Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Oncology Letters
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-1074 Online ISSN: 1792-1082
Journal Cover
December-2023 Volume 26 Issue 6

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
December-2023 Volume 26 Issue 6

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Review Open Access

Influence of tumor mycobiome on cancer pathogenesis (Review)

  • Authors:
    • Weipeng Liu
    • Zongrui Li
    • Xiaopeng Li
    • Haiyang Cao
    • He Jiang
    • Qingbin Niu
    • Baoguang Hu
  • View Affiliations / Copyright

    Affiliations: Department of Gastrointestinal Surgery, Binzhou Medical University Hospital, Binzhou, Shandong 256603, P.R. China, Breast Treatment Center, The Second Affiliated Hospital of Shandong First Medical University, Taian, Shandong 271000, P.R. China, Department of Gastrointestinal Surgery, Dongying People's Hospital, Dongying, Shandong 257091, P.R. China
    Copyright: © Liu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 541
    |
    Published online on: November 2, 2023
       https://doi.org/10.3892/ol.2023.14128
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Cancer tissues harbor a large microbiome. There is growing evidence that the tumor microbiome is significantly correlated with the prognosis of cancer patients, but the exact underlying mechanisms have remained elusive. Although the tumor mycobiome is less abundant than the biome of bacteria, it is prevalent in most cancers in humans. The present review describes in detail the impact of the tumor mycobiome on cancer pathogenesis. The tumor mycobiome promotes tumor progression and metastasis by affecting the human immune system, maintaining a pro‑inflammatory environment, producing aflatoxins, attenuating cell adhesion mechanisms and fungal‑bacterial interactions. Furthermore, the tumor mycobiome likewise has great potential for cancer prevention, diagnosis and treatment.
View Figures

Figure 1

Figure 2

Figure 3

View References

1 

Davar D, Dzutsev AK, McCulloch JA, Rodrigues RR, Chauvin JM, Morrison RM, Deblasio RN, Menna C, Ding Q, Pagliano O, et al: Fecal microbiota transplant overcomes resistance to anti-PD-1 therapy in melanoma patients. Science. 371:595–602. 2021. View Article : Google Scholar : PubMed/NCBI

2 

Dzutsev A, Badger JH, Perez-Chanona E, Roy S, Salcedo R, Smith CK and Trinchieri G: Microbes and cancer. Annu Rev Immunol. 35:199–228. 2017. View Article : Google Scholar : PubMed/NCBI

3 

Finlay BB, Goldszmid R, Honda K, Trinchieri G, Wargo J and Zitvogel L: Can we harness the microbiota to enhance the efficacy of cancer immunotherapy? Nat Rev Immunol. 20:522–528. 2020. View Article : Google Scholar : PubMed/NCBI

4 

Garrett WS: The gut microbiota and colon cancer. Science. 364:1133–1135. 2019. View Article : Google Scholar : PubMed/NCBI

5 

Grivennikov SI, Greten FR and Karin M: Immunity, inflammation, and cancer. Cell. 140:883–899. 2010. View Article : Google Scholar : PubMed/NCBI

6 

Iida N, Dzutsev A, Stewart CA, Smith L, Bouladoux N, Weingarten RA, Molina DA, Salcedo R, Back T, Cramer S, et al: Commensal bacteria control cancer response to therapy by modulating the tumor microenvironment. Science. 342:967–970. 2013. View Article : Google Scholar : PubMed/NCBI

7 

Routy B, Le Chatelier E, Derosa L, Duong CPM, Alou MT, Daillère R, Fluckiger A, Messaoudene M, Rauber C, Roberti MP, et al: Gut microbiome influences efficacy of PD-1-based immunotherapy against epithelial tumors. Science. 359:91–97. 2018. View Article : Google Scholar : PubMed/NCBI

8 

Sharma P, Hu-Lieskovan S, Wargo JA and Ribas A: Primary, adaptive, and acquired resistance to cancer immunotherapy. Cell. 168:707–723. 2017. View Article : Google Scholar : PubMed/NCBI

9 

Shiao SL, Kershaw KM, Limon JJ, You S, Yoon J, Ko EY, Guarnerio J, Potdar AA, McGovern DPB, Bose S, et al: Commensal bacteria and fungi differentially regulate tumor responses to radiation therapy. Cancer cell. 39:1202–1213.e6. 2021. View Article : Google Scholar : PubMed/NCBI

