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PEX13 is a potential immunotherapeutic indicator and prognostic biomarker for various tumors including PAAD

  • Authors:
    • Penggang Dong
    • Xuezhi Du
    • Ting Yang
    • Dandan Li
    • Yunyi Du
    • Yaqing Wei
    • Jinjin Sun
  • View Affiliations / Copyright

    Affiliations: Department of Hepatopancreatobiliary Surgery, The Second Hospital of Tianjin Medical University, Tianjin 300211, P.R. China, Central Laboratory, Changzhi People's Hospital Affiliated to Changzhi Medical College, Changzhi, Shanxi 046000, P.R. China, Department of Oncology, Changzhi People's Hospital Affiliated to Changzhi Medical College, Changzhi, Shanxi 046000, P.R. China
    Copyright: © Dong et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 512
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    Published online on: October 12, 2023
       https://doi.org/10.3892/ol.2023.14099
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Abstract

The peroxisome serves a significant role in the occurrence and development of cancers. Specifically, the peroxisomal biogenesis factor 13 (PEX13) is crucial to the occurrence of peroxisomes. However, the biological function of PEX13 in cancers remains unclear. To address this, various portals and databases such as The Cancer Genome Atlas Program, The Genotype‑Tissue Expression project, the Gene Expression Profiling Interactive Analysis 2, cBioPortal, the Genomic Identification of Significant Targets In Cancer 2.0, Tumor Immune Estimation Resource 2, SangerBox, LinkedOmics, DAVID and STRING were applied to extract and analyze PEX13 data in tumors. The correlations between PEX13 and prognosis, genetic alterations, PEX13‑related gene enrichment analysis, weighted gene co‑expression network analysis (WGCNA), protein interaction, long non‑coding (lnc)RNA/circular (circ)RNA‑micro (mi)RNA network and tumor immunity were explored in various tumors. The lncRNA‑miRNA‑PEX13 and circRNA‑miRNA‑PEX13 regulatory networks were identified via miRabel, miRDB, TargetScan and ENCORI portals and Cytoscape tool. In vitro assays were applied to verify the biological functions of PEX13 in pancreatic adenocarcinoma (PAAD) cells. The findings revealed that PEX13 is upregulated in various tumors and high PEX13 mRNA expression is associated with poor prognosis in patients with multiple cancers. Genetic alterations in PEX13 such as amplification, mutation and deep deletion have been found in multiple cancers. PEX13‑related genes were associated with T cell receptor, signaling pathway and hippo signaling pathway through ‘biological process’ subontology of Gene Ontology and Kyoto Encyclopedia of Genes and Genomes enrichment analyses. Through WGCNA analysis, it was discovered that PEX13 hub genes were mainly enriched in the Rap1, ErbB and AMPK signaling pathways in PAAD. Immune analysis showed that PEX13 was significantly related to tumor infiltration immune cells, immune checkpoint genes, microsatellite instability, TMB and tumor purity in a variety of tumors. Cell Counting Kit‑8, wound healing, Transwell and colony formation assays displayed that PEX13 knockdown could suppress PAAD cell proliferation, migration, invasion, and colony formation in vitro, respectively. Overall, PEX13 is a potential predictor of immunotherapeutic and prognostic biomarkers in various malignant tumors, including ACC, KICH, LGG, LIHC and PAAD.
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View References

1 

Fujiki Y, Okumoto K, Mukai S, Honsho M and Tamura S: Peroxisome biogenesis in mammalian cells. Front Physiol. 5:3072014. View Article : Google Scholar : PubMed/NCBI

2 

Lee MY, Sumpter RJ, Zou Z, Sirasanagandla S, Wei Y, Mishra P, Rosewich H, Crane DI and Levine B: Peroxisomal protein PEX13 functions in selective autophagy. EMBO Rep. 18:48–60. 2017. View Article : Google Scholar : PubMed/NCBI

3 

Zhang J, Kim J, Alexander A, Cai S, Tripathi DN, Dere R, Tee AR, Tait-Mulder J, Di Nardo A, Han JM, et al: A tuberous sclerosis complex signalling node at the peroxisome regulates mTORC1 and autophagy in response to ROS. Nat Cell Biol. 15:1186–1196. 2013. View Article : Google Scholar : PubMed/NCBI

4 

Dixit E, Boulant S, Zhang Y, Lee AS, Odendall C, Shum B, Hacohen N, Chen ZJ, Whelan SP, Fransen M, et al: Peroxisomes are signaling platforms for antiviral innate immunity. Cell. 141:668–681. 2010. View Article : Google Scholar : PubMed/NCBI

