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Upregulated miR‑378a‑3p expression suppresses energy metabolism and promotes apoptosis by targeting a GLUT‑1/ALDOA/PKM2 axis in esophageal carcinoma

  • Authors:
    • Yuan Qu
    • Shan Xue
    • Yujian Zheng
    • Yajing Du
    • Guoping Zhang
    • Liting Huang
    • Hui Li
    • Huiwu Li
  • View Affiliations / Copyright

    Affiliations: Department of Labour Hygiene and Sanitary Science, College of Public Health, Xinjiang Medical University, Urumqi, Xinjiang 830011, P.R. China, Medical Research Center, Yuebei People's Hospital, Shantou University, Shaoguan, Guangdong 512025, P.R. China, Medical Research Center, Yuebei People's Hospital, Shantou University, Shaoguan, Guangdong 512025, P.R. China, Tumor Department, Yuebei People's Hospital, Shantou University, Shaoguan, Guangdong 512025, P.R. China, Central Laboratory of Xinjiang Medical University, Xinjiang Medical University, Urumqi, Xinjiang 830011, P.R. China
    Copyright: © Qu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 421
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    Published online on: August 10, 2023
       https://doi.org/10.3892/ol.2023.14007
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Abstract

Esophageal squamous cell carcinoma (ESCC) is an aggressive malignancy of the digestive system with increasing incidence and mortality rates. The biological roles of microRNA (miR)‑378a‑3p in tumor cells remain contested, and the mechanisms underlying the functions, energy metabolism, and cell survival mechanisms in ESCC cells are yet to be fully elucidated. In the present study, miR‑378a‑3p overexpression and negative control plasmids were transfected into ECA‑109 cells using electroporation. Western blotting was used to detect the relative expression of proteins, and flow cytometry was used to detect cell apoptosis. Subsequently, ELISA assays were performed to determine enzyme activity, and an ATP detection kit was used to measure ATP content. Dual‑luciferase reporter assays were performed to identify the target genes of miR‑378a‑3p. The results of the present study demonstrated that miR‑378a‑3p inhibited the gene expression and enzyme activities of glucose transporter protein 1 (GLUT‑1), Aldolase A (ALDOA), and pyruvate kinase M2 (PKM2), all of which are involved in the glycolytic pathway of cells. Energy metabolism was suppressed by miR‑378a‑3p by reducing ATP content, and this downregulated the expression of Bcl‑2 and Survivin. Moreover, increased miR‑378a‑3p expression promoted cell apoptosis in the early stages by increasing the expression levels and the activity of Bad and Caspase‑3, while inhibiting the expression levels of Bcl‑2 and Survivin. The results of the present study also demonstrated that GLUT‑1/ALDOA/PKM2 were target genes of miR‑378a‑3p. Notably, miR‑378a‑3p blocked energy production and promoted the apoptosis of tumor cells via the downregulation of glycolytic enzyme expression and by reducing the mitochondrial membrane potential in ESCC. Bad, Caspase‑3, Survivin, and Bcl‑2 may be associated with blocking energy production and promoting apoptosis via miR‑378a‑3p in ESCC cells.
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View References

1 

Pennathur A, Gibson MK, Jobe BA and Luketich JD: Oesophageal carcinoma. Lancet. 381:400–412. 2013. View Article : Google Scholar : PubMed/NCBI

2 

Zheng R, Zhang S, Zeng H, Wang S, Sun K, Sun R, Li L, Wei W and Wei J: Cancer incidence and mortality in China, 2016. J National Cancer Center. 2:1–9. 2022. View Article : Google Scholar

3 

Kamangar F, Dores GM and Anderson WF: Patterns of cancer incidence, mortality, and prevalence across five continents: Defining priorities to reduce cancer disparities in different geographic regions of the world. J Clin Oncol. 24:2137–2150. 2006. View Article : Google Scholar : PubMed/NCBI

4 

Guo P, Huang ZL, Yu P and Li K: Trends in cancer mortality in China: An update. Ann Oncol. 23:2755–2762. 2012. View Article : Google Scholar : PubMed/NCBI

5 

Dubecz A, Gall I, Solymosi N, Schweigert M, Peters JH, Feith M and Stein HJ: Temporal trends in long-term survival and cure rates in esophageal cancer: A SEER database analysis. J Thorac Oncol. 7:443–447. 2012. View Article : Google Scholar : PubMed/NCBI

