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Case Report

Thyroid dysfunction induced by immune checkpoint inhibitors and tumor progression during neoadjuvant therapy of non‑small cell lung cancer: A case report and literature review

  • Authors:
    • Xinyi Li
    • Xun Wang
    • Shaodong Wang
    • Yanguo Liu
    • Ruilin Wang
    • Yi Liu
    • Lin Huang
    • Yufei Feng
    • Xiaohui Xie
    • Luwen Shi
  • View Affiliations / Copyright

    Affiliations: Department of Pharmacy Administration and Clinical Pharmacy, School of Pharmaceutical Sciences, Peking University, Beijing 100191, P.R. China, Department of Thoracic Surgery, Peking University People's Hospital, Beijing 100044, P.R. China, Department of Pharmacy, Peking University People's Hospital, Beijing 100044, P.R. China
  • Article Number: 496
    |
    Published online on: September 29, 2023
       https://doi.org/10.3892/ol.2023.14083
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Abstract

Immune checkpoint inhibitors (ICIs) have a demonstrable treatment response in patients with resectable non‑small cell lung cancer (NSCLC). However, immune‑related adverse events and tumor progression in patients administered ICIs are of great concern. The present case study is of a 59‑year‑old male with NSCLC (squamous, stage IIIA) who received neoadjuvant immunotherapy combined with chemotherapy before surgery. The patient first developed hyperthyroidism and then hypothyroidism, indicating that ICI‑related thyroid dysfunction had occurred. Furthermore, the patient suffered from tumor progression and could not undergo resection. The present case called attention to the prevention and management of irAEs, and the precaution that should be taken with regard to tumor progression. The case also suggested that the development of ICI‑related thyroid dysfunction may not predict an improved response to ICI therapies, which needs further evidence to illustrate.
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Copy and paste a formatted citation
Spandidos Publications style
Li X, Wang X, Wang S, Liu Y, Wang R, Liu Y, Huang L, Feng Y, Xie X, Shi L, Shi L, et al: Thyroid dysfunction induced by immune checkpoint inhibitors and tumor progression during neoadjuvant therapy of non‑small cell lung cancer: A case report and literature review. Oncol Lett 26: 496, 2023.
APA
Li, X., Wang, X., Wang, S., Liu, Y., Wang, R., Liu, Y. ... Shi, L. (2023). Thyroid dysfunction induced by immune checkpoint inhibitors and tumor progression during neoadjuvant therapy of non‑small cell lung cancer: A case report and literature review. Oncology Letters, 26, 496. https://doi.org/10.3892/ol.2023.14083
MLA
Li, X., Wang, X., Wang, S., Liu, Y., Wang, R., Liu, Y., Huang, L., Feng, Y., Xie, X., Shi, L."Thyroid dysfunction induced by immune checkpoint inhibitors and tumor progression during neoadjuvant therapy of non‑small cell lung cancer: A case report and literature review". Oncology Letters 26.5 (2023): 496.
Chicago
Li, X., Wang, X., Wang, S., Liu, Y., Wang, R., Liu, Y., Huang, L., Feng, Y., Xie, X., Shi, L."Thyroid dysfunction induced by immune checkpoint inhibitors and tumor progression during neoadjuvant therapy of non‑small cell lung cancer: A case report and literature review". Oncology Letters 26, no. 5 (2023): 496. https://doi.org/10.3892/ol.2023.14083
Copy and paste a formatted citation
x
Spandidos Publications style
Li X, Wang X, Wang S, Liu Y, Wang R, Liu Y, Huang L, Feng Y, Xie X, Shi L, Shi L, et al: Thyroid dysfunction induced by immune checkpoint inhibitors and tumor progression during neoadjuvant therapy of non‑small cell lung cancer: A case report and literature review. Oncol Lett 26: 496, 2023.
APA
Li, X., Wang, X., Wang, S., Liu, Y., Wang, R., Liu, Y. ... Shi, L. (2023). Thyroid dysfunction induced by immune checkpoint inhibitors and tumor progression during neoadjuvant therapy of non‑small cell lung cancer: A case report and literature review. Oncology Letters, 26, 496. https://doi.org/10.3892/ol.2023.14083
MLA
Li, X., Wang, X., Wang, S., Liu, Y., Wang, R., Liu, Y., Huang, L., Feng, Y., Xie, X., Shi, L."Thyroid dysfunction induced by immune checkpoint inhibitors and tumor progression during neoadjuvant therapy of non‑small cell lung cancer: A case report and literature review". Oncology Letters 26.5 (2023): 496.
Chicago
Li, X., Wang, X., Wang, S., Liu, Y., Wang, R., Liu, Y., Huang, L., Feng, Y., Xie, X., Shi, L."Thyroid dysfunction induced by immune checkpoint inhibitors and tumor progression during neoadjuvant therapy of non‑small cell lung cancer: A case report and literature review". Oncology Letters 26, no. 5 (2023): 496. https://doi.org/10.3892/ol.2023.14083
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