5 

Sugiura A, Mattie S, Prudent J and Mcbride HM: Newly born peroxisomes are a hybrid of mitochondrial and ER-derived pre-peroxisomes. Nature. 542:251–254. 2017. View Article : Google Scholar : PubMed/NCBI

6 

Smith JJ and Aitchison JD: Peroxisomes take shape. Nat Rev Mol Cell Biol. 14:803–817. 2013. View Article : Google Scholar : PubMed/NCBI

7 

Jain IH, Calvo SE, Markhard AL, Skinner OS, To TL, Ast T and Mootha VK: Genetic screen for cell fitness in high or low oxygen highlights mitochondrial and lipid metabolism. Cell. 181:716–727. 2020. View Article : Google Scholar : PubMed/NCBI

8 

Liu Q, Luo Q, Halim A and Song G: Targeting lipid metabolism of cancer cells: A promising therapeutic strategy for cancer. Cancer Lett. 401:39–45. 2017. View Article : Google Scholar : PubMed/NCBI

9 

Di Cara F, Savary S, Kovacs WJ, Kim P and Rachubinski RA: The peroxisome: An up-and-coming organelle in immunometabolism. Trends Cell Biol. 33:70–86. 2023. View Article : Google Scholar : PubMed/NCBI

10 

Diskin C, Zotta A, Corcoran SE, Tyrrell VJ, Zaslona Z, O'Donnell VB and O'Neill L: 4-Octyl-Itaconate and Dimethyl Fumarate inhibit COX2 expression and prostaglandin production in macrophages. J Immunol. 207:2561–2569. 2021. View Article : Google Scholar : PubMed/NCBI

11 

Wanders RJ and Waterham HR: Biochemistry of mammalian peroxisomes revisited. Annu Rev Biochem. 75:295–332. 2006. View Article : Google Scholar : PubMed/NCBI

12 

Ding L, Sun W, Balaz M, He A, Klug M, Wieland S, Caiazzo R, Raverdy V, Pattou F, Lefebvre P, et al: Peroxisomal beta-oxidation acts as a sensor for intracellular fatty acids and regulates lipolysis. Nat Metab. 3:1648–1661. 2021. View Article : Google Scholar : PubMed/NCBI

13 

Lee JY, Plakidas A, Lee WH, Heikkinen A, Chanmugam P, Bray G and Hwang DH: Differential modulation of Toll-like receptors by fatty acids: Preferential inhibition by n-3 polyunsaturated fatty acids. J Lipid Res. 44:479–486. 2003. View Article : Google Scholar : PubMed/NCBI

14 

Moreno-Fernandez ME, Giles DA, Stankiewicz TE, Sheridan R, Karns R, Cappelletti M, Lampe K, Mukherjee R, Sina C, Sallese A, et al: Peroxisomal beta-oxidation regulates whole body metabolism, inflammatory vigor, and pathogenesis of nonalcoholic fatty liver disease. JCI Insight. 3:e936262018. View Article : Google Scholar : PubMed/NCBI

15 

Demers ND, Riccio V, Jo DS, Bhandari S, Law KB, Liao W, Kim C, Mcquibban GA, Choe SK, Cho DH, et al: PEX13 prevents pexophagy by regulating ubiquitinated PEX5 and peroxisomal ROS. Autophagy. 19:1781–1802. 2023. View Article : Google Scholar : PubMed/NCBI

16 

Chen XF, Tian MX, Sun RQ, Zhang ML, Zhou LS, Jin L, Chen LL, Zhou WJ, Duan KL, Chen YJ, et al: SIRT5 inhibits peroxisomal ACOX1 to prevent oxidative damage and is downregulated in liver cancer. Embo Rep. 19:e451242018. View Article : Google Scholar : PubMed/NCBI

17 

Ahn YH, Yang Y, Gibbons DL, Creighton CJ, Yang F, Wistuba II, Lin W, Thilaganathan N, Alvarez CA, Roybal J, et al: Map2k4 functions as a tumor suppressor in lung adenocarcinoma and inhibits tumor cell invasion by decreasing peroxisome proliferator-activated receptor gamma2 expression. Mol Cell Biol. 31:4270–4285. 2011. View Article : Google Scholar : PubMed/NCBI

18 

Wei C, Wang B, Peng D, Zhang X, Li Z, Luo L, He Y, Liang H, Du X, Li S, et al: Pan-cancer analysis shows that ALKBH5 is a potential prognostic and immunotherapeutic biomarker for multiple cancer types including gliomas. Front Immunol. 13:8495922022. View Article : Google Scholar : PubMed/NCBI

