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Exploring the mechanism of resistance to vincristine in breast cancer cells using transcriptome sequencing technology

  • Authors:
    • Yao Chen
    • Lili Yang
    • Chao Wang
    • Changmiao Wang
  • View Affiliations / Copyright

    Affiliations: Department of General Surgery, The First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning 116011, P.R. China
    Copyright: © Chen et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 502
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    Published online on: October 5, 2023
       https://doi.org/10.3892/ol.2023.14089
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Abstract

Breast cancer has replaced lung cancer as the leading cancer globally, but various chemotherapy drugs for breast cancer are prone to resistance, especially in patients with distant metastases who are susceptible to multiple chemotherapy drug resistance often leading to treatment failure. Vincristine (VCR) is an alkaloid extracted from Catharanthus roseus, and is often used in combination with other chemotherapy drugs to treat various types of cancer, including breast cancer. Research on the development of resistance to VCR has been carried out using transcriptome sequencing technology. Firstly, gradient increase of VCR concentration was used to produce a VCR‑resistant breast cancer cell line. Mechanistically, RNA was extracted from the VCR‑resistant breast cancer cell line, and the transcriptome was sequenced. Further analysis showed changes in the expression levels of various genes in the aforementioned VCR‑resistant breast cancer cell line. Meanwhile, the analysis of splicing events also indicated a change in variable splicing events. Further validation showed that the expression levels of multiple genes, including interleukin‑1β, were altered in the VCR‑resistant breast cancer cell line, and these gene expression changes were related to VCR resistance. The results of the present study provide a theoretical basis for exploring the mechanism of VCR resistance clinically.
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View References

1 

Sung H, Ferlay J, Siegel RL, Laversanne M, Soerjomataram I, Jemal A and Bray F: Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 71:209–249. 2021. View Article : Google Scholar : PubMed/NCBI

2 

Goldhirsch A, Winer EP, Coates AS, Gelber RD, Piccart-Gebhart M, Thürlimann B and Senn HJ; Panel members, : Personalizing the treatment of women with early breast cancer: Highlights of the St Gallen international expert consensus on the primary therapy of early breast cancer 2013. Ann Oncol. 24:2206–2223. 2013. View Article : Google Scholar : PubMed/NCBI

3 

Coates AS, Winer EP, Goldhirsch A, Gelber RD, Gnant M, Piccart-Gebhart M, Thürlimann B and Senn HJ; Panel Members, : Tailoring therapies-improving the management of early breast cancer: St Gallen international expert consensus on the primary therapy of early breast cancer 2015. Ann Oncol. 26:1533–1546. 2015. View Article : Google Scholar : PubMed/NCBI

4 

Mehnati P and Tirtash MJ: Comparative efficacy of four imaging instruments for breast cancer screening. Asian Pac J Cancer Prev. 16:6177–6186. 2015. View Article : Google Scholar : PubMed/NCBI

5 

Yang SN, Li FJ, Liao YH, Chen YS, Shen WC and Huang TC: Identification of breast cancer using integrated information from MRI and mammography. PLoS One. 10:e01284042015. View Article : Google Scholar : PubMed/NCBI

6 

Peng J, Sengupta S and Jordan VC: Potential of selective estrogen receptor modulators as treatments and preventives of breast cancer. Anticancer Agents Med Chem. 9:481–499. 2009. View Article : Google Scholar : PubMed/NCBI

7 

Reeder JG and Vogel VG: Breast cancer prevention. Cancer Treat Res. 141:149–164. 2008. View Article : Google Scholar : PubMed/NCBI

8 

Longley DB and Johnston PG: Molecular mechanisms of drug resistance. J Pathol. 205:275–292. 2005. View Article : Google Scholar : PubMed/NCBI

9 

Liscovitch M and Lavie Y: Cancer multidrug resistance: A review of recent drug discovery research. IDrugs. 5:349–355. 2002.PubMed/NCBI