6 

Ohashi S, Miyamoto S, Kikuchi O, Goto T, Amanuma Y and Muto M: Recent advances from basic and clinical studies of esophageal squamous cell carcinoma. Gastroenterology. 149:1700–1715. 2015. View Article : Google Scholar : PubMed/NCBI

7 

Ambros V: The functions of animal microRNAs. Nature. 431:350–355. 2004. View Article : Google Scholar : PubMed/NCBI

8 

Rottiers V and Naar AM: MicroRNAs in metabolism and metabolic disorders. Nat Rev Mol Cell Biol. 13:239–250. 2012. View Article : Google Scholar : PubMed/NCBI

9 

Peng Y and Croce CM: The role of MicroRNAs in human cancer. Signal Transduct Target Ther. 1:150042016. View Article : Google Scholar : PubMed/NCBI

10 

Su Z, Yang Z, Xu Y, Chen Y and Yu QJO: MicroRNAs in apoptosis, autophagy and necroptosis. Oncotarget. 6:8474–8490. 2015. View Article : Google Scholar : PubMed/NCBI

11 

Ivey KN and Srivastava D: MicroRNAs as regulators of differentiation and cell fate decisions. Cell Stem Cell. 7:36–41. 2010. View Article : Google Scholar : PubMed/NCBI

12 

Machado IF, Teodoro JS, Palmeira CM and Rolo AP: miR-378a: A new emerging microRNA in metabolism. Cell Mol Life Sci. 77:1947–1958. 2020. View Article : Google Scholar : PubMed/NCBI

13 

Liu B, Qu J, Xu F, Guo Y, Wang Y, Yu H and Qian B: MiR-195 suppresses non-small cell lung cancer by targeting CHEK1. Oncotarget. 6:9445–9456. 2015. View Article : Google Scholar : PubMed/NCBI

14 

Valeri N, Braconi C, Gasparini P, Murgia C, Lampis A, Paulus-Hock V, Hart JR, Ueno L, Grivennikov SI, Lovat F, et al: MicroRNA-135b promotes cancer progression by acting as a downstream effector of oncogenic pathways in colon cancer. Cancer Cell. 25:469–483. 2014. View Article : Google Scholar : PubMed/NCBI

15 

Pedroza-Torres A, Campos-Parra AD, Millan-Catalan O, Loissell-Baltazar YA, Zamudio-Meza H, Cantú de León D, Montalvo-Esquivel G, Isla-Ortiz D, Herrera LA, Ángeles-Zaragoza Ó, et al: MicroRNA-125 modulates radioresistance through targeting p21 in cervical cancer. Oncol Rep. 39:1532–1540. 2018.PubMed/NCBI

16 

Pedroza-Torres A, Fernández-Retana J, Peralta-Zaragoza O, Jacobo-Herrera N, Cantú de Leon D, Cerna-Cortés JF, Lopez-Camarillo C and Pérez-Plasencia C: A microRNA expression signature for clinical response in locally advanced cervical cancer. Gynecol Oncol. 142:557–565. 2016. View Article : Google Scholar : PubMed/NCBI

17 

Chen LT, Xu SD, Xu H, Zhang JF, Ning JF and Wang SF: MicroRNA-378 is associated with non-small cell lung cancer brain metastasis by promoting cell migration, invasion and tumor angiogenesis. Med Oncol. 29:1673–1680. 2012. View Article : Google Scholar : PubMed/NCBI

18 

Qin Y, Liang R, Lu P, Lai L and Zhu X: Depicting the Implication of miR-378a in Cancers. Technol Cancer Res Treat. 21:153303382211343852022. View Article : Google Scholar : PubMed/NCBI

19 

Krist B, Florczyk U, Pietraszek-Gremplewicz K, Józkowicz A and Dulak J: The role of miR-378a in metabolism, angiogenesis, and muscle biology. Int J Endocrinol. 2015:2817562015. View Article : Google Scholar : PubMed/NCBI

20 

Wang Y and Du J: miR-378a-3p regulates glioma cell chemosensitivity to cisplatin through IGF1R. Open Life Sci. 16:1175–1181. 2021. View Article : Google Scholar : PubMed/NCBI