10 

Spencer CN, McQuade JL, Gopalakrishnan V, McCulloch JA, Vetizou M, Cogdill AP, Khan MAW, Zhang X, White MG, Peterson CB, et al: Dietary fiber and probiotics influence the gut microbiome and melanoma immunotherapy response. Science. 374:1632–1640. 2021. View Article : Google Scholar : PubMed/NCBI

11 

Tanoue T, Morita S, Plichta DR, Skelly AN, Suda W, Sugiura Y, Narushima S, Vlamakis H, Motoo I, Sugita K, et al: A defined commensal consortium elicits CD8 T cells and anti-cancer immunity. Nature. 565:600–605. 2019. View Article : Google Scholar : PubMed/NCBI

12 

Sokol H, Leducq V, Aschard H, Pham HP, Jegou S, Landman C, Cohen D, Liguori G, Bourrier A, Nion-Larmurier I, et al: Fungal microbiota dysbiosis in IBD. Gut. 66:1039–1048. 2017. View Article : Google Scholar : PubMed/NCBI

13 

Findley K, Oh J, Yang J, Conlan S, Deming C, Meyer JA, Schoenfeld D, Nomicos E, Park M; NIH Intramural Sequencing Center Comparative Sequencing Program, ; et al: Topographic diversity of fungal and bacterial communities in human skin. Nature. 498:367–370. 2013. View Article : Google Scholar : PubMed/NCBI

14 

Hoarau G, Mukherjee PK, Gower-Rousseau C, Hager C, Chandra J, Retuerto MA, Neut C, Vermeire S, Clemente J, Colombel JF, et al: Bacteriome and mycobiome interactions underscore microbial dysbiosis in familial Crohn's disease. mBio. 7:e01250–16. 2016. View Article : Google Scholar : PubMed/NCBI

15 

Leonardi I, Paramsothy S, Doron I, Semon A, Kaakoush NO, Clemente JC, Faith JJ, Borody TJ, Mitchell HM, Colombel JF, et al: Fungal trans-kingdom dynamics linked to responsiveness to fecal microbiota transplantation (FMT) therapy in ulcerative colitis. Cell Host Microbe. 27:823–829.e3. 2020. View Article : Google Scholar : PubMed/NCBI

16 

Doron I, Mesko M, Li XV, Kusakabe T, Leonardi I, Shaw DG, Fiers WD, Lin WY, Bialt-DeCelie M, Román E, et al: Mycobiota-induced IgA antibodies regulate fungal commensalism in the gut and are dysregulated in Crohn's disease. Nat Microbiol. 6:1493–1504. 2021. View Article : Google Scholar : PubMed/NCBI

17 

Lewis JD, Chen EZ, Baldassano RN, Otley AR, Griffiths AM, Lee D, Bittinger K, Bailey A, Friedman ES, Hoffmann C, et al: Inflammation, antibiotics, and diet as environmental stressors of the gut microbiome in pediatric Crohn's disease. Cell Host Microbe. 18:489–500. 2015. View Article : Google Scholar : PubMed/NCBI

18 

Liguori G, Lamas B, Richard ML, Brandi G, da Costa G, Hoffmann TW, Di Simone MP, Calabrese C, Poggioli G, Langella P, et al: Fungal dysbiosis in mucosa-associated microbiota of Crohn's disease patients. J Crohns Colitis. 10:296–305. 2016. View Article : Google Scholar : PubMed/NCBI

19 

Tipton L, Müller CL, Kurtz ZD, Huang L, Kleerup E, Morris A, Bonneau R and Ghedin E: Fungi stabilize connectivity in the lung and skin microbial ecosystems. Microbiome. 6:122018. View Article : Google Scholar : PubMed/NCBI

20 

Zhai B, Ola M, Rolling T, Tosini NL, Joshowitz S, Littmann ER, Amoretti LA, Fontana E, Wright RJ, Miranda E, et al: High-resolution mycobiota analysis reveals dynamic intestinal translocation preceding invasive candidiasis. Nat Med. 26:59–64. 2020. View Article : Google Scholar : PubMed/NCBI

21 

Zuo T, Wong SH, Cheung CP, Lam K, Lui R, Cheung K, Zhang F, Tang W, Ching JYL, Wu JCY, et al: Gut fungal dysbiosis correlates with reduced efficacy of fecal microbiota transplantation in Clostridium difficile infection. Nat Commun. 9:36632018. View Article : Google Scholar : PubMed/NCBI

