Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Oncology Letters
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-1074 Online ISSN: 1792-1082
Journal Cover
December-2023 Volume 26 Issue 6

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
December-2023 Volume 26 Issue 6

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML

  • Supplementary Files
    • Supplementary_Data.pdf
Article Open Access

Lack of association between XRCC1 SNPs and acute radiation‑induced injury or prognosis in patients with nasopharyngeal carcinoma

  • Authors:
    • Yuhong Zheng
    • Jingfeng Zong
    • Yansong Chen
    • Junying Guo
    • Tianzhu Lu
    • Xiaoqin Xin
    • Yan Chen
  • View Affiliations / Copyright

    Affiliations: Department of Clinical Laboratory, Clinical Oncology School of Fujian Medical University, Fujian Cancer Hospital, Fuzhou, Fujian 350014, P.R. China, Department of Radiation Oncology, Clinical Oncology School of Fujian Medical University, Fujian Cancer Hospital, Fuzhou, Fujian 350014, P.R. China
    Copyright: © Zheng et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 544
    |
    Published online on: November 3, 2023
       https://doi.org/10.3892/ol.2023.14130
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

The response to radiation therapy (RT) is closely associated with DNA damage repair. X‑ray repair cross‑complementing group‑1 (XRCC1) is a key gene in the DNA damage repair pathway, and SNPs in this gene alter the expression and activity of its effector protein, which may in turn affect sensitivity to RT. Therefore, the course of tumor treatment and local control rate can be influenced. In the present study, a group of 158 patients with nasopharyngeal carcinoma (NPC) who received intensity‑modulated RT at Fujian Cancer Hospital (Fuzhou, China) between July 2012 and October 2013 were included in retrospective chart review and followed up. Plasma was collected before treatment for genotype analysis of the three SNPs of XRCC1, namely Arg194Trp, Arg280His and Arg399Gln. Acute radiation‑induced injuries sustained during treatment was graded according to the Radiation Therapy Oncology Group scoring criteria. Post‑treatment follow‑up was performed until August 2020. In the 158 cases of NPC, no statistically significant association was observed between the three SNPs of the XRCC1 gene and the severity of acute radiation‑induced injury or prognosis. However, the AA genotype of XRCC1‑Arg399Gln tended to be associated with worse progression‑free survival (PFS) compared with the GA + GG genotype, although this was not significant (P=0.069). In addition, multivariate logistic analysis showed that nodal stage was significantly associated with the occurrence of acute severe radiation‑induced oral mucositis (P=0.018), and there was also a trend towards an association between nodal stage and the incidence of acute severe radiation‑induced pharyngitis; however, this was not statistically significant (P=0.061). Furthermore, multivariate Cox regression analysis showed that older age, distant metastasis and higher clinical stage were independent risk factors for PFS in patients with NPC. In conclusion, relying solely on the aforementioned SNPs of the XRCC1 gene may not provide a robust enough basis to predict the response to RT or prognosis in patients with NPC.
View Figures

Figure 1

Figure 2

View References

1 

World Health Organization: 4-Nasopharynx-fact-sheet. Global Cancer Observatory. 2020.

2 

Lee AW, Ma BB, Ng WT and Chan AT: Management of nasopharyngeal carcinoma: Current practice and future perspective. J Clin Oncol. 33:3356–3364. 2015. View Article : Google Scholar : PubMed/NCBI

3 

Chen YP, Chan ATC, Le QT, Blanchard P, Sun Y and Ma J: Nasopharyngeal carcinoma. Lancet. 394:64–80. 2019. View Article : Google Scholar : PubMed/NCBI

4 

Ma Z, Umezawa R, Yamamoto T, Ishikawa Y, Takahashi N, Takeda K, Suzuki Y, Tang L, Ito K, Kadoya N and Jingu K: IMRT improves local control in patients with NPC compared with conventional radiotherapy: Propensity score-matched analysis. Jpn J Clin Oncol. 51:1444–1451. 2021. View Article : Google Scholar : PubMed/NCBI

5 

Yeh SA, Hwang TZ, Wang CC, Yang CC, Lien CF, Wang CC, Hsu TY, Hsu RF, Shih YC, Huang YC, et al: Outcomes of patients with nasopharyngeal carcinoma treated with intensity-modulated radiotherapy. J Radiat Res. 62:438–447. 2021. View Article : Google Scholar : PubMed/NCBI