21 

Ding N, Sun X, Wang T, Huang L, Wen J and Zhou Y: miR-378a-3p exerts tumor suppressive function on the tumorigenesis of esophageal squamous cell carcinoma by targeting Rab10. Int J Mol Med. 42:381–391. 2018.PubMed/NCBI

22 

Liu H, Zhang Q, Song Y, Hao Y, Cui Y, Zhang X, Zhang X, Qin Y, Zhu G, Wang F, et al: Long non-coding RNA SLC2A1-AS1 induced by GLI3 promotes aerobic glycolysis and progression in esophageal squamous cell carcinoma by sponging miR-378a-3p to enhance GLUT-1 expression. J Exp Clin Cancer Res. 40:2872021. View Article : Google Scholar : PubMed/NCBI

23 

Hong L, Yu T, Xu H, Hou N, Cheng Q, Lai L, Wang Q, Sheng J and Huang H: Down-regulation of miR-378a-3p induces decidual cell apoptosis: A possible mechanism for early pregnancy loss. Hum Reprod. 33:11–22. 2018. View Article : Google Scholar : PubMed/NCBI

24 

Vander Heiden MG, Cantley LC and Thompson CB: Understanding the Warburg effect: The metabolic requirements of cell proliferation. Science. 324:1029–1033. 2009. View Article : Google Scholar : PubMed/NCBI

25 

Hong X, Zhong L, Xie Y, Zheng K, Pang J, Li Y, Yang Y, Xu X, Mi P, Cao H, et al: Matrine Reverses the Warburg effect and suppresses colon cancer cell growth via negatively regulating HIF-1α. Front Pharmacol. 10:14372019. View Article : Google Scholar : PubMed/NCBI

26 

Tirpe AA, Gulei D, Ciortea SM, Crivii C and Berindan-Neagoe I: Hypoxia: Overview on Hypoxia-Mediated mechanisms with a focus on the role of HIF genes. Int J Mol Sci. 20:61402019. View Article : Google Scholar : PubMed/NCBI

27 

Comelli M, Di Pancrazio F and Mavelli I: Apoptosis is induced by decline of mitochondrial ATP synthesis in erythroleukemia cells. Free Radic Biol Med. 34:1190–1199. 2003. View Article : Google Scholar : PubMed/NCBI

28 

Marzieh A, Saeed T, Elina K, Omid V, Mortaza TA, Mahshid T and Amir S: Caspase-3: Structure, function, and biotechnological aspects. Biotechnol Appl Biochem. 69:1633–1645. 2022. View Article : Google Scholar : PubMed/NCBI

29 

Altieri DC: Survivin-The inconvenient IAP. Semin Cell Dev Biol. 39:91–96. 2015. View Article : Google Scholar : PubMed/NCBI

30 

Budhidarmo R and Day CL: IAPs: Modular regulators of cell signalling. Semin Cell Dev Biol. 39:80–90. 2015. View Article : Google Scholar : PubMed/NCBI

31 

Chu SF, Zhang Z, Zhang W, Zhang MJ, Gao Y, Han N, Zuo W, Huang HY and Chen NH: Upregulating the expression of Survivin-HBXIP complex contributes to the protective role of IMM-H004 in transient global cerebral Ischemia/Reperfusion. Mol Neurobiol. 54:524–540. 2017. View Article : Google Scholar : PubMed/NCBI

32 

Dai L, Li JL, Liang XQ, Li L, Feng Y, Liu HZ, Wei WE, Ning SF and Zhang LT: Flowers of Camellia nitidissima cause growth inhibition, cell-cycle dysregulation and apoptosis in a human esophageal squamous cell carcinoma cell line. Mol Med Rep. 14:1117–1122. 2016. View Article : Google Scholar : PubMed/NCBI

33 

Zhang C, Ma Q, Shi Y, Li X, Wang M, Wang J, Ge J, Chen Z, Wang Z and Jiang H: A novel 5-fluorouracil-resistant human esophageal squamous cell carcinoma cell line Eca-109/5-FU with significant drug resistance-related characteristics. Oncol Rep. 37:2942–2954. 2017. View Article : Google Scholar : PubMed/NCBI

34 

Yao J, Shen X, Li H, Xu J, Shao S, Huang JX and Lin M: LncRNA-ECM is overexpressed in esophageal squamous cell carcinoma and promotes tumor metastasis. Oncol Lett. 16:3935–3942. 2018.PubMed/NCBI