22 

Qin J, Li R, Raes J, Arumugam M, Burgdorf KS, Manichanh C, Nielsen T, Pons N, Levenez F, Yamada T, et al: A human gut microbial gene catalogue established by metagenomic sequencing. Nature. 464:59–65. 2010. View Article : Google Scholar : PubMed/NCBI

23 

Brown GD, Denning DW, Gow NA, Levitz SM, Netea MG and White TC: Hidden killers: Human fungal infections. Sci Transl Med. 4:165rv132012. View Article : Google Scholar : PubMed/NCBI

24 

Helmink BA, Khan MAW, Hermann A, Gopalakrishnan V and Wargo JA: The microbiome, cancer, and cancer therapy. Nat Med. 25:377–388. 2019. View Article : Google Scholar : PubMed/NCBI

25 

Vogtmann E and Goedert JJ: Epidemiologic studies of the human microbiome and cancer. Br J Cancer. 114:237–242. 2016. View Article : Google Scholar : PubMed/NCBI

26 

Polk DB and Peek RM Jr: Helicobacter pylori: Gastric cancer and beyond. Nat Rev Cancer. 10:403–414. 2010. View Article : Google Scholar : PubMed/NCBI

27 

Sepich-Poore GD, Zitvogel L, Straussman R, Hasty J, Wargo JA and Knight R: The microbiome and human cancer. Science. 371:eabc45522021. View Article : Google Scholar : PubMed/NCBI

28 

Poore GD, Kopylova E, Zhu Q, Carpenter C, Fraraccio S, Wandro S, Kosciolek T, Janssen S, Metcalf J, Song SJ, et al: Microbiome analyses of blood and tissues suggest cancer diagnostic approach. Nature. 579:567–574. 2020. View Article : Google Scholar : PubMed/NCBI

29 

Dohlman AB, Arguijo Mendoza D, Ding S, Gao M, Dressman H, Iliev ID, Lipkin SM and Shen X: The cancer microbiome atlas: A pan-cancer comparative analysis to distinguish tissue-resident microbiota from contaminants. Cell Host Microbe. 29:281–298.e5. 2021. View Article : Google Scholar : PubMed/NCBI

30 

Nejman D, Livyatan I, Fuks G, Gavert N, Zwang Y, Geller LT, Rotter-Maskowitz A, Weiser R, Mallel G, Gigi E, et al: The human tumor microbiome is composed of tumor type-specific intracellular bacteria. Science. 368:973–980. 2020. View Article : Google Scholar : PubMed/NCBI

31 

Aykut B, Pushalkar S, Chen R, Li Q, Abengozar R, Kim JI, Shadaloey SA, Wu D, Preiss P, Verma N, et al: The fungal mycobiome promotes pancreatic oncogenesis via activation of MBL. Nature. 574:264–267. 2019. View Article : Google Scholar : PubMed/NCBI

32 

Elaskandrany M, Patel R, Patel M, Miller G, Saxena D and Saxena A: Fungi, host immune response, and tumorigenesis. Am J Physiol Gastrointest Liver Physiol. 321:G213–G222. 2021. View Article : Google Scholar : PubMed/NCBI

33 

Iliev ID and Leonardi I: Fungal dysbiosis: Immunity and interactions at mucosal barriers. Nat Rev Immunol. 17:635–646. 2017. View Article : Google Scholar : PubMed/NCBI

34 

Narunsky-Haziza L, Sepich-Poore GD, Livyatan I, Asraf O, Martino C, Nejman D, Gavert N, Stajich JE, Amit G, González A, et al: Pan-cancer analyses reveal cancer-type-specific fungal ecologies and bacteriome interactions. Cell. 185:3789–3806.e17. 2022. View Article : Google Scholar : PubMed/NCBI

35 

Li X and Saxena D: The tumor mycobiome: A paradigm shift in cancer pathogenesis. Cell. 185:3648–3651. 2022. View Article : Google Scholar : PubMed/NCBI

36 

Zhong M, Xiong Y, Zhao J, Gao Z, Ma J, Wu Z, Song Y and Hong X: Candida albicans disorder is associated with gastric carcinogenesis. Theranostics. 11:4945–4956. 2021. View Article : Google Scholar : PubMed/NCBI

