Solitary choroidal metastasis of distal cholangiocarcinoma: <br />A case report

Shimojima,Yukio; Hirose,Yuki; Nomura,Tatsuya; Takano,Kabuto; Hara,Hiroaki; Bamba,Takeo; Aizawa,Masaki; Nogami,Hitoshi; Matsuki,Atsushi; Maruyama,Satoshi; Takii,Yasumasa; Yabusaki,Hiroshi; Sakata,Jun; Wakai,Toshifumi; Shiozawa,Shunichi; Nakagawa,Satoru

doi:10.3892/ol.2023.14004

October-2023 Volume 26 Issue 4

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October-2023 Volume 26 Issue 4

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Case Report Open Access

Solitary choroidal metastasis of distal cholangiocarcinoma:
A case report

Authors:
- Yukio Shimojima
- Yuki Hirose
- Tatsuya Nomura
- Kabuto Takano
- Hiroaki Hara
- Takeo Bamba
- Masaki Aizawa
- Hitoshi Nogami
- Atsushi Matsuki
- Satoshi Maruyama
- Yasumasa Takii
- Hiroshi Yabusaki
- Jun Sakata
- Toshifumi Wakai
- Shunichi Shiozawa
- Satoru Nakagawa
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Affiliations: Department of Digestive Surgery, Niigata Cancer Center Hospital, Niigata 951‑8566, Japan, Department of Ophthalmology, Niigata Cancer Center Hospital, Niigata 951‑8566, Japan, Division of Digestive and General Surgery, Niigata University Graduate School of Medical and Dental Sciences, Niigata 951‑8510, Japan, Department of Surgery, Tokyo Women's Medical University, Adachi Medical Center, Tokyo 123‑8558, Japan

Copyright: © Shimojima et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
Article Number: 419
|
Published online on: August 10, 2023

https://doi.org/10.3892/ol.2023.14004
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Abstract

Metastatic choroidal carcinoma is rare and generally has a poor prognosis. The present case report describes a case of choroidal metastasis from distal cholangiocarcinoma, which was successfully managed using stereotactic radiotherapy (SRT). A 67‑year‑old Japanese man underwent pancreaticoduodenectomy for distal cholangiocarcinoma. The pathological stage was T2N0M0 stage ⅡA, according to the Union for International Cancer Control 8th edition. After surgery, the patient received adjuvant chemotherapy with oral TS‑1® for 1 month. A total of 2 months after surgery, the patient was readmitted to hospital due to decreased visual acuity. Fundoscopy revealed a macular hole in the right eye that accounted for the decreased visual acuity. Additionally, Goldmann three‑mirror contact lens examination revealed a 4‑mm choroidal mass with a yellowish color situated at a considerable distance from the optic nerve. Magnetic resonance imaging revealed an enhanced choroidal mass. Based on the findings of ophthalmologic examinations and the patient's history of cholangiocarcinoma, they were diagnosed with choroidal metastasis from distal cholangiocarcinoma. SRT was administered at a total dose of 40 Gy divided into 8 Gy fractions. A total of 1 year after SRT, the patient achieved complete remission without decreased visual acuity. The patient remains alive and in good health without recurrence, 4 years after the diagnosis of choroidal metastasis. To the best of our knowledge, this is the second reported case of intraocular metastasis from cholangiocarcinoma. In conclusion, SRT may provide an opportunity to control metastatic choroidal carcinoma without decreasing visual acuity.

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