6 

Chen L, Zhang Y, Lai SZ, Li WF, Hu WH, Sun R, Liu LZ, Zhang F, Peng H, Du XJ, et al: 10-Year results of therapeutic ratio by Intensity-Modulated radiotherapy versus Two-Dimensional radiotherapy in patients with Nasopharyngeal Carcinoma. Oncologist. 24:e38–e45. 2019. View Article : Google Scholar : PubMed/NCBI

7 

Kouloulias V, Thalassinou S, Platoni K, Zygogianni A, Kouvaris J, Antypas C, Efstathopoulos E and Nikolaos K: The treatment outcome and radiation-induced toxicity for patients with head and neck carcinoma in the IMRT era: A systematic review with dosimetric and clinical parameters. Biomed Res Int. 2013:4012612013. View Article : Google Scholar : PubMed/NCBI

8 

Yao Z and Cheng B: Morbidity in patients with nasopharyngeal carcinoma and Radiation-induced skin lesions: Cause, risk factors, and dermatitis evolution and severity. Adv Skin Wound Care. 34:1–8. 2021. View Article : Google Scholar : PubMed/NCBI

9 

Bossi P, Cossu Rocca M, Corvo R, Depenni R, Guardamagna V, Marinangeli F, Micciche F and Trippa F: The vicious circle of treatment-induced toxicities in locally advanced head and neck cancer and the impact on treatment intensity. Crit Rev Oncol Hematol. 116:82–88. 2017. View Article : Google Scholar : PubMed/NCBI

10 

Yang XL, Zhou GQ, Lin L, Zhang LL, Chen FP, Lv JW, Kou J, Wen DW, Ma J, Sun Y, et al: Prognostic value of radiation interruption in different periods for nasopharyngeal carcinoma patients in the intensity-modulated RT era. Cancer Med. 10:143–155. 2021. View Article : Google Scholar : PubMed/NCBI

11 

Yao JJ, Zhang F, Gao TS, Zhang WJ, Lawrence WR, Zhu BT, Zhou GQ, Ma J, Wang SY and Sun Y: Survival impact of radiotherapy interruption in nasopharyngeal carcinoma in the intensity-modulated radiotherapy era: A big-data intelligence platform-based analysis. Radiother Oncol. 132:178–187. 2019. View Article : Google Scholar : PubMed/NCBI

12 

Applegate KE, Ruhm W, Wojcik A, Bourguignon M, Brenner A, Hamasaki K, Imai T, Imaizumi M, Imaoka T, Kakinuma S, et al: Individual response of humans to ionising radiation: Governing factors and importance for radiological protection. Radiat Environ Biophys. 59:185–209. 2020. View Article : Google Scholar : PubMed/NCBI

13 

Wardill HR, Sonis ST, Blijlevens NMA, Van Sebille YZA, Ciorba MA, Loeffen EAH, Cheng KKF, Bossi P, Porcello L, Castillo DA, et al: Prediction of mucositis risk secondary to cancer therapy: A systematic review of current evidence and call to action. Support Care Cancer. 28:5059–5073. 2020. View Article : Google Scholar : PubMed/NCBI

14 

Yang DW, Wang TM, Zhang JB, Li XZ, He YQ, Xiao R, Xue WQ, Zheng XH, Zhang PF, Zhang SD, et al: Genome-wide association study identifies genetic susceptibility loci and pathways of radiation-induced acute oral mucositis. J Transl Med. 18:2242020. View Article : Google Scholar : PubMed/NCBI

15 

Brothwell MRS, West CM, Dunning AM, Burnet NG and Barnett GC: Radiogenomics in the era of advanced radiotherapy. Clin Oncol (R Coll Radiol). 31:319–325. 2019. View Article : Google Scholar : PubMed/NCBI

16 

Liu J, Bi K, Yang R, Li H, Nikitaki Z and Chang L: Role of DNA damage and repair in radiation cancer therapy: A current update and a look to the future. Int J Radiat Biol. 96:1329–1338. 2020. View Article : Google Scholar : PubMed/NCBI

17 

London RE: XRCC1-Strategies for coordinating and assembling a versatile DNA damage response. DNA Repair (Amst). 93:1029172020. View Article : Google Scholar : PubMed/NCBI

18 

Guo Z, Shu Y, Zhou H, Zhang W and Wang H: Radiogenomics helps to achieve personalized therapy by evaluating patient responses to radiation treatment. Carcinogenesis. 36:307–317. 2015. View Article : Google Scholar : PubMed/NCBI

