Open Access

Association between serum lactate dehydrogenase and lymph node metastasis in cervical cancer

  • Authors:
    • Qiuyuan Huang
    • Suyu Li
    • Xiaoying Chen
    • Chenqiang He
    • Youlin Chen
    • Yangbi Huang
    • Yiqun Liu
    • Yanglin Wang
    • Xiangqin Zheng
  • View Affiliations

  • Published online on: September 25, 2023     https://doi.org/10.3892/ol.2023.14069
  • Article Number: 482
  • Copyright: © Huang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

The aim of the present study was to evaluate the association between serum lactate dehydrogenase (LDH) and the risk of lymph node metastasis (LNM) in the International Federation of Gynecology and Obstetrics (FIGO) 2009 cervical cancer (CC) stages IB1‑IIA2. All patient medical records with FIGO 2009 stage IB1‑IIA2 CC between January 2012 and January 2022 were analyzed retrospectively. The association between serum LDH and LNM was assessed using uni‑ and multivariate logistic regression analyses, subgroup analyses and P‑splines. The present study included 586 patients, 91 (15.5%) of whom had LNM. Patients with an elevated LDH level were more likely to have a deep stromal invasion, lymph‑vascular space invasion, LNM and to be of an older age. Multivariate logistic regression revealed a significant association between LNM and LDH levels. After adjusting for age, FIGO stage, tumor markers and risk factors according to the Sedlis criteria, patients in the highest LDH quartile had an increased risk of LNM compared with those in the lowest LDH quartile (odds ratio, 3.5; 95% CI, 1.57‑7.81). Furthermore, P‑spline regression revealed a dependence of LNM on LDH. The predictive value of LDH level remained significant in the subgroup analysis. The present study suggested that a higher LDH level was independently associated with CC and LNM, and that LDH level may serve as a potential tumor marker and treatment‑related indicator.
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November-2023
Volume 26 Issue 5

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Online ISSN:1792-1082

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Copy and paste a formatted citation
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Spandidos Publications style
Huang Q, Li S, Chen X, He C, Chen Y, Huang Y, Liu Y, Wang Y and Zheng X: Association between serum lactate dehydrogenase and lymph node metastasis in cervical cancer. Oncol Lett 26: 482, 2023
APA
Huang, Q., Li, S., Chen, X., He, C., Chen, Y., Huang, Y. ... Zheng, X. (2023). Association between serum lactate dehydrogenase and lymph node metastasis in cervical cancer. Oncology Letters, 26, 482. https://doi.org/10.3892/ol.2023.14069
MLA
Huang, Q., Li, S., Chen, X., He, C., Chen, Y., Huang, Y., Liu, Y., Wang, Y., Zheng, X."Association between serum lactate dehydrogenase and lymph node metastasis in cervical cancer". Oncology Letters 26.5 (2023): 482.
Chicago
Huang, Q., Li, S., Chen, X., He, C., Chen, Y., Huang, Y., Liu, Y., Wang, Y., Zheng, X."Association between serum lactate dehydrogenase and lymph node metastasis in cervical cancer". Oncology Letters 26, no. 5 (2023): 482. https://doi.org/10.3892/ol.2023.14069