19 

Tang Z, Kang B, Li C, Chen T and Zhang Z: GEPIA2: An enhanced web server for large-scale expression profiling and interactive analysis. Nucleic Acids Res. 47:W556–W560. 2019. View Article : Google Scholar : PubMed/NCBI

20 

Navani S: Manual evaluation of tissue microarrays in a high-throughput research project: The contribution of Indian surgical pathology to the Human Protein Atlas (HPA) project. Proteomics. 16:1266–1270. 2016. View Article : Google Scholar : PubMed/NCBI

21 

Wu P, Heins ZJ, Muller JT, Katsnelson L, de Bruijn I, Abeshouse AA, Schultz N, Fenyo D and Gao J: Integration and analysis of CPTAC proteomics data in the context of cancer genomics in the cBioPortal. Mol Cell Proteomics. 18:1893–1898. 2019. View Article : Google Scholar : PubMed/NCBI

22 

Liefeld T, Reich M, Gould J, Zhang P, Tamayo P and Mesirov JP: GeneCruiser: A web service for the annotation of microarray data. Bioinformatics. 21:3681–3682. 2005. View Article : Google Scholar : PubMed/NCBI

23 

Mayakonda A, Lin DC, Assenov Y, Plass C and Koeffler HP: Maftools: Efficient and comprehensive analysis of somatic variants in cancer. Genome Res. 28:1747–1756. 2018. View Article : Google Scholar : PubMed/NCBI

24 

Li T, Fu J, Zeng Z, Cohen D, Li J, Chen Q, Li B and Liu XS: TIMER2.0 for analysis of tumor-infiltrating immune cells. Nucleic Acids Res. 48:W509–W514. 2020. View Article : Google Scholar : PubMed/NCBI

25 

Vasaikar SV, Straub P, Wang J and Zhang B: LinkedOmics: Analyzing multi-omics data within and across 32 cancer types. Nucleic Acids Res. 46:D956–D963. 2018. View Article : Google Scholar : PubMed/NCBI

26 

Langfelder P and Horvath S: WGCNA: An R package for weighted correlation network analysis. BMC Bioinformatics. 9:5592008. View Article : Google Scholar : PubMed/NCBI

27 

Yan Y, Zhang D, Zhou P, Li B and Huang SY: HDOCK: A web server for protein-protein and protein-DNA/RNA docking based on a hybrid strategy. Nucleic Acids Res. 45:W365–W373. 2017. View Article : Google Scholar : PubMed/NCBI

28 

Wei C, Zhang X, Peng D, Zhang X, Guo H, Lu Y, Luo L, Wang B, Li Z, He Y, et al: LncRNA HOXA11-AS promotes glioma malignant phenotypes and reduces its sensitivity to ROS via Tpl2-MEK1/2-ERK1/2 pathway. Cell Death Dis. 13:9422022. View Article : Google Scholar : PubMed/NCBI

29 

Martincorena I, Raine KM, Gerstung M, Dawson KJ, Haase K, Van Loo P, Davies H, Stratton MR and Campbell PJ: Universal patterns of selection in cancer and somatic tissues. Cell. 171:1029–1041. 2017. View Article : Google Scholar : PubMed/NCBI

30 

Luo Y, Zheng S, Wu Q, Wu J, Zhou R, Wang C, Wu Z, Rong X, Huang N, Sun L, et al: Long noncoding RNA (lncRNA) EIF3J-DT induces chemoresistance of gastric cancer via autophagy activation. Autophagy. 17:4083–4101. 2021. View Article : Google Scholar : PubMed/NCBI

31 

Wei Y, Lu C, Zhou P, Zhao L, Lyu X, Yin J, Shi Z and You Y: EIF4A3-induced circular RNA ASAP1 promotes tumorigenesis and temozolomide resistance of glioblastoma via NRAS/MEK1/ERK1-2 signaling. Neuro Oncol. 23:611–624. 2021. View Article : Google Scholar : PubMed/NCBI

32 

Baxevanis CN, Fortis SP and Perez SA: The balance between breast cancer and the immune system: Challenges for prognosis and clinical benefit from immunotherapies. Semin Cancer Biol. 72:76–89. 2021. View Article : Google Scholar : PubMed/NCBI

33 

Chen Y, Jia K, Sun Y, Zhang C, Li Y, Zhang L, Chen Z, Zhang J, Hu Y, Yuan J, et al: Predicting response to immunotherapy in gastric cancer via multi-dimensional analyses of the tumour immune microenvironment. Nat Commun. 13:48512022. View Article : Google Scholar : PubMed/NCBI