35 

Liu L, Han S, Xiao X, An X, Gladkich J, Hinz U, Hillmer S, Hoppe-Tichy T, Xu Y, Schaefer M, et al: Glucocorticoid-induced microRNA-378 signaling mediates the progression of pancreatic cancer by enhancing autophagy. Cell Death Dis. 13:10522022. View Article : Google Scholar : PubMed/NCBI

36 

Xu ZH, Yao TZ and Liu W: miR-378a-3p sensitizes ovarian cancer cells to cisplatin through targeting MAPK1/GRB2. Biomed Pharmacother. 107:1410–1417. 2018. View Article : Google Scholar : PubMed/NCBI

37 

Gao S, Yu Y, Liu L, Meng J and Li G: Circular RNA hsa_circ_0007059 restrains proliferation and epithelial-mesenchymal transition in lung cancer cells via inhibiting microRNA-378. Life Scis. 233:1166922019. View Article : Google Scholar : PubMed/NCBI

38 

Yang YJ, Luo S and Wang LS: Effects of microRNA-378 on epithelial-mesenchymal transition, migration, invasion and prognosis in gastric carcinoma by targeting BMP2. Eur Rev Med Pharmacol Sci. 23:5176–5186. 2019.PubMed/NCBI

39 

Cui Z, Sun S, Liu Q, Zhou X, Gao S, Peng P and Li Q: MicroRNA-378-3p/5p suppresses the migration and invasiveness of oral squamous carcinoma cells by inhibiting KLK4 expression. Biochem Cell Biol. 98:154–163. 2020. View Article : Google Scholar : PubMed/NCBI

40 

Fu JH, Yang S, Nan CJ, Zhou CC, Lu DQ, Li S and Mu HQ: MiR-182 affects renal cancer cell proliferation, apoptosis, and invasion by regulating PI3K/AKT/mTOR signaling pathway. Eur Rev Med Pharmacol Sci. 22:351–357. 2018.PubMed/NCBI

41 

Ou DL, Lee BS, Lin LI, Liou JY, Liao SC, Hsu C and Cheng AL: Vertical blockade of the IGFR-PI3K/Akt/mTOR pathway for the treatment of hepatocellular carcinoma: The role of survivin. Mol Cancer. 13:22014. View Article : Google Scholar : PubMed/NCBI

42 

Meng Y, Lin ZM, Ge N, Zhang DL, Huang J and Kong F: Ursolic acid induces apoptosis of prostate cancer cells via the PI3K/Akt/mTOR pathway. Am J Chin Med. 43:1471–1486. 2015. View Article : Google Scholar : PubMed/NCBI

43 

Khwairakpam AD, Monisha J, Roy NK, Bordoloi D, Padmavathi G, Banik K, Khatoon E and Kunnumakkara AB: Vietnamese coriander inhibits cell proliferation, survival and migration via suppression of Akt/mTOR pathway in oral squamous cell carcinoma. J Basic Clin Physiol Pharmacol. 312019.doi: 10.1515/jbcpp-2019-0162. PubMed/NCBI

44 

Guo RH, Wang TS, Shen H, Ge HM, Sun J, Huang ZH and Shu YQ: Involvement of mTOR and survivin inhibition in tamoxifen-induced apoptosis in human hepatoblastoma cell line HepG2. Biomed Pharmacother. 64:249–253. 2010. View Article : Google Scholar : PubMed/NCBI

45 

Li W, Du D and Li Y: Id-1 promotes reendothelialization in the early phase after vascular injury through activation of NFkB/survivin signaling pathway. Drug Des Devel Ther. 13:3799–3811. 2019. View Article : Google Scholar : PubMed/NCBI

46 

Fukayama M, Hino R and Uozaki H: Epstein-Barr virus and gastric carcinoma: Virus-host interactions leading to carcinoma. Cancer Sci. 99:1726–1733. 2008. View Article : Google Scholar : PubMed/NCBI

47 

Jeyasuria P, Subedi K, Suresh A and Condon JC: Elevated levels of uterine anti-apoptotic signaling may activate NFKB and potentially confer resistance to caspase 3-mediated apoptotic cell death during pregnancy in mice. Biol Reprod. 85:417–424. 2011. View Article : Google Scholar : PubMed/NCBI

