Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Oncology Letters
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-1074 Online ISSN: 1792-1082
Journal Cover
October-2023 Volume 26 Issue 4

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
October-2023 Volume 26 Issue 4

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML

  • Supplementary Files
    • Supplementary_Data1.pdf
    • Supplementary_Data2.pdf
Article Open Access

Monocarboxylate transporter 4 promotes the migration of non‑cancerous L929 fibroblast cells by activating the IGF1/IGF1R/PIK3R3/SGK1 axis

  • Authors:
    • Xiaoju Zhou
    • Shuo Wang
    • Yanyan Li
    • He Zhao
    • Xue Han
    • Yue Yu
    • Yu Chen
    • Yu Yang
    • Xiaonan Ma
    • Hongjing Huo
    • Manting Zhang
    • Yongshan Zhao
    • Ningning Ma
  • View Affiliations / Copyright

    Affiliations: Wuya College of Innovation, Shenyang Pharmaceutical University, Shenyang, Liaoning 110016, P.R. China, Department of Biochemistry and Molecular Biology, School of Life Science and Biopharmaceutics, Shenyang Pharmaceutical University, Shenyang, Liaoning 110016, P.R. China
    Copyright: © Zhou et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 460
    |
    Published online on: September 11, 2023
       https://doi.org/10.3892/ol.2023.14047
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

The tumor microenvironment (TME) and Warburg effect are critical for the regulation of tumor metastasis. The monocarboxylate transporter (MCT) family members, particularly MCT4, which is encoded by the solute carrier family 16 member 3 gene, play an important role in the regulation of the TME and mediation of the Warburg effect by transporting lactate out of cancer cells. Migration and invasion are two key features of metastasis. Few studies have investigated the mechanism by which MCT4 promotes cell migration, and the suggested mechanisms by which MCT4 promotes migration vary in different tumor cell models. The purpose of the present study was to use non‑cancerous cells as a research model to investigate the specific mechanism underlying the promotion of migration by MCT4. In a previous study, murine L929 cells overexpressing human MCT4 (MCT4‑L929 cells) were generated and MCT4 was demonstrated to promote the migration and invasion of these non‑cancerous cells. In the present study, MCT4‑L929 cells and control‑L929 cells were used to investigate the potential pathways and mechanisms through which MCT4 promotes cell migration. RNA sequencing analysis revealed 872 differentially expressed genes, comprising 337 and 535 upregulated and downregulated genes, respectively, in the MCT4‑L929 cells. Reverse transcription‑quantitative analysis and western blotting revealed that MCT4 overexpression increased the transcription and protein levels of insulin‑like growth factor 1 (IGF1). In a wound healing assay, the migration of exogenous mouse IGF1‑treated control‑L929 cells was similar to that of MCT4‑L929 cells. Additionally, the inhibition of IGF1 receptor (IGF1R) or serum/glucocorticoid regulated kinase 1 (SGK1), a downstream protein in the IGF1 and phosphoinositide 3‑kinase PI3K regulatory subunit 3 (PIK3R3) pathways, in MCT4‑L929 cells mitigated the cell migration‑promoting effect of MCT4. These novel findings suggest that MCT4 may promote the migration of L929 fibroblast cells via activation of the IGF1/IGF1R/PIK3R3/SGK1 axis.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

Figure 6

Figure 7

View References

1 

Chaffer C and Weinberg R: A perspective on cancer cell metastasis. Science. 331:1559–1564. 2011. View Article : Google Scholar : PubMed/NCBI

2 

Steeg PS: Tumor metastasis: Mechanistic insights and clinical challenges. Nat Med. 12:895–904. 2006. View Article : Google Scholar : PubMed/NCBI

3 

Wu Y, Zhang T, Zhang X and Gao Q: Decoding the complexity of metastasis. Cancer Biol Med. 19:284–288. 2022. View Article : Google Scholar : PubMed/NCBI

4 

Nakamura Y, Fujimoto M, Fukushima S, Nakamura A, Hayashida N, Takii R, Takaki E, Nakai A and Muto M: Heat shock factor 1 is required for migration and invasion of human melanoma in vitro and in vivo. Cancer Lett. 354:329–335. 2014. View Article : Google Scholar : PubMed/NCBI

