Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Oncology Letters
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-1074 Online ISSN: 1792-1082
Journal Cover
October-2023 Volume 26 Issue 4

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
October-2023 Volume 26 Issue 4

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

Prognostic value of nutritional and inflammatory markers in patients with hepatocellular carcinoma who receive immune checkpoint inhibitors

  • Authors:
    • Chunxun Liu
    • Haoran Zhao
    • Rujia Zhang
    • Zuoming Guo
    • Peng Wang
    • Zhaowei Qu
  • View Affiliations / Copyright

    Affiliations: Department of Hepatobiliary and Pancreatic Surgery, Harbin Medical University Cancer Hospital, Harbin Medical University, Harbin, Heilongjiang 150081, P.R. China, Department of Hepatobiliary and Pancreatic Surgery, Harbin Medical University Cancer Hospital, Harbin Medical University, Harbin, Heilongjiang 150081, P.R. China, Department of Operating Room, The Second Affiliated Hospital of Harbin Medical University, Harbin Medical University, Harbin, Heilongjiang 150086, P.R. China
    Copyright: © Liu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 437
    |
    Published online on: August 23, 2023
       https://doi.org/10.3892/ol.2023.14024
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

The emergence of immune checkpoint inhibitors (ICIs) has provided a new treatment option for patients with hepatocellular carcinoma (HCC). However, further evaluation is needed for determining biomarkers for the use of ICIs. The present study evaluated the prognostic value of certain nutritional and inflammatory markers in patients with HCC who received ICIs. In the present study, the clinical data of 151 patients with HCC who received ICIs at Harbin Medical University Cancer Hospital from January 2019 to December 2021 were collected. The blood parameters of all patients before treatment were collected to evaluate certain nutritional and inflammatory markers, including the prognostic nutrition index (PNI), nutritional risk index (NRI), geriatric NRI (GNRI), systemic immune‑inflammation index (SII), systemic inflammation response index (SIRI) and advanced lung cancer inflammation index (ALI). Patients were grouped using the cut‑off value calculated using receiver operating characteristic (ROC) curves, and the relationship between these biomarkers and prognosis was evaluated through survival analysis. Furthermore, the prognostic value of these biomarkers was assessed through multivariate Cox regression analysis and construction of nomograms. Finally, time‑ROC curves were plotted to compare the differences in predicting prognosis between the biomarkers. In the preliminary survival analysis, all inflammatory and nutritional markers included in the present study were significantly associated with the prognosis of HCC in patients who received ICIs. Similar results were obtained in a subgroup analysis of patients with different Barcelona Clinic Liver Cancer (BCLC) stages. Multivariate Cox regression analysis demonstrated that GNRI, PNI, BCLC stage and Tumor‑Node‑Metastasis (TNM) stage were significantly associated with progression‑free survival (PFS), whereas GNRI, BCLC stage and TNM stage were also significantly associated with overall survival (OS). Furthermore, the time‑ROC curves indicated that nutritional indicators had a higher prognostic value in all indexes, especially GNRI. The C‑index (95% confidence interval) of the nomograms for predicting the survival probability of patients who received ICIs were 0.801 (0.746‑0.877) and 0.823 (0.761‑0.898) for PFS and overall OS, respectively, which also showed high accuracy. In conclusion, the present study demonstrated that PNI, GNRI, NRI, SII, SIRI and ALI were all related to the efficacy of ICIs in HCC and could serve as non‑invasive biomarkers for ICI treatment effectiveness. Moreover, compared with inflammatory markers, nutritional markers had greater predictive ability, with GNRI being the biomarker with the best prognostic value.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

Figure 6

Figure 7

Figure 8

Figure 9

Figure 10

View References

1 

Wang Y and Deng B: Hepatocellular carcinoma: Molecular mechanism, targeted therapy, and biomarkers. Cancer Metastasis Rev. Feb 2–2023.(Epub ahead of print). View Article : Google Scholar

2 

Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA and Jemal A: Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 68:394–424. 2018. View Article : Google Scholar : PubMed/NCBI

