Open Access

BR vs. R‑miniCHOP in unfit patients with B‑cell non‑Hodgkin lymphoma: A randomized, two‑center, cohort study

  • Authors:
    • Dongdong Zhang
    • Yong Lin
    • Youhong Dong
    • Liling Zhang
  • View Affiliations

  • Published online on: August 23, 2023     https://doi.org/10.3892/ol.2023.14027
  • Article Number: 440
  • Copyright: © Zhang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

The aim of the present study was to compare the efficacy and safety between the bendamustine plus rituximab (BR) regimen and rituximab combined with low‑dose doxorubicin, cyclophosphamide, vincristine and prednisone (R‑miniCHOP) in the treatment of ‘unfit’ patients with diffuse large B‑cell lymphoma (DLBCL) and follicular lymphoma grade 3B (FL3B). Patients, >70 years of age with DLBCL or FL3B, defined as unfit according to Comprehensive Geriatric Assessment, were included in the present study. All patients received 4‑6 cycles of a BR or R‑miniCHOP regimen at a three‑week interval. The objective remission rate (ORR) and adverse reactions were evaluated between the two groups. A total of 35 patients, recruited between January 2020 and December 2021, were included in this prospective study. The median age was 74 years (range, 70‑82 years). The ORR in the BR group was similar to that in the R‑miniCHOP group (73.3 vs. 75.0%; P=0.606). However, the BR group exhibited a lower incidence of leukopenia than the R‑miniCHOP group (20.0 vs. 60.0%; P=0.037). The univariate analysis revealed that the ORR was influenced by the serum β2 microglobulin level. The BR regimen showed equivalent efficacy but more improved safety compared with R‑miniCHOP in unfit patients with DLBCL and FL3B. The BR regimen may be considered as an alternative treatment in these subgroups of patients.
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October-2023
Volume 26 Issue 4

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Spandidos Publications style
Zhang D, Lin Y, Dong Y and Zhang L: BR vs. R‑miniCHOP in unfit patients with B‑cell non‑Hodgkin lymphoma: A randomized, two‑center, cohort study. Oncol Lett 26: 440, 2023
APA
Zhang, D., Lin, Y., Dong, Y., & Zhang, L. (2023). BR vs. R‑miniCHOP in unfit patients with B‑cell non‑Hodgkin lymphoma: A randomized, two‑center, cohort study. Oncology Letters, 26, 440. https://doi.org/10.3892/ol.2023.14027
MLA
Zhang, D., Lin, Y., Dong, Y., Zhang, L."BR vs. R‑miniCHOP in unfit patients with B‑cell non‑Hodgkin lymphoma: A randomized, two‑center, cohort study". Oncology Letters 26.4 (2023): 440.
Chicago
Zhang, D., Lin, Y., Dong, Y., Zhang, L."BR vs. R‑miniCHOP in unfit patients with B‑cell non‑Hodgkin lymphoma: A randomized, two‑center, cohort study". Oncology Letters 26, no. 4 (2023): 440. https://doi.org/10.3892/ol.2023.14027