5 

Chiu WT, Shen SC, Chow JM, Lin CW, Shia LT and Chen YC: Contribution of reactive oxygen species to migration/invasion of human glioblastoma cells U87 via ERK-dependent COX-2/PGE(2) activation. Neurobiol Dis. 37:118–129. 2010. View Article : Google Scholar : PubMed/NCBI

6 

Ishimura N, Isomoto H, Bronk SF and Gores GJ: Trail induces cell migration and invasion in apoptosis-resistant cholangiocarcinoma cells. Am J Physiol Gastrointest Liver Physiol. 290:G129–G136. 2006. View Article : Google Scholar : PubMed/NCBI

7 

Malla RR and Kiran P: Tumor microenvironment pathways: Cross regulation in breast cancer metastasis. Genes Dis. 9:310–324. 2022. View Article : Google Scholar : PubMed/NCBI

8 

Mosier JA, Schwager SC, Boyajian DA and Reinhart-King CA: Cancer cell metabolic plasticity in migration and metastasis. Clin Exp Metastasis. 38:343–359. 2021. View Article : Google Scholar : PubMed/NCBI

9 

Hipolito A, Martins F, Mendes C, Lopes-Coelho F and Serpa J: Molecular and metabolic reprogramming: Pulling the strings toward tumor metastasis. Front Oncol. 11:6568512021. View Article : Google Scholar : PubMed/NCBI

10 

Lu J: The Warburg metabolism fuels tumor metastasis. Cancer Metastasis Rev. 38:157–164. 2019. View Article : Google Scholar : PubMed/NCBI

11 

Jiang B: Aerobic glycolysis and high level of lactate in cancer metabolism and microenvironment. Genes Dis. 4:25–27. 2017. View Article : Google Scholar : PubMed/NCBI

12 

Contreras-Baeza Y, Sandoval PY, Alarcon R, Galaz A, Cortés-Molina F, Alegría K, Baeza-Lehnert F, Arce-Molina R, Guequén A, Flores CA, et al: Monocarboxylate transporter 4 (MCT4) is a high affinity transporter capable of exporting lactate in high-lactate microenvironments. J Biol Chem. 294:20135–20147. 2019. View Article : Google Scholar : PubMed/NCBI

13 

Kong SC, Nohr-Nielsen A, Zeeberg K, Reshkin SJ, Hoffmann EK, Novak I and Pedersen SF: Monocarboxylate transporters MCT1 and MCT4 regulate migration and invasion of pancreatic ductal adenocarcinoma cells. Pancreas. 45:1036–1047. 2016. View Article : Google Scholar : PubMed/NCBI

14 

Pinheiro C, Reis RM, Ricardo S, Longatto-Filho A, Schmitt F and Baltazar F: Expression of monocarboxylate transporters 1, 2, and 4 in human tumours and their association with CD147 and CD44. J Biomed Biotechnol. 2010:4276942010. View Article : Google Scholar : PubMed/NCBI

15 

Choi JW, Kim Y, Lee JH and Kim YS: Prognostic significance of lactate/proton symporters MCT1, MCT4, and their chaperone CD147 expressions in urothelial carcinoma of the bladder. Urology. 84:245e249–215. 2014. View Article : Google Scholar

16 

Zhu J, Wu YN, Zhang W, Zhang XM, Ding X, Li HQ, Geng M, Xie ZQ and Wu HM: Monocarboxylate transporter 4 facilitates cell proliferation and migration and is associated with poor prognosis in oral squamous cell carcinoma patients. PLoS One. 9:e879042014. View Article : Google Scholar : PubMed/NCBI

17 

Dong S, Zheng L and Jiang T: Loss of Lactate/Proton monocarboxylate transporter 4 induces ferroptosis via the AMPK/ACC pathway and inhibition of autophagy on human bladder cancer 5637 cell line. J Oncol. 2023:28303062023. View Article : Google Scholar : PubMed/NCBI

18 

Izumi H, Takahashi M, Uramoto H, Nakayama Y, Oyama T, Wang KY, Sasaguri Y, Nishizawa S and Kohno K: Monocarboxylate transporters 1 and 4 are involved in the invasion activity of human lung cancer cells. Cancer Sci. 102:1007–1013. 2011. View Article : Google Scholar : PubMed/NCBI

