Molecular biomarkers for facilitating genome‑directed precision medicine in gynecological cancer (Review)
- Takeo Minaguchi
- Ayumi Shikama
- Azusa Akiyama
- Toyomi Satoh
Affiliations: Department of Obstetrics and Gynecology, Institute of Medicine, University of Tsukuba, Tsukuba, Ibaraki 305‑8575, Japan
- Published online on: August 17, 2023 https://doi.org/10.3892/ol.2023.14012
Copyright : © Minaguchi
et al. This is an open access article distributed under the
terms of Creative
Commons Attribution License [CC BY 4.0].
Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
This article is mentioned in:
Prominent recent advancements in cancer treatment include the development and clinical application of next‑generation sequencing (NGS) technologies, alongside a diverse array of novel molecular targeting therapeutics. NGS has enabled the high‑speed and low‑cost sequencing of whole genomes in individual patients, which has opened the era of genome‑based precision medicine. The development of numerous molecular targeting agents, including anti‑VEGF antibodies, poly (ADP‑ribose) polymerase inhibitors and immune checkpoint inhibitors, have all improved the efficacy of systemic cancer therapy. Accumulating bench and translational research evidence has led to identification of various cancer‑related biomarker profiles. In particular, companion diagnostics have been developed for some of these biomarkers, which can be clinically applied and are now widely used for guiding cancer therapies. Selecting biomarkers accurately will improve therapeutic efficacy, avoid overtreatment, enable earlier diagnosis and reduce the cost of preventing and treating gynecological cancer. Therefore, biomarkers are fast becoming indispensable tools in the practice of genome‑directed precision medicine. In the present review, the current evidence of cancer‑related biomarkers in the field of gynecological oncology, their molecular interpretations and future perspectives are outlined. The aim of the present review is to provide potentially useful information for the formulation of clinical trials.