Open Access

Roles of estrogen receptor α in endometrial carcinoma (Review)

  • Authors:
    • Yidong Ge
    • Xiaoqi Ni
    • Jingyun Li
    • Meng Ye
    • Xiaofeng Jin
  • View Affiliations

  • Published online on: October 25, 2023     https://doi.org/10.3892/ol.2023.14117
  • Article Number: 530
  • Copyright: © Ge et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Endometrial carcinoma (EC) is a group of endometrial epithelial malignancies, most of which are adenocarcinomas and occur in perimenopausal and postmenopausal women. It is one of the most common carcinomas of the female reproductive system. It has been shown that the occurrence and development of EC is closely associated with the interaction between estrogen (estradiol, E2) and estrogen receptors (ERs), particularly ERα. As a key nuclear transcription factor, ERα is a carcinogenic factor in EC. Its interactions with upstream and downstream effectors and co‑regulators have important implications for the proliferation, metastasis, invasion and inhibition of apoptosis of EC. In the present review, the structure of ERα and the regulation of ERα in multiple dimensions are described. In addition, the classical E2/ERα signaling pathway and the crosstalk between ERα and other EC regulators are elucidated, as well as the therapeutic targeting of ERα, which may provide a new direction for clinical applications of ERα in the future.
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December-2023
Volume 26 Issue 6

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Copy and paste a formatted citation
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Spandidos Publications style
Ge Y, Ni X, Li J, Ye M and Jin X: Roles of estrogen receptor α in endometrial carcinoma (Review). Oncol Lett 26: 530, 2023
APA
Ge, Y., Ni, X., Li, J., Ye, M., & Jin, X. (2023). Roles of estrogen receptor α in endometrial carcinoma (Review). Oncology Letters, 26, 530. https://doi.org/10.3892/ol.2023.14117
MLA
Ge, Y., Ni, X., Li, J., Ye, M., Jin, X."Roles of estrogen receptor α in endometrial carcinoma (Review)". Oncology Letters 26.6 (2023): 530.
Chicago
Ge, Y., Ni, X., Li, J., Ye, M., Jin, X."Roles of estrogen receptor α in endometrial carcinoma (Review)". Oncology Letters 26, no. 6 (2023): 530. https://doi.org/10.3892/ol.2023.14117