19 

Gao HJ, Zhao MC, Zhang YJ, Zhou DS, Xu L, Li GB, Chen MS and Liu J: Monocarboxylate transporter 4 predicts poor prognosis in hepatocellular carcinoma and is associated with cell proliferation and migration. J Cancer Res Clin Oncol. 141:1151–1162. 2015. View Article : Google Scholar : PubMed/NCBI

20 

Kong S, Nøhr-Nielsen A, Zeeberg K, Reshkin SJ, Hoffmann EK, Novak I and Pedersen SF: Monocarboxylate transporters MCT1 and MCT4 regulate migration and invasion of pancreatic ductal adenocarcinoma cells. Pancreas. 45:1036–1047. 2016. View Article : Google Scholar : PubMed/NCBI

21 

Sun Q, Hu LL and Fu Q: MCT4 promotes cell proliferation and invasion of castration-resistant prostate cancer PC-3 cell line. EXCLI J. 18:187–194. 2019.PubMed/NCBI

22 

Reuss AM, Groos D, Ghoochani A, Buchfelder M and Savaskan N: MCT4 promotes tumor malignancy in F98 glioma Cells. J Oncol. 2021:66555292021. View Article : Google Scholar : PubMed/NCBI

23 

Li Z, Wu Q and Sun S, Wu J, Li J, Zhang Y, Wang C, Yuan J and Sun S: Monocarboxylate transporters in breast cancer and adipose tissue are novel biomarkers and potential therapeutic targets. Biochem Biophys Res Commun. 501:962–967. 2018. View Article : Google Scholar : PubMed/NCBI

24 

Li X, Zhou X, Liu Y, Fan J, Huo H, Yao J, Wang L and Ma N: Overexpression of monocarboxylate transporter 4 promotes the migration and invasion of non-carcinogenic L929 fibroblast cells. Oncol Lett. 21:442021. View Article : Google Scholar : PubMed/NCBI

25 

Hu D, Zheng Y, Ou X, Zhang L, Du X and Shi S: Integrated analysis of anti-tumor roles of BAP1 in osteosarcoma. Front Oncol. 12:9739142022. View Article : Google Scholar : PubMed/NCBI

26 

Tang Y, Li M, Wang J, Pan Y and Wu FX: CytoNCA: A cytoscape plugin for centrality analysis and evaluation of protein interaction networks. Biosystems. 127:67–72. 2015. View Article : Google Scholar : PubMed/NCBI

27 

Girnita A, Girnita L, del Prete F, Bartolazzi A, Larsson O and Axelson M: Cyclolignans as inhibitors of the insulin-like growth factor-1 receptor and malignant cell growth. Cancer Res. 64:236–242. 2004. View Article : Google Scholar : PubMed/NCBI

28 

Bieghs L, Lub S, Fostier K, Maes K, Van Valckenborgh E, Menu E, Johnsen HE, Overgaard MT, Larsson O, Axelson M, et al: The IGF-1 receptor inhibitor picropodophyllin potentiates the anti-myeloma activity of a BH3-mimetic. Oncotarget. 5:11193–11208. 2014. View Article : Google Scholar : PubMed/NCBI

29 

Kong YL, Shen Y, Ni J, Shao DC, Miao NJ, Xu JL, Zhou L, Xue H, Zhang W, Wang XX and Lu LM: Insulin deficiency induces rat renal mesangial cell dysfunction via activation of IGF-1/IGF-1R pathway. Acta Pharmacol Sin. 37:217–227. 2016. View Article : Google Scholar : PubMed/NCBI

30 

Sherk AB, Frigo DE, Schnackenberg CG, Bray JD, Laping NJ, Trizna W, Hammond M, Patterson JR, Thompson SK, Kazmin D, et al: Development of a small-molecule serum- and glucocorticoid-regulated kinase-1 antagonist and its evaluation as a prostate cancer therapeutic. Cancer Res. 68:7475–7483. 2008. View Article : Google Scholar : PubMed/NCBI

31 

Mansley MK and Wilson SM: Effects of nominally selective inhibitors of the kinases PI3K, SGK1 and PKB on the insulin-dependent control of epithelial Na+ absorption. Br J Pharmacol. 161:571–588.. 2010. View Article : Google Scholar : PubMed/NCBI

