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Transarterial chemoembolization plus camrelizumab is an effective and tolerable bridging therapy for patients with intermediate‑stage hepatocellular carcinoma: A pilot study

  • Authors:
    • Haoran Huo
    • Xiaoying Wang
    • Shan Xu
    • Xiaotong Niu
    • Limin Cheng
    • Zengjiang Yuan
    • Shuang Huo
    • Pingping Fang
  • View Affiliations / Copyright

    Affiliations: Department of General Surgery, Handan Central Hospital, Handan, Hebei 056000, P.R. China, Department of Nephrology, Affiliated Hospital of Hebei University of Engineering, Handan, Hebei 056002, P.R. China, Department of Gastroenterology, Handan Central Hospital, Handan, Hebei 056000, P.R. China, Department of Neurology, Handan Central Hospital, Handan, Hebei 056000, P.R. China
    Copyright: © Huo et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 465
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    Published online on: September 14, 2023
       https://doi.org/10.3892/ol.2023.14052
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Abstract

Transarterial chemoembolization (TACE) has been reported to synergize with camrelizumab in the treatment of hepatocellular carcinoma (HCC). The present study aimed to explore the potential of TACE and camrelizumab as a bridging therapy prior to surgery for patients with HCC. For this purpose, 11 patients with HCC with intermediate stage disease [classified by China Liver Cancer (CNLC) staging] who received TACE combined with camrelizumab as a bridging therapy prior to surgery were enrolled in this study. The treatment response was evaluated at 2 weeks following TACE therapy and following camrelizumab treatment. The relapse‑free survival (RFS) and overall survival (OS) of the patients were calculated. The objective response and disease control rates were 72.7 and 100.0% following TACE treatment, and were 100.0 and 100.0% following camrelizumab treatment, respectively. The α‑fetoprotein levels gradually decreased following TACE, camrelizumab treatment and surgical resection (all P<0.05). Of note, the CNLC stage decreased following treatment (P=0.007) and the downstaging success rate was 63.6%. In terms of survival profiles, the mean RFS (95% CI) was 14.1 (11.7‑16.5) months and the 1‑year RFS rate was 77.9±14.1%. Furthermore, the mean OS (95% CI) was 15.0 (13.2‑16.8) months and the 1‑year OS rate was 80.0±17.9%. Successful downstaging was associated with RFS (P=0.041), but not OS (P=0.221). With regard to safety, 6 (54.5%) patients experienced reactive cutaneous capillary endothelial proliferation, 5 (45.5%) patients reported pain and 4 (36.4%) patients had a fever. On the whole, the present study demonstrated that TACE plus camrelizumab may be an effective and safe strategy that has potential for use as a bridging strategy prior to surgery in patients with intermediate‑stage HCC.
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Copy and paste a formatted citation
Spandidos Publications style
Huo H, Wang X, Xu S, Niu X, Cheng L, Yuan Z, Huo S and Fang P: Transarterial chemoembolization plus camrelizumab is an effective and tolerable bridging therapy for patients with intermediate‑stage hepatocellular carcinoma: A pilot study. Oncol Lett 26: 465, 2023.
APA
Huo, H., Wang, X., Xu, S., Niu, X., Cheng, L., Yuan, Z. ... Fang, P. (2023). Transarterial chemoembolization plus camrelizumab is an effective and tolerable bridging therapy for patients with intermediate‑stage hepatocellular carcinoma: A pilot study. Oncology Letters, 26, 465. https://doi.org/10.3892/ol.2023.14052
MLA
Huo, H., Wang, X., Xu, S., Niu, X., Cheng, L., Yuan, Z., Huo, S., Fang, P."Transarterial chemoembolization plus camrelizumab is an effective and tolerable bridging therapy for patients with intermediate‑stage hepatocellular carcinoma: A pilot study". Oncology Letters 26.5 (2023): 465.
Chicago
Huo, H., Wang, X., Xu, S., Niu, X., Cheng, L., Yuan, Z., Huo, S., Fang, P."Transarterial chemoembolization plus camrelizumab is an effective and tolerable bridging therapy for patients with intermediate‑stage hepatocellular carcinoma: A pilot study". Oncology Letters 26, no. 5 (2023): 465. https://doi.org/10.3892/ol.2023.14052
Copy and paste a formatted citation
x
Spandidos Publications style
Huo H, Wang X, Xu S, Niu X, Cheng L, Yuan Z, Huo S and Fang P: Transarterial chemoembolization plus camrelizumab is an effective and tolerable bridging therapy for patients with intermediate‑stage hepatocellular carcinoma: A pilot study. Oncol Lett 26: 465, 2023.
APA
Huo, H., Wang, X., Xu, S., Niu, X., Cheng, L., Yuan, Z. ... Fang, P. (2023). Transarterial chemoembolization plus camrelizumab is an effective and tolerable bridging therapy for patients with intermediate‑stage hepatocellular carcinoma: A pilot study. Oncology Letters, 26, 465. https://doi.org/10.3892/ol.2023.14052
MLA
Huo, H., Wang, X., Xu, S., Niu, X., Cheng, L., Yuan, Z., Huo, S., Fang, P."Transarterial chemoembolization plus camrelizumab is an effective and tolerable bridging therapy for patients with intermediate‑stage hepatocellular carcinoma: A pilot study". Oncology Letters 26.5 (2023): 465.
Chicago
Huo, H., Wang, X., Xu, S., Niu, X., Cheng, L., Yuan, Z., Huo, S., Fang, P."Transarterial chemoembolization plus camrelizumab is an effective and tolerable bridging therapy for patients with intermediate‑stage hepatocellular carcinoma: A pilot study". Oncology Letters 26, no. 5 (2023): 465. https://doi.org/10.3892/ol.2023.14052
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