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Article

Clinical analysis of cervical lymph node metastasis patterns and multivariate factors in differentiated thyroid carcinoma

  • Authors:
    • Jingquan Liu
    • Mingyue Guo
  • View Affiliations / Copyright

    Affiliations: Department of General Surgery, Chifeng Municipal Hospital, Inner Mongolia University, Chifeng, Inner Mongolia Autonomous Region 024000, P.R. China
  • Article Number: 431
    |
    Published online on: August 22, 2023
       https://doi.org/10.3892/ol.2023.14018
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Abstract

The incidence rate of thyroid cancer is rising rapidly in numerous parts of the world, but the mortality rate is relatively stable or even declining. The aim of the present study was to analyze the risk factors of cervical lymph node metastasis (LNM) in differentiated thyroid carcinoma (DTC). The clinical data of 846 patients with DTC were collected from the Department of General Surgery of Chifeng Municipal Hospital of Inner Mongolia Medical University (Chifeng, China) from June 2018 to June 2022. The relationship between central LNM (CLNM) and lateral LNM (LLNM) was explored in terms of sex, age, tumor diameter, multifocality, capsular invasion and Hashimoto's thyroiditis. It was revealed that male sex, age <35 years, tumor size >1 cm, multifocality and capsular invasion were associated with CLNM and LLNM (P<0.001), while there was no relationship between Hashimoto's thyroiditis, CLNM and LLNM (P>0.05). The number of positive lymph nodes in CLNM dissection, accounting for ≥50% of the total number of lymph nodes dissected, was significantly associated with LLNM (P<0.0001). In conclusion, there was no correlation between Hashimoto's thyroiditis and CLNM and LLNM. The present study revealed that patients with the characteristics of sex, age <35 years, tumor size >1 cm, multifocality and capsular invasion were associated with cervical LNM. The proportion of the number of central lymph node metastases to the total number of lymph nodes cleared during surgery is more than or equal to 50%, indicating a susceptibility to external cervical lymph node metastasis. The results of multivariate logistic analysis showed that male sex, multifocality, capsular invasion and CLNM were risk factors for LLNM, and age was a protective factor for LLNM in DTC.
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Copy and paste a formatted citation
Spandidos Publications style
Liu J and Guo M: Clinical analysis of cervical lymph node metastasis patterns and multivariate factors in differentiated thyroid carcinoma. Oncol Lett 26: 431, 2023.
APA
Liu, J., & Guo, M. (2023). Clinical analysis of cervical lymph node metastasis patterns and multivariate factors in differentiated thyroid carcinoma. Oncology Letters, 26, 431. https://doi.org/10.3892/ol.2023.14018
MLA
Liu, J., Guo, M."Clinical analysis of cervical lymph node metastasis patterns and multivariate factors in differentiated thyroid carcinoma". Oncology Letters 26.4 (2023): 431.
Chicago
Liu, J., Guo, M."Clinical analysis of cervical lymph node metastasis patterns and multivariate factors in differentiated thyroid carcinoma". Oncology Letters 26, no. 4 (2023): 431. https://doi.org/10.3892/ol.2023.14018
Copy and paste a formatted citation
x
Spandidos Publications style
Liu J and Guo M: Clinical analysis of cervical lymph node metastasis patterns and multivariate factors in differentiated thyroid carcinoma. Oncol Lett 26: 431, 2023.
APA
Liu, J., & Guo, M. (2023). Clinical analysis of cervical lymph node metastasis patterns and multivariate factors in differentiated thyroid carcinoma. Oncology Letters, 26, 431. https://doi.org/10.3892/ol.2023.14018
MLA
Liu, J., Guo, M."Clinical analysis of cervical lymph node metastasis patterns and multivariate factors in differentiated thyroid carcinoma". Oncology Letters 26.4 (2023): 431.
Chicago
Liu, J., Guo, M."Clinical analysis of cervical lymph node metastasis patterns and multivariate factors in differentiated thyroid carcinoma". Oncology Letters 26, no. 4 (2023): 431. https://doi.org/10.3892/ol.2023.14018
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