32 

Harshitha R and Arunraj DR: Real-time quantitative PCR: A tool for absolute and relative quantification. Biochem Mol Biol Educ. 49:800–812. 2021. View Article : Google Scholar : PubMed/NCBI

33 

Rodriguez LG, Wu X and Guan JL: Wound-healing assay. Methods Mol Biol. 294:23–29. 2005.PubMed/NCBI

34 

Li Q, Xu L, Li Y, Yang R, Qiao Q, Wang Y, Wang L, Guo Y and Guo C: P2RY14 is a potential biomarker of tumor microenvironment immunomodulation and favorable prognosis in patients with head and neck cancer. Front Genet. 12:6707462021. View Article : Google Scholar : PubMed/NCBI

35 

Cho J, Yusuf R, Kook S, Attar E, Lee D, Park B, Cheng T, Scadden DT and Lee BC: Purinergic P2Y(1)(4) receptor modulates stress-induced hematopoietic stem/progenitor cell senescence. J Clin Invest. 124:3159–3171. 2014. View Article : Google Scholar : PubMed/NCBI

36 

Xu T, Xu S, Yao Y, Chen X, Zhang Q, Zhao X, Wang X, Zhu J, Liu N, Zhang J, et al: P2RY14 downregulation in lung adenocarcinoma: A potential therapeutic target associated with immune infiltration. J Thorac Dis. 14:515–535. 2022. View Article : Google Scholar : PubMed/NCBI

37 

Meng L, He X, Hong Q, Qiao B, Zhang X, Wu B, Zhang X, Wei Y, Li J, Ye Z and Xiao Y: CCR4, CCR8, and P2RY14 as prognostic factors in head and neck squamous cell carcinoma are involved in the remodeling of the tumor microenvironment. Front Oncol. 11:6181872021. View Article : Google Scholar : PubMed/NCBI

38 

Wang H, Wang X, Xu L, Zhang J and Cao H: High expression levels of pyrimidine metabolic rate-limiting enzymes are adverse prognostic factors in lung adenocarcinoma: A study based on the cancer genome atlas and gene expression omnibus datasets. Purinergic Signal. 16:347–366. 2020. View Article : Google Scholar : PubMed/NCBI

39 

Shah K, Moharram SA and Kazi JU: Acute leukemia cells resistant to PI3K/mTOR inhibition display upregulation of P2RY14 expression. Clin Epigenetics. 10:832018. View Article : Google Scholar : PubMed/NCBI

40 

Woods LT, Forti KM, Shanbhag VC, Camden JM and Weisman GA: P2Y receptors for extracellular nucleotides: Contributions to cancer progression and therapeutic implications. Biochem Pharmacol. 187:1144062021. View Article : Google Scholar : PubMed/NCBI

41 

Cohen P: Serum insulin-like growth factor-i levels and prostate cancer risk-interpreting the evidence. J Natl Cancer Inst. 90:876–879. 1998. View Article : Google Scholar : PubMed/NCBI

42 

Wang X, Zhu Q, Lin Y, Wu L, Wu X, Wang K, He Q, Xu C, Wan X and Wang X: Crosstalk between TEMs and endothelial cells modulates angiogenesis and metastasis via IGF1-IGF1R signalling in epithelial ovarian cancer. Br J Cancer. 117:1371–1382. 2017. View Article : Google Scholar : PubMed/NCBI

43 

Peyrat J, Bonneterre J, Vennin P, Jammes H, Beuscart R, Hecquet B, Djiane J, Lefebvre J and Demaille A: Insulin-like growth factor 1 receptors (IGF1-R) and IGF1 in human breast tumors. J Steroid Biochem Mol Biol. 37:823–827. 1990. View Article : Google Scholar : PubMed/NCBI

44 

Liu Y, Nelson MV, Bailey C, Zhang P, Zheng P, Dome JS, Liu Y and Wang Y: Targeting the HIF-1α-IGFBP2 axis therapeutically reduces IGF1-AKT signaling and blocks the growth and metastasis of relapsed anaplastic Wilms tumor. Oncogene. 40:4809–4819. 2021. View Article : Google Scholar : PubMed/NCBI

