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Association between serum lactate dehydrogenase and lymph node metastasis in cervical cancer

  • Authors:
    • Qiuyuan Huang
    • Suyu Li
    • Xiaoying Chen
    • Chenqiang He
    • Youlin Chen
    • Yangbi Huang
    • Yiqun Liu
    • Yanglin Wang
    • Xiangqin Zheng
  • View Affiliations / Copyright

    Affiliations: Department of Radiation Oncology, Fujian Maternity and Child Health Hospital, College of Clinical Medicine for Obstetrics and Gynecology and Pediatrics, Fujian Medical University, Fuzhou, Fujian 350001, P.R. China, Department of Gynecology, Fujian Maternity and Child Health Hospital, College of Clinical Medicine for Obstetrics and Gynecology and Pediatrics, Fujian Medical University, Fuzhou, Fujian 350001, P.R. China, The Social Public Relations Sector, Fujian Province Blood Center, Fuzhou, Fujian 350001, P.R. China
    Copyright: © Huang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 482
    |
    Published online on: September 25, 2023
       https://doi.org/10.3892/ol.2023.14069
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Abstract

The aim of the present study was to evaluate the association between serum lactate dehydrogenase (LDH) and the risk of lymph node metastasis (LNM) in the International Federation of Gynecology and Obstetrics (FIGO) 2009 cervical cancer (CC) stages IB1‑IIA2. All patient medical records with FIGO 2009 stage IB1‑IIA2 CC between January 2012 and January 2022 were analyzed retrospectively. The association between serum LDH and LNM was assessed using uni‑ and multivariate logistic regression analyses, subgroup analyses and P‑splines. The present study included 586 patients, 91 (15.5%) of whom had LNM. Patients with an elevated LDH level were more likely to have a deep stromal invasion, lymph‑vascular space invasion, LNM and to be of an older age. Multivariate logistic regression revealed a significant association between LNM and LDH levels. After adjusting for age, FIGO stage, tumor markers and risk factors according to the Sedlis criteria, patients in the highest LDH quartile had an increased risk of LNM compared with those in the lowest LDH quartile (odds ratio, 3.5; 95% CI, 1.57‑7.81). Furthermore, P‑spline regression revealed a dependence of LNM on LDH. The predictive value of LDH level remained significant in the subgroup analysis. The present study suggested that a higher LDH level was independently associated with CC and LNM, and that LDH level may serve as a potential tumor marker and treatment‑related indicator.
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View References

1 

Sung H, Ferlay J, Siegel RL, Laversanne M, Soerjomataram I, Jemal A and Bray F: Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 71:209–249. 2021. View Article : Google Scholar : PubMed/NCBI

2 

Koh W, Abu-Rustum N, Bean S, Bradley K, Campos SM, Cho KR, Chon HS, Chu C, Clark R, Cohn D, et al: Cervical cancer, version 3.2019, NCCN clinical practice guidelines in oncology. J Natl Compr Canc Netw. 17:64–84. 2019. View Article : Google Scholar : PubMed/NCBI

3 

Sedlis A, Bundy BN, Rotman MZ, Lentz SS, Muderspach LI and Zaino RJ: A randomized trial of pelvic radiation therapy versus no further therapy in selected patients with stage IB carcinoma of the cervix after radical hysterectomy and pelvic lymphadenectomy: A gynecologic oncology group study. Gynecol Oncol. 73:177–183. 1999. View Article : Google Scholar : PubMed/NCBI

4 

Chao B, Ju X, Zhang L, Xu X and Zhao Y: A novel prognostic marker systemic inflammation response index (SIRI) for operable cervical cancer patients. Front Oncol. 10:7662020. View Article : Google Scholar : PubMed/NCBI

5 

Deng Q, Long Q, Liu Y, Yang Z, Du Y and Chen X: Prognostic value of preoperative peripheral blood mean platelet volume/platelet count ratio (MPV/PC) in patients with resectable cervical cancer. BMC Cancer. 21:12822021. View Article : Google Scholar : PubMed/NCBI

6 

Jiang P, Kong W, Gong C, Chen Y, Li F, Xu L, Yang Y, Gou S and Hu Z: Predicting the recurrence of operable cervical cancer patients based on hemoglobin, albumin, lymphocyte, and platelet (HALP) score and classical clinicopathological parameters. J Inflamm Res. 15:5265–5281. 2022. View Article : Google Scholar : PubMed/NCBI

7 

Markert C: Lactate dehydrogenase isozymes: Dissociation and recombination of subunits. Science. 140:1329–1330. 1963. View Article : Google Scholar : PubMed/NCBI