3 

Vogel A, Meyer T, Sapisochin G, Salem R and Saborowski A: Hepatocellular carcinoma. Lancet. 400:1345–1362. 2022. View Article : Google Scholar : PubMed/NCBI

4 

Yang JD, Hainaut P, Gores GJ, Amadou A, Plymoth A and Roberts LR: A global view of hepatocellular carcinoma: Trends, risk, prevention and management. Nat Rev Gastroenterol Hepatol. 16:589–604. 2019. View Article : Google Scholar : PubMed/NCBI

5 

Yang C, Zhang H, Zhang L, Zhu AX, Bernards R, Qin W and Wang C: Evolving therapeutic landscape of advanced hepatocellular carcinoma. Nat Rev Gastroenterol Hepatol. 20:203–222. 2023. View Article : Google Scholar : PubMed/NCBI

6 

Bagchi S, Yuan R and Engleman EG: Immune checkpoint inhibitors for the treatment of cancer: Clinical impact and mechanisms of response and resistance. Annu Rev Pathol. 16:223–249. 2021. View Article : Google Scholar : PubMed/NCBI

7 

Naimi A, Mohammed RN, Raji A, Chupradit S, Yumashev AV, Suksatan W, Shalaby MN, Thangavelu L, Kamrava S, Shomali N, et al: Tumor immunotherapies by immune checkpoint inhibitors (ICIs); the pros and cons. Cell Commun Signal. 20:442022. View Article : Google Scholar : PubMed/NCBI

8 

Yap TA, Parkes EE, Peng W, Moyers JT, Curran MA and Tawbi HA: Development of immunotherapy combination strategies in cancer. Cancer Discov. 11:1368–1397. 2021. View Article : Google Scholar : PubMed/NCBI

9 

Janjigian YY, Shitara K, Moehler M, Garrido M, Salman P, Shen L, Wyrwicz L, Yamaguchi K, Skoczylas T, Campos Bragagnoli A, et al: First-line nivolumab plus chemotherapy versus chemotherapy alone for advanced gastric, gastro-oesophageal junction, and oesophageal adenocarcinoma (CheckMate 649): A randomised, open-label, phase 3 trial. Lancet. 398:27–40. 2021. View Article : Google Scholar : PubMed/NCBI

10 

Bote H, Mesas A, Baena J, Herrera M and Paz-Ares L: Emerging immune checkpoint inhibitors for the treatment of non-small cell lung cancer. Expert Opin Emerg Drugs. 27:289–300. 2022. View Article : Google Scholar : PubMed/NCBI

11 

Jácome AA, Castro ACG, Vasconcelos JPS, Silva MHCR, Lessa MAO, Moraes ED, Andrade AC, Lima FMT, Farias JPF, Gil RA, et al: Efficacy and safety associated with immune checkpoint inhibitors in unresectable hepatocellular carcinoma: A meta-analysis. JAMA Netw Open. 4:e21361282021. View Article : Google Scholar : PubMed/NCBI

12 

Zheng Y, Wang S, Cai J, Ke A and Fan J: The progress of immune checkpoint therapy in primary liver cancer. Biochim Biophys Acta Rev Cancer. 1876:1886382021. View Article : Google Scholar : PubMed/NCBI

13 

Bai J, Liang P, Li Q, Feng R and Liu J: Cancer immunotherapy-immune checkpoint inhibitors in hepatocellular carcinoma. Recent Pat Anticancer Drug Discov. 16:239–248. 2021. View Article : Google Scholar : PubMed/NCBI

14 

Finn RS, Ryoo BY, Merle P, Kudo M, Bouattour M, Lim HY, Breder VV, Edeline J, Chao Y, Ogasawara S, et al: Results of KEYNOTE-240: Phase 3 study of pembrolizumab (Pembro) vs best supportive care (BSC) for second line therapy in advanced hepatocellular carcinoma (HCC). J Clin Oncol. 37 (15 Suppl):S40042019. View Article : Google Scholar