45 

Yang L, Tan Z, Li Y, Zhang X, Wu Y, Xu B and Wang M: Insulin-like growth factor 1 promotes proliferation and invasion of papillary thyroid cancer through the STAT3 pathway. J Clin Lab Anal. 34:e235312020. View Article : Google Scholar : PubMed/NCBI

46 

Chen ZL, Li XN, Ye CX, Chen HY and Wang ZJ: Elevated levels of circRUNX1 in colorectal cancer promote cell growth and metastasis via miR-145-5p/IGF1 signalling. Onco Targets Ther. 13:4035–4048. 2020. View Article : Google Scholar : PubMed/NCBI

47 

Wang H, Tang C, Na M, Ma W, Jiang Z, Gu Y, Ma G, Ge H, Shen H and Lin Z: miR-422a inhibits glioma proliferation and invasion by targeting IGF1 and IGF1R. Oncol Res. 25:187–194. 2017. View Article : Google Scholar : PubMed/NCBI

48 

Lu X, Song X, Hao X, Liu X, Zhang X, Yuan N, Ma H and Zhang Z: MiR-186-3p attenuates tumorigenesis of cervical cancer by targeting IGF1. World J Surg Oncol. 19:2072021. View Article : Google Scholar : PubMed/NCBI

49 

Nagle AM, Levine KM, Tasdemir N, Scott JA, Burlbaugh K, Kehm J, Katz TA, Boone DN, Jacobsen BM, Atkinson JM, et al: Loss of E-cadherin enhances IGF1-IGF1R pathway activation and sensitizes breast cancers to anti-IGF1R/InsR inhibitors. Clin Cancer Res. 24:5165–5177. 2018. View Article : Google Scholar : PubMed/NCBI

50 

Hirakawa T, Yashiro M, Doi Y, Kinoshita H, Morisaki T, Fukuoka T, Hasegawa T, Kimura K, Amano R and Hirakawa K: Pancreatic fibroblasts stimulate the motility of pancreatic cancer cells through IGF1/IGF1R signaling under hypoxia. PLoS One. 11:e01599122016. View Article : Google Scholar : PubMed/NCBI

51 

Fürstenberger G and Senn HJ: Insulin-like growth factors and cancer. Lancet Oncol. 3:298–302. 2002. View Article : Google Scholar : PubMed/NCBI

52 

Matà R, Palladino C, Nicolosi M, Lo Presti AR, Malaguarnera R, Ragusa M, Sciortino D, Morrione A, Maggiolini M, Vella V and Belfiore A: IGF-I induces upregulation of DDR1 collagen receptor in breast cancer cells by suppressing MIR-199a-5p through the PI3K/AKT pathway. Oncotarget. 7:7683–7700. 2016. View Article : Google Scholar : PubMed/NCBI

53 

Zhou J, Chen G, Tang Y, Sinha RA, Wu Y, Yap CS, Wang G, Hu J, Xia X, Tan P, et al: Genetic and bioinformatic analyses of the expression and function of PI3K regulatory subunit PIK3R3 in an Asian patient gastric cancer library. BMC Med Genomics. 5:1–8. 2012. View Article : Google Scholar : PubMed/NCBI

54 

Zhu Y, Zhao H, Rao M and Xu S: MicroRNA-365 inhibits proliferation, migration and invasion of glioma by targeting PIK3R3. Oncol Rep. 37:2185–2192. 2017. View Article : Google Scholar : PubMed/NCBI

55 

Sun H and Feng X: MicroRNA-367 directly targets PIK3R3 to inhibit proliferation and invasion of oral carcinoma cells. Biosci Rep. 40:BSR201938672020. View Article : Google Scholar : PubMed/NCBI

56 

Qi J, Wang WW, Chen W, Lu WY and Shang AQ: Mechanism of miR-137 regulating migration and invasion of melanoma cells by targeting PIK3R3 gene. J Cell Biochem. 120:8393–8400. 2018. View Article : Google Scholar : PubMed/NCBI

57 

Bruhn MA, Pearson RB, Hannan RD and Sheppard KE: Second AKT: The rise of SGK in cancer signalling. Growth Factors. 28:394–408. 2010. View Article : Google Scholar : PubMed/NCBI

58 

Sang Y, Kong P, Zhang S, Zhang L, Cao Y, Duan X, Sun T, Tao Z and Liu W: SGK1 in human cancer: Emerging roles and mechanisms. Front Oncol. 10:6087222020. View Article : Google Scholar : PubMed/NCBI