34 

Baretti M and Le DT: DNA mismatch repair in cancer. Pharmacol Ther. 189:45–62. 2018. View Article : Google Scholar : PubMed/NCBI

35 

Lin A, Zhang J and Luo P: Crosstalk between the MSI status and tumor microenvironment in colorectal cancer. Front Immunol. 11:20392020. View Article : Google Scholar : PubMed/NCBI

36 

Luchini C, Bibeau F, Ligtenberg M, Singh N, Nottegar A, Bosse T, Miller R, Riaz N, Douillard JY, Andre F, et al: ESMO recommendations on microsatellite instability testing for immunotherapy in cancer, and its relationship with PD-1/PD-L1 expression and tumour mutational burden: A systematic review-based approach. Ann Oncol. 30:1232–1243. 2019. View Article : Google Scholar : PubMed/NCBI

37 

Wu W, Wang X, Le W, Lu C, Li H, Zhu Y, Chen X, An W, Xu C, Wu Q, et al: Immune microenvironment infiltration landscape and immune-related subtypes in prostate cancer. Front Immunol. 13:10012972022. View Article : Google Scholar : PubMed/NCBI

38 

Deberardinis RJ and Chandel NS: Fundamentals of cancer metabolism. Sci Adv. 2:e16002002016. View Article : Google Scholar : PubMed/NCBI

39 

Porporato PE, Filigheddu N, Pedro J, Kroemer G and Galluzzi L: Mitochondrial metabolism and cancer. Cell Res. 28:265–280. 2018. View Article : Google Scholar : PubMed/NCBI

40 

Wanders RJ and Waterham HR: Biochemistry of mammalian peroxisomes revisited. Annu Rev Biochem. 75:295–332. 2006. View Article : Google Scholar : PubMed/NCBI

41 

Beloribi-Djefaflia S, Vasseur S and Guillaumond F: Lipid metabolic reprogramming in cancer cells. Oncogenesis. 5:e1892016. View Article : Google Scholar : PubMed/NCBI

42 

Dean JM and Lodhi IJ: Structural and functional roles of ether lipids. Protein Cell. 9:196–206. 2018. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Dong P, Du X, Yang T, Li D, Du Y, Wei Y and Sun J: PEX13 is a potential immunotherapeutic indicator and prognostic biomarker for various tumors including PAAD. Oncol Lett 26: 512, 2023.
APA
Dong, P., Du, X., Yang, T., Li, D., Du, Y., Wei, Y., & Sun, J. (2023). PEX13 is a potential immunotherapeutic indicator and prognostic biomarker for various tumors including PAAD. Oncology Letters, 26, 512. https://doi.org/10.3892/ol.2023.14099
MLA
Dong, P., Du, X., Yang, T., Li, D., Du, Y., Wei, Y., Sun, J."PEX13 is a potential immunotherapeutic indicator and prognostic biomarker for various tumors including PAAD". Oncology Letters 26.6 (2023): 512.
Chicago
Dong, P., Du, X., Yang, T., Li, D., Du, Y., Wei, Y., Sun, J."PEX13 is a potential immunotherapeutic indicator and prognostic biomarker for various tumors including PAAD". Oncology Letters 26, no. 6 (2023): 512. https://doi.org/10.3892/ol.2023.14099
Copy and paste a formatted citation
x
Spandidos Publications style
Dong P, Du X, Yang T, Li D, Du Y, Wei Y and Sun J: PEX13 is a potential immunotherapeutic indicator and prognostic biomarker for various tumors including PAAD. Oncol Lett 26: 512, 2023.
APA
Dong, P., Du, X., Yang, T., Li, D., Du, Y., Wei, Y., & Sun, J. (2023). PEX13 is a potential immunotherapeutic indicator and prognostic biomarker for various tumors including PAAD. Oncology Letters, 26, 512. https://doi.org/10.3892/ol.2023.14099
MLA
Dong, P., Du, X., Yang, T., Li, D., Du, Y., Wei, Y., Sun, J."PEX13 is a potential immunotherapeutic indicator and prognostic biomarker for various tumors including PAAD". Oncology Letters 26.6 (2023): 512.
Chicago
Dong, P., Du, X., Yang, T., Li, D., Du, Y., Wei, Y., Sun, J."PEX13 is a potential immunotherapeutic indicator and prognostic biomarker for various tumors including PAAD". Oncology Letters 26, no. 6 (2023): 512. https://doi.org/10.3892/ol.2023.14099
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