Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Oncology Letters
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-1074 Online ISSN: 1792-1082
Journal Cover
November-2023 Volume 26 Issue 5

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
November-2023 Volume 26 Issue 5

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML

  • Supplementary Files
    • Supplementary_Data1.pdf
    • Supplementary_Data2.pdf
Article Open Access

RediScore: Prospective validation of a pipeline for homologous recombination deficiency analysis

  • Authors:
    • Aikaterini Tsantikidi
    • Konstantinos Papazisis
    • Theofanis Floros
    • Maria Gazouli
    • Eirini Papadopoulou
    • Georgios Tsaousis
    • Georgios Nasioulas
    • Andra Mester
    • Kubelac Paul Milan
    • Bogdan Gozman
    • Vlad Afrasanie
    • Dana Lucia Stanculeanu
    • Oana Trifanescu
    • Florentina Pescaru
    • Claudia Militaru
    • Christos Papadimitriou
  • View Affiliations / Copyright

    Affiliations: Genekor Medical S.A., Gerakas, 15344 Athens, Greece, Department of Oncology, Euromedica General Clinic, 54645 Thessaloniki, Greece, Department of Oncology, Athens Naval and Veterans Hospital, 11521 Athens, Greece, Department of Basic Medical Sciences National, Kapodistrian University of Athens, 11527 Athens, Greece, Oncological Institute, 400015 Cluj‑Napoca, Romania, Regional Institute of Oncology, 700483 Iasi, Romania, Bucharest Oncological Institute, 700483 Bucuresti, Romania, St. Constantine Hospital, 500091 Brasov, Romania, Medisprof Cluj‑Napoca, 400641 Cluj‑Napoca, Romania, Second Department of Surgery, Aretaieion Hospital, Medical School, National and Kapodistrian University of Athens, Athens 11528, Greece
    Copyright: © Tsantikidi et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 480
    |
    Published online on: September 22, 2023
       https://doi.org/10.3892/ol.2023.14060
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Tumors harboring homologous recombination deficiency (HRD) are considered optimal candidates for poly(ADP‑ribose) polymerase 1 (PARP) inhibitor treatment. Such deficiency can be detected by analyzing breast cancer type (BRCA)1/2 gene mutations, as well as mutations in other genes of the homologous recombination pathway. The algorithmic measurement of the HRD effect by identifying genomic instability (GI) has been used as biomarker. As compared with the direct measurement of somatic gene alterations, this approach increases the number of patients who could benefit from PARP inhibitor treatment. In the present study, the performance of the Oncoscan CNV assay, accompanied by appropriate bioinformatic algorithms, was evaluated for its performance in GI calculation and was compared with that of a validated next‑generation sequencing (NGS) test (myChoice HRD test). In addition, the clinical utility of the GI score (GIS) and BRCA1/2 tumor analysis were investigated in a cohort of 444 patients with ovarian cancer. For that reason, single nucleotide polymorphism (SNP) arrays and appropriate bioinformatics algorithms were used to calculate GIS in 29 patients with ovarian cancer with known GIS status using a validated NGS test. Furthermore, BRCA1/2 analysis results were compared between the aforementioned assay and the amplicon‑based Oncomine™ BRCA Research Assay. BRCA1/2 analysis was performed in 444 patients with ovarian cancer, while GIS was calculated in 175 BRCA1/2‑negative cases. The bioinformatics algorithm developed for GIS calculation in combination with NGS BRCA1/2 analysis (RediScore), and the OncoscanR pipeline exhibited a high overall agreement with the validated test (93.1%). In addition, the Oncomine NGS assay had a 100% agreement with the validated test. The BRCA1/2 mutation frequency was 26.5% in the examined patients with ovarian cancer. GIS was positive in 40% of the BRCA1/2‑negative cases. The RediScore bioinformatics algorithm developed for GIS calculation in combination with NGS BRCA1/2 analysis is a viable and effective approach for HRD calculation in patients with ovarian cancer, offering a positive prediction for PARP inhibitor responsiveness in 55% of the patients.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

Figure 6

View References

1 

Topatana W, Juengpanich S, Li S, Cao J, Hu J, Lee J, Suliyanto K, Ma D, Zhang B, Chen M and Cai X: Advances in synthetic lethality for cancer therapy: Cellular mechanism and clinical translation. J Hematol Oncol. 13:1182020. View Article : Google Scholar : PubMed/NCBI