59 

Liang X, Lan C, Jiao G, Fu W, Long X, An Y, Wang K, Zhou J, Chen T, Li Y, et al: Therapeutic inhibition of SGK1 suppresses colorectal cancer. Exp Mol Med. 49:e3992017. View Article : Google Scholar : PubMed/NCBI

60 

Greenawalt EJ, Edmonds MD, Jain N, Adams CM, Mitra R and Eischen CM: Targeting of SGK1 by miR-576-3p inhibits lung adenocarcinoma migration and invasion. Mol Cancer Res. 17:289–298. 2019. View Article : Google Scholar : PubMed/NCBI

61 

Liu W, Wang X, Wang Y, Dai Y, Xie Y, Ping Y, Yin B, Yu P, Liu Z, Duan X, et al: SGK1 inhibition-induced autophagy impairs prostate cancer metastasis by reversing EMT. J Exp Clin Cancer Res. 37:732018. View Article : Google Scholar : PubMed/NCBI

62 

Zhu R, Yang G, Cao Z, Shen K, Zheng L, Xiao J, You L and Zhang T: The prospect of serum and glucocorticoid-inducible kinase 1 (SGK1) in cancer therapy: A rising star. Ther Adv Med Oncol. 12:17588359209409462020. View Article : Google Scholar : PubMed/NCBI

63 

Zhang Y, Shi G, Zhang H, Xiong Q, Cheng F, Wang H, Luo J, Zhang Y, Shi P, Xu J, et al: Dexamethasone enhances the lung metastasis of breast cancer via a PI3K-SGK1-CTGF pathway. Oncogene. 40:5367–5378. 2021. View Article : Google Scholar : PubMed/NCBI

64 

Gallagher SM, Castorino JJ and Philp NJ: Interaction of monocarboxylate transporter 4 with beta1-integrin and its role in cell migration. Am J Physiol Cell Physiol. 296:C414–C421. 2009. View Article : Google Scholar : PubMed/NCBI

65 

Niu Z, Yang F, Li H, Wang J, Ni Q, Ma C, Zhu H, Chang H, Zhou X, Lu J and Gao H: MCT4 promotes hepatocellular carcinoma progression by upregulating TRAPPC5 gene. J Hepatocell Carcinoma. 9:289–300. 2022. View Article : Google Scholar : PubMed/NCBI

66 

Ma J, Sawai H, Matsuo Y, Ochi N, Yasuda A, Takahashi H, Wakasugi T, Funahashi H, Sato M and Takeyama H: IGF-1 mediates PTEN suppression and enhances cell invasion and proliferation via activation of the IGF-1/PI3K/Akt signaling pathway in pancreatic cancer cells. J Surg Res. 160:90–101. 2010. View Article : Google Scholar : PubMed/NCBI

67 

Cheng CJ and Huang CL: Activation of PI3-kinase stimulates endocytosis of ROMK via Akt1/SGK1-dependent phosphorylation of WNK1. J Am Soc Nephrol. 22:460–471. 2011. View Article : Google Scholar : PubMed/NCBI

68 

Heinrich T, Sala-Hojman A, Ferretti R, Petersson C, Minguzzi S, Gondela A, Ramaswamy S, Bartosik A, Czauderna F, Crowley L, et al: Discovery of 5-2-[5-Chloro-2-(5-ethoxyquinoline-8-sulfonamido)phenyl]ethynyl-4-methoxypyridine-2-carboxylic acid, a highly selective in vivo useable chemical probe to dissect MCT4 biology. J Med Chem. 64:11904–11933. 2021. View Article : Google Scholar : PubMed/NCBI

69 

Qiang YW, Yao L, Tosato G and Rudikoff S: Insulin-like growth factor I induces migration and invasion of human multiple myeloma cells. Blood. 103:301–308. 2004. View Article : Google Scholar : PubMed/NCBI

70 

Seo SH, Hwang SY, Hwang S, Han S, Park H, Lee YS, Rho SB and Kwon Y: Hypoxia-induced ELF3 promotes tumor angiogenesis through IGF1/IGF1R. EMBO Rep. 23:e529772022. View Article : Google Scholar : PubMed/NCBI

