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December-2023 Volume 26 Issue 6

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Case Report Open Access

Enteral lorlatinib after immune hyperprogression as a treatment option for anaplastic lymphoma kinase‑positive non‑small cell lung cancer: A case report

  • Authors:
    • Huan Wang
    • Zhenyan Wu
    • Guangqing Shi
    • Jing Zhou
    • Zhenliang Xiao
  • View Affiliations / Copyright

    Affiliations: Department of Respiratory and Critical Care Medicine, General Hospital of Western Theater Command, Chengdu, Sichuan 610083, P.R. China
    Copyright: © Wang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 526
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    Published online on: October 23, 2023
       https://doi.org/10.3892/ol.2023.14113
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Abstract

Fusion of the anaplastic lymphoma kinase (ALK) gene is a rare driver in non‑small cell lung cancer (NSCLC). Lorlatinib is a third‑generation ALK inhibitor approved for the treatment of locally advanced or metastatic ALK+ NSCLC. The traditional administration method of lorlatinib is whole tablet ingestion, while the efficacy effect of gastric tube injection after water dissolution remains unclear. In the present report, a marked response to lorlatinib in a 49‑year‑old patient with ALK+ NSCLC who was administered lorlatinib through a gastric tube, was described. The patient had received chemotherapy combined with immune checkpoint inhibitors prior to targeted drug therapy and developed hyperprogression, which was mainly manifested as rapid enlargement of the primary lesion with multiple new systemic metastases, accompanied by poor performance status score, esophageal compression and difficulty eating. The patient was injected with pre‑dissolved lorlatinib through the nasogastric tube. After 6 days, related symptoms, such as dyspnea and dysphagia, were relieved. After 18 days, the esophageal stenosis was significantly alleviated, and the gastric tube was removed. In conclusion, gastric tube injection be used as a means of lorlatinib administration in patients with ALK+ NSCLC with dysphagia, regardless of previous immunotherapy‑associated hyperprogression.
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Copy and paste a formatted citation
Spandidos Publications style
Wang H, Wu Z, Shi G, Zhou J and Xiao Z: Enteral lorlatinib after immune hyperprogression as a treatment option for anaplastic lymphoma kinase‑positive non‑small cell lung cancer: A case report. Oncol Lett 26: 526, 2023.
APA
Wang, H., Wu, Z., Shi, G., Zhou, J., & Xiao, Z. (2023). Enteral lorlatinib after immune hyperprogression as a treatment option for anaplastic lymphoma kinase‑positive non‑small cell lung cancer: A case report. Oncology Letters, 26, 526. https://doi.org/10.3892/ol.2023.14113
MLA
Wang, H., Wu, Z., Shi, G., Zhou, J., Xiao, Z."Enteral lorlatinib after immune hyperprogression as a treatment option for anaplastic lymphoma kinase‑positive non‑small cell lung cancer: A case report". Oncology Letters 26.6 (2023): 526.
Chicago
Wang, H., Wu, Z., Shi, G., Zhou, J., Xiao, Z."Enteral lorlatinib after immune hyperprogression as a treatment option for anaplastic lymphoma kinase‑positive non‑small cell lung cancer: A case report". Oncology Letters 26, no. 6 (2023): 526. https://doi.org/10.3892/ol.2023.14113
Copy and paste a formatted citation
x
Spandidos Publications style
Wang H, Wu Z, Shi G, Zhou J and Xiao Z: Enteral lorlatinib after immune hyperprogression as a treatment option for anaplastic lymphoma kinase‑positive non‑small cell lung cancer: A case report. Oncol Lett 26: 526, 2023.
APA
Wang, H., Wu, Z., Shi, G., Zhou, J., & Xiao, Z. (2023). Enteral lorlatinib after immune hyperprogression as a treatment option for anaplastic lymphoma kinase‑positive non‑small cell lung cancer: A case report. Oncology Letters, 26, 526. https://doi.org/10.3892/ol.2023.14113
MLA
Wang, H., Wu, Z., Shi, G., Zhou, J., Xiao, Z."Enteral lorlatinib after immune hyperprogression as a treatment option for anaplastic lymphoma kinase‑positive non‑small cell lung cancer: A case report". Oncology Letters 26.6 (2023): 526.
Chicago
Wang, H., Wu, Z., Shi, G., Zhou, J., Xiao, Z."Enteral lorlatinib after immune hyperprogression as a treatment option for anaplastic lymphoma kinase‑positive non‑small cell lung cancer: A case report". Oncology Letters 26, no. 6 (2023): 526. https://doi.org/10.3892/ol.2023.14113
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