37 

Coker OO: Non-bacteria microbiome (virus, fungi, and archaea) in gastrointestinal cancer. J Gastroenterol Hepatol. 37:256–262. 2022. View Article : Google Scholar : PubMed/NCBI

38 

Coker OO, Nakatsu G, Dai RZ, Wu WKK, Wong SH, Ng SC, Chan FKL, Sung JJY and Yu J: Enteric fungal microbiota dysbiosis and ecological alterations in colorectal cancer. Gut. 68:654–662. 2019. View Article : Google Scholar : PubMed/NCBI

39 

Dohlman AB, Klug J, Mesko M, Gao IH, Lipkin SM, Shen X and Iliev ID: A pan-cancer mycobiome analysis reveals fungal involvement in gastrointestinal and lung tumors. Cell. 185:3807–3822.e12. 2022. View Article : Google Scholar : PubMed/NCBI

40 

Seelbinder B, Chen J, Brunke S, Vazquez-Uribe R, Santhaman R, Meyer AC, de Oliveira Lino FS, Chan KF, Loos D, Imamovic L, et al: Antibiotics create a shift from mutualism to competition in human gut communities with a longer-lasting impact on fungi than bacteria. Microbiome. 8:1332020. View Article : Google Scholar : PubMed/NCBI

41 

Viscoli C, Castagnola E and Machetti M: Antifungal treatment in patients with cancer. J Intern Med Suppl. 740:89–94. 1997. View Article : Google Scholar : PubMed/NCBI

42 

Alam A, Levanduski E, Denz P, Villavicencio HS, Bhatta M, Alhorebi L, Zhang Y, Gomez EC, Morreale B, Senchanthisai S, et al: Fungal mycobiome drives IL-33 secretion and type 2 immunity in pancreatic cancer. Cancer Cell. 40:153–167.e11. 2022. View Article : Google Scholar : PubMed/NCBI

43 

Qiu X, Zhang F, Yang X, Wu N, Jiang W, Li X, Li X and Liu Y: Changes in the composition of intestinal fungi and their role in mice with dextran sulfate sodium-induced colitis. Sci Rep. 5:104162015. View Article : Google Scholar : PubMed/NCBI

44 

Malik A, Sharma D, Malireddi RKS, Guy CS, Chang TC, Olsen SR, Neale G, Vogel P and Kanneganti TD: SYK-CARD9 signaling axis promotes gut fungi-mediated inflammasome activation to restrict colitis and colon cancer. Immunity. 49:515–530.e5. 2018. View Article : Google Scholar : PubMed/NCBI

45 

Medzhitov R: Origin and physiological roles of inflammation. Nature. 454:428–435. 2008. View Article : Google Scholar : PubMed/NCBI

46 

Bannenberg GL, Chiang N, Ariel A, Arita M, Tjonahen E, Gotlinger KH, Hong S and Serhan CN: Molecular circuits of resolution: Formation and actions of resolvins and protectins. J Immunol. 174:4345–4355. 2005. View Article : Google Scholar : PubMed/NCBI

47 

Gordon S: Phagocytosis: An immunobiologic process. Immunity. 44:463–475. 2016. View Article : Google Scholar : PubMed/NCBI

48 

Bishehsari F, Engen PA, Preite NZ, Tuncil YE, Naqib A, Shaikh M, Rossi M, Wilber S, Green SJ, Hamaker BR, et al: Dietary fiber treatment corrects the composition of gut microbiota, promotes SCFA production, and suppresses colon carcinogenesis. Genes (Basel). 9:1022018. View Article : Google Scholar : PubMed/NCBI

49 

Singh N, Baby D, Rajguru JP, Patil PB, Thakkannavar SS and Pujari VB: Inflammation and cancer. Ann Afr Med. 18:121–126. 2019. View Article : Google Scholar : PubMed/NCBI

50 

Siegel RL, Miller KD and Jemal A: Cancer statistics, 2020. CA Cancer J Clin. 70:7–30. 2020. View Article : Google Scholar : PubMed/NCBI

51 

Naylor MS, Stamp GW, Foulkes WD, Eccles D and Balkwill FR: Tumor necrosis factor and its receptors in human ovarian cancer. Potential role in disease progression. J Clin Invest. 91:2194–2206. 1993. View Article : Google Scholar : PubMed/NCBI

