusual localization and clinical presentation of primary central nervous system extranodal marginal zone B‑cell lymphoma: A case report". Oncology Letters 26, no. 3 (2023): 408. https://doi.org/10.3892/ol.2023.13994
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