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Article Open Access

Eukaryotic translation initiation factor 2α kinase 2 in pancreatic cancer: An approach towards managing clinical prognosis and molecular immunological characterization

  • Authors:
    • Hao-Xuan Du
    • Hu Wang
    • Xiao-Peng Ma
    • Hao Chen
    • Ai-Bin Dai
    • Ke-Xiang Zhu
  • View Affiliations / Copyright

    Affiliations: The First Clinical Medical College, Lanzhou University, Lanzhou, Gansu 730000, P.R. China
    Copyright: © Du et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 478
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    Published online on: September 21, 2023
       https://doi.org/10.3892/ol.2023.14066
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Abstract

Most patients with pancreatic cancer are already in the late stages of the disease when they are diagnosed, and pancreatic cancer is a deadly disease with a poor prognosis. With the advancement of research, immunotherapy has become a new focus in the treatment of tumors. To the best of our knowledge, there is currently no reliable diagnostic or prognostic marker for pancreatic cancer; therefore, the present study investigated the potential of eukaryotic translation initiation factor 2α kinase 2 (EIF2AK2) as a predictive and diagnostic marker for pancreatic cancer. Immunohistochemical staining of clinical samples independently verified that EIF2AK2 expression was significantly higher in clinically operated pancreatic cancer tissues than in adjacent pancreatic tissues., and EIF2AK2 expression and differentially expressed genes (DEGs) were identified using downloadable RNA sequencing data from The Cancer Genome Atlas and Genomic Tumor Expression Atlas. In addition, Gene Ontology/Kyoto Encyclopedia of Genes and Genomes analyses and immune cell infiltration were used for functional enrichment analysis of EIF2AK2‑associated DEGs. The clinical importance of EIF2AK2 was also determined using Kaplan‑Meier survival, Cox regression and time‑dependent survival receiver operating characteristic curve analyses, and a predictive nomogram model was generated. Finally, the functional role of EIF2AK2 was assessed in PANC‑1 cells using a short hairpin RNA‑EIF2AK2 knockdown approach, including CCK‑8, wound healing assay, cell cycle and apoptosis assays. The findings suggested that EIF2AK2 may have potential as a diagnostic and prognostic biomarker for patients with pancreatic cancer. Furthermore, EIF2AK2 may provide a new therapeutic target for patients with pancreatic cancer.
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Copy and paste a formatted citation
Spandidos Publications style
Du H, Wang H, Ma X, Chen H, Dai A and Zhu K: Eukaryotic translation initiation factor 2α kinase 2 in pancreatic cancer: An approach towards managing clinical prognosis and molecular immunological characterization. Oncol Lett 26: 478, 2023.
APA
Du, H., Wang, H., Ma, X., Chen, H., Dai, A., & Zhu, K. (2023). Eukaryotic translation initiation factor 2α kinase 2 in pancreatic cancer: An approach towards managing clinical prognosis and molecular immunological characterization. Oncology Letters, 26, 478. https://doi.org/10.3892/ol.2023.14066
MLA
Du, H., Wang, H., Ma, X., Chen, H., Dai, A., Zhu, K."Eukaryotic translation initiation factor 2α kinase 2 in pancreatic cancer: An approach towards managing clinical prognosis and molecular immunological characterization". Oncology Letters 26.5 (2023): 478.
Chicago
Du, H., Wang, H., Ma, X., Chen, H., Dai, A., Zhu, K."Eukaryotic translation initiation factor 2α kinase 2 in pancreatic cancer: An approach towards managing clinical prognosis and molecular immunological characterization". Oncology Letters 26, no. 5 (2023): 478. https://doi.org/10.3892/ol.2023.14066
Copy and paste a formatted citation
x
Spandidos Publications style
Du H, Wang H, Ma X, Chen H, Dai A and Zhu K: Eukaryotic translation initiation factor 2α kinase 2 in pancreatic cancer: An approach towards managing clinical prognosis and molecular immunological characterization. Oncol Lett 26: 478, 2023.
APA
Du, H., Wang, H., Ma, X., Chen, H., Dai, A., & Zhu, K. (2023). Eukaryotic translation initiation factor 2α kinase 2 in pancreatic cancer: An approach towards managing clinical prognosis and molecular immunological characterization. Oncology Letters, 26, 478. https://doi.org/10.3892/ol.2023.14066
MLA
Du, H., Wang, H., Ma, X., Chen, H., Dai, A., Zhu, K."Eukaryotic translation initiation factor 2α kinase 2 in pancreatic cancer: An approach towards managing clinical prognosis and molecular immunological characterization". Oncology Letters 26.5 (2023): 478.
Chicago
Du, H., Wang, H., Ma, X., Chen, H., Dai, A., Zhu, K."Eukaryotic translation initiation factor 2α kinase 2 in pancreatic cancer: An approach towards managing clinical prognosis and molecular immunological characterization". Oncology Letters 26, no. 5 (2023): 478. https://doi.org/10.3892/ol.2023.14066
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