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Case Report Open Access

Adaptive radiotherapy of locally advanced sigmoid colon cancer with intra‑fractional motion using the MRIdian system: A case report

  • Authors:
    • Chen-Han Chiang
    • Tzu-Yuan Chao
    • Ming-Yii Huang
  • View Affiliations / Copyright

    Affiliations: Department of Radiation Oncology, Kaohsiung Medical University Hospital, Kaohsiung 80756, Taiwan, R.O.C.
    Copyright: © Chiang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 487
    |
    Published online on: September 27, 2023
       https://doi.org/10.3892/ol.2023.14074
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Abstract

Neoadjuvant chemotherapy, when combined with radiotherapy, serves as an optional treatment for patients with locally advanced sigmoid colon cancer and is usually performed in conjunction with complete mesocolic excision. The substantial movement of surrounding organs in cases of sigmoid colon cancer frequently leads to toxicity in normal tissues. The present report details the case of a 76‑year‑old man diagnosed with locally advanced sigmoid colon cancer. Initially, treatment using the Tomotherapy Hi‑Art system was selected; however, during image guidance from the first to the sixth fractions, the tumor location underwent a marked change, exceeding the range of the planning target volume. Efforts to recapture the image were unsuccessful, leading to a decision to transition the patient to the MRIdian system for daily treatment with online adaptive radiotherapy. The positional variations in the tumor were evident in each treatment using the MRIdian system, with mean shifts of 2.58 cm in the right‑left direction, 1.24 cm in the cranial‑caudal direction and 0.40 cm in the anterior‑posterior direction. The mean time from the entry of the patient to treatment completion was 41 min. Adaptive treatment plans were performed for all 19 fractions, with two treatments repeated due to the tumor moving out of tracking range. Following irradiation using the MRIdian system, the gross tumor volume decreased by 62%. Notably, the patient experienced no side effects during treatment. A CT scan conducted 3 months after radiotherapy revealed a marked reduction in the tumor size, consistent with a partial response, leading to the scheduling of surgery. Following surgery, a CT scan after 6 months revealed no local recurrence in the surgical bed region. The findings in the present case support the feasibility of implementing an adaptive treatment plan using the MRIdian system for locally advanced sigmoid colon cancer in the context of neoadjuvant chemoradiotherapy.
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1 

Sung H, Ferlay J, Siegel RL, Laversanne M, Soerjomataram I, Jemal A and Bray F: Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 71:209–249. 2021. View Article : Google Scholar : PubMed/NCBI

2 

Krishnamurty DM, Hawkins AT, Wells KO, Mutch MG, Silviera ML, Glasgow SC, Hunt SR and Dharmarajan S: Neoadjuvant radiation therapy in locally advanced colon cancer: A cohort analysis. J Gastrointest Surg. 22:906–912. 2018. View Article : Google Scholar : PubMed/NCBI

3 

Hohenberger W, Weber K, Matzel K, Papadopoulos T and Merkel S: Standardized surgery for colonic cancer: Complete mesocolic excision and central ligation-technical notes and outcome. Colorectal Dis. 11:354–365. 2009. View Article : Google Scholar : PubMed/NCBI

4 

Gao Z, Wang C, Cui Y, Shen Z, Jiang K, Shen D, Wang Y, Zhan S, Guo P, Yang X, et al: Efficacy and safety of complete mesocolic excision in patients with colon cancer: Three-year results from a prospective, nonrandomized, double-blind, controlled trial. Ann Surg. 271:519–526. 2020. View Article : Google Scholar : PubMed/NCBI

5 

Buckley JG, Dowling JA, Sidhom M, Liney GP, Rai R, Metcalfe PE, Holloway LC and Keall PJ: Pelvic organ motion and dosimetric implications during horizontal patient rotation for prostate radiation therapy. Med Phys. 48:397–413. 2021. View Article : Google Scholar : PubMed/NCBI