15 

El-Khoueiry AB, Sangro B, Yau T, Crocenzi TS, Kudo M, Hsu C, Kim TY, Choo SP, Trojan J, Welling TH Rd, et al: Nivolumab in patients with advanced hepatocellular carcinoma (CheckMate 040): An open-label, non-comparative, phase 1/2 dose escalation and expansion trial. Lancet. 389:2492–2502. 2017. View Article : Google Scholar : PubMed/NCBI

16 

Doroshow DB, Bhalla S, Beasley MB, Sholl LM, Kerr KM, Gnjatic S, Wistuba II, Rimm DL, Tsao MS and Hirsch FR: PD-L1 as a biomarker of response to immune-checkpoint inhibitors. Nat Rev Clin Oncol. 18:345–362. 2021. View Article : Google Scholar : PubMed/NCBI

17 

Rizzo A, Ricci AD and Brandi G: PD-L1, TMB, MSI, and other predictors of response to immune checkpoint inhibitors in biliary tract cancer. Cancers (Basel). 13:5582021. View Article : Google Scholar : PubMed/NCBI

18 

Valero C, Lee M, Hoen D, Weiss K, Kelly DW, Adusumilli PS, Paik PK, Plitas G, Ladanyi M, Postow MA, et al: Pretreatment neutrophil-to-lymphocyte ratio and mutational burden as biomarkers of tumor response to immune checkpoint inhibitors. Nat Commun. 12:7292021. View Article : Google Scholar : PubMed/NCBI

19 

Wei J, Feng J, Weng Y, Xu Z, Jin Y, Wang P, Cui X, Ruan P, Luo R, Li N and Peng M: The prognostic value of ctDNA and bTMB on immune checkpoint inhibitors in human cancer. Front Oncol. 11:7069102021. View Article : Google Scholar : PubMed/NCBI

20 

Nabet BY, Esfahani MS, Moding EJ, Hamilton EG, Chabon JJ, Rizvi H, Steen CB, Chaudhuri AA, Liu CL, Hui AB, et al: Noninvasive early identification of therapeutic benefit from immune checkpoint inhibition. Cell. 183:363–376.e13. 2020. View Article : Google Scholar : PubMed/NCBI

21 

Alwarawrah Y, Kiernan K and MacIver NJ: Changes in nutritional status impact immune cell metabolism and function. Front Immunol. 9:10552018. View Article : Google Scholar : PubMed/NCBI

22 

Xia H, Zhang W, Zheng Q, Zhang Y, Mu X, Wei C, Wang X and Liu Y: Predictive value of the prognostic nutritional index in advanced non-small cell lung cancer patients treated with immune checkpoint inhibitors: A systematic review and meta-analysis. Heliyon. 9:e174002023. View Article : Google Scholar : PubMed/NCBI

23 

Ni L, Huang J, Ding J, Kou J, Shao T, Li J, Gao L, Zheng W and Wu Z: Prognostic nutritional index predicts response and prognosis in cancer patients treated with immune checkpoint inhibitors: A systematic review and meta-analysis. Front Nutr. 9:8230872022. View Article : Google Scholar : PubMed/NCBI

24 

Tian BW, Yang YF, Yang CC, Yan LJ, Ding ZN, Liu H, Xue JS, Dong ZR, Chen ZQ, Hong JG, et al: Systemic immune-inflammation index predicts prognosis of cancer immunotherapy: Systemic review and meta-analysis. Immunotherapy. 14:1481–1496. 2022. View Article : Google Scholar : PubMed/NCBI

25 

Kou J, Huang J, Li J, Wu Z and Ni L: Systemic immune-inflammation index predicts prognosis and responsiveness to immunotherapy in cancer patients: A systematic review and meta-analysis. Clin Exp Med. Mar 26–2023.(Epub ahead of print). View Article : Google Scholar

26 

Llovet JM, Brú C and Bruix J: Prognosis of hepatocellular carcinoma: The BCLC staging classification. Semin Liver Dis. 19:329–338. 1999. View Article : Google Scholar : PubMed/NCBI

27 

Reig M, Forner A, Rimola J, Ferrer-Fàbrega J, Burrel M, Garcia-Criado Á, Kelley RK, Galle PR, Mazzaferro V, Salem R, et al: BCLC strategy for prognosis prediction and treatment recommendation: The 2022 update. J Hepatol. 76:681–693. 2022. View Article : Google Scholar : PubMed/NCBI

