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Case Report Open Access

Assessment of the expression of microRNAs‑221‑3p, ‑146a‑5p, ‑16‑5p and BCL2 in oncocytic carcinoma of the breast: A case report

  • Authors:
    • Yumiko Koi
    • Yuki Yamamoto
    • Saori Fukunaga
    • Keiko Kajitani
    • Masahiro Ohara
    • Yutaka Daimaru
    • Hidetoshi Tahara
    • Ryuichiro Tamada
  • View Affiliations / Copyright

    Affiliations: Department of Breast Oncology, National Hospital Organization Kyushu Cancer Center, Fukuoka 811‑1395, Japan, Department of Cellular and Molecular Biology, Hiroshima University Institute of Biomedical and Health Sciences, Hiroshima 734‑8553, Japan, Department of Breast Surgery, Japan Agricultural Co‑operatives Hiroshima General Hospital, Hatsukaichi, Hiroshima 738‑8503, Japan, Section of Pathological Research and Laboratory, Japan Agricultural Co‑operatives Hiroshima General Hospital, Hiroshima 738‑8503, Japan, Department of Surgery, Nishiki Hospital, Yamaguchi 741‑0061, Japan
    Copyright: © Koi et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 535
    |
    Published online on: October 31, 2023
       https://doi.org/10.3892/ol.2023.14123
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Abstract

Oncocytic carcinoma of the breast is rare and its molecular profiles remain poorly understood. MicroRNAs (miRNAs/miRs) have been identified as contributors to carcinogenesis at the post‑transcriptional level; thus, an aberrant expression of miRNAs has attracted attention as a potential biomarker of numerous diseases, including cancer. The present study reports the case of a 76‑year‑old woman diagnosed with oncocytic carcinoma of the breast. Considering the distinctive feature of oncocytic carcinoma of the breast, which is the presence of granular eosinophilic cytoplasm containing numerous mitochondria, the present study hypothesized that the expression of mitochondria‑related miRNAs could be altered in oncocytic carcinomas. Aberrant expression levels of the miRNAs previously reported as mitochondria‑related miRNAs, such as miR‑221‑3p, ‑146a‑5p and ‑16‑5p, were revealed in tissue from specimens of oncocytic carcinoma of the breast, compared with that of a more typical type of invasive ductal carcinoma of the breast. The present study highlights the changes in miRNA expression in oncocytic carcinoma of the breast, suggesting its potential as a biomarker for diagnosis.
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Copy and paste a formatted citation
Spandidos Publications style
Koi Y, Yamamoto Y, Fukunaga S, Kajitani K, Ohara M, Daimaru Y, Tahara H and Tamada R: Assessment of the expression of microRNAs‑221‑3p, ‑146a‑5p, ‑16‑5p and BCL2 in oncocytic carcinoma of the breast: A case report. Oncol Lett 26: 535, 2023.
APA
Koi, Y., Yamamoto, Y., Fukunaga, S., Kajitani, K., Ohara, M., Daimaru, Y. ... Tamada, R. (2023). Assessment of the expression of microRNAs‑221‑3p, ‑146a‑5p, ‑16‑5p and BCL2 in oncocytic carcinoma of the breast: A case report. Oncology Letters, 26, 535. https://doi.org/10.3892/ol.2023.14123
MLA
Koi, Y., Yamamoto, Y., Fukunaga, S., Kajitani, K., Ohara, M., Daimaru, Y., Tahara, H., Tamada, R."Assessment of the expression of microRNAs‑221‑3p, ‑146a‑5p, ‑16‑5p and BCL2 in oncocytic carcinoma of the breast: A case report". Oncology Letters 26.6 (2023): 535.
Chicago
Koi, Y., Yamamoto, Y., Fukunaga, S., Kajitani, K., Ohara, M., Daimaru, Y., Tahara, H., Tamada, R."Assessment of the expression of microRNAs‑221‑3p, ‑146a‑5p, ‑16‑5p and BCL2 in oncocytic carcinoma of the breast: A case report". Oncology Letters 26, no. 6 (2023): 535. https://doi.org/10.3892/ol.2023.14123
Copy and paste a formatted citation
x
Spandidos Publications style
Koi Y, Yamamoto Y, Fukunaga S, Kajitani K, Ohara M, Daimaru Y, Tahara H and Tamada R: Assessment of the expression of microRNAs‑221‑3p, ‑146a‑5p, ‑16‑5p and BCL2 in oncocytic carcinoma of the breast: A case report. Oncol Lett 26: 535, 2023.
APA
Koi, Y., Yamamoto, Y., Fukunaga, S., Kajitani, K., Ohara, M., Daimaru, Y. ... Tamada, R. (2023). Assessment of the expression of microRNAs‑221‑3p, ‑146a‑5p, ‑16‑5p and BCL2 in oncocytic carcinoma of the breast: A case report. Oncology Letters, 26, 535. https://doi.org/10.3892/ol.2023.14123
MLA
Koi, Y., Yamamoto, Y., Fukunaga, S., Kajitani, K., Ohara, M., Daimaru, Y., Tahara, H., Tamada, R."Assessment of the expression of microRNAs‑221‑3p, ‑146a‑5p, ‑16‑5p and BCL2 in oncocytic carcinoma of the breast: A case report". Oncology Letters 26.6 (2023): 535.
Chicago
Koi, Y., Yamamoto, Y., Fukunaga, S., Kajitani, K., Ohara, M., Daimaru, Y., Tahara, H., Tamada, R."Assessment of the expression of microRNAs‑221‑3p, ‑146a‑5p, ‑16‑5p and BCL2 in oncocytic carcinoma of the breast: A case report". Oncology Letters 26, no. 6 (2023): 535. https://doi.org/10.3892/ol.2023.14123
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