52 

Haghnegahdar H, Du J, Wang D, Strieter RM, Burdick MD, Nanney LB, Cardwell N, Luan J, Shattuck-Brandt R and Richmond A: The tumorigenic and angiogenic effects of MGSA/GRO proteins in melanoma. J Leukoc Biol. 67:53–62. 2000. View Article : Google Scholar : PubMed/NCBI

53 

Thun MJ, Namboodiri MM, Calle EE, Flanders WD and Heath CW Jr: Aspirin use and risk of fatal cancer. Cancer Res. 53:1322–1327. 1993.PubMed/NCBI

54 

Yang Q, Ouyang J, Pi D, Feng L and Yang J: Malassezia in inflammatory bowel disease: Accomplice of evoking tumorigenesis. Front Immunol. 13:8464692022. View Article : Google Scholar : PubMed/NCBI

55 

Wolf AJ, Limon JJ, Nguyen C, Prince A, Castro A and Underhill DM: Malassezia spp. induce inflammatory cytokines and activate NLRP3 inflammasomes in phagocytes. J Leukoc Biol. 109:161–172. 2021. View Article : Google Scholar : PubMed/NCBI

56 

Zhang YJ, Han Y, Sun YZ, Jiang HH, Liu M, Qi RQ and Gao XH: Extracellular vesicles derived from Malassezia furfur stimulate IL-6 production in keratinocytes as demonstrated in in vitro and in vivo models. J Dermatol Sci. 93:168–175. 2019. View Article : Google Scholar : PubMed/NCBI

57 

Berti M and Vindigni A: Replication stress: Getting back on track. Nat Struct Mol Biol. 23:103–109. 2016. View Article : Google Scholar : PubMed/NCBI

58 

Kawanishi S, Ohnishi S, Ma N, Hiraku Y and Murata M: Crosstalk between DNA damage and inflammation in the multiple steps of carcinogenesis. Int J Mol Sci. 18:18082017. View Article : Google Scholar : PubMed/NCBI

59 

Sung H, Ferlay J, Siegel RL, Laversanne M, Soerjomataram I, Jemal A and Bray F: Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 71:209–249. 2021. View Article : Google Scholar : PubMed/NCBI

60 

Lin Y, Wang G, Yu J and Sung JJY: Artificial intelligence and metagenomics in intestinal diseases. J Gastroenterol Hepatol. 36:841–847. 2021. View Article : Google Scholar : PubMed/NCBI

61 

Wong SH and Yu J: Gut microbiota in colorectal cancer: Mechanisms of action and clinical applications. Nat Rev Gastroenterol Hepatol. 16:690–704. 2019. View Article : Google Scholar : PubMed/NCBI

62 

Perrone G and Gallo A: Aspergillus species and their associated mycotoxins. Methods Mol Biol. 1542:33–49. 2017. View Article : Google Scholar : PubMed/NCBI

63 

Dai Z, Coker OO, Nakatsu G, Wu WKK, Zhao L, Chen Z, Chan FKL, Kristiansen K, Sung JJY, Wong SH and Yu J: Multi-cohort analysis of colorectal cancer metagenome identified altered bacteria across populations and universal bacterial markers. Microbiome. 6:702018. View Article : Google Scholar : PubMed/NCBI

64 

Lin Y, Lau HC, Liu Y, Kang X, Wang Y, Ting NL, Kwong TN, Han J, Liu W, Liu C, et al: Altered mycobiota signatures and enriched pathogenic Aspergillus rambellii are associated with colorectal cancer based on multicohort fecal metagenomic analyses. Gastroenterology. 163:908–921. 2022. View Article : Google Scholar : PubMed/NCBI

65 

Luan C, Xie L, Yang X, Miao H, Lv N, Zhang R, Xiao X, Hu Y, Liu Y, Wu N, et al: Dysbiosis of fungal microbiota in the intestinal mucosa of patients with colorectal adenomas. Sci Rep. 5:79802015. View Article : Google Scholar : PubMed/NCBI

66 

Gao R, Kong C, Li H, Huang L, Qu X, Qin N and Qin H: Dysbiosis signature of mycobiota in colon polyp and colorectal cancer. Eur J Clin Microbiol Infect Dis. 36:2457–2468. 2017. View Article : Google Scholar : PubMed/NCBI

