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S100A6 is a potential diagnostic and prognostic biomarker for human glioma

  • Authors:
    • Bo Hong
    • Hui Zhang
    • Yufei Xiao
    • Lingwei Shen
    • Yun Qian
  • View Affiliations / Copyright

    Affiliations: Department of Pathology, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310009, P.R. China, Department of Clinical Laboratory, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310009, P.R. China, Department of Clinical Laboratory, Stomatology Hospital, School of Stomatology, Zhejiang University School of Medicine, Zhejiang Provincial Clinical Research Center for Oral Diseases, Key Laboratory of Oral Biomedical Research of Zhejiang Province, Cancer Center of Zhejiang University, Hangzhou, Zhejiang 310006, P.R. China
    Copyright: © Hong et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 458
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    Published online on: September 6, 2023
       https://doi.org/10.3892/ol.2023.14045
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Abstract

S100 calcium‑binding protein A6 (S100A6) is a protein that belongs to the S100 family. The present study aimed to investigate the function of S100A6 in the diagnosis and survival prediction of glioma and elucidated the potential processes affecting glioma development. The Cancer Genome Atlas database was searched to identify the relationship among S100A6 expression, immune cell infiltration, clinicopathological parameters and glioma prognosis. Several clinical cases were used to verify these findings. S100A6 gene expression was high in glioma tissues, suggesting its diagnostic significance. In particular, S100A6 upregulation in glioma tissues exhibited a significant and positive correlation with the World Health Organization (WHO) grade, histological type, age, sex, primary treatment outcomes, 1p/19q codeletion, isocitrate dehydrogenase (IDH) status, overall survival (OS), progression‑free interval and disease‑specific survival. Kaplan‑Meier and Cox regression analyses revealed that S100A6 gene expression can independently function as a risk factor affecting the prognosis of patients with glioma. Furthermore, Gene Ontology functional enrichment analysis revealed that S100A6 is implicated in immune responses and that the expression profiles of S100A6 are linked to the immune microenvironment. Furthermore, immunohistochemistry revealed that increased S100A6 protein levels are correlated with age, 1p/19q codeletion, IDH status, WHO grade and OS. The present findings suggest that increased S100A6 expression is an indicator of the dismal prognosis of patients with glioma and that it can be used as a potential diagnostic biomarker for this condition.
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Copy and paste a formatted citation
Spandidos Publications style
Hong B, Zhang H, Xiao Y, Shen L and Qian Y: S100A6 is a potential diagnostic and prognostic biomarker for human glioma. Oncol Lett 26: 458, 2023.
APA
Hong, B., Zhang, H., Xiao, Y., Shen, L., & Qian, Y. (2023). S100A6 is a potential diagnostic and prognostic biomarker for human glioma. Oncology Letters, 26, 458. https://doi.org/10.3892/ol.2023.14045
MLA
Hong, B., Zhang, H., Xiao, Y., Shen, L., Qian, Y."S100A6 is a potential diagnostic and prognostic biomarker for human glioma". Oncology Letters 26.4 (2023): 458.
Chicago
Hong, B., Zhang, H., Xiao, Y., Shen, L., Qian, Y."S100A6 is a potential diagnostic and prognostic biomarker for human glioma". Oncology Letters 26, no. 4 (2023): 458. https://doi.org/10.3892/ol.2023.14045
Copy and paste a formatted citation
x
Spandidos Publications style
Hong B, Zhang H, Xiao Y, Shen L and Qian Y: S100A6 is a potential diagnostic and prognostic biomarker for human glioma. Oncol Lett 26: 458, 2023.
APA
Hong, B., Zhang, H., Xiao, Y., Shen, L., & Qian, Y. (2023). S100A6 is a potential diagnostic and prognostic biomarker for human glioma. Oncology Letters, 26, 458. https://doi.org/10.3892/ol.2023.14045
MLA
Hong, B., Zhang, H., Xiao, Y., Shen, L., Qian, Y."S100A6 is a potential diagnostic and prognostic biomarker for human glioma". Oncology Letters 26.4 (2023): 458.
Chicago
Hong, B., Zhang, H., Xiao, Y., Shen, L., Qian, Y."S100A6 is a potential diagnostic and prognostic biomarker for human glioma". Oncology Letters 26, no. 4 (2023): 458. https://doi.org/10.3892/ol.2023.14045
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