2 

Swisher EM, Kwan TT, Oza AM, Tinker AV, Ray-Coquard I, Oaknin A, Coleman RL, Aghajanian C, Konecny GE, O'Malley DM, et al: Molecular and clinical determinants of response and resistance to rucaparib for recurrent ovarian cancer treatment in ARIEL2 (Parts 1 and 2). Nat Commun. 12:24872021. View Article : Google Scholar : PubMed/NCBI

3 

Konstantinopoulos PA, Ceccaldi R, Shapiro GI and D'Andrea AD: Homologous recombination deficiency: Exploiting the fundamental vulnerability of ovarian cancer. Cancer Discov. 5:1137–1154. 2015. View Article : Google Scholar : PubMed/NCBI

4 

Pujade-Lauraine E, Brown J, Barnicle A, Wessen J, Lao-Sirieix P, Criscione SW, du Bois A, Lorusso D, Romero I, Petru E, et al: Homologous recombination repair gene mutations to predict olaparib plus bevacizumab efficacy in the first-line ovarian cancer PAOLA-1/ENGOT-ov25 trial. JCO Precis Oncol. 7:e22002582023. View Article : Google Scholar : PubMed/NCBI

5 

Miller RE, Leary A, Scott CL, Serra V, Lord CJ, Bowtell D, Chang DK, Garsed DW, Jonkers J, Ledermann JA, et al: ESMO recommendations on predictive biomarker testing for homologous recombination deficiency and PARP inhibitor benefit in ovarian cancer. Ann Oncol. 31:1606–1622. 2020. View Article : Google Scholar : PubMed/NCBI

6 

Ray-Coquard I, Pautier P, Pignata S, Pérol D, González-Martín A, Berger R, Fujiwara K, Vergote I, Colombo N, Mäenpää J, et al: Olaparib plus bevacizumab as first-line maintenance in ovarian cancer. N Engl J Med. 381:2416–2428. 2019. View Article : Google Scholar : PubMed/NCBI

7 

Stewart MD, Merino Vega D, Arend RC, Baden JF, Barbash O, Beaubier N, Collins G, French T, Ghahramani N, Hinson P, et al: Homologous recombination deficiency: Concepts, definitions, and assays. Oncologist. 27:167–174. 2022. View Article : Google Scholar : PubMed/NCBI

8 

O'Sullivan Coyne G, Karlovich C, Wilsker D, Voth AR, Parchment RE, Chen AP and Doroshow JH: PARP inhibitor applicability: Detailed assays for homologous recombination repair pathway components. Onco Targets Ther. 15:165–180. 2022. View Article : Google Scholar : PubMed/NCBI

9 

Cristescu R, Liu XQ, Arreaza G, Chen C, Albright A, Qiu P and Marton MJ: Concordance between single-nucleotide polymorphism-based genomic instability assays and a next-generation sequencing-based homologous recombination deficiency test. BMC Cancer. 22:13102022. View Article : Google Scholar : PubMed/NCBI

10 

Ngoi NYL and Tan DSP: The role of homologous recombination deficiency testing in ovarian cancer and its clinical implications: do we need it? ESMO Open. 6:1001442021. View Article : Google Scholar : PubMed/NCBI

11 

Foster JM, Oumie A, Togneri FS, Vasques FR, Hau D, Taylor M, Tinkler-Hundal E, Southward K, Medlow P, McGreeghan-Crosby K, et al: Cross-laboratory validation of the OncoScan® FFPE assay, a multiplex tool for whole genome tumour profiling. BMC Med Genomics. 8:52015. View Article : Google Scholar : PubMed/NCBI

12 

Rowe LR, Thaker HM, Opitz JM, Schiffman JD, Haddadin ZM, Erickson LK and South ST: Molecular inversion probe array for the genetic evaluation of stillbirth using formalin-fixed, paraffin-embedded tissue. J Mol Diagn. 15:466–472. 2013. View Article : Google Scholar : PubMed/NCBI

13 

Wang Y, Moorhead M, Karlin-Neumann G, Falkowski M, Chen C, Siddiqui F, Davis RW, Willis TD and Faham M: Allele quantification using molecular inversion probes (MIP). Nucleic Acids Res. 33:e1832005. View Article : Google Scholar : PubMed/NCBI

14 

Ross EM, Haase K, Van Loo P and Markowetz F: Allele-specific multi-sample copy number segmentation in ASCAT. Bioinformatics. 37:1909–1911. 2021. View Article : Google Scholar : PubMed/NCBI

15 

Van Loo P, Nordgard SH, Lingjærde OC, Russnes HG, Rye IH, Sun W, Weigman VJ, Marynen P, Zetterberg A, Naume B, et al: Allele-specific copy number analysis of tumors. Proc Natl Acad Sci USA. 107:16910–16915. 2010. View Article : Google Scholar : PubMed/NCBI