28 

Colombo M and Sangiovanni A: Treatment of hepatocellular carcinoma: Beyond international guidelines. Liver Int. 35 (Suppl 1):S129–S138. 2015. View Article : Google Scholar

29 

Chonprasertsuk S and Vilaichone RK: Epidemiology and treatment of hepatocellular carcinoma in Thailand. Jpn J Clin Oncol. 47:294–297. 2017.PubMed/NCBI

30 

Huang J, Zhang Y, Peng Z, Gao H, Xu L, Jiao LR and Chen M: A modified TNM-7 staging system to better predict the survival in patients with hepatocellular carcinoma after hepatectomy. J Cancer Res Clin Oncol. 139:1709–1719. 2013. View Article : Google Scholar : PubMed/NCBI

31 

Xing R, Gao J, Cui Q and Wang Q: Strategies to improve the antitumor effect of immunotherapy for hepatocellular carcinoma. Front Immunol. 12:7832362021. View Article : Google Scholar : PubMed/NCBI

32 

Tsilimigras DI, Bagante F, Sahara K, Moris D, Hyer JM, Wu L, Ratti F, Marques HP, Soubrane O, Paredes AZ, et al: Prognosis after resection of barcelona clinic liver cancer (BCLC) stage 0, A, and B hepatocellular carcinoma: A comprehensive assessment of the current BCLC classification. Ann Surg Oncol. 26:3693–3700. 2019. View Article : Google Scholar : PubMed/NCBI

33 

Chen Y, Hu H, Yuan X, Fan X and Zhang C: Advances in immune checkpoint inhibitors for advanced hepatocellular carcinoma. Front Immunol. 13:8967522022. View Article : Google Scholar : PubMed/NCBI

34 

Wang Z, Wang Y, Gao P and Ding J: Immune checkpoint inhibitor resistance in hepatocellular carcinoma. Cancer Lett. 555:2160382023. View Article : Google Scholar : PubMed/NCBI

35 

Schoenfeld AJ and Hellmann MD: Acquired resistance to immune checkpoint inhibitors. Cancer Cell. 37:443–455. 2020. View Article : Google Scholar : PubMed/NCBI

36 

Li N, Hou X, Huang S, Tai R, Lei L, Li S, Abuliz A, Wang G and Yang S: Biomarkers related to immune checkpoint inhibitors therapy. Biomed Pharmacother. 147:1124702022. View Article : Google Scholar : PubMed/NCBI

37 

Mezquita L, Auclin E, Ferrara R, Charrier M, Remon J, Planchard D, Ponce S, Ares LP, Leroy L, Audigier-Valette C, et al: Association of the lung immune prognostic index with immune checkpoint inhibitor outcomes in patients with advanced non-small cell lung cancer. JAMA Oncol. 4:351–357. 2018. View Article : Google Scholar : PubMed/NCBI

38 

Sun H, Chen L, Huang R, Pan H, Zuo Y, Zhao R, Xue Y and Song H: Prognostic nutritional index for predicting the clinical outcomes of patients with gastric cancer who received immune checkpoint inhibitors. Front Nutr. 9:10381182022. View Article : Google Scholar : PubMed/NCBI

39 

Haas M, Lein A, Fuereder T, Brkic FF, Schnoell J, Liu DT, Kadletz-Wanke L, Heiduschka G and Jank BJ: The geriatric nutritional risk index (GNRI) as a prognostic biomarker for immune checkpoint inhibitor response in recurrent and/or metastatic head and neck cancer. Nutrients. 15:8802023. View Article : Google Scholar : PubMed/NCBI

40 

Wang Y and Ni Q: Prognostic and clinicopathological significance of systemic immune-inflammation index in cancer patients receiving immune checkpoint inhibitors: A meta-analysis. Ann Med. 55:808–819. 2023. View Article : Google Scholar : PubMed/NCBI