67 

Richard ML, Liguori G, Lamas B, Brandi G, da Costa G, Hoffmann TW, Pierluigi Di Simone M, Calabrese C, Poggioli G, et al: Mucosa-associated microbiota dysbiosis in colitis associated cancer. Gut Microbes. 9:131–142. 2018. View Article : Google Scholar : PubMed/NCBI

68 

Cary JW, Ehrlich KC, Beltz SB, Harris-Coward P and Klich MA: Characterization of the Aspergillus ochraceoroseus aflatoxin/sterigmatocystin biosynthetic gene cluster. Mycologia. 101:352–362. 2009. View Article : Google Scholar : PubMed/NCBI

69 

Frisvad JC, Skouboe P and Samson RA: Taxonomic comparison of three different groups of aflatoxin producers and a new efficient producer of aflatoxin B1, sterigmatocystin and 3-O-methylsterigmatocystin, Aspergillus rambellii sp. nov. Syst Appl Microbiol. 28:442–453. 2005. View Article : Google Scholar : PubMed/NCBI

70 

Navale V, Vamkudoth KR, Ajmera S and Dhuri V: Aspergillus derived mycotoxins in food and the environment: Prevalence, detection, and toxicity. Toxicol Rep. 8:1008–1030. 2021. View Article : Google Scholar : PubMed/NCBI

71 

Uka V, Cary JW, Lebar MD, Puel O, De Saeger S and Diana Di Mavungu J: Chemical repertoire and biosynthetic machinery of the Aspergillus flavus secondary metabolome: A review. Compr Rev Food Sci Food Saf. 19:2797–2842. 2020. View Article : Google Scholar : PubMed/NCBI

72 

McCullough AK and Lloyd RS: Mechanisms underlying aflatoxin-associated mutagenesis-implications in carcinogenesis. DNA Repair (Amst). 77:76–86. 2019. View Article : Google Scholar : PubMed/NCBI

73 

Bianco G, Russo R, Marzocco S, Velotto S, Autore G and Severino L: Modulation of macrophage activity by aflatoxins B1 and B2 and their metabolites aflatoxins M1 and M2. Toxicon. 59:644–650. 2012. View Article : Google Scholar : PubMed/NCBI

74 

Mohammadi A, Mehrzad J, Mahmoudi M and Schneider M: Environmentally relevant level of aflatoxin B1 dysregulates human dendritic cells through signaling on key toll-like receptors. Int J Toxicol. 33:175–186. 2014. View Article : Google Scholar : PubMed/NCBI

75 

Soler AP, Miller RD, Laughlin KV, Carp NZ, Klurfeld DM and Mullin JM: Increased tight junctional permeability is associated with the development of colon cancer. Carcinogenesis. 20:1425–1431. 1999. View Article : Google Scholar : PubMed/NCBI

76 

Martin TA and Jiang WG: Loss of tight junction barrier function and its role in cancer metastasis. Biochim Biophys Acta. 1788:872–891. 2009. View Article : Google Scholar : PubMed/NCBI

77 

Liu NN, Jiao N, Tan JC, Wang Z, Wu D, Wang AJ, Chen J, Tao L, Zhou C, Fang W, et al: Multi-kingdom microbiota analyses identify bacterial-fungal interactions and biomarkers of colorectal cancer across cohorts. Nat Microbiol. 7:238–250. 2022. View Article : Google Scholar : PubMed/NCBI

78 

Gmeiner WH, Hellmann GM and Shen P: Tissue-dependent and -independent gene expression changes in metastatic colon cancer. Oncol Rep. 19:245–251. 2008.PubMed/NCBI

79 

Tjalsma H, Boleij A, Marchesi JR and Dutilh BE: A bacterial driver-passenger model for colorectal cancer: Beyond the usual suspects. Nat Rev Microbiol. 10:575–582. 2012. View Article : Google Scholar : PubMed/NCBI

80 

Wirbel J, Pyl PT, Kartal E, Zych K, Kashani A, Milanese A, Fleck JS, Voigt AY, Palleja A, Ponnudurai R, et al: Meta-analysis of fecal metagenomes reveals global microbial signatures that are specific for colorectal cancer. Nat Med. 25:679–689. 2019. View Article : Google Scholar : PubMed/NCBI

81 

Thomas AM, Manghi P, Asnicar F, Pasolli E, Armanini F, Zolfo M, Beghini F, Manara S, Karcher N, Pozzi C, et al: Metagenomic analysis of colorectal cancer datasets identifies cross-cohort microbial diagnostic signatures and a link with choline degradation. Nat Med. 25:667–678. 2019. View Article : Google Scholar : PubMed/NCBI