6 

Mahantshetty U, Naga P, Nachankar A, Ghadi Y, Dheera A, Scaria L, Epili D, Chopra S, Lavanya G and Shrivastava S: Set-up errors, organ motion, tumour regression and its implications on internal target volume-planning target volume during cervical cancer radiotherapy: Results from a prospective study. Clin Oncol (R Coll Radiol). 34:189–197. 2022. View Article : Google Scholar : PubMed/NCBI

7 

Shortall J, Vasquez Osorio E, Cree A, Song Y, Dubec M, Chuter R, Price G, McWilliam A, Kirkby K, Mackay R and van Herk M: Inter- and intra-fractional stability of rectal gas in pelvic cancer patients during MRIgRT. Med Phys. 48:414–426. 2021. View Article : Google Scholar : PubMed/NCBI

8 

Benson AB III, Arnoletti JP, Bekaii-Saab T, Chan E, Chen YJ, Choti MA, Cooper HS, Dilawary RA, Engstrom PF, Enzinger PC, et al: Colon cancer. J Natl Compr Canc Netw. 9:1238–1290. 2011. View Article : Google Scholar : PubMed/NCBI

9 

Liney GP, Whelan B, Oborn B, Barton M and Keall P: MRI-linear accelerator radiotherapy systems. Clin Oncol (R Coll Radiol). 30:686–691. 2018. View Article : Google Scholar : PubMed/NCBI

10 

Avgousti R, Antypas C, Armpilia C, Simopoulou F, Liakouli Z, Karaiskos P, Kouloulias V, Kyrodimos E, Moulopoulos LA and Zygogianni A: Adaptive radiation therapy: When, how and what are the benefits that literature provides? Cancer Radiother. 26:622–636. 2022. View Article : Google Scholar : PubMed/NCBI

11 

Nierer L, Eze C, da Silva Mendes V, Braun J, Thum P, von Bestenbostel R, Kurz C, Landry G, Reiner M, Niyazi M, et al: Dosimetric benefit of MR-guided online adaptive radiotherapy in different tumor entities: Liver, lung, abdominal lymph nodes, pancreas and prostate. Radiat Oncol. 17:532022. View Article : Google Scholar : PubMed/NCBI

12 

Wen N, Cao Y and Cai J: Editorial: Magnetic resonance imaging for radiation therapy. Front Oncol. 10:4832020. View Article : Google Scholar : PubMed/NCBI

13 

Oken MM, Creech RH, Tormey DC, Horton J, Davis TE, McFadden ET and Carbone PP: Toxicity and response criteria of the eastern cooperative oncology group. Am J Clin Oncol. 5:649–656. 1982. View Article : Google Scholar : PubMed/NCBI

14 

Weiser MR: AJCC 8th edition: Colorectal cancer. Ann Surg Oncol. 25:1454–1455. 2018. View Article : Google Scholar : PubMed/NCBI

15 

Eisenhauer EA, Therasse P, Bogaerts J, Schwartz LH, Sargent D, Ford R, Dancy J, Arbuck S, Gwyher S, Mooney M, et al: New response evaluation criteria in solid tumours: Revised RECIST guideline (version 1.1). Eur J Cancer. 45:228–247. 2009. View Article : Google Scholar : PubMed/NCBI

16 

Tam SY and Wu VWC: A review on the special radiotherapy techniques of colorectal cancer. Front Oncol. 9:2082019. View Article : Google Scholar : PubMed/NCBI

17 

Sauer R, Fietkau R, Wittekind C, Rödel C, Martus P, Hohenberger W, Tschmelitsch J, Sabitzer H, Karstens JH, Becker H, et al: Adjuvant vs neoadjuvant radiochemotherapy for locally advanced rectal cancer: The German trial CAO/ARO/AIO-94. Colorectal Dis. 5:406–415. 2003. View Article : Google Scholar : PubMed/NCBI