19 

Xi T, Jones IM and Mohrenweiser HW: Many amino acid substitution variants identified in DNA repair genes during human population screenings are predicted to impact protein function. Genomics. 83:970–979. 2004. View Article : Google Scholar : PubMed/NCBI

20 

Rosen EM, Fan S, Goldberg ID and Rockwell S: Biological basis of radiation sensitivity. Part 2: Cellular and molecular determinants of radiosensitivity. Oncology. 14:741–757. 2000.PubMed/NCBI

21 

Zhao J, Zhi Z, Zhang M, Li Q, Li J, Wang X and Ma C: Predictive value of single nucleotide polymorphisms in XRCC1 for radiation-induced normal tissue toxicity. Onco Targets Ther. 11:3901–3918. 2018. View Article : Google Scholar : PubMed/NCBI

22 

Lin J, Ye Q, Wang Y, Wang Y and Zeng Y: Association between XRCC1 single-nucleotide polymorphisms and susceptibility to nasopharyngeal carcinoma: An update meta-analysis. Medicine (Baltimore). 97:e118522018. View Article : Google Scholar : PubMed/NCBI

23 

Yang J, Li L, Yin X, Wu F, Shen J, Peng Y, Liu Y, Sun Y, Lu H and Zhang Y: The association between gene polymorphisms and risk of nasopharyngeal carcinoma. Med Oncol. 32:3982015. View Article : Google Scholar : PubMed/NCBI

24 

Zhang SQ, Pan SM, Liang SX, Han YS, Chen HB and Li JC: Research status and prospects of biomarkers for nasopharyngeal carcinoma in the era of highthroughput omics (Review). Int J Oncol. 58:92021. View Article : Google Scholar : PubMed/NCBI

25 

Siak PY, Khoo AS, Leong CO, Hoh BP and Cheah SC: Current status and future perspectives about molecular biomarkers of nasopharyngeal carcinoma. Cancers (Basel). 13:34902021. View Article : Google Scholar : PubMed/NCBI

26 

Mor V, Laliberte L, Morris JN and Wiemann M: The karnofsky performance status scale. An examination of its reliability and validity in a research setting. Cancer. 53:2002–2007. 1984. View Article : Google Scholar : PubMed/NCBI

27 

Lin S, Pan J, Han L, Guo Q, Hu C, Zong J, Zhang X and Lu JJ: Update report of nasopharyngeal carcinoma treated with reduced-volume intensity-modulated RT and hypothesis of the optimal margin. Radiother Oncol. 110:385–389. 2014. View Article : Google Scholar : PubMed/NCBI

28 

Cox JD, Stetz J and Pajak TF: Toxicity criteria of the radiation therapy oncology group (RTOG) and the european organization for research and treatment of cancer (EORTC). Int J Radiat Oncol Biol Phys. 31:1341–1346. 1995. View Article : Google Scholar : PubMed/NCBI

29 

Edge SB, Byrd DR, Compton CC, Fritz AG, Greene FL and Trotti A: AJCC Cancer Staging Manual. Seventh Edition. New York; Springer: 2010

30 

Jiqian Fang: Health Statistics. People's Medical Publishing House; Beijing: pp. 150–171. 2012

31 

Prescott RJ: Two-tailed significance tests for 2×2 contingency tables: What is the alternative? Stat Med. 38:4264–4269. 2019. View Article : Google Scholar : PubMed/NCBI

32 

Wang J, Guo C, Gong X, Ao F, Huang Y, Huang L, Tang Y, Jiang C, Xie X, Dong Q, et al: The impacts of genetic polymorphisms in genes of base excision repair pathway on the efficacy and acute toxicities of (chemo)radiotherapy in patients with nasopharyngeal carcinoma. Oncotarget. 8:78633–78641. 2017. View Article : Google Scholar : PubMed/NCBI

33 

Zhai XM, Hu QC, Gu K, Wang JP, Zhang JN and Wu YW: Significance of XRCC1 Codon399 polymorphisms in Chinese patients with locally advanced nasopharyngeal carcinoma treated with radiation therapy. Asia Pac J Clin Oncol. 12:e125–e132. 2016. View Article : Google Scholar : PubMed/NCBI