71 

Fukuda R, Hirota K, Fan F, Jung YD, Ellis LM and Semenza GL: Insulin-like growth factor 1 induces hypoxia-inducible factor 1-mediated vascular endothelial growth factor expression, which is dependent on MAP kinase and phosphatidylinositol 3-kinase signaling in colon cancer cells. J Biol Chem. 277:38205–38211. 2002. View Article : Google Scholar : PubMed/NCBI

72 

Jena B, Das C, Banerjee I, Bharadwaj D, Majumder R, Das S, Biswas A, Kundu M, Roy PK, Kundu CN and Mandal M: TGF-β1 induced autophagy in cancer associated fibroblasts during hypoxia contributes EMT and glycolysis via MCT4 upregulation. Exp Cell Res. 417:1131952022. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Zhou X, Wang S, Li Y, Zhao H, Han X, Yu Y, Chen Y, Yang Y, Ma X, Huo H, Huo H, et al: Monocarboxylate transporter 4 promotes the migration of non‑cancerous L929 fibroblast cells by activating the IGF1/IGF1R/PIK3R3/SGK1 axis. Oncol Lett 26: 460, 2023.
APA
Zhou, X., Wang, S., Li, Y., Zhao, H., Han, X., Yu, Y. ... Ma, N. (2023). Monocarboxylate transporter 4 promotes the migration of non‑cancerous L929 fibroblast cells by activating the IGF1/IGF1R/PIK3R3/SGK1 axis. Oncology Letters, 26, 460. https://doi.org/10.3892/ol.2023.14047
MLA
Zhou, X., Wang, S., Li, Y., Zhao, H., Han, X., Yu, Y., Chen, Y., Yang, Y., Ma, X., Huo, H., Zhang, M., Zhao, Y., Ma, N."Monocarboxylate transporter 4 promotes the migration of non‑cancerous L929 fibroblast cells by activating the IGF1/IGF1R/PIK3R3/SGK1 axis". Oncology Letters 26.4 (2023): 460.
Chicago
Zhou, X., Wang, S., Li, Y., Zhao, H., Han, X., Yu, Y., Chen, Y., Yang, Y., Ma, X., Huo, H., Zhang, M., Zhao, Y., Ma, N."Monocarboxylate transporter 4 promotes the migration of non‑cancerous L929 fibroblast cells by activating the IGF1/IGF1R/PIK3R3/SGK1 axis". Oncology Letters 26, no. 4 (2023): 460. https://doi.org/10.3892/ol.2023.14047
Copy and paste a formatted citation
x
Spandidos Publications style
Zhou X, Wang S, Li Y, Zhao H, Han X, Yu Y, Chen Y, Yang Y, Ma X, Huo H, Huo H, et al: Monocarboxylate transporter 4 promotes the migration of non‑cancerous L929 fibroblast cells by activating the IGF1/IGF1R/PIK3R3/SGK1 axis. Oncol Lett 26: 460, 2023.
APA
Zhou, X., Wang, S., Li, Y., Zhao, H., Han, X., Yu, Y. ... Ma, N. (2023). Monocarboxylate transporter 4 promotes the migration of non‑cancerous L929 fibroblast cells by activating the IGF1/IGF1R/PIK3R3/SGK1 axis. Oncology Letters, 26, 460. https://doi.org/10.3892/ol.2023.14047
MLA
Zhou, X., Wang, S., Li, Y., Zhao, H., Han, X., Yu, Y., Chen, Y., Yang, Y., Ma, X., Huo, H., Zhang, M., Zhao, Y., Ma, N."Monocarboxylate transporter 4 promotes the migration of non‑cancerous L929 fibroblast cells by activating the IGF1/IGF1R/PIK3R3/SGK1 axis". Oncology Letters 26.4 (2023): 460.
Chicago
Zhou, X., Wang, S., Li, Y., Zhao, H., Han, X., Yu, Y., Chen, Y., Yang, Y., Ma, X., Huo, H., Zhang, M., Zhao, Y., Ma, N."Monocarboxylate transporter 4 promotes the migration of non‑cancerous L929 fibroblast cells by activating the IGF1/IGF1R/PIK3R3/SGK1 axis". Oncology Letters 26, no. 4 (2023): 460. https://doi.org/10.3892/ol.2023.14047
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team