10 

De Lena M, Brambilla C, Morabito A and Bonadonna G: Adriamycin plus vincristine compared to and combined with cyclophosphamide, methotrexate, and 5-fluorouracil for advanced breast cancer. Cancer. 35:1108–1115. 1975. View Article : Google Scholar : PubMed/NCBI

11 

Bates D and Eastman A: Microtubule destabilising agents: Far more than just antimitotic anticancer drugs. Br J Clin Pharmacol. 83:255–268. 2017. View Article : Google Scholar : PubMed/NCBI

12 

Mansoori B, Mohammadi A, Davudian S, Shirjang S and Baradaran B: The different mechanisms of cancer drug resistance: A brief review. Adv Pharm Bull. 7:339–348. 2017. View Article : Google Scholar : PubMed/NCBI

13 

Hu F, Song D, Yan Y, Huang C, Shen C, Lan J, Chen Y, Liu A, Wu Q, Sun L, et al: IL-6 regulates autophagy and chemotherapy resistance by promoting BECN1 phosphorylation. Nat Commun. 12:36512021. View Article : Google Scholar : PubMed/NCBI

14 

Novototskaya-Vlasova KA, Neznanov NS, Molodtsov I, Hall BM, Commane M, Gleiberman AS, Murray J, Haber M, Norris MD, Leonova KI and Gudkov AV: Inflammatory response to retrotransposons drives tumor drug resistance that can be prevented by reverse transcriptase inhibitors. Proc Natl Acad Sci USA. 119:e22131461192022. View Article : Google Scholar : PubMed/NCBI

15 

Duncavage EJ, Bagg A, Hasserjian RP, DiNardo CD, Godley LA, Iacobucci I, Jaiswal S, Malcovati L, Vannucchi AM, Patel KP, et al: Genomic profiling for clinical decision making in myeloid neoplasms and acute leukemia. Blood. 140:2228–2247. 2022. View Article : Google Scholar : PubMed/NCBI

16 

Marasco LE and Kornblihtt AR: The physiology of alternative splicing. Nat Rev Mol Cell Biol. 24:242–254. 2023. View Article : Google Scholar : PubMed/NCBI

17 

Lv Y, Zhang W, Zhao J, Sun B, Qi Y, Ji H, Chen C, Zhang J, Sheng J, Wang T, et al: SRSF1 inhibits autophagy through regulating Bcl-x splicing and interacting with PIK3C3 in lung cancer. Signal Transduct Target Ther. 6:1082021. View Article : Google Scholar : PubMed/NCBI

18 

Kitamura K and Nimura K: Regulation of RNA splicing: Aberrant splicing regulation and therapeutic targets in cancer. Cells. 10:9232021. View Article : Google Scholar : PubMed/NCBI

19 

Read A and Natrajan R: Splicing dysregulation as a driver of breast cancer. Endocr Relat Cancer. 25:R467–R478. 2018. View Article : Google Scholar : PubMed/NCBI

20 

Zhou Y, Zhou B, Pache L, Chang M, Khodabakhshi AH, Tanaseichuk O, Benner C and Chanda SK: Metascape provides a biologist-oriented resource for the analysis of systems-level datasets. Nat Commun. 10:15232019. View Article : Google Scholar : PubMed/NCBI

21 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(−Delta Delta C(T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

22 

Li X, Hu Z, Shi H, Wang C, Lei J and Cheng Y: Inhibition of VEGFA increases the sensitivity of ovarian cancer cells to chemotherapy by suppressing VEGFA-mediated autophagy. Onco Targets Ther. 13:8161–8171. 2020. View Article : Google Scholar : PubMed/NCBI

23 

Wang BW, Jiang Y, Yao ZL, Chen PS, Yu B and Wang SN: Aucubin protects chondrocytes against IL-1β-induced apoptosis in vitro and inhibits osteoarthritis in mice model. Drug Des Devel Ther. 13:3529–3538. 2019. View Article : Google Scholar : PubMed/NCBI

