Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Oncology Letters
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-1074 Online ISSN: 1792-1082
Journal Cover
January-2024 Volume 27 Issue 1

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
January-2024 Volume 27 Issue 1

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Case Report Open Access

Rectal ulcer associated with lenvatinib 15 years after definitive radiotherapy for prostate cancer: A case report

  • Authors:
    • Yujiro Kawata
    • Kenta Watanabe
    • Ryoji Tokiya
    • Yoshiyuki Miyaji
    • Akiko Shiotani
    • Kuniaki Katsui
  • View Affiliations / Copyright

    Affiliations: Department of Radiology, Kawasaki Medical School, Kurashiki, Okayama 701‑0192, Japan, Department of Urology, Kawasaki Medical School, Kurashiki, Okayama 701‑0192, Japan, Department of Gastroenterology and Hepatology, Kawasaki Medical School, Kurashiki, Okayama 701‑0192, Japan
    Copyright: © Kawata et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 6
    |
    Published online on: November 8, 2023
       https://doi.org/10.3892/ol.2023.14139
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Lenvatinib is a multi‑kinase inhibitor that blocks vascular endothelial growth factor, fibroblast growth factor and platelet‑derived growth factor receptors. The present study describes a case of rectal ulceration triggered by lenvatinib treatment for hepatocellular carcinoma 15 years after definitive radiotherapy for prostate cancer. A 58‑year‑old man underwent definitive external beam radiotherapy and high‑dose‑rate brachytherapy for prostate cancer. A total of 15 years after radiotherapy for prostate cancer, the patient was diagnosed with hepatocellular carcinoma with multiple metastases. Treatment with 12 mg/day lenvatinib was commenced. A total of 4 months after starting lenvatinib therapy, the patient experienced persistent anal pain with a deep ulceration of the anterior wall of the lower rectum. As the pain did not improve, the patient chose to undergo a colostomy, resulting in the resolution of the anorectal pain. To the best of our knowledge, the present case report is the first to report on lenvatinib‑induced rectal ulcers after radiotherapy.
View Figures

Figure 1

Figure 2

Figure 3

View References

1 

Motzer RJ, Taylor MH, Evans TRJ, Okusaka T, Glen H, Lubiniecki GM, Dutcus C, Smith AD, Okpara CE, Hussein Z, et al: Lenvatinib dose, efficacy, and safety in the treatment of multiple malignancies. Expert Rev Anticancer Ther. 22:383–400. 2022. View Article : Google Scholar : PubMed/NCBI

2 

Hao Z and Wang P: Lenvatinib in management of solid tumors. Oncologist. 25:e302–e310. 2020. View Article : Google Scholar : PubMed/NCBI

3 

Gore E, Currey A and Choong N: Tracheoesophageal fistula associated with bevacizumab 21 months after completion of radiation therapy. J Thorac Oncol. 4:1590–1591. 2009. View Article : Google Scholar : PubMed/NCBI

4 

Lordick F, Geinitz H, Theisen J, Sendler A and Sarbia M: Increased risk of ischemic bowel complications during treatment with bevacizumab after pelvic irradiation: Report of three cases. Int J Radiat Oncol Biol Phys. 64:1295–1298. 2006. View Article : Google Scholar : PubMed/NCBI

5 

Kozloff M, Yood MU, Berlin J, Flynn PJ, Kabbinavar FF, Purdie DM, Ashby MA, Dong W, Sugrue MM, Grothey A, et al: Clinical outcomes associated with bevacizumab-containing treatment of metastatic colorectal cancer: The BRiTE observational cohort study. Oncologist. 14:862–870. 2009. View Article : Google Scholar : PubMed/NCBI

6 

Basille D, Andrejak M, Bentayeb H, Kanaan M, Fournier C, Lecuyer E, Boutemy M, Garidi R, Douadi Y and Dayen C: Bronchial fistula associated with sunitinib in a patient previously treated with radiation therapy. Ann Pharmacother. 44:383–386. 2010. View Article : Google Scholar : PubMed/NCBI

7 

Peters NA, Richel DJ, Verhoeff JJ and Stalpers LJ: Bowel perforation after radiotherapy in a patient receiving sorafenib. J Clin Oncol. 26:2405–2406. 2008. View Article : Google Scholar : PubMed/NCBI

8 

Jo Y, Hiratsuka J, Fujii T, Takenaka A and Fujisawa M: High-dose-rate iridium-192 afterloading therapy combined with external beam radiotherapy for T1c-T3bN0M0 prostate cancer. Urology. 64:556–560. 2004. View Article : Google Scholar : PubMed/NCBI

9 

Wachsberger P, Burd R and Dicker AP: Tumor response to ionizing radiation combined with antiangiogenesis or vascular targeting agents: Exploring mechanisms of interaction. Clin Cancer Res. 9:1957–1971. 2003.PubMed/NCBI

10 

Kleibeuker EA, Ten Hooven MA, Verheul HM, Slotman BJ and Thijssen VL: Combining radiotherapy with sunitinib: lessons (to be) learned. Angiogenesis. 18:385–395. 2015. View Article : Google Scholar : PubMed/NCBI

