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Interaction between miR‑206 and lncRNA MALAT1 in regulating viability and invasion in hepatocellular carcinoma

  • Authors:
    • Jun Wang
    • Guoliang Yao
    • Beike Zhang
    • Zerui Zhao
    • Yonggang Fan
  • View Affiliations / Copyright

    Affiliations: Department of Hepatobiliary and Pancreatic Surgery, The First Affiliated Hospital, and College of Clinical Medicine of Henan University of Science and Technology, Luoyang, Henan 471003, P.R. China
    Copyright: © Wang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 5
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    Published online on: November 7, 2023
       https://doi.org/10.3892/ol.2023.14138
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Abstract

MicroRNAs (miRNAs) are strongly associated to the progression of hepatocellular carcinoma (HCC), which presents a high potential for diagnosis and treatment; however, the role of miRNAs is still largely unknown. The aim of the present study was to examine the expression and the biological role of miRNA (miR)‑206 in the development of HCC, and to identify the underlying molecular mechanism. Results from this study show that miR‑206 was significantly downregulated in HCC tissues and cell lines. It was observed that low expression of miR‑206 was linked to advanced TNM stage, tumor nodularity and venous infiltration in patients with HCC; low miR‑206 expression was associated with shorter survival times. miR‑206 overexpression using miR‑206 mimics notably decreased the proliferative ability and increased apoptosis of MHCC97‑H and HCCLM3 HCC cell lines. Overexpression of miR‑206 suppressed invasiveness associated with reduced epithelial‑mesenchymal transition. Moreover, the c‑Met oncogene, which is upregulated in HCC tissues, was negatively associated with the expression of miR‑206. Notably, it was shown that miR‑206 may exert its antitumor effect through suppressing c‑Met/Akt/mTOR signaling. Low expression of miR‑206 was shown to be regulated by lncRNA MALAT1 in HCC. Collectively, this study presented evidence that miR‑206 was controlled by lncRNA MALAT1 and partially suppressed the proliferation and invasion of HCC through the c‑Met/Akt/mTOR signaling pathway. According to these results, understanding MALAT1/miR‑206‑dependent regulation may lead to potential approaches for diagnosis and prospective treatment of HCC.
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Copy and paste a formatted citation
Spandidos Publications style
Wang J, Yao G, Zhang B, Zhao Z and Fan Y: Interaction between miR‑206 and lncRNA MALAT1 in regulating viability and invasion in hepatocellular carcinoma. Oncol Lett 27: 5, 2024.
APA
Wang, J., Yao, G., Zhang, B., Zhao, Z., & Fan, Y. (2024). Interaction between miR‑206 and lncRNA MALAT1 in regulating viability and invasion in hepatocellular carcinoma. Oncology Letters, 27, 5. https://doi.org/10.3892/ol.2023.14138
MLA
Wang, J., Yao, G., Zhang, B., Zhao, Z., Fan, Y."Interaction between miR‑206 and lncRNA MALAT1 in regulating viability and invasion in hepatocellular carcinoma". Oncology Letters 27.1 (2024): 5.
Chicago
Wang, J., Yao, G., Zhang, B., Zhao, Z., Fan, Y."Interaction between miR‑206 and lncRNA MALAT1 in regulating viability and invasion in hepatocellular carcinoma". Oncology Letters 27, no. 1 (2024): 5. https://doi.org/10.3892/ol.2023.14138
Copy and paste a formatted citation
x
Spandidos Publications style
Wang J, Yao G, Zhang B, Zhao Z and Fan Y: Interaction between miR‑206 and lncRNA MALAT1 in regulating viability and invasion in hepatocellular carcinoma. Oncol Lett 27: 5, 2024.
APA
Wang, J., Yao, G., Zhang, B., Zhao, Z., & Fan, Y. (2024). Interaction between miR‑206 and lncRNA MALAT1 in regulating viability and invasion in hepatocellular carcinoma. Oncology Letters, 27, 5. https://doi.org/10.3892/ol.2023.14138
MLA
Wang, J., Yao, G., Zhang, B., Zhao, Z., Fan, Y."Interaction between miR‑206 and lncRNA MALAT1 in regulating viability and invasion in hepatocellular carcinoma". Oncology Letters 27.1 (2024): 5.
Chicago
Wang, J., Yao, G., Zhang, B., Zhao, Z., Fan, Y."Interaction between miR‑206 and lncRNA MALAT1 in regulating viability and invasion in hepatocellular carcinoma". Oncology Letters 27, no. 1 (2024): 5. https://doi.org/10.3892/ol.2023.14138
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