24 

Jemal A, Bray F, Center MM, Ferlay J, Ward E and Forman D: Global cancer statistics. CA Cancer J Clin. 61:69–90. 2011. View Article : Google Scholar : PubMed/NCBI

25 

Siegel RL, Miller KD and Jemal A: Cancer statistics, 2015. CA Cancer J Clin. 65:5–29. 2015. View Article : Google Scholar : PubMed/NCBI

26 

Parkin DM, Bray F, Ferlay J and Pisani P: Estimating the world cancer burden: Globocan 2000. Int J Cancer. 94:153–156. 2001. View Article : Google Scholar : PubMed/NCBI

27 

Wooster R and Weber BL: Breast and ovarian cancer. N Engl J Med. 348:2339–2347. 2003. View Article : Google Scholar : PubMed/NCBI

28 

Kavallaris M, Tait AS, Walsh BJ, He L, Horwitz SB, Norris MD and Haber M: Multiple microtubule alterations are associated with vinca alkaloid resistance in human leukemia cells. Cancer Res. 61:5803–5809. 2001.PubMed/NCBI

29 

Sirotnak FM, Danenberg KD, Chen J, Fritz F and Danenberg PV: Markedly decreased binding of vincristine to tubulin in vinca alkaloid-resistant Chinese hamster cells is associated with selective overexpression of alpha and beta tubulin isoforms. Biochem Biophys Res Commun. 269:21–24. 2000. View Article : Google Scholar : PubMed/NCBI

30 

Verrills NM, Walsh BJ, Cobon GS, Hains PG and Kavallaris M: Proteome analysis of vinca alkaloid response and resistance in acute lymphoblastic leukemia reveals novel cytoskeletal alterations. J Biol Chem. 278:45082–45093. 2003. View Article : Google Scholar : PubMed/NCBI

31 

Gottesman MM, Fojo T and Bates SE: Multidrug resistance in cancer: Role of ATP-dependent transporters. Nat Rev Cancer. 2:48–58. 2002. View Article : Google Scholar : PubMed/NCBI

32 

Stow MW and Warr JR: Reduced influx is a factor in accounting for reduced vincristine accumulation in certain verapamil-hypersensitive multidrug-resistant CHO cell lines. FEBS Lett. 320:87–91. 1993. View Article : Google Scholar : PubMed/NCBI

33 

Yao D, Ding S, Burchell B, Wolf CR and Friedberg T: Detoxication of vinca alkaloids by human P450 CYP3A4-mediated metabolism: Implications for the development of drug resistance. J Pharmacol Exp Ther. 294:387–395. 2000.PubMed/NCBI

34 

Kontos CK, Christodoulou MI and Scorilas A: Apoptosis-related BCL2-family members: Key players in chemotherapy. Anticancer Agents Med Chem. 14:353–374. 2014. View Article : Google Scholar : PubMed/NCBI

35 

Urfali-Mamatoglu C, Kazan HH and Gündüz U: Dual function of programmed cell death 10 (PDCD10) in drug resistance. Biomed Pharmacother. 101:129–136. 2018. View Article : Google Scholar : PubMed/NCBI

36 

Ferrara N: Vascular endothelial growth factor: Basic science and clinical progress. Endocr Rev. 25:581–611. 2004. View Article : Google Scholar : PubMed/NCBI

37 

Delforce SJ, Lumbers ER, Morosin SK, Wang Y and Pringle KG: The Angiotensin II type 1 receptor mediates the effects of low oxygen on early placental angiogenesis. Placenta. 75:54–61. 2019. View Article : Google Scholar : PubMed/NCBI

38 

Takahashi T, Yamaguchi S, Chida K and Shibuya M: A single autophosphorylation site on KDR/Flk-1 is essential for VEGF-A-dependent activation of PLC-gamma and DNA synthesis in vascular endothelial cells. EMBO J. 20:2768–2778. 2001. View Article : Google Scholar : PubMed/NCBI