11 

Schlumberger M, Tahara M, Wirth LJ, Robinson B, Brose MS, Elisei R, Habra MA, Newbold K, Shah MH, Hoff AO, et al: Lenvatinib versus placebo in radioiodine-refractory thyroid cancer. N Engl J Med. 372:621–630. 2015. View Article : Google Scholar : PubMed/NCBI

12 

Ishiyama H, Kamitani N, Kawamura H, Kato S, Aoki M, Kariya S, Matsumura T, Kaidu M, Yoshida K, Hashimoto Y, et al: Nationwide multi-institutional retrospective analysis of high-dose-rate brachytherapy combined with external beam radiotherapy for localized prostate cancer: An Asian Prostate HDR-BT Consortium. Brachytherapy. 16:503–510. 2017. View Article : Google Scholar : PubMed/NCBI

13 

Clark BG, Souhami L, Roman TN, Chappell R, Evans MD and Fowler JF: The prediction of late rectal complications in patients treated with high dose-rate brachytherapy for carcinoma of the cervix. Int J Radiat Oncol Biol Phys. 38:989–993. 1997. View Article : Google Scholar : PubMed/NCBI

14 

Nakano T, Kato S, Ohno T, Tsujii H, Sato S, Fukuhisa K and Arai T: Long-term results of high-dose rate intracavitary brachytherapy for squamous cell carcinoma of the uterine cervix. Cancer. 103:92–101. 2005. View Article : Google Scholar : PubMed/NCBI

15 

Pollom EL, Deng L, Pai RK, Brown JM, Giaccia A, Loo BW Jr, Shultz DB, Le QT, Koong AC and Chang DT: Gastrointestinal toxicities with combined antiangiogenic and stereotactic body radiation therapy. Int J Radiat Oncol Biol Phys. 92:568–576. 2015. View Article : Google Scholar : PubMed/NCBI

16 

Zips D, Eicheler W, Geyer P, Hessel F, Dörfler A, Thames HD, Haberey M and Baumann M: Enhanced susceptibility of irradiated tumor vessels to vascular endothelial growth factor receptor tyrosine kinase inhibition. Cancer Res. 65:5374–5379. 2005. View Article : Google Scholar : PubMed/NCBI

17 

Metcalfe C, Kljavin NM, Ybarra R and de Sauvage FJ: Lgr5+ stem cells are indispensable for radiation-induced intestinal regeneration. Cell Stem Cell. 14:149–159. 2014. View Article : Google Scholar : PubMed/NCBI

18 

Valerio L, Giani C, Agate L, Molinaro E, Viola D, Bottici V, Matrone A, Puleo L, Lorusso L, Cappagli V, et al: Prevalence and risk factors of developing fistula or organ perforation in patients treated with lenvatinib for radioiodine-refractory thyroid cancer. Eur Thyroid J. 10:399–407. 2021. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Kawata Y, Watanabe K, Tokiya R, Miyaji Y, Shiotani A and Katsui K: Rectal ulcer associated with lenvatinib 15 years after definitive radiotherapy for prostate cancer: A case report. Oncol Lett 27: 6, 2024.
APA
Kawata, Y., Watanabe, K., Tokiya, R., Miyaji, Y., Shiotani, A., & Katsui, K. (2024). Rectal ulcer associated with lenvatinib 15 years after definitive radiotherapy for prostate cancer: A case report. Oncology Letters, 27, 6. https://doi.org/10.3892/ol.2023.14139
MLA
Kawata, Y., Watanabe, K., Tokiya, R., Miyaji, Y., Shiotani, A., Katsui, K."Rectal ulcer associated with lenvatinib 15 years after definitive radiotherapy for prostate cancer: A case report". Oncology Letters 27.1 (2024): 6.
Chicago
Kawata, Y., Watanabe, K., Tokiya, R., Miyaji, Y., Shiotani, A., Katsui, K."Rectal ulcer associated with lenvatinib 15 years after definitive radiotherapy for prostate cancer: A case report". Oncology Letters 27, no. 1 (2024): 6. https://doi.org/10.3892/ol.2023.14139
Copy and paste a formatted citation
x
Spandidos Publications style
Kawata Y, Watanabe K, Tokiya R, Miyaji Y, Shiotani A and Katsui K: Rectal ulcer associated with lenvatinib 15 years after definitive radiotherapy for prostate cancer: A case report. Oncol Lett 27: 6, 2024.
APA
Kawata, Y., Watanabe, K., Tokiya, R., Miyaji, Y., Shiotani, A., & Katsui, K. (2024). Rectal ulcer associated with lenvatinib 15 years after definitive radiotherapy for prostate cancer: A case report. Oncology Letters, 27, 6. https://doi.org/10.3892/ol.2023.14139
MLA
Kawata, Y., Watanabe, K., Tokiya, R., Miyaji, Y., Shiotani, A., Katsui, K."Rectal ulcer associated with lenvatinib 15 years after definitive radiotherapy for prostate cancer: A case report". Oncology Letters 27.1 (2024): 6.
Chicago
Kawata, Y., Watanabe, K., Tokiya, R., Miyaji, Y., Shiotani, A., Katsui, K."Rectal ulcer associated with lenvatinib 15 years after definitive radiotherapy for prostate cancer: A case report". Oncology Letters 27, no. 1 (2024): 6. https://doi.org/10.3892/ol.2023.14139
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team