18 

Intven MPW, de Mol van Otterloo SR, Mook S, Doornaert PAH, de Groot-van Breugel EN, Sikkes GG, Willemsen-Bosman ME, van Zijp HM and Tijssen RHN: Online adaptive MR-guided radiotherapy for rectal cancer; feasibility of the workflow on a 1.5T MR-linac: Clinical implementation and initial experience. Radiother Oncol. 154:172–178. 2021. View Article : Google Scholar : PubMed/NCBI

19 

de Jong R, Visser J, van Wieringen N, Wiersma J, Geijsen D and Bel A: Feasibility of Conebeam CT-based online adaptive radiotherapy for neoadjuvant treatment of rectal cancer. Radiat Oncol. 16:1362021. View Article : Google Scholar : PubMed/NCBI

20 

Klüter S: Technical design and concept of a 0.35 T MR-Linac. Clin Transl Radiat Oncol. 18:98–101. 2019.PubMed/NCBI

21 

Ozhasoglu C and Murphy MJ: Issues in respiratory motion compensation during external-beam radiotherapy. Int J Radiat Oncol Biol Phys. 52:1389–1399. 2002. View Article : Google Scholar : PubMed/NCBI

22 

Abbas H, Chang B and Chen ZJ: Motion management in gastrointestinal cancers. J Gastrointest Oncol. 5:223–235. 2014.PubMed/NCBI

23 

de Jong R, Visser J, Crama KF, van Wieringen N, Wiersma J, Geijsen ED and Bel A: Dosimetric benefit of an adaptive treatment by means of plan selection for rectal cancer patients in both short and long course radiation therapy. Radiat Oncol. 15:132020. View Article : Google Scholar : PubMed/NCBI

24 

Keall PJ, Mageras GS, Balter JM, Emery RS, Forster KM, Jiang SB, Kapatoes JM, Low DA, Murphy MJ, Murray BR, et al: The management of respiratory motion in radiation oncology report of AAPM Task Group 76. Med Phys. 33:3874–3900. 2006. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Chiang C, Chao T and Huang M: Adaptive radiotherapy of locally advanced sigmoid colon cancer with intra‑fractional motion using the MRIdian system: A case report. Oncol Lett 26: 487, 2023.
APA
Chiang, C., Chao, T., & Huang, M. (2023). Adaptive radiotherapy of locally advanced sigmoid colon cancer with intra‑fractional motion using the MRIdian system: A case report. Oncology Letters, 26, 487. https://doi.org/10.3892/ol.2023.14074
MLA
Chiang, C., Chao, T., Huang, M."Adaptive radiotherapy of locally advanced sigmoid colon cancer with intra‑fractional motion using the MRIdian system: A case report". Oncology Letters 26.5 (2023): 487.
Chicago
Chiang, C., Chao, T., Huang, M."Adaptive radiotherapy of locally advanced sigmoid colon cancer with intra‑fractional motion using the MRIdian system: A case report". Oncology Letters 26, no. 5 (2023): 487. https://doi.org/10.3892/ol.2023.14074
Copy and paste a formatted citation
x
Spandidos Publications style
Chiang C, Chao T and Huang M: Adaptive radiotherapy of locally advanced sigmoid colon cancer with intra‑fractional motion using the MRIdian system: A case report. Oncol Lett 26: 487, 2023.
APA
Chiang, C., Chao, T., & Huang, M. (2023). Adaptive radiotherapy of locally advanced sigmoid colon cancer with intra‑fractional motion using the MRIdian system: A case report. Oncology Letters, 26, 487. https://doi.org/10.3892/ol.2023.14074
MLA
Chiang, C., Chao, T., Huang, M."Adaptive radiotherapy of locally advanced sigmoid colon cancer with intra‑fractional motion using the MRIdian system: A case report". Oncology Letters 26.5 (2023): 487.
Chicago
Chiang, C., Chao, T., Huang, M."Adaptive radiotherapy of locally advanced sigmoid colon cancer with intra‑fractional motion using the MRIdian system: A case report". Oncology Letters 26, no. 5 (2023): 487. https://doi.org/10.3892/ol.2023.14074
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