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December-2023 Volume 26 Issue 6

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Review

Mechanistic insights into UHRF1‑mediated DNA methylation by structure‑based functional clarification of UHRF1 domains (Review)

  • Authors:
    • Yiying Song
    • Haiting Liu
    • Qingqing Xian
    • Chengzhi Gui
    • Mingjie Xu
    • Yunying Zhou
  • View Affiliations / Copyright

    Affiliations: Department of Clinical Laboratory Diagnosis, Jinan Central Hospital, Shandong University, Jinan, Shandong 250012, P.R. China, Department of Critical Care Medicine, Jinan Zhangqiu Hospital of Traditional Chinese Medicine, Jinan, Shandong 250200, P.R. China, Department of Clinical Laboratory Diagnosis, Shandong First Medical University, Jinan, Shandong 250012, P.R. China, Medical Research and Laboratory Diagnostic Center, Central Hospital Affiliated to Shandong First Medical University, Jinan, Shandong 250013, P.R. China
  • Article Number: 542
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    Published online on: November 2, 2023
       https://doi.org/10.3892/ol.2023.14129
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Abstract

Epigenetic modification is crucial for transmitting genetic information, while abnormalities in DNA methylation modification are primarily associated with cancer and neurological diseases. As a multifunctional epigenetic modifier, ubiquitin like with PHD and ring finger domains 1 (UHRF1) mainly affects cell energy metabolism and cell cycle control. It also inhibits the transcription of tumor suppressor genes through DNA and/or histone methylation modifications, promoting the occurrence and development of cancer. Therefore, comprehensively understanding the molecular mechanism of the epigenetic modification of UHRF1 in tumors will help identify targets for inhibiting the expression and function of UHRF1. Notably, each domain of UHRF1 functions as a whole and differently. Thus, the abnormality of any domain can lead to a change in phenotype or disease. However, the specific regulatory mechanism and proteins of each domain have not been fully elucidated. The present review aimed to contribute to the study of the regulatory mechanism of UHRF1 to a greater extent in different cancers and provide ideas for drug research by clarifying the function of UHRF1 domains.
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Copy and paste a formatted citation
Spandidos Publications style
Song Y, Liu H, Xian Q, Gui C, Xu M and Zhou Y: Mechanistic insights into UHRF1‑mediated DNA methylation by structure‑based functional clarification of UHRF1 domains (Review). Oncol Lett 26: 542, 2023.
APA
Song, Y., Liu, H., Xian, Q., Gui, C., Xu, M., & Zhou, Y. (2023). Mechanistic insights into UHRF1‑mediated DNA methylation by structure‑based functional clarification of UHRF1 domains (Review). Oncology Letters, 26, 542. https://doi.org/10.3892/ol.2023.14129
MLA
Song, Y., Liu, H., Xian, Q., Gui, C., Xu, M., Zhou, Y."Mechanistic insights into UHRF1‑mediated DNA methylation by structure‑based functional clarification of UHRF1 domains (Review)". Oncology Letters 26.6 (2023): 542.
Chicago
Song, Y., Liu, H., Xian, Q., Gui, C., Xu, M., Zhou, Y."Mechanistic insights into UHRF1‑mediated DNA methylation by structure‑based functional clarification of UHRF1 domains (Review)". Oncology Letters 26, no. 6 (2023): 542. https://doi.org/10.3892/ol.2023.14129
Copy and paste a formatted citation
x
Spandidos Publications style
Song Y, Liu H, Xian Q, Gui C, Xu M and Zhou Y: Mechanistic insights into UHRF1‑mediated DNA methylation by structure‑based functional clarification of UHRF1 domains (Review). Oncol Lett 26: 542, 2023.
APA
Song, Y., Liu, H., Xian, Q., Gui, C., Xu, M., & Zhou, Y. (2023). Mechanistic insights into UHRF1‑mediated DNA methylation by structure‑based functional clarification of UHRF1 domains (Review). Oncology Letters, 26, 542. https://doi.org/10.3892/ol.2023.14129
MLA
Song, Y., Liu, H., Xian, Q., Gui, C., Xu, M., Zhou, Y."Mechanistic insights into UHRF1‑mediated DNA methylation by structure‑based functional clarification of UHRF1 domains (Review)". Oncology Letters 26.6 (2023): 542.
Chicago
Song, Y., Liu, H., Xian, Q., Gui, C., Xu, M., Zhou, Y."Mechanistic insights into UHRF1‑mediated DNA methylation by structure‑based functional clarification of UHRF1 domains (Review)". Oncology Letters 26, no. 6 (2023): 542. https://doi.org/10.3892/ol.2023.14129
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