34 

Chen H, Wu M, Li G, Hua L, Chen S and Huang H: Association between XRCC1 single-nucleotide polymorphism and acute radiation reaction in patients with nasopharyngeal carcinoma: A cohort study. Medicine (Baltimore). 96:e82022017. View Article : Google Scholar : PubMed/NCBI

35 

Li H, You Y, Lin C, Zheng M, Hong C, Chen J, Li D, Au WW and Chen Z: XRCC1 codon 399Gln polymorphism is associated with radiotherapy-induced acute dermatitis and mucositis in nasopharyngeal carcinoma patients. Radiat Oncol. 8:312013. View Article : Google Scholar : PubMed/NCBI

36 

Jin H, Xie X, Wang H, Hu J, Liu F, Liu Z, Zhou J, Zhang Y, Xi X, Hu B, et al: ERCC1 Cys8092Ala and XRCC1 Arg399Gln polymorphisms predict progression-free survival after curative radiotherapy for nasopharyngeal carcinoma. PLoS One. 9:e1012562014. View Article : Google Scholar : PubMed/NCBI

37 

Chiang CL, Guo Q, Ng WT, Lin S, Ma TSW, Xu Z, Xiao Y, Li J, Lu T, Choi HCW, et al: Prognostic factors for overall survival in nasopharyngeal cancer and implication for TNM staging by UICC: A systematic review of the literature. Front Oncol. 11:7039952021. View Article : Google Scholar : PubMed/NCBI

38 

Alami IE, Gihbid A, Charoute H, Khaali W, Brahim SM, Tawfiq N, Cadi R, Belghmi K, El Mzibri M and Khyatti M: Prognostic value of Epstein-Barr virus DNA load in nasopharyngeal carcinoma: A meta-analysis. Pan Afr Med J. 41:62022. View Article : Google Scholar : PubMed/NCBI

39 

Qu H, Huang Y, Zhao S, Zhou Y and Lv W: Prognostic value of Epstein-Barr virus DNA level for nasopharyngeal carcinoma: A meta-analysis of 8128 cases. Eur Arch Otorhinolaryngol. 277:9–18. 2020. View Article : Google Scholar : PubMed/NCBI

40 

Zong J, Zheng Y, Lin C, Chen Y, Chen C, Pan J and Lin S: The value of plasma EBV DNA in monitoring the therapeutic effect of nasopharyngeal carcinoma. Chin J Radiat Oncol. 28:881–885. 2019.

41 

Zong JF, Zheng YH, Weng YI, Chen LS, Yun XU, Chen Y, Pan JJ and Lin SJ: Prognostic Value of Pre-treatment plasma EBV DNA in nasopharyngeal carcinoma patients treated with intensity-modulated radiation therapy. J Chin Oncol. 22:810–815. 2016.

42 

Nanda SS, Gandhi AK, Rastogi M, Khurana R, Hadi R, Sahni K, Mishra SP, Srivastava AK, Bhatt MLB and Parmar D: Evaluation of XRCC1 gene polymorphism as a biomarker in head and neck cancer patients undergoing chemoradiation therapy. Int J Radiat Oncol Biol Phys. 101:593–601. 2018. View Article : Google Scholar : PubMed/NCBI

43 

Leopold SS and Porcher R: Editorial: Sparse-data Bias-What the savvy reader needs to know. Clin Orthop Relat Res. 476:657–659. 2018. View Article : Google Scholar : PubMed/NCBI

44 

Greenland S, Mansournia MA and Altman DG: Sparse-data bias: A problem hiding in plain sight. BMJ. 352:i19812016. View Article : Google Scholar : PubMed/NCBI

45 

Vera-Llonch M, Oster G, Hagiwara M and Sonis S: Oral mucositis in patients undergoing radiation treatment for head and neck carcinoma. Cancer. 106:329–336. 2006. View Article : Google Scholar : PubMed/NCBI

46 

Wang C, Wang F, Min X, Zhang Q, Shen LJ, Jiang Y and Yan J: Toxicities of chemoradiotherapy and radiotherapy in nasopharyngeal carcinoma: An updated meta-analysis. J Int Med Res. 47:2832–2847. 2019. View Article : Google Scholar : PubMed/NCBI

47 

Xu YC, Chen KH, Liang ZG and Zhu XD: A systematic review and Meta-Analysis of studies comparing concurrent chemoradiotherapy with radiotherapy alone in the treatment of stage II Nasopharyngeal carcinoma. Front Oncol. 12:8436752022. View Article : Google Scholar : PubMed/NCBI