8 

Passardi A, Scarpi E, Tamberi S, Cavanna L, Tassinari D, Fontana A, Pini S, Bernardini I, Accettura C, Ulivi P, et al: Impact of pre-treatment lactate dehydrogenase levels on prognosis and bevacizumab efficacy in patients with metastatic colorectal cancer. PLoS One. 10:e01347322015. View Article : Google Scholar : PubMed/NCBI

9 

Valvona CJ, Fillmore HL, Nunn PB and Pilkington GJ: The regulation and function of lactate dehydrogenase A: Therapeutic potential in brain tumor. Brain Pathol. 26:3–17. 2016. View Article : Google Scholar : PubMed/NCBI

10 

Koch A, Fohlin H and Sörenson S: Prognostic significance of C-reactive protein and smoking in patients with advanced non-small cell lung cancer treated with first-line palliative chemotherapy. J Thorac Oncol. 4:326–332. 2009. View Article : Google Scholar : PubMed/NCBI

11 

Kim CH, Oh HG, Lee SY, Lim JK, Lee YH, Seo H, Yoo SS, Lee SY, Cha SI, Park JY and Lee J: Differential diagnosis between lymphoma-associated malignant pleural effusion and tuberculous pleural effusion. Ann Transl Med. 7:3732019. View Article : Google Scholar : PubMed/NCBI

12 

Li J, Wu MF, Lu HW, Chen Q, Lin ZQ and Wang LJ: Pretreatment serum lactate dehydrogenase is an independent prognostic factor for patients receiving neoadjuvant chemotherapy for locally advanced cervical cancer. Cancer Med. 5:1863–1872. 2016. View Article : Google Scholar : PubMed/NCBI

13 

Wang H, Wang MS, Zhou YH, Shi JP and Wang WJ: Prognostic values of LDH and CRP in cervical cancer. Onco Targets Ther. 13:1255–1263. 2020. View Article : Google Scholar : PubMed/NCBI

14 

Ye Y, Chen M, Chen X, Xiao J, Liao L and Lin F: Clinical significance and prognostic value of lactate dehydrogenase expression in cervical cancer. Genet Test Mol Biomarkers. 26:107–117. 2022. View Article : Google Scholar : PubMed/NCBI

15 

Tholen DW, Musiolkroll EM, Kroll M, Astles JR, Caffo AL, Happe TM and Lasky F: Evaluation of the linearity of quantitative measurement procedures: A statistical approach; approved guideline. Clinical and Laboratory Standards Institute; 2003

16 

Tholen DW, Linnet K, Kondratovich M, Armbruster DA, Garrett PE, Jones RL, Kroll MH, Lequin RM, Pankratz TJ, Scassellati GA, et al: Protocols for determination of limits of detection and limits of quantitation; approved guidelines. Clinical and Laboratory Standards Institute; 2004

17 

White IR, Royston P and Wood AM: Multiple imputation using chained equations: Issues and guidance for practice. Stat Med. 30:377–399. 2011. View Article : Google Scholar : PubMed/NCBI

18 

Meira-Machado L, Cadarso-Suárez C, Gude F and Araújo A: smoothHR: An R package for pointwise nonparametric estimation of hazard ratio curves of continuous predictors. Comput Math Methods Med. 2013:7457422013. View Article : Google Scholar : PubMed/NCBI

19 

Yang Y, Cao JZ, Lan SM, Wu JX, Wu T, Zhu SY, Qian LT, Hou XR, Zhang FQ, Zhang YJ, et al: Association of improved locoregional control with prolonged survival in early-stage extranodal nasal-type natural killer/T-cell lymphoma. JAMA Oncol. 3:83–91. 2017. View Article : Google Scholar : PubMed/NCBI

20 

Koukourakis M, Kontomanolis E, Giatromanolaki A, Sivridis E and Liberis V: Serum and tissue LDH levels in patients with breast/gynaecological cancer and benign diseases. Gynecol Obstet Invest. 67:162–168. 2009. View Article : Google Scholar : PubMed/NCBI

21 

Burgner JW II and Ray WJ Jr: On the origin of the lactate dehydrogenase induced rate effect. Biochemistry. 23:3636–3648. 1984. View Article : Google Scholar : PubMed/NCBI

22 

Harris A: Hypoxia-a key regulator factor in tumor growth. Nat Rev Cancer. 2:38–47. 2002. View Article : Google Scholar : PubMed/NCBI

23 

Zhu S, Zhou HY, Deng SC, Deng SJ, He C, Li X, Chen JY, Jin Y, Hu ZL, Wang F, et al: ASIC1 and ASIC3 contribute to acidity-induced EMT of pancreatic cancer through activating Ca2+/RhoA pathway. Cell Death Dis. 8:e28062017. View Article : Google Scholar : PubMed/NCBI