48 

Zeng W, Li H, Chen Y, Lv H, Liu L, Ran J, Sun X, Bieerkehazhi S, Liu Y, Li X, et al: Survivin activates NF-κB p65 via the IKKβ promoter in esophageal squamous cell carcinoma. Mol Med Rep. 13:1869–1880. 2016. View Article : Google Scholar : PubMed/NCBI

49 

Eichner LJ, Perry MC, Dufour CR, Bertos N, Park M, St-Pierre J and Giguère V: miR-378(*) mediates metabolic shift in breast cancer cells via the PGC-1β/ERRγ transcriptional pathway. Cell Metab. 12:352–361. 2010. View Article : Google Scholar : PubMed/NCBI

50 

Wang Y, Zhang X, Wang Z, Hu Q, Wu J, Li Y, Ren X, Wu T, Tao X, Chen X, et al: LncRNA-p23154 promotes the invasion-metastasis potential of oral squamous cell carcinoma by regulating GLUT-1-mediated glycolysis. Cancer Lett. 434:172–183. 2018. View Article : Google Scholar : PubMed/NCBI

51 

Chen Y, Sun R, Han W, Zhang Y, Song Q, Di C and Ma D: Nuclear translocation of PDCD5 (TFAR19): An early signal for apoptosis? FEBS Lett. 509:191–196. 2011. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Qu Y, Xue S, Zheng Y, Du Y, Zhang G, Huang L, Li H and Li H: Upregulated miR‑378a‑3p expression suppresses energy metabolism and promotes apoptosis by targeting a GLUT‑1/ALDOA/PKM2 axis in esophageal carcinoma. Oncol Lett 26: 421, 2023.
APA
Qu, Y., Xue, S., Zheng, Y., Du, Y., Zhang, G., Huang, L. ... Li, H. (2023). Upregulated miR‑378a‑3p expression suppresses energy metabolism and promotes apoptosis by targeting a GLUT‑1/ALDOA/PKM2 axis in esophageal carcinoma. Oncology Letters, 26, 421. https://doi.org/10.3892/ol.2023.14007
MLA
Qu, Y., Xue, S., Zheng, Y., Du, Y., Zhang, G., Huang, L., Li, H., Li, H."Upregulated miR‑378a‑3p expression suppresses energy metabolism and promotes apoptosis by targeting a GLUT‑1/ALDOA/PKM2 axis in esophageal carcinoma". Oncology Letters 26.4 (2023): 421.
Chicago
Qu, Y., Xue, S., Zheng, Y., Du, Y., Zhang, G., Huang, L., Li, H., Li, H."Upregulated miR‑378a‑3p expression suppresses energy metabolism and promotes apoptosis by targeting a GLUT‑1/ALDOA/PKM2 axis in esophageal carcinoma". Oncology Letters 26, no. 4 (2023): 421. https://doi.org/10.3892/ol.2023.14007
Copy and paste a formatted citation
x
Spandidos Publications style
Qu Y, Xue S, Zheng Y, Du Y, Zhang G, Huang L, Li H and Li H: Upregulated miR‑378a‑3p expression suppresses energy metabolism and promotes apoptosis by targeting a GLUT‑1/ALDOA/PKM2 axis in esophageal carcinoma. Oncol Lett 26: 421, 2023.
APA
Qu, Y., Xue, S., Zheng, Y., Du, Y., Zhang, G., Huang, L. ... Li, H. (2023). Upregulated miR‑378a‑3p expression suppresses energy metabolism and promotes apoptosis by targeting a GLUT‑1/ALDOA/PKM2 axis in esophageal carcinoma. Oncology Letters, 26, 421. https://doi.org/10.3892/ol.2023.14007
MLA
Qu, Y., Xue, S., Zheng, Y., Du, Y., Zhang, G., Huang, L., Li, H., Li, H."Upregulated miR‑378a‑3p expression suppresses energy metabolism and promotes apoptosis by targeting a GLUT‑1/ALDOA/PKM2 axis in esophageal carcinoma". Oncology Letters 26.4 (2023): 421.
Chicago
Qu, Y., Xue, S., Zheng, Y., Du, Y., Zhang, G., Huang, L., Li, H., Li, H."Upregulated miR‑378a‑3p expression suppresses energy metabolism and promotes apoptosis by targeting a GLUT‑1/ALDOA/PKM2 axis in esophageal carcinoma". Oncology Letters 26, no. 4 (2023): 421. https://doi.org/10.3892/ol.2023.14007
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