82 

Zhu F, Willette-Brown J, Song NY, Lomada D, Song Y, Xue L, Gray Z, Zhao Z, Davis SR, Sun Z, et al: Autoreactive T cells and chronic fungal infection drive esophageal carcinogenesis. Cell Host Microbe. 21:478–493.e7. 2017. View Article : Google Scholar : PubMed/NCBI

83 

Azad MAK, Sarker M, Li T and Yin J: Probiotic species in the modulation of gut microbiota: An overview. Biomed Res Int. 2018:94786302018. View Article : Google Scholar : PubMed/NCBI

84 

Mozaffari Namin B, Daryani NE, Mirshafiey A, Yazdi MKS and Dallal MMS: Effect of probiotics on the expression of Barrett's oesophagus biomarkers. J Med Microbiol. 64:348–354. 2015. View Article : Google Scholar : PubMed/NCBI

85 

Rosania R, Minenna MF, Giorgio F, Facciorusso A, De Francesco V, Hassan C, Panella C and Ierardi E: Probiotic multistrain treatment may eradicate Helicobacter pylori from the stomach of dyspeptics: A placebo-controlled pilot study. Inflamm Allergy Drug Targets. 11:244–249. 2012. View Article : Google Scholar : PubMed/NCBI

86 

Zhu R, Chen K, Zheng YY, Zhang HW, Wang JS, Xia YJ, Dai WQ, Wang F, Shen M, Cheng P, et al: Meta-analysis of the efficacy of probiotics in Helicobacter pylori eradication therapy. World J Gastroenterol. 20:18013–18021. 2014. View Article : Google Scholar : PubMed/NCBI

87 

Kumar V, Yadav AN, Verma P, Sangwan P, Saxena A, Kumar K and Singh B: β-Propeller phytases: Diversity, catalytic attributes, current developments and potential biotechnological applications. Int J Biol Macromol. 98:595–609. 2017. View Article : Google Scholar : PubMed/NCBI

88 

Lipke PN and Ovalle R: Cell wall architecture in yeast: New structure and new challenges. J Bacteriol. 180:3735–3740. 1998. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Liu W, Li Z, Li X, Cao H, Jiang H, Niu Q and Hu B: Influence of tumor mycobiome on cancer pathogenesis (Review). Oncol Lett 26: 541, 2023.
APA
Liu, W., Li, Z., Li, X., Cao, H., Jiang, H., Niu, Q., & Hu, B. (2023). Influence of tumor mycobiome on cancer pathogenesis (Review). Oncology Letters, 26, 541. https://doi.org/10.3892/ol.2023.14128
MLA
Liu, W., Li, Z., Li, X., Cao, H., Jiang, H., Niu, Q., Hu, B."Influence of tumor mycobiome on cancer pathogenesis (Review)". Oncology Letters 26.6 (2023): 541.
Chicago
Liu, W., Li, Z., Li, X., Cao, H., Jiang, H., Niu, Q., Hu, B."Influence of tumor mycobiome on cancer pathogenesis (Review)". Oncology Letters 26, no. 6 (2023): 541. https://doi.org/10.3892/ol.2023.14128
Copy and paste a formatted citation
x
Spandidos Publications style
Liu W, Li Z, Li X, Cao H, Jiang H, Niu Q and Hu B: Influence of tumor mycobiome on cancer pathogenesis (Review). Oncol Lett 26: 541, 2023.
APA
Liu, W., Li, Z., Li, X., Cao, H., Jiang, H., Niu, Q., & Hu, B. (2023). Influence of tumor mycobiome on cancer pathogenesis (Review). Oncology Letters, 26, 541. https://doi.org/10.3892/ol.2023.14128
MLA
Liu, W., Li, Z., Li, X., Cao, H., Jiang, H., Niu, Q., Hu, B."Influence of tumor mycobiome on cancer pathogenesis (Review)". Oncology Letters 26.6 (2023): 541.
Chicago
Liu, W., Li, Z., Li, X., Cao, H., Jiang, H., Niu, Q., Hu, B."Influence of tumor mycobiome on cancer pathogenesis (Review)". Oncology Letters 26, no. 6 (2023): 541. https://doi.org/10.3892/ol.2023.14128
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team