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A novel fluorescent dye selectively images and kills cancer stem cells by targeting mitochondria: Evidence from a cell line‑based zebrafish xenograft model

  • Authors:
    • Tao Ren
    • Meng-Zhe Yang
    • Wei-Ming Zhang
    • Liu-Jie Qin
    • Shou-Chang Zhou
    • Nan-Nan Cheng
    • Yuan-Jiao Huang
    • Jing Sun
    • Ning Xu
    • Hua-Bing Sun
    • Bei-Bei Zhang
  • View Affiliations / Copyright

    Affiliations: Department of Clinical Oncology, The Fifth Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi 530000, P.R. China, Graduate School, Beijing TongRen Hospital, Capital Medical University, Beijing 100069, P.R. China, Department of Clinical Oncology, Wuming Hospital of Guangxi Medical University, Nanning, Guangxi 530199, P.R. China, School of Basic Medical Sciences, Guangxi Medical University, Nanning, Guangxi 530000, P.R. China, Life Science Institute, Guangxi Medical University, Nanning, Guangxi 530000, P.R. China, Laboratory of Clinical Medicine, The Affiliated Hospital of Youjiang Medical University for Nationalities, Baise, Guangxi 533000, P.R. China, School of Pharmacy, Tianjin Medical University, Tianjin 300070, P.R. China, Institute of Biomedical Research, Yunnan University, Kunming, Yunnan 650500, P.R. China
    Copyright: © Ren et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 472
    |
    Published online on: September 20, 2023
       https://doi.org/10.3892/ol.2023.14058
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Abstract

Numerous agents such as near‑infrared dyes that are characterized by specialized cancer imaging and cytotoxicity effects have key roles in cancer diagnosis and therapy via molecularly targeting special biological tissues, organelles and processes. In the present study, a novel fluorescent compound was demonstrated to inhibit cancer cell proliferation in a zebrafish model with slight in vivo toxicity. Further studies demonstrated selective staining of cancer cells and even putative cancer stem cells via accumulation of the dye in the mitochondria of cancer cells, compared with normal cells. Moreover, this compound was also used to image cancer cells in vivo using a zebrafish model. The compound displayed no apparent toxicity to the host animal. Overall, the data indicated that this compound was worthy of further evaluation due to its low toxicity and selective cancer cell imaging and killing effects. It could be a useful tool in cancer research.
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Copy and paste a formatted citation
Spandidos Publications style
Ren T, Yang M, Zhang W, Qin L, Zhou S, Cheng N, Huang Y, Sun J, Xu N, Sun H, Sun H, et al: A novel fluorescent dye selectively images and kills cancer stem cells by targeting mitochondria: Evidence from a cell line‑based zebrafish xenograft model. Oncol Lett 26: 472, 2023.
APA
Ren, T., Yang, M., Zhang, W., Qin, L., Zhou, S., Cheng, N. ... Zhang, B. (2023). A novel fluorescent dye selectively images and kills cancer stem cells by targeting mitochondria: Evidence from a cell line‑based zebrafish xenograft model. Oncology Letters, 26, 472. https://doi.org/10.3892/ol.2023.14058
MLA
Ren, T., Yang, M., Zhang, W., Qin, L., Zhou, S., Cheng, N., Huang, Y., Sun, J., Xu, N., Sun, H., Zhang, B."A novel fluorescent dye selectively images and kills cancer stem cells by targeting mitochondria: Evidence from a cell line‑based zebrafish xenograft model". Oncology Letters 26.5 (2023): 472.
Chicago
Ren, T., Yang, M., Zhang, W., Qin, L., Zhou, S., Cheng, N., Huang, Y., Sun, J., Xu, N., Sun, H., Zhang, B."A novel fluorescent dye selectively images and kills cancer stem cells by targeting mitochondria: Evidence from a cell line‑based zebrafish xenograft model". Oncology Letters 26, no. 5 (2023): 472. https://doi.org/10.3892/ol.2023.14058
Copy and paste a formatted citation
x
Spandidos Publications style
Ren T, Yang M, Zhang W, Qin L, Zhou S, Cheng N, Huang Y, Sun J, Xu N, Sun H, Sun H, et al: A novel fluorescent dye selectively images and kills cancer stem cells by targeting mitochondria: Evidence from a cell line‑based zebrafish xenograft model. Oncol Lett 26: 472, 2023.
APA
Ren, T., Yang, M., Zhang, W., Qin, L., Zhou, S., Cheng, N. ... Zhang, B. (2023). A novel fluorescent dye selectively images and kills cancer stem cells by targeting mitochondria: Evidence from a cell line‑based zebrafish xenograft model. Oncology Letters, 26, 472. https://doi.org/10.3892/ol.2023.14058
MLA
Ren, T., Yang, M., Zhang, W., Qin, L., Zhou, S., Cheng, N., Huang, Y., Sun, J., Xu, N., Sun, H., Zhang, B."A novel fluorescent dye selectively images and kills cancer stem cells by targeting mitochondria: Evidence from a cell line‑based zebrafish xenograft model". Oncology Letters 26.5 (2023): 472.
Chicago
Ren, T., Yang, M., Zhang, W., Qin, L., Zhou, S., Cheng, N., Huang, Y., Sun, J., Xu, N., Sun, H., Zhang, B."A novel fluorescent dye selectively images and kills cancer stem cells by targeting mitochondria: Evidence from a cell line‑based zebrafish xenograft model". Oncology Letters 26, no. 5 (2023): 472. https://doi.org/10.3892/ol.2023.14058
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