16 

Imanishi S, Naoi Y, Shimazu K, Shimoda M, Kagara N, Tanei T, Miyake T, Kim SJ and Noguchi S: Clinicopathological analysis of homologous recombination-deficient breast cancers with special reference to response to neoadjuvant paclitaxel followed by FEC. Breast Cancer Res Trea. 174:627–637. 2019. View Article : Google Scholar : PubMed/NCBI

17 

Abkevich V, Timms KM, Hennessy BT, Potter J, Carey MS, Meyer LA, Smith-McCune K, Broaddus R, Lu KH, Chen J, et al: Patterns of genomic loss of heterozygosity predict homologous recombination repair defects in epithelial ovarian cancer. Br J Cancer. 107:1776–1782. 2012. View Article : Google Scholar : PubMed/NCBI

18 

Birkbak NJ, Wang ZC, Kim JY, Eklund AC, Li Q, Tian R, Bowman-Colin C, Li Y, Greene-Colozzi A, Iglehart JD, et al: Telomeric allelic imbalance indicates defective DNA repair and sensitivity to DNA-damaging agents. Cancer Discov. 2:366–375. 2012. View Article : Google Scholar : PubMed/NCBI

19 

Popova T, Manié E, Rieunier G, Caux-Moncoutier V, Tirapo C, Dubois T, Delattre O, Sigal-Zafrani B, Bollet M, Longy M, et al: Ploidy and large-scale genomic instability consistently identify basal-like breast carcinomas with BRCA1/2 inactivation. Cancer Res. 72:5454–5462. 2012. View Article : Google Scholar : PubMed/NCBI

20 

Timms KM, Abkevich V, Hughes E, Neff C, Reid J, Morris B, Kalva S, Potter J, Tran TV, Chen J, et al: Association of BRCA1/2 defects with genomic scores predictive of DNA damage repair deficiency among breast cancer subtypes. Breast Cancer Res. 16:4752014. View Article : Google Scholar : PubMed/NCBI

21 

Popova T, Manié E and Stern MH: Genomic signature of homologous recombination deficiency in breast and ovarian cancers. Bio-Protocol. 3:2013. View Article : Google Scholar

22 

Christinat Y, Ho L, Clément S, Genestie C, Sehouli J, Gonzalez Martin A, Denison U, Fujiwara K, Vergote I, Tognon G, et al: Normalized LST is an efficient biomarker for homologous recombination deficiency and Olaparib response in ovarian carcinoma. medRxiv. 2022.08.22.22278669. 2022.

23 

Wiggans AJ, Cass GKS, Bryant A, Lawrie TA and Morrison J: Poly(ADP-ribose) polymerase (PARP) inhibitors for the treatment of ovarian cancer. Cochrane Database Syst Rev. 2015:CD0079292015.PubMed/NCBI

24 

Konecny GE and Kristeleit RS: PARP inhibitors for BRCA1/2-mutated and sporadic ovarian cancer: Current practice and future directions. Br J Cancer. 115:1157–1173. 2016. View Article : Google Scholar : PubMed/NCBI

25 

Sabatier R, Rousseau F, Joly F, Cropet C, Montégut C, Frindte J, Cinieri S, Guerra Alía EM, Polterauer S, Yoshida H, et al: Efficacy and safety of maintenance olaparib and bevacizumab in ovarian cancer patients aged ≥65 years from the PAOLA-1/ENGOT-ov25 trial. Eur J Cancer. 181:42–52. 2023. View Article : Google Scholar : PubMed/NCBI

26 

Labidi-Galy SI, Rodrigues M, Sandoval JL, Kurtz JE, Heitz F, Mosconi AM, Romero I, Denison U, Nagao S, Vergote I, et al: Association of location of BRCA1 and BRCA2 mutations with benefit from olaparib and bevacizumab maintenance in high-grade ovarian cancer: Phase III PAOLA-1/ENGOT-ov25 trial subgroup exploratory analysis. Ann Oncol. 34:152–162. 2023. View Article : Google Scholar : PubMed/NCBI

27 

Telli ML, Timms KM, Reid J, Hennessy B, Mills GB, Jensen KC, Szallasi Z, Barry WT, Winer EP, Tung NM, et al: Homologous recombination deficiency (HRD) score predicts response to platinum-containing neoadjuvant chemotherapy in patients with triple-negative breast cancer. Clin Cancer Re. 22:3764–3773. 2016. View Article : Google Scholar : PubMed/NCBI