48 

Ma WL, Liu R, Huang LH, Zou C, Huang J, Wang J, Chen SJ, Meng XG, Yang JK, Li H, et al: Impact of polymorphisms in angiogenesis-related genes on clinical outcomes of radiotherapy in patients with nasopharyngeal carcinoma. Clin Exp Pharmacol Physiol. 44:539–548. 2017. View Article : Google Scholar : PubMed/NCBI

49 

Yang Z and Liu Z: Potentially functional variants of autophagy-related genes are associated with the efficacy and toxicity of radiotherapy in patients with Nasopharyngeal carcinoma. Mol Genet Genomic Med. 7:e10302019. View Article : Google Scholar : PubMed/NCBI

50 

Yu J, Huang Y, Liu L, Wang J, Yin J, Huang L, Chen S, Li J, Yuan H, Yang G, et al: Genetic polymorphisms of Wnt/β-catenin pathway genes are associated with the efficacy and toxicities of radiotherapy in patients with nasopharyngeal carcinoma. Oncotarget. 7:82528–82537. 2016. View Article : Google Scholar : PubMed/NCBI

51 

Guo C, Huang Y, Yu J, Liu L, Gong X, Huang M, Jiang C, Liao Y, Huang L, Yang G and Li J: The impacts of single nucleotide polymorphisms in genes of cell cycle and NF-kB pathways on the efficacy and acute toxicities of radiotherapy in patients with nasopharyngeal carcinoma. Oncotarget. 8:25334–25344. 2017. View Article : Google Scholar : PubMed/NCBI

52 

Andreassen CN, Schack LM, Laursen LV and Alsner J: Radiogenomics-current status, challenges and future directions. Cancer Lett. 382:127–136. 2016. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Zheng Y, Zong J, Chen Y, Guo J, Lu T, Xin X and Chen Y: Lack of association between XRCC1 SNPs and acute radiation‑induced injury or prognosis in patients with nasopharyngeal carcinoma. Oncol Lett 26: 544, 2023.
APA
Zheng, Y., Zong, J., Chen, Y., Guo, J., Lu, T., Xin, X., & Chen, Y. (2023). Lack of association between XRCC1 SNPs and acute radiation‑induced injury or prognosis in patients with nasopharyngeal carcinoma. Oncology Letters, 26, 544. https://doi.org/10.3892/ol.2023.14130
MLA
Zheng, Y., Zong, J., Chen, Y., Guo, J., Lu, T., Xin, X., Chen, Y."Lack of association between XRCC1 SNPs and acute radiation‑induced injury or prognosis in patients with nasopharyngeal carcinoma". Oncology Letters 26.6 (2023): 544.
Chicago
Zheng, Y., Zong, J., Chen, Y., Guo, J., Lu, T., Xin, X., Chen, Y."Lack of association between XRCC1 SNPs and acute radiation‑induced injury or prognosis in patients with nasopharyngeal carcinoma". Oncology Letters 26, no. 6 (2023): 544. https://doi.org/10.3892/ol.2023.14130
Copy and paste a formatted citation
x
Spandidos Publications style
Zheng Y, Zong J, Chen Y, Guo J, Lu T, Xin X and Chen Y: Lack of association between XRCC1 SNPs and acute radiation‑induced injury or prognosis in patients with nasopharyngeal carcinoma. Oncol Lett 26: 544, 2023.
APA
Zheng, Y., Zong, J., Chen, Y., Guo, J., Lu, T., Xin, X., & Chen, Y. (2023). Lack of association between XRCC1 SNPs and acute radiation‑induced injury or prognosis in patients with nasopharyngeal carcinoma. Oncology Letters, 26, 544. https://doi.org/10.3892/ol.2023.14130
MLA
Zheng, Y., Zong, J., Chen, Y., Guo, J., Lu, T., Xin, X., Chen, Y."Lack of association between XRCC1 SNPs and acute radiation‑induced injury or prognosis in patients with nasopharyngeal carcinoma". Oncology Letters 26.6 (2023): 544.
Chicago
Zheng, Y., Zong, J., Chen, Y., Guo, J., Lu, T., Xin, X., Chen, Y."Lack of association between XRCC1 SNPs and acute radiation‑induced injury or prognosis in patients with nasopharyngeal carcinoma". Oncology Letters 26, no. 6 (2023): 544. https://doi.org/10.3892/ol.2023.14130
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team