24 

Giatromanolaki A, Sivridis E, Gatter K, Turley H, Harris A, Koukourakis M and Tumour; Angiogenesis Research Group, : Lactate dehydrogenase 5 (LDH-5) expression in endometrial cancer relates to the activated VEGF/VEGFR2(KDR) pathway and prognosis. Gynecol Oncol. 103:912–918. 2006. View Article : Google Scholar : PubMed/NCBI

25 

Scartozzi M, Giampieri R, Maccaroni E, Del Prete M, Faloppi L, Bianconi M, Galizia E, Loretelli C, Belvederesi L, Bittoni A and Cascinu S: Pre-treatment lactate dehydrogenase levels as predictor of efficacy of first-line bevacizumab-based therapy in metastatic colorectal cancer patients. Br J Cancer. 106:799–804. 2012. View Article : Google Scholar : PubMed/NCBI

26 

Tewari KS, Sill MW, Long HJ III, Penson RT, Huang H, Ramondetta LM, Landrum LM, Oaknin A, Reid TJ, Leitao MM, et al: Improved survival with bevacizumab in advanced cervical cancer. N Engl J Med. 370:734–743. 2014. View Article : Google Scholar : PubMed/NCBI

27 

Li Y, Liao X and Ma L: ERCC1 is a potential biomarker for predicting prognosis, immunotherapy, chemotherapy efficacy, and expression validation in HER2 over-expressing breast cancer. Front Oncol. 12:9557192022. View Article : Google Scholar : PubMed/NCBI

28 

Doherty JR and Cleveland JL: Targeting lactate metabolism for cancer therapeutics. J Clin Invest. 123:3685–3692. 2013. View Article : Google Scholar : PubMed/NCBI

29 

Hummitzsch L, Zitta K, Rusch R, Cremer J, Steinfath M, Gross J, Fandrich F, Berndt R and Albrecht M: Characterization of the angiogenic potential of human regulatory macrophages (Mreg) after ischemia/reperfusion injury in vitro. Stem Cells Int. 2019:37258632019. View Article : Google Scholar : PubMed/NCBI

30 

Zhang J, Yao YH, Li BG, Yang Q, Zhang PY and Wang HT: Prognostic value of pretreatment serum lactate dehydrogenase level in patients with solid tumors: A systematic review and meta-analysis. Sci Rep. 5:98002015. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Huang Q, Li S, Chen X, He C, Chen Y, Huang Y, Liu Y, Wang Y and Zheng X: Association between serum lactate dehydrogenase and lymph node metastasis in cervical cancer. Oncol Lett 26: 482, 2023.
APA
Huang, Q., Li, S., Chen, X., He, C., Chen, Y., Huang, Y. ... Zheng, X. (2023). Association between serum lactate dehydrogenase and lymph node metastasis in cervical cancer. Oncology Letters, 26, 482. https://doi.org/10.3892/ol.2023.14069
MLA
Huang, Q., Li, S., Chen, X., He, C., Chen, Y., Huang, Y., Liu, Y., Wang, Y., Zheng, X."Association between serum lactate dehydrogenase and lymph node metastasis in cervical cancer". Oncology Letters 26.5 (2023): 482.
Chicago
Huang, Q., Li, S., Chen, X., He, C., Chen, Y., Huang, Y., Liu, Y., Wang, Y., Zheng, X."Association between serum lactate dehydrogenase and lymph node metastasis in cervical cancer". Oncology Letters 26, no. 5 (2023): 482. https://doi.org/10.3892/ol.2023.14069
Copy and paste a formatted citation
x
Spandidos Publications style
Huang Q, Li S, Chen X, He C, Chen Y, Huang Y, Liu Y, Wang Y and Zheng X: Association between serum lactate dehydrogenase and lymph node metastasis in cervical cancer. Oncol Lett 26: 482, 2023.
APA
Huang, Q., Li, S., Chen, X., He, C., Chen, Y., Huang, Y. ... Zheng, X. (2023). Association between serum lactate dehydrogenase and lymph node metastasis in cervical cancer. Oncology Letters, 26, 482. https://doi.org/10.3892/ol.2023.14069
MLA
Huang, Q., Li, S., Chen, X., He, C., Chen, Y., Huang, Y., Liu, Y., Wang, Y., Zheng, X."Association between serum lactate dehydrogenase and lymph node metastasis in cervical cancer". Oncology Letters 26.5 (2023): 482.
Chicago
Huang, Q., Li, S., Chen, X., He, C., Chen, Y., Huang, Y., Liu, Y., Wang, Y., Zheng, X."Association between serum lactate dehydrogenase and lymph node metastasis in cervical cancer". Oncology Letters 26, no. 5 (2023): 482. https://doi.org/10.3892/ol.2023.14069
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