28 

Doig KD, Fellowes AP and Fox SB: Homologous recombination repair deficiency: An overview for pathologists. Mod Pathol. 36:1000492023. View Article : Google Scholar : PubMed/NCBI

29 

Fumagalli C, Betella I, Ranghiero A, Guerini-Rocco E, Bonaldo G, Rappa A, Vacirca D, Colombo N and Barberis M: In-house testing for homologous recombination repair deficiency (HRD) testing in ovarian carcinoma: A feasibility study comparing AmoyDx HRD focus panel with myriad myChoiceCDx assay. Pathologica. 114:288–294. 2022. View Article : Google Scholar : PubMed/NCBI

30 

Stronach EA, Paul J, Timms KM, Hughes E, Brown K, Neff C, Perry M, Gutin A, El-Bahrawy M, Steel JH, et al: Biomarker assessment of HR deficiency, tumor BRCA1/2 mutations, and CCNE1 copy number in ovarian cancer: Associations with clinical outcome following platinum monotherapy. Mol Cancer Res. 16:1103–1111. 2018. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Tsantikidi A, Papazisis K, Floros T, Gazouli M, Papadopoulou E, Tsaousis G, Nasioulas G, Mester A, Milan KP, Gozman B, Gozman B, et al: RediScore: Prospective validation of a pipeline for homologous recombination deficiency analysis. Oncol Lett 26: 480, 2023.
APA
Tsantikidi, A., Papazisis, K., Floros, T., Gazouli, M., Papadopoulou, E., Tsaousis, G. ... Papadimitriou, C. (2023). RediScore: Prospective validation of a pipeline for homologous recombination deficiency analysis. Oncology Letters, 26, 480. https://doi.org/10.3892/ol.2023.14060
MLA
Tsantikidi, A., Papazisis, K., Floros, T., Gazouli, M., Papadopoulou, E., Tsaousis, G., Nasioulas, G., Mester, A., Milan, K. P., Gozman, B., Afrasanie, V., Stanculeanu, D. L., Trifanescu, O., Pescaru, F., Militaru, C., Papadimitriou, C."RediScore: Prospective validation of a pipeline for homologous recombination deficiency analysis". Oncology Letters 26.5 (2023): 480.
Chicago
Tsantikidi, A., Papazisis, K., Floros, T., Gazouli, M., Papadopoulou, E., Tsaousis, G., Nasioulas, G., Mester, A., Milan, K. P., Gozman, B., Afrasanie, V., Stanculeanu, D. L., Trifanescu, O., Pescaru, F., Militaru, C., Papadimitriou, C."RediScore: Prospective validation of a pipeline for homologous recombination deficiency analysis". Oncology Letters 26, no. 5 (2023): 480. https://doi.org/10.3892/ol.2023.14060
Copy and paste a formatted citation
x
Spandidos Publications style
Tsantikidi A, Papazisis K, Floros T, Gazouli M, Papadopoulou E, Tsaousis G, Nasioulas G, Mester A, Milan KP, Gozman B, Gozman B, et al: RediScore: Prospective validation of a pipeline for homologous recombination deficiency analysis. Oncol Lett 26: 480, 2023.
APA
Tsantikidi, A., Papazisis, K., Floros, T., Gazouli, M., Papadopoulou, E., Tsaousis, G. ... Papadimitriou, C. (2023). RediScore: Prospective validation of a pipeline for homologous recombination deficiency analysis. Oncology Letters, 26, 480. https://doi.org/10.3892/ol.2023.14060
MLA
Tsantikidi, A., Papazisis, K., Floros, T., Gazouli, M., Papadopoulou, E., Tsaousis, G., Nasioulas, G., Mester, A., Milan, K. P., Gozman, B., Afrasanie, V., Stanculeanu, D. L., Trifanescu, O., Pescaru, F., Militaru, C., Papadimitriou, C."RediScore: Prospective validation of a pipeline for homologous recombination deficiency analysis". Oncology Letters 26.5 (2023): 480.
Chicago
Tsantikidi, A., Papazisis, K., Floros, T., Gazouli, M., Papadopoulou, E., Tsaousis, G., Nasioulas, G., Mester, A., Milan, K. P., Gozman, B., Afrasanie, V., Stanculeanu, D. L., Trifanescu, O., Pescaru, F., Militaru, C., Papadimitriou, C."RediScore: Prospective validation of a pipeline for homologous recombination deficiency analysis". Oncology Letters 26, no. 5 (2023): 480. https://doi.org/10.3892/ol.2023.14060
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team