41 

Lee JH, Hyung S, Lee J and Choi SH: Visceral adiposity and systemic inflammation in the obesity paradox in patients with unresectable or metastatic melanoma undergoing immune checkpoint inhibitor therapy: A retrospective cohort study. J Immunother Cancer. 10:e0052262022. View Article : Google Scholar : PubMed/NCBI

42 

Sonehara K, Tateishi K, Araki T, Komatsu M, Yamamoto H and Hanaoka M: Prognostic value of the geriatric nutritional risk index among patients with previously treated advanced non-small cell lung cancer who subsequently underwent immunotherapy. Thorac Cancer. 12:1366–1372. 2021. View Article : Google Scholar : PubMed/NCBI

43 

Shoji F, Takeoka H, Kozuma Y, Toyokawa G, Yamazaki K, Ichiki M and Takeo S: Pretreatment prognostic nutritional index as a novel biomarker in non-small cell lung cancer patients treated with immune checkpoint inhibitors. Lung Cancer. 136:45–51. 2019. View Article : Google Scholar : PubMed/NCBI

44 

Ren B, Shen J, Qian Y and Zhou T: Sarcopenia as a determinant of the efficacy of immune checkpoint inhibitors in non-small cell lung cancer: A meta-analysis. Nutr Cancer. 75:685–695. 2023. View Article : Google Scholar : PubMed/NCBI

45 

Stühler V, Herrmann L, Rausch S, Stenzl A and Bedke J: Role of the systemic immune-inflammation index in patients with metastatic renal cell carcinoma treated with first-line ipilimumab plus nivolumab. Cancers (Basel). 14:29722022. View Article : Google Scholar : PubMed/NCBI

46 

Qi WX, Xiang Y, Zhao S and Chen J: Assessment of systematic inflammatory and nutritional indexes in extensive-stage small-cell lung cancer treated with first-line chemotherapy and atezolizumab. Cancer Immunol Immunother. 70:3199–3206. 2021. View Article : Google Scholar : PubMed/NCBI

47 

Mountzios G, Samantas E, Senghas K, Zervas E, Krisam J, Samitas K, Bozorgmehr F, Kuon J, Agelaki S, Baka S, et al: Association of the advanced lung cancer inflammation index (ALI) with immune checkpoint inhibitor efficacy in patients with advanced non-small-cell lung cancer. ESMO Open. 6:1002542021. View Article : Google Scholar : PubMed/NCBI

48 

Zhang X, Wang D, Sun T, Li W and Dang C: Advanced lung cancer inflammation index (ALI) predicts prognosis of patients with gastric cancer after surgical resection. BMC Cancer. 22:6842022. View Article : Google Scholar : PubMed/NCBI

49 

Barth DA, Brenner C, Riedl JM, Prinz F, Klocker EV, Schlick K, Kornprat P, Lackner K, Stöger H, Stotz M, et al: External validation of the prognostic relevance of the advanced lung cancer inflammation index (ALI) in pancreatic cancer patients. Cancer Med. 9:5473–5479. 2020. View Article : Google Scholar : PubMed/NCBI

50 

Pian G, Hong SY and Oh SY: Prognostic value of advanced lung cancer inflammation index in patients with colorectal cancer liver metastases undergoing surgery. Tumori. 108:56–62. 2022. View Article : Google Scholar : PubMed/NCBI

51 

Xiong B, Fu B, Wu Y, Gao F and Hou C: Body composition predicts prognosis of hepatocellular carcinoma patients undergoing immune checkpoint inhibitors. J Cancer Res Clin Oncol. Jul 4–2023.(Epub ahead of print). View Article : Google Scholar

52 

Zhu HF, Feng JK, Xiang YJ, Wang K, Zhou LP, Liu ZH, Cheng YQ, Shi J, Guo WX and Cheng SQ: Combination of alpha-fetoprotein and neutrophil-to-lymphocyte ratio to predict treatment response and survival outcomes of patients with unresectable hepatocellular carcinoma treated with immune checkpoint inhibitors. BMC Cancer. 23:5472023. View Article : Google Scholar : PubMed/NCBI

