[Corrigendum] Cross regulation of signaling pathways in gastrointestinal stromal tumor

Qi,Yijun; Zhao,Wendi; Wang,Zhengguang; Xie,Qingsong; Cao,Jing; Meng,Xiangling

doi:10.3892/ol.2023.14103

December-2023 Volume 26 Issue 6

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December-2023 Volume 26 Issue 6

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Correction Open Access

[Corrigendum] Cross regulation of signaling pathways in gastrointestinal stromal tumor

Authors:
- Yijun Qi
- Wendi Zhao
- Zhengguang Wang
- Qingsong Xie
- Jing Cao
- Xiangling Meng
View Affiliations / Copyright

Affiliations: Department of General Surgery, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui 230032, P.R. China, Department of Pathology, Anhui Medical University, Hefei, Anhui 230032, P.R. China, Laboratory Medicine, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui 230032, P.R. China

Copyright: © Qi et al. This is an open access article distributed under the terms of Creative Commons Attribution License [CC BY 4.0].
Article Number: 516
|
Published online on: October 16, 2023

https://doi.org/10.3892/ol.2023.14103
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Oncol Lett 16: [Related article:] 6770–6776, 2018; DOI: 10.3892/ol.2018.9494

Subsequently to the publication of this paper, the authors contacted the Editorial Office to explain that errors had been made in terms of the assembly of Fig. 1, Fig. 2, Fig. 3; essentially, in Figs. 1 and 2, the Gli-1 data were set out incorrectly in the various figure parts, and in all three figures, owing to errors made during the filing of the data, the incorrect α-tubulin data were shown.

Figure 1.

Effect of N-Shh on GIST-H1 cell signaling pathways. (A and B) Representative gels and quantification of (C) the effect of N-Shh on GIST-H1 cell AKT activation and the comparison of the effect from each treatment factor; (D) the effect of N-Shh on GIST-H1 cell ERK activation and the comparison of the effect from each treatment factor; (E) the effect of N-Shh on GIST-H1 cell Gli-1 expression and the comparison of the effect from each treatment factor; and (F) the effect of N-Shh on GIST-H1 cell Gli-1 expression and the comparison of the effect from each treatment factor (*P<0.05, **P<0.01 vs. ctrl-NC; #P<0.05, ##P<0.05 vs. N-Shh-NC). N-Shh, recombinant Sonic hedgehog; GIST, gastrointestinal stromal tumor; EGF, endothelial growth factor; Gil-1, glioma-associated oncogene-1; NC, normal control; Cyc, cyclopamine; PD, PD98059; C+P, CPN-KAAD+PD98059; Wor, wortmannin; C+W, CPN-KAAD + wortmannin.

Figure 2.

Effect of N-Shh on GIST-H1 cell signaling pathways. (A and B) Representative gels and quantification of (C) the effect of N-Shh on GIST-H1 cell AKT activation and the comparison of the effect from each treatment factor; (D) the effect of N-Shh on GIST-H1 cell ERK activation and the comparison of the effect from each treatment factor; (E) the effect of N-Shh on GIST-H1 cell Gli-1 expression and the comparison of the effect from each treatment factor; and (F) the effect of N-Shh on GIST-H1 cell Gli-1 expression and the comparison of the effect from each treatment factor (*P<0.05, **P<0.01 vs. ctrl-NC; #P<0.05, ##P<0.05 vs. N-Shh-NC). N-Shh, recombinant Sonic hedgehog; GIST, gastrointestinal stromal tumor; EGF, endothelial growth factor; NC, normal control, Cyc, cyclopamine, PD, PD98059, C+P, CPN-KAAD+PD98059, Wor, wortmannin, C+W, CPN- KAAD+wortmannin.

Figure 3.

Effect of inhibiting Shh, PI3K and (or) MAPK signaling pathway on the expression of caspase-3 in GIST cells. (A) The influence on the expression of caspase-3 by inhibiting Shh and (or) PI3K signaling pathway in GIST cells. (B) The caspase-3/Tubulin relative intensity ratios of each treatment factor resulted from EGF-mediated cell apoptosis actions by inhibiting Shh and (or) PI3K signaling pathway. (C) The influence on the expression of caspase-3 by inhibiting Shh and (or) MAPK signaling pathway in GIST cells. (D) The caspase-3/Tubulin relative intensity ratios of each treatment factor resulted from EGF-mediated cell apoptosis actions by inhibiting Shh and (or) MAPK signaling pathway (*P<0.05, **P<0.05 vs. ctrl-NC; #P<0.05, ##P<0.05 vs. EGF-NC). N-Shh, recombinant Sonic hedgehog; GIST, gastrointestinal stromal tumor; EGF, endothelial growth factor; NC, normal control, Sta, starvation, Cyc, cyclopamine, PD, PD98059, Wor-wortmannin.

The revised versions of Figs. 1, 2 and 3, containing the reorganized data for the Gli-1 blots and the correct data for the α-tubulin blots, are shown opposite and on the next page. The authors regret the errors that were made in the compilation of the original figures, and are grateful to the editor of Oncology Letters for allowing them the opportunity to publish a Corrigendum. Furthermore, they apologize to the readership for any inconvenience caused.

Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

[Corrigendum] Cross regulation of signaling pathways in gastrointestinal stromal tumor

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