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Extracellular vesicle biomarkers in circulation for the diagnosis of gastric cancer: A systematic review and meta‑analysis

  • Authors:
    • Jinru Xue
    • Shaoyou Qin
    • Na Ren
    • Bo Guo
    • Xianquan Shi
    • Erna Jia
  • View Affiliations / Copyright

    Affiliations: Department of Thoracic Surgery, China‑Japan Union Hospital of Jilin University, Jilin, Changchun 130000, P.R. China, Department of Gastroenterology, China‑Japan Union Hospital of Jilin University, Jilin, Changchun 130000, P.R. China, Department of Ultrasound, Beijing Friendship Hospital of Capital Medical University, Beijing 100050, P.R. China
    Copyright: © Xue et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 423
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    Published online on: August 11, 2023
       https://doi.org/10.3892/ol.2023.14009
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Abstract

The prognosis of a gastric cancer (GC) diagnosis is poor due to the current lack of effective early diagnostic methods. Extracellular vesicle (EV) biomarkers have previously demonstrated strong diagnostic efficiency for certain types of cancer, including pancreatic and lung cancer. The present review aimed to summarize the diagnostic value of circulating EV biomarkers for early stage GC. The PubMed, Medline and Web of Science databases were searched from May 1983 to September 18, 2022. All studies that reported the diagnostic performance of EV biomarkers for GC were included for analysis. Overall, 27 studies were selected containing 2,831 patients with GC and 2,117 controls. A total of 58 EV RNAs were reported in 26 studies, including 39 microRNAs (miRNAs), 10 long non‑coding RNAs (lncRNAs), five circular RNAs, three PIWI‑interacting RNAs and one mRNA, in addition to one protein in the remaining study. Meta‑analysis of the aforementioned studies demonstrated that the pooled sensitivity, specificity and AUC value of the total RNAs were 84, 67% and 0.822, respectively. The diagnostic values of miRNAs were consistent with the total RNA, as the pooled sensitivity, specificity and AUC value were 84, 67% and 0.808, respectively. The pooled sensitivity, specificity and AUC values of lncRNAs were 89, 69% and 0.872, respectively, markedly higher compared with that of miRNAs. A total of five studies reported the diagnostic performance of EV RNA panels for early stage GC and reported powerful diagnostic values with a pooled sensitivity, specificity and AUC value of 80, 77% and 0.879, respectively. Circulating EV RNAs could have the potential to be used in the future as effective, noninvasive biomarkers for early GC diagnosis. Further research in this field is necessary to translate these findings into clinical practice.
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Copy and paste a formatted citation
Spandidos Publications style
Xue J, Qin S, Ren N, Guo B, Shi X and Jia E: Extracellular vesicle biomarkers in circulation for the diagnosis of gastric cancer: A systematic review and meta‑analysis. Oncol Lett 26: 423, 2023.
APA
Xue, J., Qin, S., Ren, N., Guo, B., Shi, X., & Jia, E. (2023). Extracellular vesicle biomarkers in circulation for the diagnosis of gastric cancer: A systematic review and meta‑analysis. Oncology Letters, 26, 423. https://doi.org/10.3892/ol.2023.14009
MLA
Xue, J., Qin, S., Ren, N., Guo, B., Shi, X., Jia, E."Extracellular vesicle biomarkers in circulation for the diagnosis of gastric cancer: A systematic review and meta‑analysis". Oncology Letters 26.4 (2023): 423.
Chicago
Xue, J., Qin, S., Ren, N., Guo, B., Shi, X., Jia, E."Extracellular vesicle biomarkers in circulation for the diagnosis of gastric cancer: A systematic review and meta‑analysis". Oncology Letters 26, no. 4 (2023): 423. https://doi.org/10.3892/ol.2023.14009
Copy and paste a formatted citation
x
Spandidos Publications style
Xue J, Qin S, Ren N, Guo B, Shi X and Jia E: Extracellular vesicle biomarkers in circulation for the diagnosis of gastric cancer: A systematic review and meta‑analysis. Oncol Lett 26: 423, 2023.
APA
Xue, J., Qin, S., Ren, N., Guo, B., Shi, X., & Jia, E. (2023). Extracellular vesicle biomarkers in circulation for the diagnosis of gastric cancer: A systematic review and meta‑analysis. Oncology Letters, 26, 423. https://doi.org/10.3892/ol.2023.14009
MLA
Xue, J., Qin, S., Ren, N., Guo, B., Shi, X., Jia, E."Extracellular vesicle biomarkers in circulation for the diagnosis of gastric cancer: A systematic review and meta‑analysis". Oncology Letters 26.4 (2023): 423.
Chicago
Xue, J., Qin, S., Ren, N., Guo, B., Shi, X., Jia, E."Extracellular vesicle biomarkers in circulation for the diagnosis of gastric cancer: A systematic review and meta‑analysis". Oncology Letters 26, no. 4 (2023): 423. https://doi.org/10.3892/ol.2023.14009
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