53 

Zhang L, Feng J, Kuang T, Chai D, Qiu Z, Deng W, Dong K, Zhao K and Wang W: Blood biomarkers predict outcomes in patients with hepatocellular carcinoma treated with immune checkpoint Inhibitors: A pooled analysis of 44 retrospective sudies. Int Immunopharmacol. 118:1100192023. View Article : Google Scholar : PubMed/NCBI

54 

Chen L, Sun H, Zhao R, Huang R, Pan H, Zuo Y, Zhang L, Xue Y, Song H and Li X: Controlling nutritional status (CONUT) predicts survival in gastric cancer patients with immune checkpoint inhibitor (PD-1/PD-L1) outcomes. Front Pharmacol. 13:8369582022. View Article : Google Scholar : PubMed/NCBI

55 

van de Donk PP, Kist de Ruijter L, Lub-de Hooge MN, Brouwers AH, van der Wekken AJ, Oosting SF, Fehrmann RS, de Groot DJA and de Vries EG: Molecular imaging biomarkers for immune checkpoint inhibitor therapy. Theranostics. 10:1708–1718. 2020. View Article : Google Scholar : PubMed/NCBI

56 

Collins N and Belkaid Y: Control of immunity via nutritional interventions. Immunity. 55:210–223. 2022. View Article : Google Scholar : PubMed/NCBI

57 

Di Giosia P, Stamerra CA, Giorgini P, Jamialahamdi T, Butler AE and Sahebkar A: The role of nutrition in inflammaging. Ageing Res Rev. 77:1015962022. View Article : Google Scholar : PubMed/NCBI

58 

Childs CE, Calder PC and Miles EA: Diet and immune function. Nutrients. 11:19332019. View Article : Google Scholar : PubMed/NCBI

59 

Swarbrick GM, Gela A, Cansler ME, Null MD, Duncan RB, Nemes E, Shey M, Nsereko M, Mayanja-Kizza H, Kiguli S, et al: Postnatal expansion, maturation, and functionality of MR1T cells in humans. Front Immunol. 11:5566952020. View Article : Google Scholar : PubMed/NCBI

60 

Divangahi M, Aaby P, Khader SA, Barreiro LB, Bekkering S, Chavakis T, van Crevel R, Curtis N, DiNardo AR, Dominguez-Andres J, et al: Trained immunity, tolerance, priming and differentiation: Distinct immunological processes. Nat Immunol. 22:2–6. 2021. View Article : Google Scholar : PubMed/NCBI

61 

Barrea L, Di Somma C, Muscogiuri G, Tarantino G, Tenore GC, Orio F, Colao A and Savastano S: Nutrition, inflammation and liver-spleen axis. Crit Rev Food Sci Nutr. 58:3141–3158. 2018. View Article : Google Scholar : PubMed/NCBI

62 

Iddir M, Brito A, Dingeo G, Fernandez Del Campo SSF, Samouda H, La Frano MR and Bohn T: Strengthening the immune system and reducing inflammation and oxidative stress through diet and nutrition: Considerations during the COVID-19 crisis. Nutrients. 12:15622020. View Article : Google Scholar : PubMed/NCBI

63 

Dong J, Zhang W, Zhang T, Chen X, Zhao J, Zeng Y, Chen Y, Wei X, Lei T, Wang P, et al: Baseline nutritional status could be a predictor for radiation esophagitis in esophageal cancer patients undergoing radiotherapy. Ann Transl Med. 8:11482020. View Article : Google Scholar : PubMed/NCBI

64 

Kaymak Cerkesli ZA, Ozkan EE and Ozseven A: The esophageal dose-volume parameters for predicting Grade I–II acute esophagitis correlated with weight loss and serum albumin decrease in lung cancer radiotherapy. J Cancer Res Ther. 17:94–98. 2021. View Article : Google Scholar : PubMed/NCBI

65 

Zheng C, Liu S, Feng J and Zhao X: Prognostic value of inflammation biomarkers for survival of patients with neuroblastoma. Cancer Manag Res. 12:2415–2425. 2020. View Article : Google Scholar : PubMed/NCBI

