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Case Report Open Access

Primary ovarian insufficiency associated with lenvatinib therapy in a patient with hepatocellular carcinoma: A case report

  • Authors:
    • Yoichi Aoki
    • Yosuke Inoue
    • Naoki Sasahira
    • Makiko Ono
    • Kentaro Inamura
    • Akemi Kataoka
    • Toshimi Takano
    • Hiroyuki Kanao
    • Masayuki Watanabe
  • View Affiliations / Copyright

    Affiliations: Department of Gynecologic Oncology, Cancer Institute Hospital, Tokyo 135‑8550, Japan, Department of Hepato‑Biliary‑Pancreatic Surgery, Cancer Institute Hospital, Tokyo 135‑8550, Japan, Department of Hepato‑Biliary‑Pancreatic Medicine, Cancer Institute Hospital, Tokyo 135‑8550, Japan, Total Care Center, Cancer Institute Hospital, Tokyo 135‑8550, Japan, Division of Pathology, The Cancer Institute, Japanese Foundation for Cancer Research, Cancer Institute Hospital, Tokyo 135‑8550, Japan
    Copyright: © Aoki et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 450
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    Published online on: August 31, 2023
       https://doi.org/10.3892/ol.2023.14037
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Abstract

The therapeutic effects of molecular targeted drugs are, in some cases, more pronounced than those of conventional chemotherapy, and their introduction as a standard treatment is increasing. The present report describes a case of ovarian insufficiency in a young woman caused by tyrosine kinase inhibitor lenvatinib. The 25‑year‑old woman received lenvatinib (8 mg/day) for 98 days as preoperative chemotherapy for hepatocellular carcinoma. Blood testing the day before starting lenvatinib administration indicated 4.40 mIU/ml luteinizing hormone (LH), 5.2 mIU/ml follicle‑stimulating hormone (FSH) and age‑equivalent hormone values. Amenorrhea occurred after the start of administration, and 48 days later, the LH level was 41.8 mIU/ml and the FSH level was 44 mIU/ml, indicating a decrease in ovarian function. The patient underwent hepatectomy, and 49 days after the end of lenvatinib administration, the LH level had improved to 4.5 mIU/ml and the FSH level had improved to 2.5 mIU/ml. After the hepatectomy, the patient began to have regular menstrual cycles once again. Ovarian toxicity has not been recognized as a side effect of lenvatinib. However, the present report describes primary ovarian insufficiency considered to be caused by this drug. Potential damage to ovarian function may need to be considered when molecular targeted drugs with the same mechanism of action as lenvatinib are used in young women.
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Copy and paste a formatted citation
Spandidos Publications style
Aoki Y, Inoue Y, Sasahira N, Ono M, Inamura K, Kataoka A, Takano T, Kanao H and Watanabe M: Primary ovarian insufficiency associated with lenvatinib therapy in a patient with hepatocellular carcinoma: A case report. Oncol Lett 26: 450, 2023.
APA
Aoki, Y., Inoue, Y., Sasahira, N., Ono, M., Inamura, K., Kataoka, A. ... Watanabe, M. (2023). Primary ovarian insufficiency associated with lenvatinib therapy in a patient with hepatocellular carcinoma: A case report. Oncology Letters, 26, 450. https://doi.org/10.3892/ol.2023.14037
MLA
Aoki, Y., Inoue, Y., Sasahira, N., Ono, M., Inamura, K., Kataoka, A., Takano, T., Kanao, H., Watanabe, M."Primary ovarian insufficiency associated with lenvatinib therapy in a patient with hepatocellular carcinoma: A case report". Oncology Letters 26.4 (2023): 450.
Chicago
Aoki, Y., Inoue, Y., Sasahira, N., Ono, M., Inamura, K., Kataoka, A., Takano, T., Kanao, H., Watanabe, M."Primary ovarian insufficiency associated with lenvatinib therapy in a patient with hepatocellular carcinoma: A case report". Oncology Letters 26, no. 4 (2023): 450. https://doi.org/10.3892/ol.2023.14037
Copy and paste a formatted citation
x
Spandidos Publications style
Aoki Y, Inoue Y, Sasahira N, Ono M, Inamura K, Kataoka A, Takano T, Kanao H and Watanabe M: Primary ovarian insufficiency associated with lenvatinib therapy in a patient with hepatocellular carcinoma: A case report. Oncol Lett 26: 450, 2023.
APA
Aoki, Y., Inoue, Y., Sasahira, N., Ono, M., Inamura, K., Kataoka, A. ... Watanabe, M. (2023). Primary ovarian insufficiency associated with lenvatinib therapy in a patient with hepatocellular carcinoma: A case report. Oncology Letters, 26, 450. https://doi.org/10.3892/ol.2023.14037
MLA
Aoki, Y., Inoue, Y., Sasahira, N., Ono, M., Inamura, K., Kataoka, A., Takano, T., Kanao, H., Watanabe, M."Primary ovarian insufficiency associated with lenvatinib therapy in a patient with hepatocellular carcinoma: A case report". Oncology Letters 26.4 (2023): 450.
Chicago
Aoki, Y., Inoue, Y., Sasahira, N., Ono, M., Inamura, K., Kataoka, A., Takano, T., Kanao, H., Watanabe, M."Primary ovarian insufficiency associated with lenvatinib therapy in a patient with hepatocellular carcinoma: A case report". Oncology Letters 26, no. 4 (2023): 450. https://doi.org/10.3892/ol.2023.14037
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