39 

Jiang BH and Liu LZ: PI3K/PTEN signaling in angiogenesis and tumorigenesis. Adv Cancer Res. 102:19–65. 2009. View Article : Google Scholar : PubMed/NCBI

40 

van Hinsbergh VW and Koolwijk P: Endothelial sprouting and angiogenesis: Matrix metalloproteinases in the lead. Cardiovasc Res. 78:203–212. 2008. View Article : Google Scholar : PubMed/NCBI

41 

Garlanda C, Dinarello CA and Mantovani A: The interleukin-1 family: Back to the future. Immunity. 39:1003–1018. 2013. View Article : Google Scholar : PubMed/NCBI

42 

Brough D, Tyrrell PJ and Allan SM: Regulation of interleukin-1 in acute brain injury. Trends Pharmacol Sci. 32:617–622. 2011. View Article : Google Scholar : PubMed/NCBI

43 

Baroja-Mazo A, Martín-Sánchez F, Gomez AI, Martínez CM, Amores-Iniesta J, Compan V, Barberà-Cremades M, Yagüe J, Ruiz-Ortiz E, Antón J, et al: The NLRP3 inflammasome is released as a particulate danger signal that amplifies the inflammatory response. Nat Immunol. 15:738–748. 2014. View Article : Google Scholar : PubMed/NCBI

44 

Dinarello CA: Interleukin-1. Cytokine Growth Factor Rev. 8:253–265. 1997. View Article : Google Scholar : PubMed/NCBI

45 

Tulotta C and Ottewell P: The role of IL-1B in breast cancer bone metastasis. Endocr Relat Cancer. 25:R421–R434. 2018. View Article : Google Scholar : PubMed/NCBI

46 

Jang K, Kim M, Gilbert CA, Simpkins F, Ince TA and Slingerland JM: VEGFA activates an epigenetic pathway upregulating ovarian cancer-initiating cells. EMBO Mol Med. 9:304–318. 2017. View Article : Google Scholar : PubMed/NCBI

47 

Wang W, Ren F, Wu Q, Jiang D, Li H and Shi H: MicroRNA-497 suppresses angiogenesis by targeting vascular endothelial growth factor A through the PI3K/AKT and MAPK/ERK pathways in ovarian cancer. Oncol Rep. 32:2127–2133. 2014. View Article : Google Scholar : PubMed/NCBI

48 

Yan JJ, Zhang YN, Liao JZ, Ke KP, Chang Y, Li PY, Wang M, Lin JS and He XX: MiR-497 suppresses angiogenesis and metastasis of hepatocellular carcinoma by inhibiting VEGFA and AEG-1. Oncotarget. 6:29527–29542. 2015. View Article : Google Scholar : PubMed/NCBI

49 

Zeng FC, Zeng MQ, Huang L, Li YL, Gao BM, Chen JJ, Xue RZ and Tang ZY: Downregulation of VEGFA inhibits proliferation, promotes apoptosis, and suppresses migration and invasion of renal clear cell carcinoma. Onco Targets Ther. 9:2131–2141. 2016.PubMed/NCBI

50 

Zhang W, Zou C, Pan L, Xu Y, Qi W, Ma G, Hou Y and Jiang P: MicroRNA-140-5p inhibits the progression of colorectal cancer by targeting VEGFA. Cell Physiol Biochem. 37:1123–1133. 2015. View Article : Google Scholar : PubMed/NCBI

51 

Adams J, Carder PJ, Downey S, Forbes MA, MacLennan K, Allgar V, Kaufman S, Hallam S, Bicknell R, Walker JJ, et al: Vascular endothelial growth factor (VEGF) in breast cancer: Comparison of plasma, serum, and tissue VEGF and microvessel density and effects of tamoxifen. Cancer Res. 60:2898–2905. 2000.PubMed/NCBI

52 

Lawicki S, Będkowska GE, Gacuta-Szumarska E and Szmitkowski M: The plasma concentration of VEGF, HE4 and CA125 as a new biomarkers panel in different stages and sub-types of epithelial ovarian tumors. J Ovarian Res. 6:452013. View Article : Google Scholar : PubMed/NCBI