66 

Golovtchenko AM and Raichvarg D: Lymphocytes. Roles in cellular immunity and humoral immunity. Ann Biol Clin (Paris). 33:63–74. 1975.(In French). PubMed/NCBI

67 

Cancro MP and Tomayko MM: Memory B cells and plasma cells: The differentiative continuum of humoral immunity. Immunol Rev. 303:72–82. 2021. View Article : Google Scholar : PubMed/NCBI

68 

Papayannopoulos V: Neutrophil extracellular traps in immunity and disease. Nat Rev Immunol. 18:134–147. 2018. View Article : Google Scholar : PubMed/NCBI

69 

Quail DF, Amulic B, Aziz M, Barnes BJ, Eruslanov E, Fridlender ZG, Goodridge HS, Granot Z, Hidalgo A, Huttenlocher A, et al: Neutrophil phenotypes and functions in cancer: A consensus statement. J Exp Med. 219:e202200112022. View Article : Google Scholar : PubMed/NCBI

70 

Junqueira C, Crespo Â, Ranjbar S, de Lacerda LB, Lewandrowski M, Ingber J, Parry B, Ravid S, Clark S, Schrimpf MR, et al: FcγR-mediated SARS-CoV-2 infection of monocytes activates inflammation. Nature. 606:576–584. 2022. View Article : Google Scholar : PubMed/NCBI

71 

Kapellos TS, Bonaguro L, Gemünd I, Reusch N, Saglam A, Hinkley ER and Schultze JL: Human monocyte subsets and phenotypes in major chronic inflammatory diseases. Front Immunol. 10:20352019. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Liu C, Zhao H, Zhang R, Guo Z, Wang P and Qu Z: Prognostic value of nutritional and inflammatory markers in patients with hepatocellular carcinoma who receive immune checkpoint inhibitors. Oncol Lett 26: 437, 2023.
APA
Liu, C., Zhao, H., Zhang, R., Guo, Z., Wang, P., & Qu, Z. (2023). Prognostic value of nutritional and inflammatory markers in patients with hepatocellular carcinoma who receive immune checkpoint inhibitors. Oncology Letters, 26, 437. https://doi.org/10.3892/ol.2023.14024
MLA
Liu, C., Zhao, H., Zhang, R., Guo, Z., Wang, P., Qu, Z."Prognostic value of nutritional and inflammatory markers in patients with hepatocellular carcinoma who receive immune checkpoint inhibitors". Oncology Letters 26.4 (2023): 437.
Chicago
Liu, C., Zhao, H., Zhang, R., Guo, Z., Wang, P., Qu, Z."Prognostic value of nutritional and inflammatory markers in patients with hepatocellular carcinoma who receive immune checkpoint inhibitors". Oncology Letters 26, no. 4 (2023): 437. https://doi.org/10.3892/ol.2023.14024
Copy and paste a formatted citation
x
Spandidos Publications style
Liu C, Zhao H, Zhang R, Guo Z, Wang P and Qu Z: Prognostic value of nutritional and inflammatory markers in patients with hepatocellular carcinoma who receive immune checkpoint inhibitors. Oncol Lett 26: 437, 2023.
APA
Liu, C., Zhao, H., Zhang, R., Guo, Z., Wang, P., & Qu, Z. (2023). Prognostic value of nutritional and inflammatory markers in patients with hepatocellular carcinoma who receive immune checkpoint inhibitors. Oncology Letters, 26, 437. https://doi.org/10.3892/ol.2023.14024
MLA
Liu, C., Zhao, H., Zhang, R., Guo, Z., Wang, P., Qu, Z."Prognostic value of nutritional and inflammatory markers in patients with hepatocellular carcinoma who receive immune checkpoint inhibitors". Oncology Letters 26.4 (2023): 437.
Chicago
Liu, C., Zhao, H., Zhang, R., Guo, Z., Wang, P., Qu, Z."Prognostic value of nutritional and inflammatory markers in patients with hepatocellular carcinoma who receive immune checkpoint inhibitors". Oncology Letters 26, no. 4 (2023): 437. https://doi.org/10.3892/ol.2023.14024
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team