53 

Fleming ND, Coleman RL, Tung C, Westin SN, Hu W, Sun Y, Bhosale P, Munsell MF and Sood AK: Phase II trial of bevacizumab with dose-dense paclitaxel as first-line treatment in patients with advanced ovarian cancer. Gynecol Oncol. 147:41–46. 2017. View Article : Google Scholar : PubMed/NCBI

54 

Fahmy K, Gonzalez A, Arafa M, Peixoto P, Bellahcène A, Turtoi A, Delvenne P, Thiry M, Castronovo V and Peulen O: Myoferlin plays a key role in VEGFA secretion and impacts tumor-associated angiogenesis in human pancreas cancer. Int J Cancer. 138:652–663. 2016. View Article : Google Scholar : PubMed/NCBI

55 

Bent R, Moll L, Grabbe S and Bros M: Interleukin-1 beta-A friend or foe in malignancies? Int J Mol Sci. 19:21552018. View Article : Google Scholar : PubMed/NCBI

56 

Apte RN, Dotan S, Elkabets M, White MR, Reich E, Carmi Y, Song X, Dvozkin T, Krelin Y and Voronov E: The involvement of IL-1 in tumorigenesis, tumor invasiveness, metastasis and tumor-host interactions. Cancer Metastasis Rev. 25:387–408. 2006. View Article : Google Scholar : PubMed/NCBI

57 

Saijo Y, Tanaka M, Miki M, Usui K, Suzuki T, Maemondo M, Hong X, Tazawa R, Kikuchi T, Matsushima K and Nukiwa T: Proinflammatory cytokine IL-1 beta promotes tumor growth of Lewis lung carcinoma by induction of angiogenic factors: In vivo analysis of tumor-stromal interaction. J Immunol. 169:469–475. 2002. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Chen Y, Yang L, Wang C and Wang C: Exploring the mechanism of resistance to vincristine in breast cancer cells using transcriptome sequencing technology. Oncol Lett 26: 502, 2023.
APA
Chen, Y., Yang, L., Wang, C., & Wang, C. (2023). Exploring the mechanism of resistance to vincristine in breast cancer cells using transcriptome sequencing technology. Oncology Letters, 26, 502. https://doi.org/10.3892/ol.2023.14089
MLA
Chen, Y., Yang, L., Wang, C., Wang, C."Exploring the mechanism of resistance to vincristine in breast cancer cells using transcriptome sequencing technology". Oncology Letters 26.6 (2023): 502.
Chicago
Chen, Y., Yang, L., Wang, C., Wang, C."Exploring the mechanism of resistance to vincristine in breast cancer cells using transcriptome sequencing technology". Oncology Letters 26, no. 6 (2023): 502. https://doi.org/10.3892/ol.2023.14089
Copy and paste a formatted citation
x
Spandidos Publications style
Chen Y, Yang L, Wang C and Wang C: Exploring the mechanism of resistance to vincristine in breast cancer cells using transcriptome sequencing technology. Oncol Lett 26: 502, 2023.
APA
Chen, Y., Yang, L., Wang, C., & Wang, C. (2023). Exploring the mechanism of resistance to vincristine in breast cancer cells using transcriptome sequencing technology. Oncology Letters, 26, 502. https://doi.org/10.3892/ol.2023.14089
MLA
Chen, Y., Yang, L., Wang, C., Wang, C."Exploring the mechanism of resistance to vincristine in breast cancer cells using transcriptome sequencing technology". Oncology Letters 26.6 (2023): 502.
Chicago
Chen, Y., Yang, L., Wang, C., Wang, C."Exploring the mechanism of resistance to vincristine in breast cancer cells using transcriptome sequencing technology". Oncology Letters 26, no. 6 (2023): 502. https://doi.org/10.3892/ol.2023.14089
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